Chief Medical Officer

Company Overview TwoStep Therapeutics is a biotechnology company developing a pipeline built around a unique tumor-targeting polyspecific integrin-binding peptide (PIP) that can selectively bind several targets that are highly expressed on solid tumors. This multi-targeting feature enables the agent’s broad applicability to a wide range of tumor types and patient populations, overcoming the limitations of single-antigen targeting approaches. The company has leveraged this technology to create a pipeline of targeted cancer therapies for cytotoxic drug delivery and radioligand therapy. TwoStep Therapeutics was co-founded by CEO, Caitlyn Miller, in collaboration with leading academic entrepreneurs at Stanford University, including Nobel Laureate Carolyn Bertozzi, Jennifer Cochran, and Ronald Levy. For more information, visit www.twosteptx.com http://www.twosteptx.com or download our 2025 scientific poster (linked here https://docsend.com/view/huarxpbsngwuui28). Position Overview We are seeking a Chief Medical Officer (CMO) to oversee and advance a differentiated pipeline of targeted drug conjugates and radioligand therapies designed to address high unmet needs across multiple solid tumor indications. The ideal candidate is a proven cross-functional development leader with experience advancing targeted oncology modalities (e.g., ADCs, peptide-drug conjugates, radioligands) from IND-enabling through late-stage clinical development. Key Responsibilities - Lead the overarching clinical development strategy and execution for the pipeline, ensuring seamless alignment with corporate goals, scientific innovation, and long-term patient impact. - Serve as the primary medical expert for novel therapeutics to deliver rigorous, high-quality clinical, scientific, and regulatory outcomes. - Collaborate closely with R&D, and external partners to align clinical strategies with corporate priorities, manufacturing capabilities, and development plans. - Lead the preparation, review, and submission of critical regulatory documents (e.g., protocols, Investigator's Brochures) to enable efficient early-phase clinical development. - Cultivate and maintain relationships with Key Opinion Leaders (KOLs), academic investigators, advisory boards, CROs, and trial sites. - Engage effectively with investors, board members, and external stakeholders to communicate program progress, scientific rationale, and strategic value. Essential Qualifications - Education: MD with board certification in a relevant specialty (e.g., oncology, nuclear medicine, radiation oncology, or related therapeutic area). - 15+ years of progressive clinical leadership experience in the biotech or pharmaceutical industry, with a demonstrated track record of successfully advancing novel therapeutics from preclinical/early clinical stages through pivotal development. - Proven expertise in global regulatory interactions, including successful submissions, negotiations, and approvals with major agencies (FDA, EMA, and others) across early and late-stage programs. - Prior experience in a CMO, senior VP of Clinical Development, or equivalent medical leadership role in a biotech or pharmaceutical organization, ideally in a fast-paced, innovative environment. - Hands-on, execution-oriented mindset with a willingness to actively contribute to pipeline advancement, including protocol design, data interpretation, and cross-functional problem-solving. - Exceptional scientific judgment, strategic thinking, and communication skills Preferred Qualifications - Expertise with drug conjugates (i.e., peptide-drug conjugates, ADCs) and/or radioligand programs What We Offer At TwoStep Therapeutics, we envision a future where every cancer patient has access to targeted, safe, and effective therapeutic options. We prioritize a diverse, inclusive work environment that fosters personal and professional growth. Our comprehensive benefits include: - Competitive base salary, performance bonuses, and equity compensation - Unlimited Paid Time Off (PTO) - Comprehensive medical, dental, and vision benefits for individuals and families - 401(k) plan - Company-paid basic life insurance Equal Opportunity Employer TwoStep Therapeutics is an equal opportunity employer. We prohibit unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law. If you require assistance in submitting an application due to incompatible assistive technology or a disability, please contact us at hiring@twosteptx.com. We are committed to accommodating your needs promptly. Join Us If you are passionate about advancing cancer therapies and want to make a meaningful impact in the field, we invite you to apply for the Chief Medical Officer position at TwoStep Therapeutics. Together, we can shape the future of cancer treatment.