Associate Director, Translational Biology

<p><strong><span data-contrast="auto">What if…</span></strong><span data-contrast="auto"> you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies to transform health care and sustainability?</span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></p> <p><span data-contrast="auto">Flagship Labs 101 (FL101) is a stealth, Series A funded biotechnology company with a mission to discover and develop therapeutics through the lens of cell-cell contact. We are seeking an experienced Associate Director to lead target validation efforts and mechanistic strategy development, while designing and executing novel therapeutic discovery programs. This role requires a scientist who can provide scientific and technical leadership while maintaining an active presence at the bench, bridging target biology with drug discovery, translating biological insights into actionable therapeutic strategies. This is a unique opportunity to be one of the early employees of a biotech startup that combines an innovative mindset with the resources and know-how of Flagship Pioneering.</span><span data-ccp-props="{"201341983":0,"335559740":276}"> </span></p> <p><strong><span data-contrast="auto">Key Responsibilities</span></strong><span data-ccp-props="{"201341983":0,"335559740":276}"> </span></p> <p><strong><span data-contrast="auto">Target Validation & Mechanistic Strategy</span></strong><span data-ccp-props="{"201341983":0,"335559740":276}"> </span></p> <ul> <li data-leveltext="" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto">Lead comprehensive target validation efforts using disease-relevant model systems to establish therapeutic rationale</span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":276}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="2" data-aria-level="1"><span data-contrast="auto">Design and oversee mechanistic studies to understand target biology, pathway dependencies, and potential for therapeutic intervention</span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":276}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="3" data-aria-level="1"><span data-contrast="auto">Develop validation strategies that integrate genetic, pharmacological, and functional approaches</span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":276}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="4" data-aria-level="1"><span data-contrast="auto">Establish target product profiles and go/no-go criteria for therapeutic programs</span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":276}"> </span></li> </ul> <p><strong><span data-contrast="auto">Therapeutic Discovery Program Leadership</span></strong><span data-ccp-props="{"201341983":0,"335559740":276}"> </span></p> <ul> <li data-leveltext="" data-font="Symbol" data-listid="8" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto">Design and execute end-to-end therapeutic discovery programs from target identification through lead optimization</span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":276}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="8" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="2" data-aria-level="1"><span data-contrast="auto">Define program strategy, milestones, and success criteria in collaboration with cross-functional teams</span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":276}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="8" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="3" data-aria-level="1"><span data-contrast="auto">Oversee experimental design and data interpretation to drive program advancement</span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":276}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="8" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="4" data-aria-level="1"><span data-contrast="auto">Present program updates and strategic recommendations to senior leadership</span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":276}"> </span></li> </ul> <p><strong><span data-contrast="auto">Scientific Leadership</span></strong><span data-ccp-props="{"201341983":0,"335559740":276}"> </span></p> <ul> <li data-leveltext="" data-font="Symbol" data-listid="3" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto">Supervise and mentor scientists and research associates in target validation and disease modeling</span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":276}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="3" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="2" data-aria-level="1"><span data-contrast="auto">Foster collaboration across discovery biology, translational science, and drug discovery teams</span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":276}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="3" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="3" data-aria-level="1"><span data-contrast="auto">Stay current with emerging technologies and scientific literature to enhance discovery capabilities</span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":276}"> </span></li> </ul> <p><strong><span data-contrast="auto">Required Qualifications</span></strong><span data-ccp-props="{"201341983":0,"335559740":276}"> </span></p> <ul> <li data-leveltext="" data-font="Symbol" data-listid="4" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto">Advanced degree in biology, pharmacology, immunology, or related field with PhD plus 5 years experience in biotech or pharma, or MS plus 10 years. </span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":276}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="4" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="2" data-aria-level="1"><span data-contrast="auto">Minimum of 3-4 years in a leadership capacity leading project or program teams and experience mentoring direct reports.</span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":276}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="4" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="3" data-aria-level="1"><span data-contrast="auto">Proven track record of leading target validation efforts and contributing to therapeutic program advancement</span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":276}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="4" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="4" data-aria-level="1"><span data-contrast="auto">Strong understanding of drug discovery principles and translational medicine</span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":276}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="4" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="5" data-aria-level="1"><span data-contrast="auto">Experience designing and interpreting complex biological studies with clear decision-making frameworks</span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":276}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="4" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="6" data-aria-level="1"><span data-contrast="auto">Demonstrated ability to think critically, solve problems independently, and drive projects forward</span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":276}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="4" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="7" data-aria-level="1"><span data-contrast="auto">Excellent communication skills with ability to influence cross-functional stakeholders</span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":276}"> </span></li> </ul> <p><strong><span data-contrast="auto">Preferred Qualifications</span></strong><span data-ccp-props="{"201341983":0,"335559740":276}"> </span></p> <ul> <li data-leveltext="" data-font="Symbol" data-listid="5" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto">Hands-on experience with primary cell culture systems and functional assays</span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":276}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="5" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="2" data-aria-level="1"><span data-contrast="auto">Expertise in 3D cell culture models (organoids, spheroids, tissue-engineered constructs)</span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":276}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="5" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="3" data-aria-level="1"><span data-contrast="auto">Proficiency with iPSC-derived cellular models and differentiation protocols</span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":276}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="5" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="4" data-aria-level="1"><span data-contrast="auto">Experience integrating multi-omic approaches (genomics, transcriptomics, proteomics) into target validation</span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":276}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="5" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="5" data-aria-level="1"><span data-contrast="auto">Track record of publications in peer-reviewed journals</span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":276}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="5" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="6" data-aria-level="1"><span data-contrast="auto">Disease area expertise across areas such as inflammatory disorders, fibrosis, or oncology</span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":276}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="5" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="7" data-aria-level="1"><span data-contrast="auto">Stays current with AI/ML tools that accelerate target and drug discovery workflows.</span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":276}"> </span></li> </ul> <p><strong><span data-contrast="auto">Recruitment & Staffing Agencies:</span></strong><span data-contrast="auto"> </span><em><span data-contrast="auto">Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.</span></em><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></p><p id="pay-transparency" style="margin: 0 !important; padding: 0 !important; float: none !important; clear: both !important; display: block;">The salary range for this role is $154,000 - $203,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. FL101 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL101's good faith estimate as of the date of publication and may be modified in the future.</p>