Associate Director, Research Operations

<div class="content-intro"><p><strong><u>About Stoke:</u></strong></p> <p>Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary approach, the company is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights</p> <p>STK-002 is Stoke’s proprietary antisense oligonucleotide (ASO) in clinical development for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. STK-002 has been granted orphan drug designation by the FDA. A Phase 1 study (OSPREY) of STK-002 in people with ADOA is now underway. The company is also conducting early research in Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals.</p> <p>Stoke’s initial focus is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company’s proprietary approach.</p></div><p><strong><u>Position Purpose:</u></strong></p> <p>The Associate Director / Director, Research Operations will serve as a strategic and operational partner to Research leadership, enabling efficient execution of the Research portfolio through strong governance support, portfolio and resource management, and effective vendor oversight. This role will drive rigor, transparency, and operational excellence across Research programs while allowing scientific teams to focus on discovery and innovation. This position will report into the SVP and Head of Research. </p> <p><strong><u>Key Responsibilities:</u></strong></p> <p><strong><em>Research Team & Governance Support</em></strong></p> <ul> <li>Serve as the operational lead for Research team forums, including agenda development, coordination of meeting materials, minutes, and action tracking</li> <li>Plan, coordinate, and execute Scientific & Technical Review Committee (STRC) and other Research governance meetings</li> <li>Partner with Research leadership to ensure effective decision-making, clear documentation, and follow-through on priorities</li> <li>Own Research calendaring, cadence planning, and cross-functional coordination related to governance activities</li> </ul> <p><strong><em>Research Portfolio & Program Management</em></strong></p> <ul> <li>Provide project and portfolio management support across the Research portfolio</li> <li>In partnership with Research Leads, support the development and maintenance of integrated timelines, milestones, and dependencies across Research programs</li> <li>Support resource planning and capacity assessments in collaboration with Research leadership</li> <li>Identify risks, opportunities for acceleration, and scenario-based tradeoffs across the portfolio</li> <li>Prepare portfolio views and summaries to support leadership decision-making</li> </ul> <p><strong><em>Vendor Management & Outsourcing Oversight</em></strong></p> <ul> <li>Support vendor strategy, selection, and oversight for Research-related outsourced activities</li> <li>Coordinate CRO selection processes, including RFP development, evaluation, and onboarding</li> <li>Identify and support sourcing of external capabilities (e.g., NHP sourcing, specialized assays, academic collaborations)</li> <li>Partner with Procurement, Legal, and Finance to support contracting, budgeting, and vendor performance tracking</li> <li>Monitor vendor deliverables, timelines, and issue resolution in collaboration with scientific leads </li> </ul> <p><strong><u>Required Skills & Experience: </u></strong></p> <ul> <li>6–10+ years of experience in Research Operations, Project Management, or scientific program management within biotech or pharma</li> <li>Strong project management skills, including timeline development, risk management, and resource planning</li> <li>Experience working with external vendors, CROs, and research service providers</li> <li>Ability to translate complex scientific plans into clear operational frameworks and execution plans</li> <li>Exceptional organizational, communication, and stakeholder management skills</li> <li>High degree of judgment, discretion, and comfort operating in a fast-paced, evolving research environment</li> <li>Proficiency with project management and collaboration tools (e.g., MS Project, Smartsheet, PowerPoint, Teams/SharePoint)  </li> </ul> <p><strong><u>Location(s): </u></strong></p> <p>Stoke is located in Bedford, MA, and will be moving to a new location in Waltham, MA by the end of 2026. This position is a hybrid position currently based in Bedford and will later be based in Waltham.</p> <p><strong><u>Travel:</u></strong></p> <p>This position will require approximately 5% travel.</p> <p><strong><u>Compensation & Benefits:</u></strong></p> <p>At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program.</p> <p>The anticipated salary range for this role is $192,000 - $218,000.<strong> </strong>The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation.</p> <p>Our benefits package includes medical, dental and vision insurance; life, long- and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP).</p><div class="content-conclusion"><p><strong><u>Culture & Values:</u></strong></p> <p>At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.</p> <p>Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do. </p> <p><strong>Interested candidates: Please visit Stoke’s website to learn more and apply directly to the position listed on our Career Center:</strong></p> <p><a href="https://www.stoketherapeutics.com/careers/">https://www.stoketherapeutics.com/careers/</a></p> <p>For more information, visit https://www.stoketherapeutics.com/.</p> <p>All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.</p> <p>Stoke participates in E-Verify.</p></div>