Associate Director, Data Management

 

Why Join Us?

As a member of the Parabilis Medicines team, you will be a part of an organization dedicated to creating extraordinary medicines for diseases with urgent unmet needs, harnessing our proprietary peptide platform to transform treatment possibilities for patients. Parabilis is a clinical-stage biopharmaceutical company dedicated to unlocking high-impact protein targets long-considered undruggable. The company has developed a new class of stabilized, cell-penetrant alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that are inaccessible to traditional drug modalities.

Headquartered in Cambridge, Mass., Parabilis is advancing a focused pipeline of multiple first-in-class therapies across both rare and common cancers. Its lead asset, zolucatetide (FOG-001), is a first-in-class, clinically validated direct inhibitor of the interaction between β-catenin and the T-cell factor (TCF) family of transcription factors, implicated in millions of cancer cases annually, including in colorectal cancer, desmoid tumors, hepatocellular carcinoma and a range of other Wnt/β-catenin-driven tumors. In Phase 1 clinical trials, zolucatetide produced the first-ever clinical evidence that it can directly inhibit this interaction, once previously considered “undruggable” despite its role across multiple cancer types. Parabilis is also advancing investigational degraders of ERG and ARON into clinical development for the treatment of prostate cancer, as well as progressing other preclinical programs. Backed by a recent $305 million Series F financing, Parabilis is entering an exciting phase of growth and execution.

What’s the opportunity?

The Associate Director, Data Management provides strategic and operational leadership for clinical data management activities across one or more clinical programs. This role is critical to ensuring the integrity, quality, and timely delivery of clinical trial data to support regulatory submissions and key development decisions.  This is a very hands-on role with the clinical data while utilizing an outsourcing model.

You will partner closely with cross-functional teams including Clinical Operations, Biostatistics, Regulatory, and external vendors, serving as a key leader within Biometrics. This position offers the opportunity to influence data management strategy, drive process improvements, and contribute to the successful execution of Parabilis’ growing clinical pipeline.

Key responsibilities:

• Provide strategic leadership and oversight of data management activities across multiple clinical programs, ensuring high-quality, inspection-ready data deliverables.
• Lead and develop data management staff while fostering collaboration across internal teams and external partners, including CROs and vendors.
• Oversee the end-to-end data management lifecycle, including study start-up, database build, data review, and database lock.
• Drive vendor oversight, study execution, and cross-functional coordination to ensure timelines, budgets, and quality expectations are met.
• Establish and enhance data management standards, SOPs, and processes to ensure compliance with GCP, ICH, and regulatory requirements.
• Provide strategic input into resource planning, budgeting, and continuous improvement initiatives across the function.

What you’ll need to be successful:

• Bachelor’s degree (or higher) in life sciences, mathematics, or related field.
• 10+ years of clinical data management experience in biotech, pharmaceutical, or CRO environments.
• Demonstrated experience leading multiple studies and/or programs, including vendor oversight.
• Prior people management experience strongly preferred.
• Previous experience leading a Phase 3 trial and interactions or readiness for Health Authority interactions
• Strong knowledge of GCP, ICH guidelines, FDA regulations, and clinical data standards.
• Experience with EDC systems (e.g., Veeva, Medidata RAVE) and CDISC standards (CDASH, SDTM, ADaM).
• Experience working with data visualization and query tools
• Proven leadership, strategic thinking, and problem-solving skills.
• Excellent communication and cross-functional collaboration abilities.
• Demonstrated ability to utilize AI tools for day-to-day work; baseline proficiency is expected, and advanced or innovative use of AI is a strong plus.

Core Values

Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Growth-Minded. We’re inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.
• In(ter)dependent. We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.
• Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• All-In. We’re All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.

The base salary range for this position is $165,000-$210,000, depending on experience, qualifications, and internal practices. Parabilis’s total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees’ overall well-being.

As an equal opportunity employer, Parabilis Medicines values an inclusive workplace and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive    |     Cambridge, MA 02140    |    www.parabilismed.com