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Weight Gain

5
Pipeline Programs
9
Companies
13
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
2
0
1
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Peptide
2100%
+ 12 programs with unclassified modality

Competitive Landscape

9 companies ranked by most advanced pipeline stage

Prevail Therapeutics
4 programs
1
2
ExenatidePhase 4Peptide1 trial
olanzapinePhase 41 trial
zonisamidePhase 31 trial
Olanzapine plus modafinilN/A1 trial
Active Trials
NCT00636896Completed50Est. Aug 2007
NCT00363376Completed42Est. Feb 2011
NCT00845507Completed54Est. Jul 2015
+1 more trials
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
2 programs
1
Dose escalation to 2 mg semaglutide weekly then semaglutide microdosing at 0.5 mg weeklyPhase 2Peptide1 trial
Plant based toddler nutritionN/A1 trial
Active Trials
NCT05576870Unknown128Est. May 2023
NCT07325500Recruiting30Est. Jun 2029
Medical 21
Medical 21MN - Minneapolis
1 program
1
chromium piccolinatePhase 21 trial
Active Trials
NCT00759993Terminated60Est. Mar 2013
Innovation Pharmaceuticals
2 programs
Fluid intake appN/A1 trial
Fluid intake appN/A1 trial
Active Trials
NCT03759847Completed28Est. Sep 2023
NCT04194164Completed33Est. Nov 2021
Impact Therapeutics
Impact TherapeuticsChina - Shanghai
1 program
Egg interventionN/A1 trial
Active Trials
NCT04694235Active Not Recruiting702Est. Sep 2024
IQVIA
IQVIADURHAM, NC
1 program
New Infant FormulaN/A1 trial
Active Trials
NCT05508750Completed420Est. Jan 2024
Baxter
BaxterCosta Rica - Cartago
1 program
Numeta G13N/A
Baxter International
1 program
Numeta G13N/A1 trial
Active Trials
NCT04168749Unknown200Est. May 2020
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
1 program
Relation of Consummatory and Anticipatory Food Reward to ObesityN/A1 trial
Active Trials
NCT01807572Completed162Est. Jul 2015

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
Prevail TherapeuticsExenatide
Prevail Therapeuticsolanzapine
Prevail Therapeuticszonisamide
Colorado TherapeuticsDose escalation to 2 mg semaglutide weekly then semaglutide microdosing at 0.5 mg weekly
Medical 21chromium piccolinate
Colorado TherapeuticsPlant based toddler nutrition
IQVIANew Infant Formula
Impact TherapeuticsEgg intervention
Innovation PharmaceuticalsFluid intake app
Baxter InternationalNumeta G13
Innovation PharmaceuticalsFluid intake app
Oregon TherapeuticsRelation of Consummatory and Anticipatory Food Reward to Obesity
Prevail TherapeuticsOlanzapine plus modafinil

Clinical Trials (13)

Total enrollment: 1,969 patients across 13 trials

NCT00845507Prevail TherapeuticsExenatide

Exenatide for the Treatment of Weight Gain Associated With Olanzapine in Obese Adults

Start: Dec 2008Est. completion: Jul 201554 patients
Phase 4Completed
NCT00191828Prevail Therapeuticsolanzapine

A Study on Induced Weight Gain During Atypical Antipsychotic Treatment and Its Management With Psychoeducational Programme

Start: Mar 2003Est. completion: Aug 200560 patients
Phase 4Completed
NCT00363376Prevail Therapeuticszonisamide

A Study of Zonisamide to Prevent Olanzapine-Associated Weight Gain

Start: Jan 2008Est. completion: Feb 201142 patients
Phase 3Completed
NCT07325500Colorado TherapeuticsDose escalation to 2 mg semaglutide weekly then semaglutide microdosing at 0.5 mg weekly

Incretin Microdosing for Cardiometabolic Health in People With HIV

Start: Feb 2026Est. completion: Jun 202930 patients
Phase 2Recruiting
NCT00759993Medical 21chromium piccolinate

Chromium Piccolinate in the Prevention of Weight Gain Induced by Serotonergic Medications Initiated on Psychiatric Inpatient Units.

Start: Sep 2008Est. completion: Mar 201360 patients
Phase 2Terminated
NCT05576870Colorado TherapeuticsPlant based toddler nutrition

Growth Study Using Else Toddler Nutritional Drink vs. a. Dairy Based Toddler Drink (Control) in Healthy Toddlers

Start: Oct 2022Est. completion: May 2023128 patients
N/AUnknown
NCT05508750IQVIANew Infant Formula

Growth and Safety Clinical Trial on a New Infant Formula

Start: Sep 2022Est. completion: Jan 2024420 patients
N/ACompleted
NCT04694235Impact TherapeuticsEgg intervention

Egg Intervention During Pregnancy in Indonesia

Start: Feb 2021Est. completion: Sep 2024702 patients
N/AActive Not Recruiting
NCT04194164Innovation PharmaceuticalsFluid intake app

Development of Fluid Intake App for Management of Fluid Intake During Hemodialysis , Full Scale Trial

Start: Dec 2019Est. completion: Nov 202133 patients
N/ACompleted
NCT04168749Baxter InternationalNumeta G13

Efficacy and Safety of Industrially Prepared 3 Chamber Bag Parenteral Nutrition for Premature Infant

Start: Nov 2019Est. completion: May 2020200 patients
N/AUnknown
NCT03759847Innovation PharmaceuticalsFluid intake app

Development of Fluid Intake App for Management of Fluid Intake During Hemodialysis

Start: Jan 2019Est. completion: Sep 202328 patients
N/ACompleted
NCT01807572Oregon TherapeuticsRelation of Consummatory and Anticipatory Food Reward to Obesity

Relation of Consummatory and Anticipatory Food Reward to Obesity

Start: Jun 2009Est. completion: Jul 2015162 patients
N/ACompleted
NCT00636896Prevail TherapeuticsOlanzapine plus modafinil

Effects of Modafinil on Olanzapine Weight Gain

Start: Jul 2006Est. completion: Aug 200750 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 1,969 patients
9 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.