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Volunteers

3
Pipeline Programs
5
Companies
5
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
0
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
267%
Vaccine
133%
+ 1 programs with unclassified modality

Competitive Landscape

3 companies ranked by most advanced pipeline stage

Syndax Pharmaceuticals
2 programs
2
EntinostatPhase 1Small Molecule1 trial
entinostatPhase 1Small Molecule1 trial
Active Trials
NCT02922946Completed47Est. Jun 2017
NCT02922933Completed66Est. May 2017
BioAegis Therapeutics
BioAegis TherapeuticsNJ - North Brunswick
1 program
1
Recombinant human plasma gelsolinPhase 11 trial
Active Trials
NCT05789745Completed32Est. May 2023
Sanofi
SanofiPARIS, France
1 program
Flu VaccinePHASE_4Vaccine2 trials
Active Trials
NCT06824779Active Not Recruiting30Est. Mar 2026
NCT01666782Completed105Est. Dec 2015

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
SanofiFlu Vaccine
SanofiFlu Vaccine
BioAegis TherapeuticsRecombinant human plasma gelsolin
Syndax Pharmaceuticalsentinostat
Syndax PharmaceuticalsEntinostat

Clinical Trials (5)

Total enrollment: 280 patients across 5 trials

NCT06824779SanofiFlu Vaccine

Impact of FLU Vaccination on Nasal Resident Memory Immune Responses and Peripheral Respiratory-tropic Memory Immune Responses

Start: Dec 2025Est. completion: Mar 202630 patients
Phase 4Active Not Recruiting
NCT01666782SanofiFlu Vaccine

Study Comparing High-Dose Flu Vaccine to Standard Vaccine in Cancer Patients Less Than 65 Receiving Chemotherapy

Start: Aug 2012Est. completion: Dec 2015105 patients
Phase 2Completed
NCT05789745BioAegis TherapeuticsRecombinant human plasma gelsolin

A Study to Evaluate Plasma Gelsolin in Healthy Volunteers

Start: Mar 2023Est. completion: May 202332 patients
Phase 1Completed
NCT02922933Syndax Pharmaceuticalsentinostat

A Study to Examine the Effect of Omeprazole, Famotidine, and an Acidic Beverage on the Pharmacokinetics of Entinostat in Healthy Adult Subjects

Start: Oct 2016Est. completion: May 201766 patients
Phase 1Completed
NCT02922946Syndax PharmaceuticalsEntinostat

Study to Determine the Effect of the Timing of a Meal on the Pharmacokinetics of Entinostat

Start: Oct 2016Est. completion: Jun 201747 patients
Phase 1Completed

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

Small Molecule is the dominant modality (67% of programs)
5 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.