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Venous Leg Ulcer

7
Pipeline Programs
19
Companies
25
Clinical Trials
3 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
1
2
0
1
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

19 companies ranked by most advanced pipeline stage

Eppendorf
EppendorfGermany - Hamburg
1 program
1
Concurrent optical and magnetic stimulationPhase 41 trial
Active Trials
NCT06528873Recruiting122Est. Sep 2026
RHEACELL
RHEACELLGermany - Heidelberg
1 program
1
allo-APZ2-CVUPhase 31 trial
Active Trials
NCT06489028Active Not Recruiting250Est. Sep 2027
SolasCure
SolasCureUK - Cambridge
1 program
1
Aurase Wound gelPhase 21 trial
Active Trials
NCT04956900Completed43Est. Feb 2023
Energenesis Biomedical
Energenesis BiomedicalTaiwan - Taipei
1 program
1
ENERGI-F703 GELPhase 21 trial
Active Trials
NCT04078555Unknown80Est. Jun 2025
Xintela
XintelaSweden - Lund
1 program
1
XSTEM-VLUPhase 1/21 trial
Active Trials
NCT05549609Recruiting6Est. Oct 2025
Biocorp
BiocorpFrance - Issoire
1 program
1
GranexinPhase 11 trial
Active Trials
NCT02652572Completed10Est. May 2018
Xequel Bio
Xequel BioSC - Mount Pleasant
1 program
1
GranexinPhase 1
ConvaTec
ConvaTecNJ - Bridgewater
2 programs
AQUACEL® Ag+ Extra™N/A1 trial
AQUACEL® Ag+ Extra™ vs Cutimed® Sorbact®N/A1 trial
Active Trials
NCT05892341Completed203Est. Feb 2024
NCT07308678Completed105Est. May 2025
Organogenesis
OrganogenesisCANTON, MA
2 programs
AffinityN/A1 trial
DermagraftPHASE_31 trial
Active Trials
NCT04901013Unknown200Est. Jun 2023
NCT00909870Completed537Est. Aug 2011
Coloplast
ColoplastAustralia - Mulgrave
2 programs
Biatain Fiber Ag applied to participantsN/A1 trial
Biatain® SiliconeN/A1 trial
Active Trials
NCT05873257Completed50Est. May 2024
NCT05786612Completed102Est. Dec 2023
Tactile Medical
Tactile MedicalMN - Minneapolis
2 programs
Dual Action Pneumatic CompressionN/A1 trial
Dual Action Pneumatic Compression DeviceN/A1 trial
Active Trials
NCT02395302Completed28Est. Nov 2015
NCT02680834Terminated56Est. Jun 2017
Omeza
OmezaFL - Sarasota
2 programs
Omeza® OCM™N/A1 trial
Wound dressingN/A1 trial
Active Trials
NCT05291169Completed54Est. Mar 2024
NCT04198441Unknown78Est. Dec 2021
MediWound
MediWoundYAVNE, Israel
2 programs
EscharExPHASE_21 trial
EscharExPHASE_21 trial
Active Trials
NCT03588130Completed120Est. Mar 2022
NCT04817228Completed12Est. May 2022
Enterprise Therapeutics
1 program
Compression Therapy System PrototypeN/A1 trial
Active Trials
NCT05610241Completed11Est. Mar 2023
Medtronic
MedtronicNJ - Phillipsburg
1 program
Cyanoacrylate closureN/A1 trial
Active Trials
NCT04011371Completed21Est. Jun 2022
B. Braun
B. BraunGermany - Melsungen
1 program
HM242N/A3 trials
Active Trials
NCT04902612Unknown142Est. Dec 2022
NCT04902651Terminated73Est. Feb 2022
NCT04192123Completed20Est. Jun 2020
Biolab Pharma
Biolab PharmaBrazil - São Paulo
1 program
Membrane Wrap™N/A1 trial
Active Trials
NCT06544564Recruiting150Est. Sep 2026
Boston Scientific
Boston ScientificCA - Valencia
1 program
VarithenaN/A1 trial
Active Trials
NCT03257254Completed76Est. Sep 2020
T-Therapeutics
T-TherapeuticsUK - Cambridge
1 program
Concurrent optical and magnetic stimulationPHASE_4

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
EppendorfConcurrent optical and magnetic stimulation
RHEACELLallo-APZ2-CVU
OrganogenesisDermagraft
Energenesis BiomedicalENERGI-F703 GEL
SolasCureAurase Wound gel
MediWoundEscharEx
MediWoundEscharEx
XintelaXSTEM-VLU
BiocorpGranexin
ConvaTecAQUACEL® Ag+ Extra™ vs Cutimed® Sorbact®
Biolab PharmaMembrane Wrap™
ColoplastBiatain Fiber Ag applied to participants
Enterprise TherapeuticsCompression Therapy System Prototype
ColoplastBiatain® Silicone
ConvaTecAQUACEL® Ag+ Extra™

Showing 15 of 25 trials with date data

Clinical Trials (25)

Total enrollment: 2,549 patients across 25 trials

NCT06528873EppendorfConcurrent optical and magnetic stimulation

COMS for Chronic Ulcers Treatment

Start: Oct 2025Est. completion: Sep 2026122 patients
Phase 4Recruiting
NCT06489028RHEACELLallo-APZ2-CVU

Allogeneic ABCB5-positive Dermal Mesenchymal Stromal Cells for Treatment of Therapy-resistant CVU (Phase III)

Start: Dec 2024Est. completion: Sep 2027250 patients
Phase 3Active Not Recruiting

Pivotal Trial of Dermagraft(R) to Treat Venous Leg Ulcers

Start: Jun 2009Est. completion: Aug 2011537 patients
Phase 3Completed

A Study to Evaluate ENERGI-F703 GEL in Venous Leg Ulcer

Start: Jul 2022Est. completion: Jun 202580 patients
Phase 2Unknown
NCT04956900SolasCureAurase Wound gel

Clinical Trial Enzyme Application Targeting Venous Leg Ulcers

Start: Aug 2021Est. completion: Feb 202343 patients
Phase 2Completed

A Study to Evaluate the Clinical Performance, Safety and Pharmacology Effect of EscharEx in Patients With Lower Leg Ulcers

Start: Apr 2021Est. completion: May 202212 patients
Phase 2Completed

A Study to Evaluate the Safety and the Efficacy of EscharEx (EX-02 Formulation) in Debridement of Venous Leg Ulcers

Start: Dec 2019Est. completion: Mar 2022120 patients
Phase 2Completed

A Study of XSTEM-VLU in Patients With Difficult-to-heal Venous Leg Ulcers

Start: Oct 2022Est. completion: Oct 20256 patients
Phase 1/2Recruiting

Safety Study to Examine the Systemic Exposure of Granexin® Gel After Topical Application to Venous Leg Ulcers

Start: Sep 2015Est. completion: May 201810 patients
Phase 1Completed
NCT07308678ConvaTecAQUACEL® Ag+ Extra™ vs Cutimed® Sorbact®

AQUACEL® Ag+ Extra™ vs Cutimed® Sorbact®

Start: Apr 2025Est. completion: May 2025105 patients
N/ACompleted
NCT06544564Biolab PharmaMembrane Wrap™

Human Amniotic Membrane On Venous Leg Ulcers In an Elderly Population

Start: Mar 2025Est. completion: Sep 2026150 patients
N/ARecruiting
NCT05873257ColoplastBiatain Fiber Ag applied to participants

Investigation of the Clinical Performance of Biatain Fiber Ag on Venous Leg Ulcers

Start: Jul 2023Est. completion: May 202450 patients
N/ACompleted
NCT05610241Enterprise TherapeuticsCompression Therapy System Prototype

Preliminary Investigation of a Smart Compression Therapy Prototype

Start: Mar 2023Est. completion: Mar 202311 patients
N/ACompleted
NCT05786612ColoplastBiatain® Silicone

Clinical Performance and Cost Effectiveness of Biatain® Silicone Compared With Standard of Care

Start: Jan 2023Est. completion: Dec 2023102 patients
N/ACompleted
NCT05892341ConvaTecAQUACEL® Ag+ Extra™

AQUACEL® Ag+ Extra™ and Cutimed™ Sorbact® Dressing in the Management of Venous Leg Ulcers Over a 12-week Period

Start: Dec 2022Est. completion: Feb 2024203 patients
N/ACompleted
NCT05291169OmezaOmeza® OCM™

Omeza Combination Therapy With Standard of Care to Standard of Care Alone for Chronic Venous Leg Ulcers

Start: Apr 2022Est. completion: Mar 202454 patients
N/ACompleted

Clinical Study Of Affinity Versus SOC In The Management Of VLUs

Start: Jun 2021Est. completion: Jun 2023200 patients
N/AUnknown

HM242-Solution vs Comparator

Start: May 2021Est. completion: Dec 2022142 patients
N/AUnknown

HM242-Gel vs Comparator

Start: May 2021Est. completion: Feb 202273 patients
N/ATerminated
NCT04198441OmezaWound dressing

The Omeza Protocol for Chronic Ulcers

Start: Jun 2020Est. completion: Dec 202178 patients
N/AUnknown

Open-Label Test of the HM242 Medical Devices to Evaluate Safety and Local Tolerability

Start: May 2020Est. completion: Jun 202020 patients
N/ACompleted
NCT04011371MedtronicCyanoacrylate closure

Cyanoacrylate Closure for Treatment of Venous Leg Ulcers

Start: Sep 2019Est. completion: Jun 202221 patients
N/ACompleted

Effect of VarIthena on Wound Healing in Venous Leg Ulcers (VLU)

Start: Sep 2017Est. completion: Sep 202076 patients
N/ACompleted
NCT02680834Tactile MedicalDual Action Pneumatic Compression Device

VLU Non-Inferiority Study Comparing a Dual Action Pneumatic Compression Device to Multi-Layer Bandaging

Start: Feb 2016Est. completion: Jun 201756 patients
N/ATerminated
NCT02395302Tactile MedicalDual Action Pneumatic Compression

Evaluation of a Dual Action Pneumatic Compression System: Tolerance and Comfort in Patients With Venous Leg Ulcers (VLUs)

Start: Dec 2014Est. completion: Nov 201528 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
3 actively recruiting trials targeting 2,549 patients
19 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.