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Vasomotor Rhinitis

5
Pipeline Programs
7
Companies
6
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
3
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 6 programs with unclassified modality

On Market (1)

Approved therapies currently available

OLOPATADINE HYDROCHLORIDEApproved
olopatadine hcl
Unknown Company
ophthalmic2015

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Alcon
AlconFORT WORTH, TX
1 program
1
Olopatadine HCLPhase 41 trial
Active Trials
NCT00979615Completed129
ViiV Healthcare
ViiV HealthcareNC - Durham
1 program
1
GW685698XPhase 3
Bayer
BayerLEVERKUSEN, Germany
1 program
1
Phenylephrine HydrochloridePhase 31 trial
Active Trials
NCT00976209Completed331Est. Nov 2009
Hanmi Pharmaceutical
1 program
1
Pseudoephedrine / LevocetirizinePhase 31 trial
Active Trials
NCT01509209Completed137Est. Apr 2013
HELP Therapeutics
HELP TherapeuticsChina - Nanjing
1 program
Cold-dry air provocationN/A1 trial
Active Trials
NCT00415493CompletedEst. May 2008
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
esomeprazoleN/ASmall Molecule1 trial
Active Trials
NCT00745849Completed43Est. Mar 2008
GSK
GSKLONDON, United Kingdom
1 program
GW685698XPHASE_31 trial
Active Trials
NCT00118703Completed350Est. Feb 2006

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
AlconOlopatadine HCL
Hanmi PharmaceuticalPseudoephedrine / Levocetirizine
BayerPhenylephrine Hydrochloride
GSKGW685698X
HELP TherapeuticsCold-dry air provocation
AstraZenecaesomeprazole

Clinical Trials (6)

Total enrollment: 990 patients across 6 trials

NCT00979615AlconOlopatadine HCL

Safety and Efficacy of Olopatadine 0.6% and Azelastine 137 Mcg in Vasomotor Rhinitis

Start: Sep 2009129 patients
Phase 4Completed
NCT01509209Hanmi PharmaceuticalPseudoephedrine / Levocetirizine

Efficacy/Safety of Pseudoephedrine Plus Levocetirizine Versus Placebo in Patients With Vasomotor Rhinitis

Start: May 2011Est. completion: Apr 2013137 patients
Phase 3Completed
NCT00976209BayerPhenylephrine Hydrochloride

Consumer Preference Study of Two Formulations of Phenylephrine Hydrochloride (Study CL2008-15)(P07530)(COMPLETED)

Start: Aug 2009Est. completion: Nov 2009331 patients
Phase 3Completed
NCT00118703GSKGW685698X

Once-Daily Investigational Nasal Spray In Adults And Adolescents With Vasomotor Rhinitis

Start: Jul 2005Est. completion: Feb 2006350 patients
Phase 3Completed
NCT00415493HELP TherapeuticsCold-dry air provocation

Nasal Physiologic Reactivity of Nonallergic Rhinitics to Cold Air Provocation

Start: Dec 2006Est. completion: May 2008
N/ACompleted
NCT00745849AstraZenecaesomeprazole

Efficacy of Esomeprazole for Non-Allergic Rhinitis: A Double-blind, Placebo Controlled Trial

Start: Jun 2005Est. completion: Mar 200843 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

3 late-stage (Phase 3) programs, potential near-term approvals
7 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.