Various

0
Pipeline Programs
5
Companies
27
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
133%
Monoclonal Antibody
133%
ADC
133%
+ 8 programs with unclassified modality

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Bristol Myers Squibb
4 programs
Anti-IL8N/A1 trial
BET InhibitorN/A1 trial
IberdomideN/A1 trial
RelatlimabN/AMonoclonal Antibody1 trial
Active Trials
NCT05210894No Longer Available
NCT05301972No Longer Available
NCT07434960Available
+1 more trials
Armata Pharmaceuticals
Armata PharmaceuticalsLOS ANGELES, CA
2 programs
AB-PA01N/A1 trial
AB-SA01N/A1 trial
Active Trials
NCT03395743No Longer Available
NCT03395769No Longer Available
Amgen
AmgenTHOUSAND OAKS, CA
2 programs
AMG 701N/A3 trials
OlpasiranN/A1 trial
Active Trials
NCT05256446No Longer Available
NCT04998747Withdrawn0Est. Aug 2025
NCT03287908Terminated174Est. Jun 2023
+1 more trials
Pfizer
PfizerNEW YORK, NY
2 programs
LorlatinibN/ASmall Molecule5 trials
ladiratuzumab vedotinN/AADC1 trial
Active Trials
NCT03127618Approved For Marketing
NCT06333899Recruiting15Est. Jun 2035
NCT06678555Active Not Recruiting35Est. Jun 2026
+3 more trials
CSL Behring
CSL BehringIL - Bradley
1 program
CSL830N/A1 trial
Active Trials
NCT03177005Approved For Marketing

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
PfizerLorlatinib
PfizerLorlatinib
PfizerLorlatinib
PfizerLorlatinib
PfizerLorlatinib
PfizerLorlatinib
AmgenAMG 701
PfizerLorlatinib
PfizerLorlatinib
PfizerLorlatinib
AmgenAMG 701
PfizerLorlatinib
PfizerLorlatinib
PfizerLorlatinib
PfizerLorlatinib

Showing 15 of 16 trials with date data

Clinical Trials (27)

Total enrollment: 702 patients across 27 trials

Lorlatinib Continuation Study

Start: Dec 2021Est. completion: Dec 202676 patients
Phase 4Active Not Recruiting

Lorlatinib in Combination With Chemotherapy in Participants With Metastatic Anaplastic Lymphoma Kinase Positive (ALK+) Non-small Cell Lung Cancer (NSCLC) Who Progressed on Single-agent Lorlatinib

Start: Nov 2023Est. completion: Sep 20250
Phase 2Withdrawn

A Study of Lorlatinib in Subjects With ROS1-Positive Non-Small Cell Lung Cancer

Start: May 2022Est. completion: May 202670 patients
Phase 2Active Not Recruiting

A Study of Lorlatinib in ALK Inhibitor-Treated ALK-Positive NSCLC in China

Start: Apr 2019Est. completion: Oct 2024109 patients
Phase 2Completed

A Study of Oral Lorlatinib in Patients With Relapsed ALK Positive Lymphoma

Start: Oct 2017Est. completion: Dec 202412 patients
Phase 2Unknown

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

Start: Aug 2025Est. completion: Jun 203515 patients
Phase 1Recruiting

A Study of Subcutaneous (SC) AMG 701 in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

Start: Aug 2023Est. completion: Aug 20250
Phase 1Withdrawn

A Study to Learn About the Study Medicine (Called Lorlatinib) in People With Liver Dysfunction

Start: Apr 2022Est. completion: Aug 202421 patients
Phase 1Completed

Effect of Multiple Doses of Modafinil on the Pharmacokinetics of Single Dose Lorlatinib in Healthy Participants

Start: Aug 2019Est. completion: Dec 201916 patients
Phase 1Completed

Lorlatinib Renal Impairment Study

Start: Aug 2018Est. completion: Feb 202029 patients
Phase 1Completed

A Study to Assess AMG 701 Montherapy, or in Combination With Pomalidomide, With or Without, Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma

Start: Nov 2017Est. completion: Jun 2023174 patients
Phase 1Terminated

Single-dose Study of [14C]Lorlatinib (PF-06463922) Metabolism In Healthy Male Volunteers

Start: Jul 2017Est. completion: Aug 20176 patients
Phase 1Completed

Olpasiran Expanded Access Program

N/AAvailable

Individual Patient Expanded Access for AB-SA01, an Investigational Anti-Staphylococcus Aureus Bacteriophage Therapeutic

N/ANo Longer Available

Lorlatinib - PF-06463922

N/AApproved For Marketing

Individual Patient Expanded Access for AB-PA01, an Investigational Anti-Pseudomonas Aeruginosa Bacteriophage Therapeutic

N/ANo Longer Available

Expanded Access for Iberdomide

N/AAvailable

Expanded Access for Anti-IL8

N/ANo Longer Available

Expanded Access for Bromodomain and Extra-Terminal (BET) Inhibitor

N/ANo Longer Available

Expanded Access for Relatlimab

N/ANo Longer Available

Expanded Access for Hereditary Angioedema (HAE)

N/AApproved For Marketing
NCT06362590Pfizerladiratuzumab vedotin

Expanded Access Use of Ladiratuzumab Vedotin in Advanced Solid Tumors

N/AAvailable

AMG 701 Expanded Access Program

N/ANo Longer Available

A Study to Learn About Lorlatinib in Patients With Non-Small Cell Lung Cancer (NSCLC) Which Has Spread Out.

Start: Jul 2025Est. completion: Jun 202635 patients
N/AActive Not Recruiting

Study to Evaluate Clinical Real World Outcomes of Lorlatinib After Alectinib in ALK-Positive NSCLC Japanese Patients

Start: Aug 2021Est. completion: Dec 202151 patients
N/ACompleted

Real World Data Collection Pediatric Neuroblastoma Treated With Lorlatinib

Start: Mar 2021Est. completion: Sep 202215 patients
N/ATerminated

A Study to Learn About Lorlatinib in Patients With Non-Small Cell Lung Cancer Which Could Not Be Controlled

Start: Jul 2020Est. completion: Jan 202173 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 actively recruiting trials targeting 702 patients
5 companies competing in this space