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Trigeminal Neuralgia

3
Pipeline Programs
7
Companies
10
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
1
0
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
1100%
+ 8 programs with unclassified modality

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Prevail Therapeutics
1 program
1
GalcanezumabPhase 4Monoclonal Antibody1 trial
Active Trials
NCT04158752Completed26Est. Jan 2023
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
1
Oxtellar XR 150Mg Extended Release TabletPhase 41 trial
Active Trials
NCT03374709Withdrawn0Est. Dec 2018
Noema Pharma
Noema PharmaSwitzerland - Basel
2 programs
1
BasimglurantPhase 2/31 trial
Pain Diary useN/A1 trial
Active Trials
NCT06019338Completed30Est. Aug 2023
NCT05217628Active Not Recruiting166Est. Apr 2027
Biogen
BiogenCAMBRIDGE, MA
2 programs
CNV1014802PHASE_12 trials
BIIB074PHASE_31 trial
Active Trials
NCT02359344Completed32Est. Apr 2015
NCT01540630Completed67Est. Jun 2014
NCT03637387Withdrawn0Est. Sep 2026
Insightec
InsightecFL - Miami
1 program
ExAblate Transcranial treatmentN/A1 trial
Active Trials
NCT04579692Active Not Recruiting10Est. May 2026
Relief Therapeutics
Relief TherapeuticsSwitzerland - Geneva
1 program
LidocaineN/A1 trial
Active Trials
NCT01955967Completed20
NanoVibronix
NanoVibronixIsrael - Nesher
1 program
PainShield SAW Patch DeviceN/A1 trial
Active Trials
NCT02801630Unknown60Est. Aug 2017

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Prevail TherapeuticsGalcanezumab
Colorado TherapeuticsOxtellar XR 150Mg Extended Release Tablet
BiogenBIIB074
Noema PharmaBasimglurant
BiogenCNV1014802
BiogenCNV1014802
Noema PharmaPain Diary use
InsightecExAblate Transcranial treatment
NanoVibronixPainShield SAW Patch Device
Relief TherapeuticsLidocaine

Clinical Trials (10)

Total enrollment: 411 patients across 10 trials

NCT04158752Prevail TherapeuticsGalcanezumab

Anti-CGRP for Inflammation and Pain Modulation in Small Fiber Neuropathy/Fibromyalgia

Start: Jul 2020Est. completion: Jan 202326 patients
Phase 4Completed
NCT03374709Colorado TherapeuticsOxtellar XR 150Mg Extended Release Tablet

Oxtellar Extended Release (Oxcarbazepine Extended Release) Patients With Trigeminal Neuralgia

Start: Dec 2018Est. completion: Dec 20180
Phase 4Withdrawn
NCT03637387BiogenBIIB074

802NP302 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia

Start: Mar 2023Est. completion: Sep 20260
Phase 3Withdrawn
NCT05217628Noema PharmaBasimglurant

An Efficacy and Safety Study of Basimglurant (NOE-101) in Patients With Trigeminal Neuralgia.

Start: Jan 2022Est. completion: Apr 2027166 patients
Phase 2/3Active Not Recruiting
NCT01540630BiogenCNV1014802

A Phase IIa Withdrawal Study of CNV1014802 in Patients With Trigeminal Neuralgia

Start: Mar 2012Est. completion: Jun 201467 patients
Phase 2Completed
NCT02359344BiogenCNV1014802

PK & Tolerability of CNV1014802 in Young and Elderly Healthy Volunteers

Start: Feb 2015Est. completion: Apr 201532 patients
Phase 1Completed
NCT06019338Noema PharmaPain Diary use

A Study to Validate a Pain Diary for Patient With Trigeminal Neuralgia

Start: Nov 2021Est. completion: Aug 202330 patients
N/ACompleted
NCT04579692InsightecExAblate Transcranial treatment

MR Guided Focused Ultrasound (FUS) for the Treatment of Trigeminal Neuralgia

Start: Aug 2021Est. completion: May 202610 patients
N/AActive Not Recruiting
NCT02801630NanoVibronixPainShield SAW Patch Device

An Evaluation of the Effect of a Surface Acoustic Wave Patch Device on the Symptons of Trigeminal Neuralgia

Start: Sep 2016Est. completion: Aug 201760 patients
N/AUnknown
NCT01955967Relief TherapeuticsLidocaine

The Effect of Intravenous Lidocaine on Trigeminal Neuralgia

Start: Apr 200620 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

7 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.