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Tricuspid Valve Regurgitation

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Pipeline Programs
6
Companies
12
Clinical Trials
5 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
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Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

6 companies ranked by most advanced pipeline stage

Edwards Lifesciences
6 programs
EW Tricuspid Transcatheter Repair SystemN/A1 trial
Edwards EVOQUE SystemN/A1 trial
Edwards EWJ-202 Transcatheter Tricuspid Valve Replacement SystemN/A1 trial
Edwards FORMA Tricuspid Transcatheter Repair SystemN/A1 trial
Transcatheter Tricuspid Valve ReplacementN/A1 trial
+1 more programs
Active Trials
NCT02787408Completed25Est. Dec 2020
NCT04482062Active Not Recruiting864Est. Jun 2030
NCT05760989Active Not Recruiting45Est. Sep 2029
+3 more trials
TRiCares
TRiCaresGermany - Aschheim
2 programs
Transcatheter Tricuspid Valve ReplacementN/A1 trial
Transcatheter Tricuspid Valve ReplacementN/A1 trial
Active Trials
NCT06506942Recruiting15Est. Mar 2031
NCT06581471Recruiting80Est. Dec 2030
Medtronic
MedtronicNJ - Phillipsburg
1 program
Contour 3D® implant for tricuspid valve repairN/A1 trial
Active Trials
NCT01585779Completed64Est. Jun 2016
inQB8 Medical Technologies
1 program
Transcatheter Tricuspid Valve ReplacementN/A1 trial
Active Trials
NCT06611579Recruiting50Est. Oct 2029
Abbott
AbbottABBOTT PARK, IL
1 program
Transcatheter heart valve procedureN/A1 trial
Active Trials
NCT04483089Active Not Recruiting511Est. Jan 2028
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
1 program
Tricuspid Valve Replacement System via jugular veinN/A1 trial
Active Trials
NCT05194423Recruiting150Est. Mar 2027

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
inQB8 Medical TechnologiesTranscatheter Tricuspid Valve Replacement
Edwards LifesciencesTranscatheter Tricuspid Valve Replacement
TRiCaresTranscatheter Tricuspid Valve Replacement
TRiCaresTranscatheter Tricuspid Valve Replacement
Edwards LifesciencesEdwards EWJ-202 Transcatheter Tricuspid Valve Replacement System
UNION therapeuticsTricuspid Valve Replacement System via jugular vein
Edwards LifesciencesEdwards EVOQUE System
AbbottTranscatheter heart valve procedure
Edwards LifesciencesTranscatheter Tricuspid Valve Replacement
Edwards LifesciencesEW Tricuspid Transcatheter Repair System
Edwards LifesciencesEdwards FORMA Tricuspid Transcatheter Repair System
MedtronicContour 3D® implant for tricuspid valve repair

Clinical Trials (12)

Total enrollment: 2,566 patients across 12 trials

NCT06611579inQB8 Medical TechnologiesTranscatheter Tricuspid Valve Replacement

Clinical Study of the inQB8 TTVR System

Start: Jun 2025Est. completion: Oct 202950 patients
N/ARecruiting
NCT06569602Edwards LifesciencesTranscatheter Tricuspid Valve Replacement

Real World European Investigation of Safety and Clinical Efficacy of the EVOQUE System (TRISCEND III EU)

Start: Oct 2024Est. completion: Sep 2033500 patients
N/ARecruiting
NCT06506942TRiCaresTranscatheter Tricuspid Valve Replacement

The TRICURE EFS Study

Start: Sep 2024Est. completion: Mar 203115 patients
N/ARecruiting
NCT06581471TRiCaresTranscatheter Tricuspid Valve Replacement

The TRICURE EU Pivotal Study

Start: Aug 2024Est. completion: Dec 203080 patients
N/ARecruiting
NCT05760989Edwards LifesciencesEdwards EWJ-202 Transcatheter Tricuspid Valve Replacement System

TRISCEND JAPAN Study

Start: Feb 2023Est. completion: Sep 202945 patients
N/AActive Not Recruiting
NCT05194423UNION therapeuticsTricuspid Valve Replacement System via jugular vein

THE TRAVEL II TRIAL: Transcatheter Right Atrial-ventricular Valve rEplacement With LuX-Valve Via Jugular Vein

Start: Mar 2022Est. completion: Mar 2027150 patients
N/ARecruiting
NCT04482062Edwards LifesciencesEdwards EVOQUE System

TRISCEND II Pivotal Trial

Start: Apr 2021Est. completion: Jun 2030864 patients
N/AActive Not Recruiting
NCT04483089AbbottTranscatheter heart valve procedure

An Observational Real-world Study Evaluating Severe Tricuspid Regurgitation Patients Treated with the Abbott TriClip™ Device (bRIGHT)

Start: Aug 2020Est. completion: Jan 2028511 patients
N/AActive Not Recruiting
NCT04221490Edwards LifesciencesTranscatheter Tricuspid Valve Replacement

2019-06 TRISCEND Study

Start: May 2020Est. completion: Jan 2029228 patients
N/AActive Not Recruiting
NCT02787408Edwards LifesciencesEW Tricuspid Transcatheter Repair System

The SPACER Trial - Repair of Tricuspid Valve Regurgitation Using the Edwards TricuSPid TrAnsCatheter REpaiR System

Start: Sep 2016Est. completion: Dec 202025 patients
N/ACompleted
NCT02471807Edwards LifesciencesEdwards FORMA Tricuspid Transcatheter Repair System

Early Feasibility Study of the Edwards FORMA Tricuspid Transcatheter Repair System

Start: Dec 2015Est. completion: Jan 202334 patients
N/ACompleted
NCT01585779MedtronicContour 3D® implant for tricuspid valve repair

Contour 3D®/TriAd® Tricuspid Annuloplasty Ring Post-Market Clinical Trial

Start: May 2012Est. completion: Jun 201664 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

5 actively recruiting trials targeting 2,566 patients
6 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.