Tricuspid Regurgitation

Pipeline Programs

Companies

Clinical Trials

12 recruiting

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule

1100%

+ 21 programs with unclassified modality

Competitive Landscape

12 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

AbbottABBOTT PARK, IL

4 programs

EchoPhase 41 trial

The TriClip SystemN/A1 trial

TriClipTM DeviceN/A1 trial

Active Trials

NCT07509658Recruiting250Est. Dec 2029

NCT06920745Recruiting2,200Est. Jul 2032

NCT03904147Active Not Recruiting572Est. Apr 2029

+1 more trials

Chong Kun Dang PharmaceuticalKorea - Seodaemun

1 program

Carvedilol+EmpagliflozinPhase 3Small Molecule1 trial

Active Trials

NCT04345796Completed56Est. Jun 2024

Edwards LifesciencesCA - Irvine

5 programs

EVOQUEN/A1 trial

Edwards PASCAL SystemN/A1 trial

Edwards PASCAL Transcatheter Valve Repair SystemN/A1 trial

Transcatheter Tricuspid Valve RepairN/A1 trial

Active Trials

NCT06833476Recruiting2,044Est. Dec 2032

NCT04097145Recruiting870Est. Dec 2031

NCT03745313Completed65Est. May 2025

+2 more trials

Rhine PharmaGermany - Heidelberg

2 programs

CT Prediction for Transcatheter Tricuspid InterventionsN/A

Interventional treatment of tricuspid regurgitationN/A1 trial

Active Trials

NCT04653428Recruiting600Est. Dec 2030

CroiValveIreland - Dublin

2 programs

DUO Transcatheter Tricuspid Coaptation Valve SystemN/A1 trial

Transcatheter Tricuspid Valve ImplantationN/A1 trial

Active Trials

NCT05913908Recruiting15Est. Oct 2029

NCT05296148Active Not Recruiting10Est. Jul 2026

Laplace InterventionalMN - Plymouth

2 programs

Laplace TTVR SystemN/A1 trial

Active Trials

NCT06183684Recruiting45Est. Dec 2030

NCT07171060Recruiting15Est. Jan 2031

Berlin HeartTX - The Woodlands

1 program

CT Prediction for Transcatheter Tricuspid InterventionsN/A1 trial

Active Trials

NCT06951126Recruiting500Est. Jun 2030

MedtronicNJ - Phillipsburg

1 program

Intrepid™ TTVR SystemN/A1 trial

Active Trials

NCT04433065Recruiting150Est. Jul 2031

Micro Interventional DevicesPA - Newtown

1 program

MIA, Minimally Invasive Annuloplasty Device - SurgicalN/A1 trial

Active Trials

NCT03692598Recruiting60Est. Dec 2026

TRiCaresGermany - Aschheim

1 program

Topaz TTVR SystemN/A1 trial

Active Trials

NCT05126030Active Not Recruiting20Est. May 2029

EppendorfGermany - Hamburg

1 program

Tricuspid RegUrgitaTion Hamburg CohortN/A1 trial

Active Trials

NCT04755842Recruiting2,000Est. Dec 2030

Versa VascularCA - Santa Cruz

1 program

Versa ImplantN/A1 trial

Active Trials

NCT06368401Active Not Recruiting10Est. Oct 2025

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

2027

2028

2029

2030

2031

AbbottEcho

Chong Kun Dang PharmaceuticalCarvedilol+Empagliflozin

AbbottThe TriClip System

Edwards LifesciencesEVOQUE

CroiValveDUO Transcatheter Tricuspid Coaptation Valve System

Versa VascularVersa Implant

Laplace InterventionalLaplace TTVR System

Berlin HeartCT Prediction for Transcatheter Tricuspid Interventions

TRiCaresTopaz TTVR System

CroiValveTranscatheter Tricuspid Valve Implantation

MedtronicIntrepid™ TTVR System

Rhine PharmaInterventional treatment of tricuspid regurgitation

EppendorfTricuspid RegUrgitaTion Hamburg Cohort

Showing 15 of 21 trials with date data

Clinical Trials (21)

Total enrollment: 9,826 patients across 21 trials

NCT01093001 AbbottEcho

Tricuspid Regurgitation Study

Start: May 2010Est. completion: May 2016119 patients

Phase 4Completed

NCT04345796 Chong Kun Dang PharmaceuticalCarvedilol+Empagliflozin

Pharmacological Reduction of Right Ventricular Enlargement

Start: Feb 2021Est. completion: Jun 202456 patients

Phase 3Completed

NCT07509658 AbbottThe TriClip System

TriClip Japan Post-Approval Study

Start: Mar 2026Est. completion: Dec 2029250 patients

N/ARecruiting

NCT06920745 AbbottThe TriClip System

TriClip CED RWE Study

Start: Jul 2025Est. completion: Jul 20322,200 patients

N/ARecruiting

NCT06833476 Edwards LifesciencesEVOQUE

TTVR STRONG Under Coverage With Evidence Development (CED) Study

Start: Mar 2025Est. completion: Dec 20322,044 patients

N/ARecruiting

NCT05913908 CroiValveDUO Transcatheter Tricuspid Coaptation Valve System

EFS of the DUO System for Tricuspid Regurgitation

Start: Aug 2024Est. completion: Oct 202915 patients

N/ARecruiting

NCT06368401 Versa VascularVersa Implant

A First in Human Study for the Versa Device for Tricuspid Regurgitation

Start: Aug 2024Est. completion: Oct 202510 patients

N/AActive Not Recruiting

NCT07171060 Laplace InterventionalLaplace TTVR System

Laplace Early Feasibility Study - Canada

Start: Jun 2024Est. completion: Jan 203115 patients

N/ARecruiting

NCT06183684 Laplace InterventionalLaplace TTVR System

Early Feasibility Study (EFS) Laplace Transcatheter Tricuspid Valve Replacement (TTVR) System

Start: Feb 2024Est. completion: Dec 203045 patients

N/ARecruiting

NCT06951126 Berlin HeartCT Prediction for Transcatheter Tricuspid Interventions

CT Prediction for Transcatheter Tricuspid Interventions

Start: Jul 2023Est. completion: Jun 2030500 patients

N/ARecruiting

NCT05126030 TRiCaresTopaz TTVR System

The TRICURE First in Human Trial

Start: Jul 2022Est. completion: May 202920 patients

N/AActive Not Recruiting

NCT05296148 CroiValveTranscatheter Tricuspid Valve Implantation

A Feasibility Study of the CroíValve DUO System for Tricuspid Regurgitation

Start: Jun 2022Est. completion: Jul 202610 patients

N/AActive Not Recruiting

NCT04433065 MedtronicIntrepid™ TTVR System

TTVR Early Feasibility Study

Start: Oct 2020Est. completion: Jul 2031150 patients

N/ARecruiting

NCT04653428 Rhine PharmaInterventional treatment of tricuspid regurgitation

German Registry for Transcatheter Tricuspid Valve Interventions

Start: Oct 2020Est. completion: Dec 2030600 patients

N/ARecruiting

NCT04755842 EppendorfTricuspid RegUrgitaTion Hamburg Cohort

Tricuspid RegUrgitaTion Hamburg Cohort

Start: Jun 2020Est. completion: Dec 20302,000 patients

N/ARecruiting

NCT04097145 Edwards LifesciencesEdwards PASCAL System

Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

Start: Dec 2019Est. completion: Dec 2031870 patients

N/ARecruiting

NCT03904147 AbbottTriClipTM Device

TRILUMINATE Pivotal Trial

Start: Aug 2019Est. completion: Apr 2029572 patients

N/AActive Not Recruiting

NCT03779490 Edwards LifesciencesTranscatheter Tricuspid Valve Repair

Transcatheter Repair of Tricuspid Regurgitation With Edwards Cardioband TR System Post Market Study (TriBAND)

Start: Jul 2019Est. completion: Dec 2027150 patients

N/AActive Not Recruiting

NCT03745313 Edwards LifesciencesEdwards PASCAL Transcatheter Valve Repair System

Edwards CLASP TR EFS

Start: Feb 2019Est. completion: May 202565 patients

N/ACompleted

NCT03382457 Edwards LifesciencesTranscatheter Tricuspid Valve Repair

Clinical Study of Edwards Cardioband FIT Valve Repair System

Start: Jul 2018Est. completion: Dec 203175 patients

N/AActive Not Recruiting

NCT03692598 Micro Interventional DevicesMIA, Minimally Invasive Annuloplasty Device - Surgical

Study of Transcatheter Tricuspid Annular Repair

Start: Dec 2016Est. completion: Dec 202660 patients

N/ARecruiting

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals

12 actively recruiting trials targeting 9,826 patients

12 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.