Transplant-Associated Thrombotic Microangiopathy

3
Pipeline Programs
3
Companies
2
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
3
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Peptide
1100%
+ 2 programs with unclassified modality

Competitive Landscape

3 companies ranked by most advanced pipeline stage

Jazz Pharmaceuticals
Jazz PharmaceuticalsCA - Palo Alto
1 program
1
DefibrotidePhase 2Peptide1 trial
Active Trials
NCT06182410Withdrawn0Est. May 2027
Swedish Orphan Biovitrum
1 program
1
PegcetacoplanPhase 2
Apellis Pharmaceuticals
Apellis PharmaceuticalsAustralia - Hawthorn East
1 program
1
PegcetacoplanPhase 21 trial
Active Trials
NCT05148299CompletedEst. Dec 2024

Trial Timeline

Clinical trial activity over time

2022
2023
2024
2025
2026
2027
Jazz PharmaceuticalsDefibrotide
Apellis PharmaceuticalsPegcetacoplan

Clinical Trials (2)

Defibrotide Prophylaxis of Transplant Associated-Thrombotic Microangiopathy for Neuroblastoma

Start: Aug 2024Est. completion: May 20270
Phase 2Withdrawn

A Study of Pegcetacoplan for Patients With Transplant-associated Thrombotic Microangiopathy After Hematopoietic Stem Cell Transplantation

Start: Feb 2022Est. completion: Dec 2024
Phase 2Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

3 companies competing in this space