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Total Knee Replacement

3
Pipeline Programs
11
Companies
11
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
2
0
0
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

9 companies ranked by most advanced pipeline stage

Zimmer Biomet
Zimmer BiometFL - Jacksonville
2 programs
1
MIS™ Minimally Invasive Solutions™ TKA SystemPhase 41 trial
PersonaN/A1 trial
Active Trials
NCT04677907Recruiting144Est. Jun 2035
NCT00160797Withdrawn0Est. Oct 2005
Innovation Pharmaceuticals
1 program
1
Bupivacaine HClPhase 21 trial
Active Trials
NCT03541655Completed20Est. Mar 2020
Prevail Therapeutics
1 program
1
LY517717Phase 21 trial
Active Trials
NCT00074828Completed511Est. May 2005
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
2 programs
Clinical decision supportN/A1 trial
Evaluation of Patellar Crepitus Following Total Knee ArthroplastyN/A1 trial
Active Trials
NCT05900453Completed675Est. Dec 2022
NCT01340144Completed1,250Est. Sep 2014
SPR Therapeutics
SPR TherapeuticsOH - Cleveland
2 programs
SPRINT Beta SystemN/A1 trial
SPRINT Peripheral Nerve StimulationN/A1 trial
Active Trials
NCT03286543Completed47Est. Apr 2020
NCT02468934Completed24Est. Jul 2017
Theragen
TheragenFL - Jacksonville
1 program
Kneehab XPN/A1 trial
Active Trials
NCT01548040Completed111Est. Oct 2016
Nordic Pharma
Nordic PharmaFrance - Paris
1 program
Mako cementless TKAN/A1 trial
Active Trials
NCT06929871Recruiting120Est. Aug 2031
Stryker
StrykerCA - San Jose
1 program
Mako cementless TKAN/A
Marius Pharmaceuticals
1 program
Standard post-operative rehabilitationN/A1 trial
Active Trials
NCT02982785Completed364Est. Dec 2019

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Zimmer BiometMIS™ Minimally Invasive Solutions™ TKA System
Innovation PharmaceuticalsBupivacaine HCl
Prevail TherapeuticsLY517717
Nordic PharmaMako cementless TKA
Zimmer BiometPersona
Colorado TherapeuticsClinical decision support
SPR TherapeuticsSPRINT Beta System
Marius PharmaceuticalsStandard post-operative rehabilitation
SPR TherapeuticsSPRINT Peripheral Nerve Stimulation
TheragenKneehab XP
Colorado TherapeuticsEvaluation of Patellar Crepitus Following Total Knee Arthroplasty

Clinical Trials (11)

Total enrollment: 3,266 patients across 11 trials

NCT00160797Zimmer BiometMIS™ Minimally Invasive Solutions™ TKA System

Total Knee Arthroplasty Outcome Study

Start: Aug 2005Est. completion: Oct 20050
Phase 4Withdrawn
NCT03541655Innovation PharmaceuticalsBupivacaine HCl

Safety and Activity of F14 for Management of Pain Following Total Knee Replacement

Start: May 2018Est. completion: Mar 202020 patients
Phase 2Completed
NCT00074828Prevail TherapeuticsLY517717

New Oral Anticoagulant Therapy for the Prevention of Blood Clots Following Hip or Knee Replacement Surgery

Start: Dec 2003Est. completion: May 2005511 patients
Phase 2Completed
NCT06929871Nordic PharmaMako cementless TKA

Mako Cementless TKA vs Mako Cemented TKA

Start: Sep 2025Est. completion: Aug 2031120 patients
N/ARecruiting
NCT04677907Zimmer BiometPersona

TRabecular Metal Economic and Clinical Knee Trial

Start: May 2022Est. completion: Jun 2035144 patients
N/ARecruiting
NCT05900453Colorado TherapeuticsClinical decision support

Novel Strategies for Personalized Clinical Decisions in Knee Arthroplasty

Start: May 2018Est. completion: Dec 2022675 patients
N/ACompleted
NCT03286543SPR TherapeuticsSPRINT Beta System

Electrical Stimulation for the Treatment of Pain Following Total Knee Arthroplasty Using the SPRINT Beta System

Start: Sep 2017Est. completion: Apr 202047 patients
N/ACompleted
NCT02982785Marius PharmaceuticalsStandard post-operative rehabilitation

Knee Replacement Outcome Predicted by Physiotherapists

Start: Dec 2016Est. completion: Dec 2019364 patients
N/ACompleted
NCT02468934SPR TherapeuticsSPRINT Peripheral Nerve Stimulation

Electrical Stimulation for the Treatment of Pain Following Total Knee Arthroplasty (TKA) Using the SPRINT System

Start: Oct 2015Est. completion: Jul 201724 patients
N/ACompleted
NCT01548040TheragenKneehab XP

Controlled Study of Kneehab XP for Patients Undergoing Total Knee Replacement

Start: Mar 2012Est. completion: Oct 2016111 patients
N/ACompleted
NCT01340144Colorado TherapeuticsEvaluation of Patellar Crepitus Following Total Knee Arthroplasty

Evaluation of Patellar Crepitus Following Total Knee Arthroplasty

Start: Apr 2011Est. completion: Sep 20141,250 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 actively recruiting trials targeting 3,266 patients
11 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.