Total Knee Arthroplasty

Pipeline Programs

Companies

Clinical Trials

3 recruiting

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

11 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

StrykerCA - San Jose

6 programs

ShapeMatch TechnologyPhase 41 trial

Ambulatory continuous femoral nerve block for 100 hoursN/A1 trial

Computer assisted navigationN/A1 trial

Knee prosthesis implementation with additional cementN/A

Total knee arthroplasty with the Stryker's MAKO™ systemN/A1 trial

+1 more programs

Active Trials

NCT00419276Completed81Est. Aug 2010

NCT00409266Withdrawn0Est. Jun 2007

NCT03566875Unknown60Est. Sep 2020

+2 more trials

Integrated BiosciencesCA - San Carlos

1 program

DonepezilPhase 41 trial

Active Trials

NCT04423276Unknown360Est. Dec 2022

Oregon TherapeuticsFrance - Paris

1 program

Liposomal Bupivacaine Peri-articular InjectionPhase 41 trial

Active Trials

NCT04086186Completed60Est. Dec 2018

Human BioSciencesWV - Martinsburg

1 program

Neuromuscular electrical stimulationPhase 11 trial

Active Trials

NCT00224913Unknown200

Zimmer BiometFL - Jacksonville

6 programs

MPS-Flex Total Knee Joint ProsthesesN/A1 trial

NexGen CR-Flex Fixed Bearing KneeN/A1 trial

NexGen Gender Fixed Bearing Knee prosthesisN/A1 trial

NexGen LPS-Flex Fixed Bearing KneeN/A1 trial

The Zimmer NexGen Legacy Knee System, modular cemented tibiaN/A1 trial

+1 more programs

Active Trials

NCT04427722Suspended250Est. Dec 2024

NCT00761956Completed189Est. Dec 2010

NCT00901329Unknown24Est. Dec 2010

+3 more trials

Colorado TherapeuticsCO - Louisville

5 programs

ControlN/A3 trials

DePuy Synthes Attune PS RPN/A1 trial

Immediate Compression GarmentN/A1 trial

NMESN/A1 trial

Standard Rehabilitation + Neuromuscular Electrical Stimulation and Blood Flow RestrictionN/A1 trial

Active Trials

NCT07897123Completed23Est. Oct 2025

NCT03325062Completed138Est. Dec 2024

NCT03367845Active Not Recruiting1,005Est. Jun 2028

+4 more trials

CorinUK - Cirencester

3 programs

HLS KneeTec Deep DishN/A1 trial

patient with knee arthroplastyN/A1 trial

Active Trials

NCT05211141Terminated119Est. Dec 2022

NCT04727060Terminated2,146Est. Nov 2023

NCT04872855Terminated163Est. Dec 2024

MedactaSwitzerland - Castel San Pietro

2 programs

3D Metal Tibial and Femoral conesN/A1 trial

Implantation of GMK Sphere with conventional instrumentationN/A1 trial

Active Trials

NCT06578897Completed118Est. Feb 2025

NCT05863741Recruiting100Est. May 2026

MicroPortChina - Shanghai

2 programs

MicroPort Medial Pivot TKAN/A1 trial

Total Knee Arthroplasty with Evolution® NitrX™ Knee SystemN/A1 trial

Active Trials

NCT04103502Withdrawn0Est. Dec 2025

NCT05151315Active Not Recruiting50Est. Feb 2027

Nordic PharmaFrance - Paris

1 program

Knee prosthesis implementation with additional cementN/A1 trial

Active Trials

NCT04692714Recruiting200Est. Oct 2028

ExactechFL - Gainesville

1 program

TKA using computer navigationN/A1 trial

Active Trials

NCT06678750Withdrawn0Est. Jun 2026

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

2027

2028

2029

Integrated BiosciencesDonepezil

Oregon TherapeuticsLiposomal Bupivacaine Peri-articular Injection

StrykerShapeMatch Technology

Human BioSciencesNeuromuscular electrical stimulation

Colorado TherapeuticsNMES

MicroPortMicroPort Medial Pivot TKA

Colorado TherapeuticsControl

ExactechTKA using computer navigation

Medacta3D Metal Tibial and Femoral cones

MicroPortTotal Knee Arthroplasty with Evolution® NitrX™ Knee System

Nordic PharmaKnee prosthesis implementation with additional cement

MedactaImplantation of GMK Sphere with conventional instrumentation

Colorado TherapeuticsImmediate Compression Garment

Zimmer BiometMPS-Flex Total Knee Joint Prostheses

Corinpatient with knee arthroplasty

Showing 15 of 30 trials with date data

Clinical Trials (30)

Total enrollment: 9,726 patients across 30 trials

NCT04423276 Integrated BiosciencesDonepezil

Efficiency of Donepezil in Elderly Patients for Prevention of POCD Dysfunction

Start: Jun 2020Est. completion: Dec 2022360 patients

Phase 4Unknown

NCT04086186 Oregon TherapeuticsLiposomal Bupivacaine Peri-articular Injection

Adductor Canal Block Versus Liposomal Bupivacaine in TKA

Start: Mar 2017Est. completion: Dec 201860 patients

Phase 4Completed

NCT01483066 StrykerShapeMatch Technology

Clinical Outcomes and Cost-effectiveness Analysis of ShapeMatch Technology

Start: Jun 2012Est. completion: Jun 201538 patients

Phase 4Terminated

NCT00224913 Human BioSciencesNeuromuscular electrical stimulation

Electrical Stimulation After Total Knee Arthroplasty

Start: Mar 2002200 patients

Phase 1Unknown

NCT06953375 Colorado TherapeuticsNMES

Implementation of Neuromuscular Electrical Stimulation After Total Knee Arthroplasty

Start: May 2025Est. completion: Apr 20293,250 patients

N/ARecruiting

NCT04103502 MicroPortMicroPort Medial Pivot TKA

In Vivo Kinematics for Subjects Having a MicroPort Medial Pivot or DePuy Attune PCR TKA

Start: May 2025Est. completion: Dec 20250

N/AWithdrawn

NCT07897123 Colorado TherapeuticsControl

Effects of Mounted vs Unmounted Human-Equine Interaction on Autistic Youth

Start: Feb 2025Est. completion: Oct 202523 patients

N/ACompleted

NCT06678750 ExactechTKA using computer navigation

A Prospective Clinical Study Evaluating the Newton™ TKA Protocol

Start: Dec 2024Est. completion: Jun 20260

N/AWithdrawn

NCT06578897 Medacta3D Metal Tibial and Femoral cones

A Post-Market, Retrospective Study on 3D Metal Tibial and Femoral Cones

Start: Feb 2024Est. completion: Feb 2025118 patients

N/ACompleted

NCT05151315 MicroPortTotal Knee Arthroplasty with Evolution® NitrX™ Knee System

NitrX Total Knee Arthroplasty RSA

Start: Aug 2022Est. completion: Feb 202750 patients

N/AActive Not Recruiting

NCT04692714 Nordic PharmaKnee prosthesis implementation with additional cement

Evaluation of Two Surgical Strategies for Robotic Implantation of Total Knee Prostheses (Stryker), Cemented Versus Uncemented

Start: May 2022Est. completion: Oct 2028200 patients

N/ARecruiting

NCT05863741 MedactaImplantation of GMK Sphere with conventional instrumentation

Clinical Utility and Gait Analysis of NextAR System AUS

Start: May 2022Est. completion: May 2026100 patients

N/ARecruiting

NCT04841356 Colorado TherapeuticsImmediate Compression Garment

Swelling Management After Total Knee Arthroplasty

Start: Apr 2021Est. completion: Jul 202221 patients

N/ACompleted

NCT04427722 Zimmer BiometMPS-Flex Total Knee Joint Prostheses

PMCF Study of MPS-Flex® Knee System in TKA

Start: Feb 2021Est. completion: Dec 2024250 patients

N/ASuspended

NCT04872855 Corinpatient with knee arthroplasty

Observational Study to Evaluate Clinical Performance and Safety in Total Knee Arthroplasty

Start: Jul 2020Est. completion: Dec 2024163 patients

N/ATerminated

NCT04347343 Colorado TherapeuticsStandard Rehabilitation + Neuromuscular Electrical Stimulation and Blood Flow Restriction

Combined NMES and BFR Training After TKA

Start: Nov 2019Est. completion: Feb 202218 patients

N/ACompleted

NCT03566875 StrykerTotal knee arthroplasty with the Stryker's MAKO™ system

Total Knee Arthroplasty Robot Assisted With MAKO™ Robotic System Compared to the Conventional Total Knee Arthroplasty by Mechanical Ancillary

Start: Apr 2018Est. completion: Sep 202060 patients

N/AUnknown

NCT03325062 Colorado TherapeuticsControl

Movement Pattern Biofeedback Training After Total Knee Arthroplasty

Start: Jan 2018Est. completion: Dec 2024138 patients

N/ACompleted

NCT05211141 CorinHLS KneeTec Deep Dish

Study to Evaluate Long Term Performance and Safety of the Knee Prosthesis (HLS KneeTec Deep Dish)

Start: Feb 2017Est. completion: Dec 2022119 patients

N/ATerminated

NCT03367845 Colorado TherapeuticsControl

Efficacy of Family Programs for Improving Child and Family Health and Development

Start: Jan 2017Est. completion: Jun 20281,005 patients

N/AActive Not Recruiting

NCT02532933 Colorado TherapeuticsDePuy Synthes Attune PS RP

Stereo Radiography of TKA Patella Mechanics

Start: Jul 2015Est. completion: Dec 201744 patients

N/ACompleted

NCT04727060 Corinpatient with knee arthroplasty

Open Label Study to Collect Clinical Data to Document Clinical Performance and Safety in Total Knee Arthroplasty

Start: Dec 2011Est. completion: Nov 20232,146 patients

N/ATerminated

NCT00763113 Zimmer BiometVanguard PS Knee

A Prospective Randomized Study on Vanguard Cruciate Retaining Versus Vanguard High Flex Posterior Stabilized Total Knee System in the Early Range of Motion

Start: Jun 2007Est. completion: Jul 2012173 patients

N/ACompleted

NCT00901329 Zimmer BiometNexGen Gender Fixed Bearing Knee prosthesis

NexGen Gender Fixed Bearing Knee Versus NexGen Legacy Knee Posterior Stabilized (LPS) - Flex Fixed Bearing Knee: A Study Comparing Two Different Knee Prostheses

Start: May 2007Est. completion: Dec 201024 patients

N/AUnknown

NCT00419276 StrykerAmbulatory continuous femoral nerve block for 100 hours

Effect of Ambulatory Continuous Femoral Nerve Blocks on Readiness-for-Discharge Following Total Knee Replacement

Start: Apr 2007Est. completion: Aug 201081 patients

N/ACompleted

NCT00409266 StrykerComputer assisted navigation

CT Assessment of Minimally Invasive Surgery and Computer Assisted Navigation in Total Knee Arthroplasty

Start: Jan 2007Est. completion: Jun 20070

N/AWithdrawn

NCT02535741 StrykerTriathlon CR Total Knee System

Clinical Outcome Study for the Triathlon Cruciate Retaining (CR) Total Knee

Start: Oct 2006Est. completion: May 2016168 patients

N/ACompleted

NCT00761956 Zimmer BiometNexGen CR-Flex Fixed Bearing Knee

A Study to Compare the NexGen CR and CR-Flex Knee Implants

Start: Sep 2004Est. completion: Dec 2010189 patients

N/ACompleted

NCT00589147 Zimmer BiometThe Zimmer NexGen Legacy Knee System, modular cemented tibia

A Prospective, Randomized, Controlled Study Comparing Three Tibial Component Designs in Total Knee Arthoplasty

Start: Aug 2003Est. completion: Jun 2007397 patients

N/ACompleted

NCT00763386 Zimmer BiometNexGen LPS-Flex Fixed Bearing Knee

A Study to Compare the NexGen LPS and LPS-Flex Knee Implants

Start: Jun 2001Est. completion: Mar 2010331 patients

N/ACompleted

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

3 actively recruiting trials targeting 9,726 patients

13 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.