Total Knee Arthroplasty

Pipeline Programs

Companies

Clinical Trials

3 recruiting

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

11 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

StrykerCA - San Jose

6 programs

ShapeMatch TechnologyPhase 41 trial

Ambulatory continuous femoral nerve block for 100 hoursN/A1 trial

Computer assisted navigationN/A1 trial

Knee prosthesis implementation with additional cementN/A

Total knee arthroplasty with the Stryker's MAKO™ systemN/A1 trial

+1 more programs

Active Trials

NCT00419276Completed81Est. Aug 2010

NCT00409266Withdrawn0Est. Jun 2007

NCT03566875Unknown60Est. Sep 2020

+2 more trials

Integrated BiosciencesCA - San Carlos

1 program

DonepezilPhase 41 trial

Active Trials

NCT04423276Unknown360Est. Dec 2022

Oregon TherapeuticsFrance - Paris

1 program

Liposomal Bupivacaine Peri-articular InjectionPhase 41 trial

Active Trials

NCT04086186Completed60Est. Dec 2018

Human BioSciencesWV - Martinsburg

1 program

Neuromuscular electrical stimulationPhase 11 trial

Active Trials

NCT00224913Unknown200

Zimmer BiometFL - Jacksonville

6 programs

MPS-Flex Total Knee Joint ProsthesesN/A1 trial

NexGen CR-Flex Fixed Bearing KneeN/A1 trial

NexGen Gender Fixed Bearing Knee prosthesisN/A1 trial

NexGen LPS-Flex Fixed Bearing KneeN/A1 trial

The Zimmer NexGen Legacy Knee System, modular cemented tibiaN/A1 trial

+1 more programs

Active Trials

NCT04427722Suspended250Est. Dec 2024

NCT00761956Completed189Est. Dec 2010

NCT00901329Unknown24Est. Dec 2010

+3 more trials

Colorado TherapeuticsCO - Louisville

5 programs

ControlN/A1 trial

DePuy Synthes Attune PS RPN/A1 trial

Immediate Compression GarmentN/A1 trial

NMESN/A1 trial

Standard Rehabilitation + Neuromuscular Electrical Stimulation and Blood Flow RestrictionN/A1 trial

Active Trials

NCT03325062Completed138Est. Dec 2024

NCT02532933Completed44Est. Dec 2017

NCT04841356Completed21Est. Jul 2022

+2 more trials

CorinUK - Cirencester

3 programs

HLS KneeTec Deep DishN/A1 trial

patient with knee arthroplastyN/A1 trial

Active Trials

NCT05211141Terminated119Est. Dec 2022

NCT04872855Terminated163Est. Dec 2024

NCT04727060Terminated2,146Est. Nov 2023

MedactaSwitzerland - Castel San Pietro

2 programs

3D Metal Tibial and Femoral conesN/A1 trial

Implantation of GMK Sphere with conventional instrumentationN/A1 trial

Active Trials

NCT06578897Completed118Est. Feb 2025

NCT05863741Recruiting100Est. May 2026

MicroPortChina - Shanghai

2 programs

MicroPort Medial Pivot TKAN/A1 trial

Total Knee Arthroplasty with Evolution® NitrX™ Knee SystemN/A1 trial

Active Trials

NCT04103502Not Yet Recruiting24Est. Dec 2024

NCT05151315Active Not Recruiting50Est. Feb 2026

Nordic PharmaFrance - Paris

1 program

Knee prosthesis implementation with additional cementN/A1 trial

Active Trials

NCT04692714Recruiting200Est. Oct 2028

ExactechFL - Gainesville

1 program

TKA using computer navigationN/A1 trial

Active Trials

NCT06678750Withdrawn0Est. Jun 2026

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

2027

2028

2029

Integrated BiosciencesDonepezil

Oregon TherapeuticsLiposomal Bupivacaine Peri-articular Injection

StrykerShapeMatch Technology

Human BioSciencesNeuromuscular electrical stimulation

Colorado TherapeuticsNMES

ExactechTKA using computer navigation

MicroPortMicroPort Medial Pivot TKA

Medacta3D Metal Tibial and Femoral cones

MicroPortTotal Knee Arthroplasty with Evolution® NitrX™ Knee System

Nordic PharmaKnee prosthesis implementation with additional cement

MedactaImplantation of GMK Sphere with conventional instrumentation

Colorado TherapeuticsImmediate Compression Garment

Zimmer BiometMPS-Flex Total Knee Joint Prostheses

Corinpatient with knee arthroplasty

Colorado TherapeuticsStandard Rehabilitation + Neuromuscular Electrical Stimulation and Blood Flow Restriction

Showing 15 of 28 trials with date data

Clinical Trials (28)

Total enrollment: 8,722 patients across 28 trials

NCT04423276 Integrated BiosciencesDonepezil

Efficiency of Donepezil in Elderly Patients for Prevention of POCD Dysfunction

Start: Jun 2020Est. completion: Dec 2022360 patients

Phase 4Unknown

NCT04086186 Oregon TherapeuticsLiposomal Bupivacaine Peri-articular Injection

Adductor Canal Block Versus Liposomal Bupivacaine in TKA

Start: Mar 2017Est. completion: Dec 201860 patients

Phase 4Completed

NCT01483066 StrykerShapeMatch Technology

Clinical Outcomes and Cost-effectiveness Analysis of ShapeMatch Technology

Start: Jun 2012Est. completion: Jun 201538 patients

Phase 4Terminated

NCT00224913 Human BioSciencesNeuromuscular electrical stimulation

Electrical Stimulation After Total Knee Arthroplasty

Start: Mar 2002200 patients

Phase 1Unknown

NCT06953375 Colorado TherapeuticsNMES

Implementation of Neuromuscular Electrical Stimulation After Total Knee Arthroplasty

Start: May 2025Est. completion: Apr 20293,250 patients

N/ARecruiting

NCT06678750 ExactechTKA using computer navigation

A Prospective Clinical Study Evaluating the Newton™ TKA Protocol

Start: Dec 2024Est. completion: Jun 20260

N/AWithdrawn

NCT04103502 MicroPortMicroPort Medial Pivot TKA

In Vivo Kinematics for Subjects Having a MicroPort Medial Pivot or DePuy Attune PCR TKA

Start: May 2024Est. completion: Dec 202424 patients

N/ANot Yet Recruiting

NCT06578897 Medacta3D Metal Tibial and Femoral cones

A Post-Market, Retrospective Study on 3D Metal Tibial and Femoral Cones

Start: Feb 2024Est. completion: Feb 2025118 patients

N/ACompleted

NCT05151315 MicroPortTotal Knee Arthroplasty with Evolution® NitrX™ Knee System

NitrX Total Knee Arthroplasty RSA

Start: Aug 2022Est. completion: Feb 202650 patients

N/AActive Not Recruiting

NCT04692714 Nordic PharmaKnee prosthesis implementation with additional cement

Evaluation of Two Surgical Strategies for Robotic Implantation of Total Knee Prostheses (Stryker), Cemented Versus Uncemented

Start: May 2022Est. completion: Oct 2028200 patients

N/ARecruiting

NCT05863741 MedactaImplantation of GMK Sphere with conventional instrumentation

Clinical Utility and Gait Analysis of NextAR System AUS

Start: May 2022Est. completion: May 2026100 patients

N/ARecruiting

NCT04841356 Colorado TherapeuticsImmediate Compression Garment

Swelling Management After Total Knee Arthroplasty

Start: Apr 2021Est. completion: Jul 202221 patients

N/ACompleted

NCT04427722 Zimmer BiometMPS-Flex Total Knee Joint Prostheses

PMCF Study of MPS-Flex® Knee System in TKA

Start: Feb 2021Est. completion: Dec 2024250 patients

N/ASuspended

NCT04872855 Corinpatient with knee arthroplasty

Observational Study to Evaluate Clinical Performance and Safety in Total Knee Arthroplasty

Start: Jul 2020Est. completion: Dec 2024163 patients

N/ATerminated

NCT04347343 Colorado TherapeuticsStandard Rehabilitation + Neuromuscular Electrical Stimulation and Blood Flow Restriction

Combined NMES and BFR Training After TKA

Start: Nov 2019Est. completion: Feb 202218 patients

N/ACompleted

NCT03566875 StrykerTotal knee arthroplasty with the Stryker's MAKO™ system

Total Knee Arthroplasty Robot Assisted With MAKO™ Robotic System Compared to the Conventional Total Knee Arthroplasty by Mechanical Ancillary

Start: Apr 2018Est. completion: Sep 202060 patients

N/AUnknown

NCT03325062 Colorado TherapeuticsControl

Movement Pattern Biofeedback Training After Total Knee Arthroplasty

Start: Jan 2018Est. completion: Dec 2024138 patients

N/ACompleted

NCT05211141 CorinHLS KneeTec Deep Dish

Study to Evaluate Long Term Performance and Safety of the Knee Prosthesis (HLS KneeTec Deep Dish)

Start: Feb 2017Est. completion: Dec 2022119 patients

N/ATerminated

NCT02532933 Colorado TherapeuticsDePuy Synthes Attune PS RP

Stereo Radiography of TKA Patella Mechanics

Start: Jul 2015Est. completion: Dec 201744 patients

N/ACompleted

NCT04727060 Corinpatient with knee arthroplasty

Open Label Study to Collect Clinical Data to Document Clinical Performance and Safety in Total Knee Arthroplasty

Start: Dec 2011Est. completion: Nov 20232,146 patients

N/ATerminated

NCT00763113 Zimmer BiometVanguard PS Knee

A Prospective Randomized Study on Vanguard Cruciate Retaining Versus Vanguard High Flex Posterior Stabilized Total Knee System in the Early Range of Motion

Start: Jun 2007Est. completion: Jul 2012173 patients

N/ACompleted

NCT00901329 Zimmer BiometNexGen Gender Fixed Bearing Knee prosthesis

NexGen Gender Fixed Bearing Knee Versus NexGen Legacy Knee Posterior Stabilized (LPS) - Flex Fixed Bearing Knee: A Study Comparing Two Different Knee Prostheses

Start: May 2007Est. completion: Dec 201024 patients

N/AUnknown

NCT00419276 StrykerAmbulatory continuous femoral nerve block for 100 hours

Effect of Ambulatory Continuous Femoral Nerve Blocks on Readiness-for-Discharge Following Total Knee Replacement

Start: Apr 2007Est. completion: Aug 201081 patients

N/ACompleted

NCT00409266 StrykerComputer assisted navigation

CT Assessment of Minimally Invasive Surgery and Computer Assisted Navigation in Total Knee Arthroplasty

Start: Jan 2007Est. completion: Jun 20070

N/AWithdrawn

NCT02535741 StrykerTriathlon CR Total Knee System

Clinical Outcome Study for the Triathlon Cruciate Retaining (CR) Total Knee

Start: Oct 2006Est. completion: May 2016168 patients

N/ACompleted

NCT00761956 Zimmer BiometNexGen CR-Flex Fixed Bearing Knee

A Study to Compare the NexGen CR and CR-Flex Knee Implants

Start: Sep 2004Est. completion: Dec 2010189 patients

N/ACompleted

NCT00589147 Zimmer BiometThe Zimmer NexGen Legacy Knee System, modular cemented tibia

A Prospective, Randomized, Controlled Study Comparing Three Tibial Component Designs in Total Knee Arthoplasty

Start: Aug 2003Est. completion: Jun 2007397 patients

N/ACompleted

NCT00763386 Zimmer BiometNexGen LPS-Flex Fixed Bearing Knee

A Study to Compare the NexGen LPS and LPS-Flex Knee Implants

Start: Jun 2001Est. completion: Mar 2010331 patients

N/ACompleted

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

3 actively recruiting trials targeting 8,722 patients

14 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.