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Tobacco Use Cessation

5
Pipeline Programs
8
Companies
11
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
1
3
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

Pfizer
CHANTIXApproved
varenicline tartrate
Pfizer
oral2006
88K Part D

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
2 programs
2
VareniclinePhase 41 trial
Varenicline TartratePhase 41 trial
Active Trials
NCT02162849Active Not Recruiting204Est. Feb 2028
NCT00717093Completed432Est. Jul 2009
ViiV Healthcare
ViiV HealthcareNC - Durham
1 program
1
10-week smoking cessation group therapy combined with NicoDerm CQPhase 3
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
2 programs
1
5 APhase 21 trial
Multimedia Support InterventionN/A1 trial
Active Trials
NCT01885221Completed1,100Est. Aug 2018
NCT00384254Completed2,177Est. Jan 2008
Healis Therapeutics
Healis TherapeuticsMA - Cambridge
4 programs
Intervention ProgramN/A1 trial
Smart phone based trainingN/A1 trial
Tobacco Free Teachers, Tobacco Free SocietyN/A1 trial
Tobacco Free Teachers, Tobacco Free Society programN/A1 trial
Active Trials
NCT01841879Completed6,880Est. Jun 2016
NCT05500235Active Not Recruiting2,040Est. Jul 2025
NCT01722747Completed945
+1 more trials
Alliance Pharmaceuticals
1 program
Healthy Futures: Alternative-to-Suspension CurriculumN/A1 trial
Active Trials
NCT06483412Enrolling By Invitation2,540Est. Aug 2027
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
Smoking Cessation Intervention BundleN/A1 trial
Active Trials
NCT02281864Completed600Est. Mar 2022
GSK
GSKLONDON, United Kingdom
1 program
10-week smoking cessation group therapy combined with NicoDerm CQPHASE_31 trial
Active Trials
NCT00110630Completed250Est. Sep 2007

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
PfizerVarenicline
PfizerVarenicline Tartrate
GSK10-week smoking cessation group therapy combined with NicoDerm CQ
Oregon Therapeutics5 A
Alliance PharmaceuticalsHealthy Futures: Alternative-to-Suspension Curriculum
Healis TherapeuticsSmart phone based training
Healis TherapeuticsTobacco Free Teachers, Tobacco Free Society program
Colorado TherapeuticsSmoking Cessation Intervention Bundle
Oregon TherapeuticsMultimedia Support Intervention
Healis TherapeuticsIntervention Program
Healis TherapeuticsTobacco Free Teachers, Tobacco Free Society

Clinical Trials (11)

Total enrollment: 18,270 patients across 11 trials

NCT02162849PfizerVarenicline

Reward Sensitivity and Pharmacotherapy for Smoking Cessation

Start: Dec 2015Est. completion: Feb 2028204 patients
Phase 4Active Not Recruiting
NCT00717093PfizerVarenicline Tartrate

Study Evaluating The Efficacy Of Varenicline In Cessation Of Oral Smokeless Tobacco Use

Start: Aug 2008Est. completion: Jul 2009432 patients
Phase 4Completed
NCT00110630GSK10-week smoking cessation group therapy combined with NicoDerm CQ

Smoking Treatment of Prisoners

Start: Jun 2005Est. completion: Sep 2007250 patients
Phase 3Completed
NCT00384254Oregon Therapeutics5 A

Tobacco Quitlines:Adjunct to Dental Office Tobacco Intervention

Start: Jan 2004Est. completion: Jan 20082,177 patients
Phase 2Completed
NCT06483412Alliance PharmaceuticalsHealthy Futures: Alternative-to-Suspension Curriculum

An Evaluation of the Tobacco Prevention Toolkit Healthy Futures: Alternative-to-Suspension Vaping Intervention

Start: Mar 2025Est. completion: Aug 20272,540 patients
N/AEnrolling By Invitation
NCT05500235Healis TherapeuticsSmart phone based training

Comparing Smartphone to In-person Training to Scale Up a Tobacco Control Program for Teachers in India

Start: Jun 2023Est. completion: Jul 20252,040 patients
N/AActive Not Recruiting
NCT05346991Healis TherapeuticsTobacco Free Teachers, Tobacco Free Society program

Disseminating an Evidence-based Tobacco Control Intervention for School Teachers in India

Start: Jun 2018Est. completion: Jul 20201,102 patients
N/ACompleted
NCT02281864Colorado TherapeuticsSmoking Cessation Intervention Bundle

Interventions to Help Smoking Parents of Inpatients Reduce Exposure (INSPIRE)

Start: Dec 2014Est. completion: Mar 2022600 patients
N/ACompleted
NCT01885221Oregon TherapeuticsMultimedia Support Intervention

A Multi-Media Approach to Partner Support in Smokeless Tobacco Cessation (UCare-ChewFree)

Start: Sep 2012Est. completion: Aug 20181,100 patients
N/ACompleted
NCT01841879Healis TherapeuticsIntervention Program

Mumbai Worksite Tobacco Control Study

Start: Jun 2010Est. completion: Jun 20166,880 patients
N/ACompleted
NCT01722747Healis TherapeuticsTobacco Free Teachers, Tobacco Free Society

Bihar School Teachers Study

Start: Jun 2009945 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
8 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.