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Tetanus

20
Pipeline Programs
8
Companies
38
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
1
5
0
12
1
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Vaccine
15100%
+ 28 programs with unclassified modality

Competitive Landscape

8 companies ranked by most advanced pipeline stage

MCM Vaccines
MCM VaccinesNetherlands - Leiden
1 program
1
Td5apPhase 41 trial
Active Trials
NCT00870350Unknown400Est. Jun 2010
ViiV Healthcare
ViiV HealthcareNC - Durham
15 programs
5
10
BoostrixPhase 31 trial
BoostrixPhase 31 trial
Boostrix®Phase 31 trial
DTPa-IPVPhase 31 trial
GSK Biologicals'Kinrix®Phase 31 trial
+10 more programs
Active Trials
NCT01171989Completed391Est. Dec 2010
NCT00871741Terminated16Est. Jun 2009
NCT01090453Completed480Est. Oct 2011
+12 more trials
CanSino Biologics
CanSino BiologicsChina - Tianjin
2 programs
1
1
TTVAPhase 31 trial
TTVAPhase 11 trial
Active Trials
NCT06123663Completed60Est. Jun 2024
NCT06120751Completed1,000Est. Sep 2024
Sinovac Biotech
Sinovac BiotechChina - Beijing
2 programs
1
1
Investigational tetanus vaccine, adsorbedPhase 3Vaccine1 trial
SNA02-48Phase 1/22 trials
Active Trials
NCT07633119Not Yet Recruiting600Est. May 2027
NCT06939777Completed255Est. Mar 2026
NCT06049940Completed1,260Est. Mar 2024
GSK
GSKLONDON, United Kingdom
15 programs
GSK2202083A vaccinePHASE_2Vaccine
GSK2202083A vaccinePHASE_2Vaccine
GSK2202083A vaccinePHASE_2Vaccine
GSK2202083A vaccinePHASE_2Vaccine
Infanrix hexa™PHASE_2
+10 more programs
Sanofi
SanofiPARIS, France
5 programs
Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine Adsorbed Formulation 1PHASE_1_2Vaccine1 trial
TdapPHASE_35 trials
Adacel®: Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis AdsorbedPHASE_41 trial
Tetanus Toxoid, Diphtheria Toxoid and Pertussis VaccinePHASE_4Vaccine1 trial
Tetanus-diphtheria-acellular pertussisPHASE_41 trial
Active Trials
NCT02587520Completed1,363Est. Feb 2017
NCT06258057Active Not Recruiting365,000Est. Dec 2026
NCT05264662Completed511Est. Mar 2025
+6 more trials
GC Biopharma
GC BiopharmaKorea - Yongin
2 programs
Biological: GC3111 vaccinePHASE_1_2Vaccine1 trial
GC3111 vaccinePHASE_2Vaccine1 trial
Active Trials
NCT02813486Unknown220Est. Nov 2016
NCT04238975Unknown213Est. May 2021
Grifols
GrifolsNEW YORK, NY
1 program
Tetanus Immune GlobulinPHASE_41 trial
Active Trials
NCT00437671Terminated6Est. Sep 2007

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
SanofiTdap
SanofiTdap
SanofiTetanus Toxoid, Diphtheria Toxoid and Pertussis Vaccine
SanofiAdacel®: Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Adsorbed
MCM VaccinesTd5ap
GrifolsTetanus Immune Globulin
SanofiTetanus-diphtheria-acellular pertussis
Sinovac BiotechSNA02-48
CanSino BiologicsTTVA
Sinovac BiotechInvestigational tetanus vaccine, adsorbed
SanofiTdap
SanofiTdap
ViiV HealthcareBoostrix
ViiV HealthcareInfanrix-IPV/Hib™
SanofiTdap

Showing 15 of 38 trials with date data

Clinical Trials (38)

Total enrollment: 389,016 patients across 38 trials

Pertussis Vaccination Among HIV-infected and HIV-uninfected Pregnant Women

Start: Mar 2022Est. completion: Mar 2025511 patients
Phase 4Completed

Study to Evaluate the Immune Response After Booster Vaccination With Tdap-IPV Vaccine (Against Tetanus, Diphtheria, Pertussis and Poliomyelitis) in Children Who Received Different Pertussis Primary Vaccine Regimens in Republic of South Africa

Start: Jan 2021Est. completion: Jan 2023273 patients
Phase 4Completed
NCT01439165SanofiTetanus Toxoid, Diphtheria Toxoid and Pertussis Vaccine

Safety and Immunogenicity in Adults of Revaccination With Adacel® Vaccine 10 Years After a Previous Dose

Start: Nov 2011Est. completion: Feb 20171,330 patients
Phase 4Completed
NCT01311557SanofiAdacel®: Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Adsorbed

Study of Adacel® Vaccine Administered to Persons 10 Years of Age

Start: Mar 2011Est. completion: Jan 20121,302 patients
Phase 4Completed

An Immunogenicity and Safety Study of Tetanus, Diphtheria and Acellular Pertussis Vaccine Booster

Start: Apr 2009Est. completion: Jun 2010400 patients
Phase 4Unknown
NCT00437671GrifolsTetanus Immune Globulin

Tetanus Immunization in Subjects With No Immunization History or With Tetanus Antibody Levels Below Protective Levels

Start: Mar 2007Est. completion: Sep 20076 patients
Phase 4Terminated
NCT00347958SanofiTetanus-diphtheria-acellular pertussis

Descriptive, Open-label, Multicenter Study of the Safety of Redosing With ADACEL® Vaccine

Start: Aug 2006Est. completion: Oct 2008545 patients
Phase 4Completed

A Phase Ⅲ Clinical Study of SNA02-48 Injection

Start: Jun 2026Est. completion: May 2027600 patients
Phase 3Not Yet Recruiting

A Clinical Trial to Evaluate the Safety and Immunogenicity of a Single Dose of Adsorbed Tetanus Vaccine in a Population Aged 18 Years and Over

Start: Mar 2024Est. completion: Sep 20241,000 patients
Phase 3Completed
NCT06049940Sinovac BiotechInvestigational tetanus vaccine, adsorbed

Safety and Immunogenicity of Tetanus Vaccine, Adsorbed in 18~44 Years Old Population

Start: Sep 2023Est. completion: Mar 20241,260 patients
Phase 3Completed

Study of SP306 Given Intramuscularly Compared to DT Given Subcutaneously in Japanese Adolescents 11 - 12 Years Old

Start: Mar 2014Est. completion: Mar 2015534 patients
Phase 3Completed

Sanofi Pasteur's Tdap Combined Vaccine as a Booster Versus Local DT Vaccine in Children or Versus Local Td Vaccine in Adolescents and Adults in China.

Start: Nov 2013Est. completion: Apr 20151,440 patients
Phase 3Completed

Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Boostrix™ Vaccine in Previously Boosted Young Adults

Start: Jan 2013Est. completion: Apr 2014165 patients
Phase 3Completed
NCT01086423ViiV HealthcareInfanrix-IPV/Hib™

Immunogenicity and Safety Study of GSK Biologicals' Infanrix-IPV+Hib™ Vaccine

Start: Mar 2010Est. completion: Nov 2010985 patients
Phase 3Completed

Study Comparing a Tdap-IPV Combined Vaccine With a Tetanus Monovalent Vaccine in Healthy Adults

Start: Jul 2009Est. completion: Dec 200952 patients
Phase 3Completed
NCT00871117ViiV HealthcareGSK Biologicals'Kinrix®

Immunogenicity and Safety of Kinrix + (Measles Mumps Rubella) MMR Vaccine With and Without Varicella Vaccine in Healthy Children 4-6 Years

Start: Mar 2009Est. completion: Jun 2010478 patients
Phase 3Completed

Evaluation of GlaxoSmithKline Biologicals' Boostrix® Vaccine in Comparison With Decavac™ Vaccine.

Start: Feb 2009Est. completion: Oct 20091,332 patients
Phase 3Completed

Safety and Immunogenicity of Tdap Vaccine Compared to DTaP Vaccine in Children 4 to 6 Years of Age

Start: Apr 2007Est. completion: Dec 20091,045 patients
Phase 3Completed

Study to Assess Safety & Immunogenicity of GSK Biologicals' DTPa/Hib Vaccine vs Separate Administration of DTPa and Hib.

Start: Jan 2007Est. completion: Jun 2007660 patients
Phase 3Completed

Study to Assess the Safety & Reactogenicity of GSK Biologicals' dTpa Vaccine (Boostrix) When Given at 6-8 Years of Age.

Start: Jan 2007Est. completion: Feb 200730 patients
Phase 3Completed
NCT00379977ViiV Healthcarediphtheria, tetanus, pertussis & Hib vaccine

Study to Assess the Safety & Reactogenicity of GSK Biologicals' DTPa/Hib Vaccine When Given at 3, 4 and 5 Months of Age

Start: Sep 2006Est. completion: Dec 200630 patients
Phase 3Completed
NCT00197275ViiV HealthcareHib-MenAC mixed with Tritanrix™-HepB

Lot-to-lot Consistency of Tritanrix™-HepB/Hib-MenAC & Its Non-inferiority vs Tritanrix™-HepB/Hiberix™ in Infants

Start: Feb 2006Est. completion: Nov 2006800 patients
Phase 3Completed

Evaluation of the Immunogenicity, Safety and Reactogenicity of the Combined DTPa-IPV Vaccine in Healthy Infants

Start: Jan 2006Est. completion: Jan 2007458 patients
Phase 3Completed

Immune Response and Safety Comparison of 3 Lots of GSK Biologicals' DTaP-IPV Candidate Vaccine to DTaP + IPV Vaccines

Start: Jan 2005Est. completion: Dec 20064,209 patients
Phase 3Completed

Pertussis Maternal Immunization Study

Start: Nov 2007Est. completion: Dec 2015320 patients
Phase 2/3Completed

A Study to Evaluate the Safety and Efficacy(Immunogenicity) of GC3111 in Healthy Adults

Start: Oct 2019Est. completion: May 2021213 patients
Phase 2Unknown

Safety and Immunogenicity of New Formulations of GlaxoSmithKline Biologicals' DTPa-HBV-IPV/Hib Vaccine (GSK217744)

Start: Dec 2010Est. completion: Jan 2012721 patients
Phase 2Completed
NCT01171989ViiV HealthcareGSK2202083A vaccine

Immunogenicity and Safety Study of GlaxoSmithKline Biologicals' GSK2202083A Vaccine Administered as a Booster Dose

Start: Aug 2010Est. completion: Dec 2010391 patients
Phase 2Completed
NCT01090453ViiV HealthcareGSK2202083A vaccine

Study of GlaxoSmithKline Biologicals' GSK2202083A Vaccine in Healthy Infants

Start: May 2010Est. completion: Oct 2011480 patients
Phase 2Completed
NCT00970307ViiV HealthcareGSK2202083A vaccine

Immunogenicity and Safety Study of GSK Biologicals' GSK2202083A Vaccine in Healthy Infants at 2, 3 and 4 Months of Age

Start: Aug 2009Est. completion: Jan 2010421 patients
Phase 2Completed
NCT00871741ViiV HealthcareGSK2202083A vaccine

Feasibility Study of GlaxoSmithKline Biologicals' GSK2202083A Vaccine in Healthy Infants at 3, 5 and 11 Months of Age.

Start: Apr 2009Est. completion: Jun 200916 patients
Phase 2Terminated

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SNA02-48 Injection in Chinese Adult Participants

Start: Apr 2025Est. completion: Mar 2026255 patients
Phase 1/2Completed
NCT02813486GC BiopharmaBiological: GC3111 vaccine

Safety and Immunogenicity Study of Tetanus, Diphtheria and Acellular Pertussis (Tdap) Vaccine

Start: Jun 2016Est. completion: Nov 2016220 patients
Phase 1/2Unknown
NCT02587520SanofiTetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine Adsorbed Formulation 1

Study of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine Adsorbed in Healthy Subjects

Start: Oct 2015Est. completion: Feb 20171,363 patients
Phase 1/2Completed

A Study to Evaluate the Safety and Immunogenicity of a Single Dose of Adsorbed Tetanus Vaccine in a Population Aged 18 Years and Over

Start: Dec 2023Est. completion: Jun 202460 patients
Phase 1Completed

A Study to Describe the Safety Profile and Compare the Immune Response of 4 Different Formulations of an Investigational Tdap Vaccine When Compared to Licensed Tdap Vaccine in Young Adults in Canada

Start: Jun 2019Est. completion: Apr 202171 patients
Phase 1Completed

Study of the Tdap Combined Vaccine (ADACEL™) as a Booster Dose in Healthy Adults and Children in China

Start: Aug 2013Est. completion: Jan 201440 patients
Phase 1Completed

Safety of Tetanus, Diphtheria, Acellular Pertussis With 5 Acellular Pertussis Components (Tdap5) Vaccination During Pregnancy

Start: Jan 2024Est. completion: Dec 2026365,000 patients
N/AActive Not Recruiting

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

12 late-stage (Phase 3) programs, potential near-term approvals
8 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.