SURGICAL SITE INFECTION

Pipeline Programs

Companies

Clinical Trials

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule

1100%

+ 16 programs with unclassified modality

Competitive Landscape

13 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

Colorado TherapeuticsCO - Louisville

1 program

Administration of VancomycinPhase 41 trial

Active Trials

NCT03453684Completed60Est. Jul 2015

Angeles TherapeuticsCA - Los Angeles

1 program

CefazolinPhase 41 trial

Active Trials

NCT04834310Withdrawn0Est. Jul 2024

SolventumMN - St. Paul

1 program

mupirocin calcium ointment, 2%Phase 41 trial

Active Trials

NCT01313182Completed1,874Est. Sep 2012

MenariniGermany - Dresden

1 program

DelafloxacinPhase 3Small Molecule1 trial

Active Trials

NCT04042077Terminated268Est. Oct 2020

Sharp TherapeuticsPA - Pittsburgh

2 programs

ErtapenemPhase 2/3

3M Skin and Nasal AntisepticN/A1 trial

Active Trials

NCT01148030Terminated333Est. Jul 2012

MSDIreland - Ballydine

1 program

ErtapenemPhase 2/31 trial

Active Trials

NCT01203046Completed56Est. Oct 2011

HK SurgicalCA - San Clemente

1 program

Tumescent Anesthesia and antibiotic deliveryPhase 2/31 trial

Active Trials

NCT03226626Unknown330Est. Jul 2022

Dr. Reddy's LaboratoriesGA - Norcross

1 program

DFA-02Phase 1/21 trial

Active Trials

NCT01496352Completed30Est. Jun 2013

Verona PharmaUK - London

3 programs

AlexisN/A1 trial

Antibiotic Stewardship ProgramN/A1 trial

Disposable negative wound pressure deviceN/A1 trial

Active Trials

NCT03820648Terminated212Est. Dec 2019

NCT04199494Unknown1,200Est. Dec 2022

NCT03700086Completed100Est. Oct 2019

GetingeChina - Suzhou

2 programs

Conventional ventilation + instrumental tables with integrated laminar airflowN/A1 trial

Investigation of Environmental Parameters in Operating RoomsN/A1 trial

Active Trials

NCT04676841Unknown100Est. Nov 2022

NCT05816135Unknown5,000Est. Dec 2023

Innovation PharmaceuticalsMA - Wakefield

1 program

Implementation of the AO Trauma SSI Prevention BundleN/A1 trial

Active Trials

NCT03380273Terminated222Est. Dec 2021

Combined TherapeuticsUK - London

1 program

Purse string closure of IleostomyN/A1 trial

Active Trials

NCT04757623Unknown140Est. Mar 2022

TakedaTOKYO, Japan

1 program

AmpicillinPHASE_41 trial

Active Trials

NCT06368102Completed70Est. Sep 2025

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

TakedaAmpicillin

Angeles TherapeuticsCefazolin

Colorado TherapeuticsAdministration of Vancomycin

Solventummupirocin calcium ointment, 2%

MenariniDelafloxacin

HK SurgicalTumescent Anesthesia and antibiotic delivery

MSDErtapenem

Dr. Reddy's LaboratoriesDFA-02

Combined TherapeuticsPurse string closure of Ileostomy

GetingeInvestigation of Environmental Parameters in Operating Rooms

Verona PharmaAntibiotic Stewardship Program

Innovation PharmaceuticalsImplementation of the AO Trauma SSI Prevention Bundle

GetingeConventional ventilation + instrumental tables with integrated laminar airflow

Verona PharmaDisposable negative wound pressure device

Verona PharmaAlexis

Showing 15 of 16 trials with date data

Clinical Trials (16)

Total enrollment: 9,995 patients across 16 trials

NCT06368102 TakedaAmpicillin

Prophylactic Effects for Preventing Surgical Site Infection in Third Molar Surgery

Start: May 2024Est. completion: Sep 202570 patients

Phase 4Completed

NCT04834310 Angeles TherapeuticsCefazolin

Postoperative Antibiotics Following Primary and Secondary Breast Augmentation

Start: Apr 2021Est. completion: Jul 20240

Phase 4Withdrawn

NCT03453684 Colorado TherapeuticsAdministration of Vancomycin

Pharmacokinetics of Preoperative Vancomycin

Start: Dec 2012Est. completion: Jul 201560 patients

Phase 4Completed

NCT01313182 Solventummupirocin calcium ointment, 2%

Prevention of Surgical Site Infections: Effectiveness of Nasal Povidone-Iodine and Nasal Mupirocin

Start: Mar 2011Est. completion: Sep 20121,874 patients

Phase 4Completed

NCT04042077 MenariniDelafloxacin

Delafloxacin IV and OS Administration Compared to Best Available Therapy in Patients With Surgical Site Infections

Start: Sep 2019Est. completion: Oct 2020268 patients

Phase 3Terminated

NCT03226626 HK SurgicalTumescent Anesthesia and antibiotic delivery

Tumescent Anesthesia Antibiotic Delivery (TAAD)

Start: Dec 2021Est. completion: Jul 2022330 patients

Phase 2/3Unknown

NCT01203046 MSDErtapenem

Early Short-term Antibiotic Therapy in Penetrating Abdominal Trauma, 3 vs 7 Days

Start: Dec 2010Est. completion: Oct 201156 patients

Phase 2/3Completed

NCT01496352 Dr. Reddy's LaboratoriesDFA-02

DFA-02 in Patients Undergoing Colorectal Surgery

Start: Feb 2012Est. completion: Jun 201330 patients

Phase 1/2Completed

NCT04757623 Combined TherapeuticsPurse string closure of Ileostomy

COMPARISON OF PURSE-STRING CLOSURE VERSUS CONVENTIONAL PRIMARY CLOSURE FOLLOWING STOMA REVERSAL TO REDUCE SURGICAL SITE INFECTION RATE"

Start: Feb 2021Est. completion: Mar 2022140 patients

N/AUnknown

NCT05816135 GetingeInvestigation of Environmental Parameters in Operating Rooms

Investigation of Environmental Parameters in Operating Rooms

Start: Jan 2021Est. completion: Dec 20235,000 patients

N/AUnknown

NCT04199494 Verona PharmaAntibiotic Stewardship Program

Antibiotic Stewardship Program in Pancreatic Surgery: a Multicenter Time Series Analysis (BIOSTEPS).

Start: Dec 2019Est. completion: Dec 20221,200 patients

N/AUnknown

NCT03380273 Innovation PharmaceuticalsImplementation of the AO Trauma SSI Prevention Bundle

AO Multicenter Intervention Trial for Prevention of Surgical Site Infection

Start: Dec 2019Est. completion: Dec 2021222 patients

N/ATerminated

NCT04676841 GetingeConventional ventilation + instrumental tables with integrated laminar airflow

Wound Contamination During Orthopaedic Surgery

Start: Sep 2019Est. completion: Nov 2022100 patients

N/AUnknown

NCT03700086 Verona PharmaDisposable negative wound pressure device

Efficacy of NPWT in Reducing the Incidence of Wound Infection After Pancreatic Surgery

Start: Jul 2018Est. completion: Oct 2019100 patients

N/ACompleted

NCT03820648 Verona PharmaAlexis

Wound Protector Dual-ring Alexis® in Pancreaticoduodenectomy

Start: Sep 2017Est. completion: Dec 2019212 patients

N/ATerminated

NCT01148030 Sharp Therapeutics3M Skin and Nasal Antiseptic

Impact of Pre-surgical Nasal Bacterial Reduction on Postoperative Surgical Site Infections / Standard Care Change

Start: Jun 2010Est. completion: Jul 2012333 patients

N/ATerminated

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals

14 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.