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Substance Abuse

7
Pipeline Programs
11
Companies
20
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
0
2
0
1
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

11 companies ranked by most advanced pipeline stage

Abbott
AbbottABBOTT PARK, IL
1 program
1
divalproex sodium ERPhase 41 trial
Active Trials
NCT00203528Completed30Est. Feb 2007
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
6 programs
3
1
Brief Strategic Family TherapyPhase 31 trial
CBT, Cognitive Behavioral TherapyPhase 11 trial
ITSANPhase 11 trial
MTI, Minimal Transitional InterventionPhase 11 trial
Contingency ManagementN/A1 trial
+1 more programs
Active Trials
NCT03015805Completed310Est. Jun 2023
NCT04711681Completed13,498Est. Mar 2015
NCT00680576Completed140Est. Aug 2013
+3 more trials
Polaris Pharma
Polaris PharmaCA - San Diego
1 program
1
STaRSPhase 21 trial
Active Trials
NCT01488630Completed60Est. Mar 2013
Prevail Therapeutics
1 program
1
atomoxetinePhase 21 trial
Active Trials
NCT00617201Completed50Est. Aug 2011
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
4 programs
Contingency management: voucher/monetary incentives for treatment attendanceN/A1 trial
JUSTN/A1 trial
SHADE therapy + CONNECT FaceBook supportN/A1 trial
Trauma-focused Substance Abuse InterventionN/A1 trial
Active Trials
NCT01090245Completed202Est. Aug 2014
NCT02449057Completed150Est. Jun 2016
NCT03727659Completed39Est. Dec 2018
+1 more trials
iNova Pharmaceuticals
iNova PharmaceuticalsAustralia - Chatswood
2 programs
Dual ProcessingN/A1 trial
Parenting Mindfully ProgramN/A1 trial
Active Trials
NCT01320748Completed29Est. Jan 2013
NCT02038231Completed100Est. Jul 2019
Mott
MottCT - Farmington
1 program
Family Spirit curriculumN/A1 trial
Active Trials
NCT00356551Completed320Est. Sep 2005
Innovation Pharmaceuticals
1 program
Master MindN/A1 trial
Active Trials
NCT03212066Completed518Est. Aug 2019
Integrated Biosciences
Integrated BiosciencesCA - San Carlos
1 program
Peer Recovery SupportN/A1 trial
Active Trials
NCT04700696Completed117Est. Sep 2023
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
Strengths-based case managementN/A1 trial
Active Trials
NCT00786630Completed726Est. Feb 2013
Temple Therapeutics
Temple TherapeuticsNetherlands - Geleen
1 program
Tool to provide re-entry support and improve linkage to healthcare and social servicesN/A1 trial
Active Trials
NCT07432555Not Yet Recruiting74Est. Aug 2026

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Abbottdivalproex sodium ER
Oregon TherapeuticsBrief Strategic Family Therapy
Polaris PharmaSTaRS
Prevail Therapeuticsatomoxetine
Oregon TherapeuticsCBT, Cognitive Behavioral Therapy
Oregon TherapeuticsITSAN
Oregon TherapeuticsMTI, Minimal Transitional Intervention
Temple TherapeuticsTool to provide re-entry support and improve linkage to healthcare and social services
Integrated BiosciencesPeer Recovery Support
Oregon TherapeuticsContingency Management
Innovation PharmaceuticalsMaster Mind
Angeles TherapeuticsSHADE therapy + CONNECT FaceBook support
Angeles TherapeuticsJUST
iNova PharmaceuticalsParenting Mindfully Program
Angeles TherapeuticsTrauma-focused Substance Abuse Intervention

Showing 15 of 20 trials with date data

Clinical Trials (20)

Total enrollment: 17,081 patients across 20 trials

NCT00203528Abbottdivalproex sodium ER

Divalproex ER vs. Risperidone for Bipolar Disorder With Comorbid Substance Use Disorder

Start: Jan 2004Est. completion: Feb 200730 patients
Phase 4Completed
NCT00095303Oregon TherapeuticsBrief Strategic Family Therapy

Brief Strategic Family Therapy for Adolescent Drug Abusers

Start: Aug 2004Est. completion: Aug 2011480 patients
Phase 3Completed
NCT01488630Polaris PharmaSTaRS

Substance Treatment and HIV Testing and Referral System

Start: Dec 2011Est. completion: Mar 201360 patients
Phase 2Completed
NCT00617201Prevail Therapeuticsatomoxetine

Evaluation of Atomoxetine for Cocaine Dependence: A Pilot Trial

Start: Jul 2007Est. completion: Aug 201150 patients
Phase 2Completed
NCT00680576Oregon TherapeuticsCBT, Cognitive Behavioral Therapy

Adolescent Substance Abuse: Progressive Treatment

Start: Mar 2008Est. completion: Aug 2013140 patients
Phase 1Completed
NCT01188434Oregon TherapeuticsITSAN

Integrating Interventions for Maternal Substance Abuse

Start: Sep 2007Est. completion: Aug 201231 patients
Phase 1Completed
NCT00680381Oregon TherapeuticsMTI, Minimal Transitional Intervention

Transitional Treatment of Adolescents in Family Therapy

Start: Jan 2004Est. completion: Jul 201490 patients
Phase 1Completed
NCT07432555Temple TherapeuticsTool to provide re-entry support and improve linkage to healthcare and social services

Testing a Mobile Health Application to Improve HIV Prevention and Substance Use Treatment Among Women Involved in the Carceral System

Start: Mar 2026Est. completion: Aug 202674 patients
N/ANot Yet Recruiting
NCT04700696Integrated BiosciencesPeer Recovery Support

Enhancing Permanency in Children and Families

Start: Oct 2017Est. completion: Sep 2023117 patients
N/ACompleted
NCT03015805Oregon TherapeuticsContingency Management

Teen Success Project

Start: Oct 2017Est. completion: Jun 2023310 patients
N/ACompleted
NCT03212066Innovation PharmaceuticalsMaster Mind

Master Mind Program Evaluation Study

Start: Aug 2017Est. completion: Aug 2019518 patients
N/ACompleted
NCT03727659Angeles TherapeuticsSHADE therapy + CONNECT FaceBook support

CONNECT for Depressed Cannabis Users Trial

Start: Mar 2017Est. completion: Dec 201839 patients
N/ACompleted
NCT02449057Angeles TherapeuticsJUST

An Evaluation of JUST Court in Yuma County, AZ

Start: Mar 2014Est. completion: Jun 2016150 patients
N/ACompleted
NCT02038231iNova PharmaceuticalsParenting Mindfully Program

Parenting Mindfully Study

Start: Feb 2014Est. completion: Jul 2019100 patients
N/ACompleted
NCT01825694Angeles TherapeuticsTrauma-focused Substance Abuse Intervention

An Integrated Treatment for Comorbid PTSD and Substance Abuse in Adolescents

Start: Apr 2013Est. completion: May 2015117 patients
N/ACompleted
NCT01320748iNova PharmaceuticalsDual Processing

fMRI Study of a Dual Process Treatment Protocol With Substance Dependent Adults

Start: Feb 2011Est. completion: Jan 201329 patients
N/ACompleted
NCT01090245Angeles TherapeuticsContingency management: voucher/monetary incentives for treatment attendance

Using Incentives to Improve Parolee Participation and Attendance in Community Treatment

Start: Apr 2010Est. completion: Aug 2014202 patients
N/ACompleted
NCT00786630Colorado TherapeuticsStrengths-based case management

Intervention to Reduce Injection Drug Use

Start: Nov 2007Est. completion: Feb 2013726 patients
N/ACompleted
NCT04711681Oregon TherapeuticsPositive Behavior Supports in Middle Schools

Implementing School Wide PBS in Middle Schools: The Foundation for Effective Prevention

Start: Aug 2006Est. completion: Mar 201513,498 patients
N/ACompleted
NCT00356551MottFamily Spirit curriculum

Family Spirit Study

Start: May 2002Est. completion: Sep 2005320 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
11 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.