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Spondylolisthesis

3
Pipeline Programs
9
Companies
8
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
1
1
0
0
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

6 companies ranked by most advanced pipeline stage

Zimmer Biomet
Zimmer BiometFL - Jacksonville
4 programs
1
1
Trabecular Metal Intervertebral Cage with RSA beadsPhase 41 trial
CopiosPhase 21 trial
Aspen Spinous Process Fixation DeviceN/A1 trial
Posterior Lateral Fusion (PLF) With DynesysN/A1 trial
Active Trials
NCT01560273Terminated25Est. Sep 2015
NCT00791180Completed38Est. Mar 2011
NCT01123850Terminated45Est. Oct 2012
+1 more trials
Novadip Biosciences
Novadip BiosciencesBelgium - Mont-Saint-Guibert
1 program
1
NVD-001Phase 1/21 trial
Active Trials
NCT03100032Completed48Est. Jun 2021
Paradigm Therapeutics
Paradigm TherapeuticsSC - Mount Pleasant
1 program
Dynamic Stabilization SystemN/A1 trial
Active Trials
NCT01461005Terminated1Est. Sep 2016
Spine BioPharma
Spine BioPharmaNY - New York
1 program
Dynamic Stabilization SystemN/A
Bioventus
BioventusDURHAM, NC
1 program
OsteoAMPN/A1 trial
Active Trials
NCT02225444Completed42Est. Oct 2019
Elutia
ElutiaSILVER SPRING, MD
1 program
ViBone®N/A1 trial
Active Trials
NCT03896347Withdrawn0Est. Feb 2020

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Zimmer BiometTrabecular Metal Intervertebral Cage with RSA beads
Zimmer BiometCopios
Novadip BiosciencesNVD-001
ElutiaViBone®
BioventusOsteoAMP
Zimmer BiometAspen Spinous Process Fixation Device
Paradigm TherapeuticsDynamic Stabilization System
Zimmer BiometPosterior Lateral Fusion (PLF) With Dynesys

Clinical Trials (8)

Total enrollment: 216 patients across 8 trials

NCT00493558Zimmer BiometTrabecular Metal Intervertebral Cage with RSA beads

Spine Research With Roentgen Stereophotogrammetric Analysis

Start: Jul 2007Est. completion: Jun 201217 patients
Phase 4Completed
NCT01123850Zimmer BiometCopios

CopiOs Posterolateral Fusion Procedure

Start: Jun 2010Est. completion: Oct 201245 patients
Phase 2Terminated
NCT03100032Novadip BiosciencesNVD-001

Safety and Preliminary Effectiveness of NVD-001 for the Treatment of Low Grade Degenerative Lumbar Spondylolisthesis

Start: Jan 2017Est. completion: Jun 202148 patients
Phase 1/2Completed
NCT03896347ElutiaViBone®

A Study Evaluating 3-Level OLIF Spine Fusion

Start: Jul 2019Est. completion: Feb 20200
N/AWithdrawn
NCT02225444BioventusOsteoAMP

A Prospective Study of Instrumented, Posterolateral Lumbar Fusions (PLF) With OsteoAMP®

Start: Nov 2015Est. completion: Oct 201942 patients
N/ACompleted
NCT01560273Zimmer BiometAspen Spinous Process Fixation Device

Aspen Spinous Process Fixation System for Use in PLF in Patients With Spondylolisthesis

Start: Feb 2012Est. completion: Sep 201525 patients
N/ATerminated
NCT01461005Paradigm TherapeuticsDynamic Stabilization System

A Postmarket Surveillance Study of the Paradigm Spine Dynamic Stabilization System (DSS)

Start: Sep 2011Est. completion: Sep 20161 patients
N/ATerminated
NCT00791180Zimmer BiometPosterior Lateral Fusion (PLF) With Dynesys

Posterior Lateral Fusion (PLF) With Dynesys

Start: Mar 2006Est. completion: Mar 201138 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

9 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.