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Spine Surgery

5
Pipeline Programs
9
Companies
7
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
0
5
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

Merck & Co.
BRIDIONApproved
sugammadex
Merck & Co.
intravenous2015

Competitive Landscape

9 companies ranked by most advanced pipeline stage

Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
2 programs
2
SugammadexPhase 41 trial
sugammadexPhase 41 trial
Active Trials
NCT05887375Completed118Est. Jan 2026
NCT03112993Completed40Est. Aug 2018
MSD
MSDIreland - Ballydine
2 programs
2
SugammadexPhase 4
sugammadexPhase 4
Merck & Co.
Merck & Co.RAHWAY, NJ
1 program
1
sugammadexPHASE_4
Pfizer
PfizerNEW YORK, NY
1 program
DexmedetomidineN/A1 trial
Active Trials
NCT00494832Completed40Est. May 2010
Medasense Biometrics
Medasense BiometricsIsrael - Ramat Gan
1 program
NOL guided intraoperative analgesiaN/A1 trial
Active Trials
NCT07608276Not Yet Recruiting100Est. Mar 2027
NuVasive
NuVasiveCA - San Diego
1 program
NuvaMap O.R.N/A
Globus Medical
Globus MedicalAUDUBON, PA
1 program
NuvaMap O.R.N/A1 trial
Active Trials
NCT02606695Completed306Est. Dec 2020
Medtronic
MedtronicNJ - Phillipsburg
1 program
Solera™ MedtronicN/A1 trial
Active Trials
NCT02551302Unknown60Est. Dec 2017
Surgify Medical
Surgify MedicalFinland - Espoo
1 program
Surgify Safety BurrN/A1 trial
Active Trials
NCT05269836Completed22Est. Nov 2022

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Sharp TherapeuticsSugammadex
Sharp Therapeuticssugammadex
Medasense BiometricsNOL guided intraoperative analgesia
Surgify MedicalSurgify Safety Burr
Globus MedicalNuvaMap O.R.
MedtronicSolera™ Medtronic
PfizerDexmedetomidine

Clinical Trials (7)

Total enrollment: 686 patients across 7 trials

Sugammadex vs Neostigmine/Glycopyrrolate on Urinary Retention After Spine Surgery

Start: Aug 2023Est. completion: Jan 2026118 patients
Phase 4Completed

Speed of Recovery of Reversal of Neuromuscular Blockade in Geriatric Patients Undergoing Spine Surgery

Start: May 2017Est. completion: Aug 201840 patients
Phase 4Completed
NCT07608276Medasense BiometricsNOL guided intraoperative analgesia

Impact of NOL - Nociception Level Index Intraoperative Monitoring on Perioperative Outcomes in Spine Surgery - a Quality Improvement Pilot

Start: May 2026Est. completion: Mar 2027100 patients
N/ANot Yet Recruiting
NCT05269836Surgify MedicalSurgify Safety Burr

Use of Surgify Safety Burr in Hard Tissue Cutting, Head and Spine Area

Start: Mar 2022Est. completion: Nov 202222 patients
N/ACompleted

Comprehensive Spinal Alignment Planning Study

Start: Mar 2016Est. completion: Dec 2020306 patients
N/ACompleted
NCT02551302MedtronicSolera™ Medtronic

"Efficacy of Hybrid Systems ("Topping Off") Versus Rigid Spinal Fusion in Lumbar Fusion Surgery: A Dual-center, Prospective, Randomized Pilot Study ("CD Horizon BalanC")"

Start: Oct 2015Est. completion: Dec 201760 patients
N/AUnknown
NCT00494832PfizerDexmedetomidine

Influence of Dexmedetomidine on the Evoked Potentials During Spine Surgery

Start: Feb 2008Est. completion: May 201040 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

9 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.