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Spasticity

6
Pipeline Programs
10
Companies
16
Clinical Trials
1 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
1
0
2
0
3
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

Ipsen
DYSPORTApproved
botulinum toxin type a
Ipsen
Acetylcholine Release Inhibitor [EPC]injection2009
3M Part D

Competitive Landscape

10 companies ranked by most advanced pipeline stage

Ipsen
IpsenChina - Tianjin
3 programs
1
Adult Subjects Suffering From Lower Limb Spasticity Following StrokeN/A1 trial
Botulinum toxin type A injectionN/A1 trial
IPN10200PHASE_1_21 trial
Active Trials
NCT01444794Completed100Est. Feb 2013
NCT04673240Unknown70Est. Jun 2022
NCT04752774Recruiting240Est. Oct 2027
AbbVie
AbbVieNORTH CHICAGO, IL
3 programs
1
Botulinum Toxin Type APhase 4
Electrical stimulationN/A1 trial
Prevalence of Spasticity in Veterans Living in a Long-term Care FacilityN/A1 trial
Active Trials
NCT02334683Completed20Est. Mar 2020
NCT01879449Completed54Est. May 2014
Medtronic
MedtronicNJ - Phillipsburg
1 program
1
Botulinum Toxin Type APhase 41 trial
Active Trials
NCT00179114Completed20Est. Feb 2006
Supernus Pharmaceuticals
2 programs
2
Phase 2; Low Dose MYOBLOCPhase 2/31 trial
Phase 2; Low Dose MYOBLOCPhase 2/31 trial
Active Trials
NCT04099667Unknown272Est. Jul 2024
NCT04815967Active Not Recruiting272Est. Jul 2024
Human BioSciences
Human BioSciencesWV - Martinsburg
1 program
1
baclofenPhase 1/21 trial
Active Trials
NCT00607542Completed61Est. Jan 2011
Jazz Pharmaceuticals
Jazz PharmaceuticalsCA - Palo Alto
3 programs
SativexPHASE_31 trial
Sativex®PHASE_31 trial
Sativex®PHASE_31 trial
Active Trials
NCT00702468Completed36Est. Jan 2009
NCT00711646Completed189Est. Mar 2004
NCT00681538Completed572Est. Jan 2009
Nevro
NevroCA - Redwood City
1 program
High-frequency nerve conduction blockN/A1 trial
Active Trials
NCT06868342Completed4Est. Dec 2024
Teva
TevaIsrael - Petach Tikva
1 program
sublingual tizanidine 12 mgPHASE_1_21 trial
Active Trials
NCT00464958Terminated10Est. Dec 2008
Saol Therapeutics
Saol TherapeuticsGA - Roswell
1 program
SL-1002PHASE_21 trial
Active Trials
NCT05311215Unknown32Est. Sep 2023
Flowonix Medical
Flowonix MedicalNJ - Hackettstown
1 program
Prometra Programmable Implantable Pump SystemPHASE_31 trial
Active Trials
NCT01051128Withdrawn0Est. Dec 2010

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
MedtronicBotulinum Toxin Type A
Flowonix MedicalPrometra Programmable Implantable Pump System
Jazz PharmaceuticalsSativex®
Jazz PharmaceuticalsSativex
Jazz PharmaceuticalsSativex®
Supernus PharmaceuticalsPhase 2; Low Dose MYOBLOC
Supernus PharmaceuticalsPhase 2; Low Dose MYOBLOC
Saol TherapeuticsSL-1002
IpsenIPN10200
Human BioSciencesbaclofen
Tevasublingual tizanidine 12 mg
NevroHigh-frequency nerve conduction block
IpsenBotulinum toxin type A injection
AbbVieElectrical stimulation
AbbViePrevalence of Spasticity in Veterans Living in a Long-term Care Facility

Showing 15 of 16 trials with date data

Clinical Trials (16)

Total enrollment: 1,952 patients across 16 trials

NCT00179114MedtronicBotulinum Toxin Type A

Vanderbilt University Spasticity Management Program Evaluation Plan

Start: Aug 2002Est. completion: Feb 200620 patients
Phase 4Completed
NCT01051128Flowonix MedicalPrometra Programmable Implantable Pump System

Continuous Intrathecal Baclofen Infusion for Chronic Spasticity

Start: Jan 2010Est. completion: Dec 20100
Phase 3Withdrawn
NCT00681538Jazz PharmaceuticalsSativex®

A Study of the Safety and Effectiveness of Sativex®, for the Relief of Symptoms of Spasticity in Subjects, From Phase B, With Multiple Sclerosis (MS)

Start: Jan 2008Est. completion: Jan 2009572 patients
Phase 3Completed
NCT00702468Jazz PharmaceuticalsSativex

Evaluate the Maintenance of Effect After Long-term Treatment With Sativex® in Subjects With Symptoms of Spasticity Due to Multiple Sclerosis

Start: Nov 2007Est. completion: Jan 200936 patients
Phase 3Completed
NCT00711646Jazz PharmaceuticalsSativex®

A Study of Sativex® for Relief of Spasticity in Subjects With Multiple Sclerosis.

Start: Jun 2002Est. completion: Mar 2004189 patients
Phase 3Completed
NCT04815967Supernus PharmaceuticalsPhase 2; Low Dose MYOBLOC

Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity

Start: Nov 2021Est. completion: Jul 2024272 patients
Phase 2/3Active Not Recruiting
NCT04099667Supernus PharmaceuticalsPhase 2; Low Dose MYOBLOC

Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Lower Limb Spasticity

Start: Dec 2019Est. completion: Jul 2024272 patients
Phase 2/3Unknown
NCT05311215Saol TherapeuticsSL-1002

Phase II Study to Assess Safety, Pharmacokinetics and Efficacy of SL-1002 for Limb Spasticity

Start: Apr 2022Est. completion: Sep 202332 patients
Phase 2Unknown
NCT04752774IpsenIPN10200

A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.

Start: Apr 2021Est. completion: Oct 2027240 patients
Phase 1/2Recruiting
NCT00607542Human BioSciencesbaclofen

Oral Baclofen Pharmacokinetics and Pharmacodynamics in Children With Spasticity

Start: Nov 2008Est. completion: Jan 201161 patients
Phase 1/2Completed
NCT00464958Tevasublingual tizanidine 12 mg

One Year Extension Study To Protocol C2/5/TZ:MS-05

Start: Jan 2008Est. completion: Dec 200810 patients
Phase 1/2Terminated
NCT06868342NevroHigh-frequency nerve conduction block

Nerve Root Block in Spasticity

Start: Jan 2024Est. completion: Dec 20244 patients
N/ACompleted
NCT04673240IpsenBotulinum toxin type A injection

CLINICAL EFFECT OF BOTULINUM TOXIN TYPE A IN TREATMENT OF SPASTICITY

Start: Mar 2019Est. completion: Jun 202270 patients
N/AUnknown
NCT02334683AbbVieElectrical stimulation

Compare Two Guidance Techniques for Botulinum Toxin Injections for the Treatment of Limb Spasticity and Focal Dystonia

Start: Oct 2015Est. completion: Mar 202020 patients
N/ACompleted
NCT01879449AbbViePrevalence of Spasticity in Veterans Living in a Long-term Care Facility

Prevalence of Spasticity in Veterans Living in a Long-term Care Facility

Start: Feb 2013Est. completion: May 201454 patients
N/ACompleted
NCT01444794IpsenAdult Subjects Suffering From Lower Limb Spasticity Following Stroke

Adult Subjects Suffering From Lower Limb Spasticity Following Stroke

Start: Sep 2011Est. completion: Feb 2013100 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 actively recruiting trials targeting 1,952 patients
10 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.