Smallpox
Pipeline by Development Stage
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Clinical trial activity over time
Showing 15 of 40 trials with date data
Clinical Trials (40)
Total enrollment: 928,916 patients across 40 trials
Drug-drug Interaction Study of TPOXX When Co-administered With Phosphate Binders
Safety, Tolerability and PK of TPOXX in Adults Weighing More Than 120 KG
Safety, Tolerability and Pharmacokinetics of TPOXX When Administered Orally for 28 Days
Freeze-Dried MVA-BN® Lot Consistency Smallpox Trial
A Trial to Assess the Safety, Tolerability, and Pharmacokinetics of the Anti-Orthopoxvirus Compound Tecovirimat
A Trial to Evaluate Immunogenicity and Safety of Three Consecutive Production Lots of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in Healthy, Vaccinia-naïve Subjects
APSV in Vaccinia Naive Adults
A Study of Dryvax Vaccine Against Smallpox in Previously Unvaccinated Adults
Study to Assess the Safety and Immunogenicity of TPOXX® When Administered Orally for 28 Days With JYNNEOS
Randomized, Open-label Phase II Trial to Assess the Safety and Immunogenicity of MVA-BN Smallpox Vaccine in Immunocompromised Subjects With HIV Infection
Phase II Trial to Assess Safety and Immunogenicity of IMVAMUNE®
A Phase II Trial to Compare a Liquid-frozen and a Freeze-dried Formulation of IMVAMUNE (MVA-BN®) Smallpox Vaccine in Vaccinia-naïve Healthy Subjects
Lyophilized IMVAMUNE® (1x10^8 TCID50) Versus Liquid IMVAMUNE® (1x10^8 TCID50) Administered Subcutaneously and a Lower Dose Liquid IMVAMUNE® (2x10^7 TCID50) Administered Intradermally
A Study to Evaluate Safety and Immunogenicity of One and Two Doses of IMVAMUNE® Smallpox Vaccine in 56-80 Year Old Vaccinia-experienced Subjects
High Dose IMVAMUNE® in Vaccinia-Naive Individuals
Evaluation of Take and Safety of a Smallpox Vaccine in Healthy Young Adults
Dryvax Dilution-Prev Vacc Adults
Dose-finding Study to Evaluate Immunogenicity of Three Different Dose Levels of the IMVAMUNE (MVA-BN) Smallpox Vaccine.
Dose Study of ACAM2000 Smallpox Vaccine in Previously Vaccinated Adults
Effect of Dose, Safety, Tolerability of a New Smallpox Vaccine in Adults Without Previous Smallpox Vaccination
Expanded Dryvax Dilution Study in Previously Vaccinated Adults
Dose Safety, Tolerability, and Immunogenicity of a New Smallpox Vaccine in Adults Without Previous Smallpox Vaccination
A Study to Investigate The Safety, Tolerability, And Immune Response of a Range of Doses of mRNA-1769 Compared With Placebo in Healthy Participants From ≥18 Years of Age to <50 Years of Age
MVA Post-Event: Administration Timing and Boost Study
ACAM 3000 MVA at Harvard Medical School
Dressing Preparations for Smallpox
Vaccinia Virus Vaccine (APSV) in Vaccinia- Naive Subjects: PILOT
Human Immune Responses Smallpox
Study Evaluating the Bioequivalence of Brincidofovir Form H and Form II Tablets in Healthy Adults
A Trial to Evaluate the Safety, Reactogenicity, and Immunogenicity of MVA-BN Yellow Fever Vaccine With and Without Montanide ISA-720 Adjuvant in 18-45 Year Old Healthy Volunteers
Safety Study of MVA Smallpox Vaccine in Subjects With a History of Atopic Dermatitis (AD)
Safety Study of MVA Smallpox Vaccine in HIV-positive Subjects Who Are Vaccinia Naive
Combination Study With MVA BN and Dryvax
Safety, Tolerability, and Immune Response of ACAM3000 Modified Vaccinia Ankara (MVA) Smallpox Vaccine in Adults
Take Rate, Immunogenicity and Safety of Elstree-BN Smallpox Vaccine in Healthy Vaccinia-Naive Subjects
Study on Safety, Tolerability and Immunogenicity of an MVA Vaccine Administered to Healthy Subjects
A Phase 4, Observational Field Study to Evaluate TPOXX in Patients With Smallpox
Post-licensure Department of Defense (DOD) Screening Accuracy Study in Military Personnel
Safety Surveillance Cohort Study of Vaccinia Vaccine (ACAM2000®)
Safety Surveillance Study of ACAM2000® Vaccinia Vaccine
Phase Legend
Key Insights
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.