SLE

Pipeline Programs

Companies

Clinical Trials

2 recruiting

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

Ascentage PharmaChina - Beijing

1 program

APG-2575Phase 1/21 trial

Active Trials

NCT06182969Recruiting40Est. Dec 2026

Cullinan TherapeuticsMA - Cambridge

1 program

CLN-978Phase 11 trial

Active Trials

NCT06613360Recruiting24Est. Dec 2027

UNION therapeuticsDenmark - Hellerup

1 program

CIMT and baPWV measurementN/A1 trial

Active Trials

NCT04037293Unknown500Est. Dec 2021

PfizerNEW YORK, NY

1 program

No Medical InterventionN/A

Alliance PharmaceuticalsUK - Wiltshire

1 program

No Medical InterventionN/A1 trial

Active Trials

NCT03142711Completed80Est. Jul 2018

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

2027

Ascentage PharmaAPG-2575

Cullinan TherapeuticsCLN-978

Alliance PharmaceuticalsNo Medical Intervention

UNION therapeuticsCIMT and baPWV measurement

Clinical Trials (4)

Total enrollment: 644 patients across 4 trials

NCT06182969 Ascentage PharmaAPG-2575

A Study of APG-2575 in Patients With Mild-to-moderate Systemic Lupus Erythematosus.

Start: Aug 2024Est. completion: Dec 202640 patients

Phase 1/2Recruiting

NCT06613360 Cullinan TherapeuticsCLN-978

A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Systemic Lupus Erythematosus

Start: Jan 2025Est. completion: Dec 202724 patients

Phase 1Recruiting

NCT03142711 Alliance PharmaceuticalsNo Medical Intervention

Validation of a Mobile Phone Based on EPRO Tool in Subjects With Systemic Lupus Erythematosus

Start: Aug 2017Est. completion: Jul 201880 patients

N/ACompleted

NCT04037293 UNION therapeuticsCIMT and baPWV measurement

Premature Atherosclerosis in Systemic Lupus Erythematosus

Start: May 2013Est. completion: Dec 2021500 patients

N/AUnknown

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

2 actively recruiting trials targeting 644 patients

5 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.