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Sinusitis

6
Pipeline Programs
13
Companies
18
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
3
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
5100%
+ 14 programs with unclassified modality

Competitive Landscape

13 companies ranked by most advanced pipeline stage

Bayer
BayerLEVERKUSEN, Germany
2 programs
1
1
MoxifloxacinPhase 4Small Molecule1 trial
MoxifloxacinPhase 3Small Molecule1 trial
Active Trials
NCT00492024Completed374Est. Mar 2008
NCT00493038Terminated293Est. Jan 2008
Sandoz
SandozAustria - Kundl
1 program
1
Anti-IgE antibody omalizumab or placeboPhase 41 trial
Active Trials
NCT00117611Completed14Est. Jan 2009
Sunshine Biopharma
Sunshine BiopharmaQC - Varennes
2 programs
1
1
611Phase 31 trial
611Phase 21 trial
Active Trials
NCT05865496Unknown90Est. Jul 2024
NCT06639295Active Not Recruiting243Est. Aug 2026
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
1 program
1
Mometasone furoate nasal spray hormonePhase 31 trial
Active Trials
NCT05390255Unknown87Est. Dec 2024
Integra LifeSciences
Integra LifeSciencesAustralia - Clayton
3 programs
Balloon sinus dilationN/A1 trial
Relieva Balloon Sinuplasty SystemN/A1 trial
Stratus Microflow Ethmoid SpacerN/A1 trial
Active Trials
NCT01685229Completed198Est. Aug 2015
NCT01107379Completed203Est. Jul 2012
NCT00791934Completed63Est. Nov 2011
3NT Medical
3NT MedicalIsrael - Rosh Ha’ayin
2 programs
3NT flexible endoscopeN/A1 trial
3NT flexible endoscopeN/A1 trial
Active Trials
NCT02502084Completed17Est. Jun 2017
NCT03390257Completed14Est. May 2019
Ortho Development
2 programs
levofloxacinPHASE_3Small Molecule1 trial
levofloxacinPHASE_3Small Molecule1 trial
Active Trials
NCT00249210Completed614Est. Jul 1994
NCT00236522Completed784Est. Apr 2004
Medtronic
MedtronicNJ - Phillipsburg
1 program
Endoscopic polypectomy in clinicN/A1 trial
Active Trials
NCT02975310Recruiting140Est. Dec 2026
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
1 program
Sinusitis in Children and the Nasopharyngeal MicrobiomeN/A1 trial
Active Trials
NCT01492868Completed323Est. Jun 2017
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
1 program
TriamcinoloneN/A1 trial
Active Trials
NCT04841343Completed22Est. Sep 2022
Sanofi
SanofiPARIS, France
1 program
all macrolide antibioticsN/A1 trial
Active Trials
NCT00245427Completed200Est. Mar 2006
Chia Tai TianQing Pharmaceutical Group
1 program
300mg of TQH2722 injectionPHASE_21 trial
Active Trials
NCT06089278Completed160Est. Apr 2025
Johnson & Johnson
Johnson & JohnsonNEW BRUNSWICK, NJ
1 program
levofloxacinPHASE_3Small Molecule

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
BayerMoxifloxacin
SandozAnti-IgE antibody omalizumab or placebo
Sunshine Biopharma611
UNION therapeuticsMometasone furoate nasal spray hormone
BayerMoxifloxacin
Ortho Developmentlevofloxacin
Ortho Developmentlevofloxacin
Chia Tai TianQing Pharmaceutical Group300mg of TQH2722 injection
Sunshine Biopharma611
Angeles TherapeuticsTriamcinolone
3NT Medical3NT flexible endoscope
MedtronicEndoscopic polypectomy in clinic
3NT Medical3NT flexible endoscope
Integra LifeSciencesBalloon sinus dilation
Allergy TherapeuticsSinusitis in Children and the Nasopharyngeal Microbiome

Showing 15 of 18 trials with date data

Clinical Trials (18)

Total enrollment: 3,839 patients across 18 trials

NCT00493038BayerMoxifloxacin

Study to Evaluate the Efficacy and Safety of Moxifloxacin Versus Amoxicillin/Clavulanate in the Treatment of Acute Bacterial Rhinosinusitis

Start: Feb 2006Est. completion: Jan 2008293 patients
Phase 4Terminated
NCT00117611SandozAnti-IgE antibody omalizumab or placebo

Xolair in Patients With Chronic Sinusitis

Start: Jul 2005Est. completion: Jan 200914 patients
Phase 4Completed
NCT06639295Sunshine Biopharma611

A Study to Evaluate 611 in Patients With Chronic Rhinosinusitis With Nasal Polyps

Start: Nov 2024Est. completion: Aug 2026243 patients
Phase 3Active Not Recruiting
NCT05390255UNION therapeuticsMometasone furoate nasal spray hormone

Establishment of Precise Diagnosis and Treatment System for Refractory Chronic Rhinosinusitis

Start: May 2022Est. completion: Dec 202487 patients
Phase 3Unknown
NCT00492024BayerMoxifloxacin

BAY12-8039: 5 Days for Sinusitis vs Placebo

Start: Jan 2005Est. completion: Mar 2008374 patients
Phase 3Completed
NCT00236522Ortho Developmentlevofloxacin

A Comparison of the Safety and Efficacy of Two Different Regimens of Levofloxacin in the Treatment of Acute Bacterial Sinusitis(Sinus Infection) in Adults.

Start: Oct 2002Est. completion: Apr 2004784 patients
Phase 3Completed
NCT00249210Ortho Developmentlevofloxacin

A Study of the Safety and Effectiveness of Levofloxacin Compared With Amoxicillin/Clavulanate Potassium in the Treatment of Adults With Rapid Onset of Severe Inflammation/Infection of the Sinuses

Start: Aug 1993Est. completion: Jul 1994614 patients
Phase 3Completed
NCT06089278Chia Tai TianQing Pharmaceutical Group300mg of TQH2722 injection

A Clinical Study of TQH2722 Injection in the Treatment of Chronic Sinusitis With or Without Nasal Polyps.

Start: Dec 2023Est. completion: Apr 2025160 patients
Phase 2Completed
NCT05865496Sunshine Biopharma611

A Study to Evaluate 611 in Patients With Chronic Rhinosinusitis With Nasal Polyps

Start: Jun 2023Est. completion: Jul 202490 patients
Phase 2Unknown
NCT04841343Angeles TherapeuticsTriamcinolone

Triamcinolone Packing Following Endoscopic Sinus Surgery

Start: Jan 2021Est. completion: Sep 202222 patients
N/ACompleted
NCT033902573NT Medical3NT flexible endoscope

Study to Evaluate the Safety and Initial Effectiveness of the Sinusway™ for Endoscopy of Sinuses in Conjunction With BSD

Start: Apr 2017Est. completion: May 201914 patients
N/ACompleted
NCT02975310MedtronicEndoscopic polypectomy in clinic

In-clinic Endoscopic Polypectomy for Chronic Sinusitis With Nasal Polyps

Start: Apr 2017Est. completion: Dec 2026140 patients
N/ARecruiting
NCT025020843NT Medical3NT flexible endoscope

Safety and Effectiveness Evaluation of the Sinusway Device for Endoscopy of the Nasal Cavity and Paranasal Sinuses

Start: Aug 2015Est. completion: Jun 201717 patients
N/ACompleted
NCT01685229Integra LifeSciencesBalloon sinus dilation

Medical Therapy Versus Balloon Sinus Dilation for Patients With Chronic Rhinosinusitis

Start: Sep 2012Est. completion: Aug 2015198 patients
N/ACompleted
NCT01492868Allergy TherapeuticsSinusitis in Children and the Nasopharyngeal Microbiome

Sinusitis in Children and the Nasopharyngeal Microbiome

Start: Jan 2012Est. completion: Jun 2017323 patients
N/ACompleted
NCT01107379Integra LifeSciencesRelieva Balloon Sinuplasty System

Optimization and Refinement of Technique in In-Office Sinus Dilation 2

Start: Apr 2010Est. completion: Jul 2012203 patients
N/ACompleted
NCT00791934Integra LifeSciencesStratus Microflow Ethmoid Spacer

Clinical Study of Safety and Efficacy for the Relieva Stratus With Elution of Triamcinolone Acetonide

Start: Aug 2008Est. completion: Nov 201163 patients
N/ACompleted
NCT00245427Sanofiall macrolide antibiotics

Outcomes of Patients Not Responding to Antibiotics in the Community

Start: Dec 2005Est. completion: Mar 2006200 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

3 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 3,839 patients
13 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.