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Shock

4
Pipeline Programs
11
Companies
10
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
3
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

11 companies ranked by most advanced pipeline stage

UNION therapeutics
UNION therapeuticsDenmark - Hellerup
2 programs
1
Compound sodium acetate ringer injectionPhase 41 trial
Synchronous Data Acquisition of EIT and Pulmonary Artery CatheterN/A1 trial
Active Trials
NCT07385963Not Yet Recruiting19Est. Mar 2027
NCT05463471Not Yet Recruiting500Est. Dec 2027
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
1
Lactated RingerPhase 3
Human BioSciences
Human BioSciencesWV - Martinsburg
1 program
1
Lactated RingerPhase 3
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
1 program
1
Lactated RingerPhase 31 trial
Active Trials
NCT04102371Completed9,041Est. Jan 2026
Medtronic
MedtronicNJ - Phillipsburg
2 programs
Enhanced Surveillance of RV Lead Integrity Alert (RVLIA)N/A1 trial
Passive Leg RaiseN/A1 trial
Active Trials
NCT00824915Completed1,779Est. Feb 2011
NCT01656954Completed7Est. Apr 2014
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
1 program
CaspofunginN/A
MSD
MSDIreland - Ballydine
1 program
CaspofunginN/A1 trial
Active Trials
NCT02596984Completed50Est. May 2018
Zoll
ZollCA - San Jose
1 program
Full SWOT ModelN/A1 trial
Active Trials
NCT05073354Completed27Est. Apr 2024
Abbott
AbbottABBOTT PARK, IL
1 program
ICD/ CRT-DN/A1 trial
Active Trials
NCT00743522Completed1,670Est. Dec 2011
Philips
PhilipsNetherlands - Amsterdam
1 program
patient assessmentN/A1 trial
Active Trials
NCT02185521Terminated127Est. Nov 2016
Proveca Pharma
Proveca PharmaUK - Manchester
1 program
DobutaminePHASE_1_21 trial
Active Trials
NCT03311178Terminated15Est. Oct 2017

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
UNION therapeuticsCompound sodium acetate ringer injection
Angeles TherapeuticsLactated Ringer
Proveca PharmaDobutamine
UNION therapeuticsSynchronous Data Acquisition of EIT and Pulmonary Artery Catheter
ZollFull SWOT Model
Philipspatient assessment
MSDCaspofungin
MedtronicPassive Leg Raise
AbbottICD/ CRT-D
MedtronicEnhanced Surveillance of RV Lead Integrity Alert (RVLIA)

Clinical Trials (10)

Total enrollment: 13,235 patients across 10 trials

NCT05463471UNION therapeuticsCompound sodium acetate ringer injection

Effect of Balanced Saline Solution and Albumin on Volume Expansion in Shock Patients

Start: Aug 2022Est. completion: Dec 2027500 patients
Phase 4Not Yet Recruiting
NCT04102371Angeles TherapeuticsLactated Ringer

Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis

Start: Aug 2020Est. completion: Jan 20269,041 patients
Phase 3Completed
NCT03311178Proveca PharmaDobutamine

Dobutamine in the Treatment of Haemodynamic Insufficiency in the Immediate Postnatal Period

Start: May 2014Est. completion: Oct 201715 patients
Phase 1/2Terminated
NCT07385963UNION therapeuticsSynchronous Data Acquisition of EIT and Pulmonary Artery Catheter

Correlation Between EIT-based Pulse Wave Method for Pulmonary Perfusion Monitoring and Pulmonary Artery Catheter-based Stroke Volume Measurement

Start: Feb 2026Est. completion: Mar 202719 patients
N/ANot Yet Recruiting
NCT05073354ZollFull SWOT Model

Rapid Treatment of Shock Without Trauma

Start: Jun 2021Est. completion: Apr 202427 patients
N/ACompleted
NCT02185521Philipspatient assessment

Hemodynamic Instability Index: The Impact to Care With a New Predictive Indicator

Start: Mar 2016Est. completion: Nov 2016127 patients
N/ATerminated
NCT02596984MSDCaspofungin

Evaluation of the Pharmacokinetics of Caspofungin in ICU Patients

Start: Mar 2015Est. completion: May 201850 patients
N/ACompleted
NCT01656954MedtronicPassive Leg Raise

Predicting Volume Response Study

Start: Aug 2011Est. completion: Apr 20147 patients
N/ACompleted
NCT00743522AbbottICD/ CRT-D

Programming Implantable Cardioverter Defibrillators in Patients With Primary Prevention Indication

Start: Sep 2008Est. completion: Dec 20111,670 patients
N/ACompleted
NCT00824915MedtronicEnhanced Surveillance of RV Lead Integrity Alert (RVLIA)

Enhanced Surveillance of RV Lead Integrity Alert (RVLIA)

Start: Aug 2008Est. completion: Feb 20111,779 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

3 late-stage (Phase 3) programs, potential near-term approvals
11 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.