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Scleroderma, Systemic

4
Pipeline Programs
5
Companies
6
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
3
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 7 programs with unclassified modality

Competitive Landscape

5 companies ranked by most advanced pipeline stage

ViiV Healthcare
ViiV HealthcareNC - Durham
2 programs
1
1
GSK2330811Phase 2
GSK2330811Phase 1
Certa Therapeutics
Certa TherapeuticsAustralia - Melbourne
1 program
1
FT011Phase 21 trial
Active Trials
NCT04647890Completed30Est. Nov 2022
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
1 program
1
PirfenidonePhase 21 trial
Active Trials
NCT03221257Completed51Est. Jun 2022
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
3 programs
MicrogynonPHASE_11 trial
AvenciguatPHASE_21 trial
NintedanibPHASE_3Small Molecule1 trial
Active Trials
NCT03675581Completed17Est. Oct 2019
NCT05559580Completed214Est. Jan 2026
NCT02597933Completed580Est. Nov 2018
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
1 program
currently available therapy in the communityN/A1 trial
Active Trials
NCT00860548Completed19Est. Mar 2016

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Boehringer IngelheimNintedanib
Boehringer IngelheimAvenciguat
Certa TherapeuticsFT011
Angeles TherapeuticsPirfenidone
Boehringer IngelheimMicrogynon
Allergy Therapeuticscurrently available therapy in the community

Clinical Trials (6)

Total enrollment: 911 patients across 6 trials

A Trial to Compare Nintedanib With Placebo for Patients With Scleroderma Related Lung Fibrosis

Start: Nov 2015Est. completion: Nov 2018580 patients
Phase 3Completed

A Study in People With Systemic Sclerosis to Test Whether Avenciguat (BI 685509) Has an Effect on Lung Function and Other Systemic Sclerosis Symptoms

Start: Dec 2022Est. completion: Jan 2026214 patients
Phase 2Completed

Effects of FT011 in Systemic Sclerosis

Start: Jul 2021Est. completion: Nov 202230 patients
Phase 2Completed

Scleroderma Lung Study III - Combining Pirfenidone With Mycophenolate

Start: Nov 2017Est. completion: Jun 202251 patients
Phase 2Completed

A Study to Test Whether Nintedanib Influences the Components of Birth-control Pills in Women With Systemic Sclerosis Associated Interstitial Lung Disease (SSc-ILD)

Start: Nov 2018Est. completion: Oct 201917 patients
Phase 1Completed
NCT00860548Allergy Therapeuticscurrently available therapy in the community

SCOT Scleroderma Treatment Alternative Registry (STAR Registry)

Start: Jun 2005Est. completion: Mar 201619 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

5 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.