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Schistosomiasis

6
Pipeline Programs
4
Companies
10
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
0
1
0
1
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
4 programs
3
1
PraziquantelPhase 41 trial
GLA-AFPhase 11 trial
PraziquantelPhase 12 trials
Sm-p80Phase 11 trial
Active Trials
NCT03110757Completed60Est. Nov 2019
NCT07754617Not Yet Recruiting600Est. Nov 2029
NCT01288872Completed47Est. Aug 2013
+2 more trials
Hikma
HikmaNJ - Berkeley Heights
1 program
1
praziquantelPhase 31 trial
Active Trials
NCT01558336Completed520Est. Sep 2012
Human BioSciences
Human BioSciencesWV - Martinsburg
1 program
1
PraziquantelPhase 21 trial
Active Trials
NCT03640377Completed354Est. Jun 2024
Merck & Co.
Merck & Co.RAHWAY, NJ
3 programs
BiltricidePHASE_21 trial
Praziquantel 600Mg Oral Tablet x 5PHASE_2_31 trial
L-PZQ ODT 50 mg/kgPHASE_31 trial
Active Trials
NCT02806232Completed444Est. Nov 2018
NCT04115072Completed116Est. Feb 2020
NCT03845140Completed288Est. Oct 2021

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
Allergy TherapeuticsPraziquantel
Merck & Co.L-PZQ ODT 50 mg/kg
Hikmapraziquantel
Allergy TherapeuticsPraziquantel
Merck & Co.Praziquantel 600Mg Oral Tablet x 5
Human BioSciencesPraziquantel
Merck & Co.Biltricide
Allergy TherapeuticsSm-p80
Allergy TherapeuticsGLA-AF
Allergy TherapeuticsPraziquantel

Clinical Trials (10)

Total enrollment: 2,474 patients across 10 trials

Effect of Concomitant Mansonella Perstans Microfilaremia on Immune Responses Following Single Dose Praziquantel in People With Schistosomiasis

Start: Apr 2016Est. completion: Dec 20180
Phase 4Withdrawn
NCT03845140Merck & Co.L-PZQ ODT 50 mg/kg

L-PZQ ODT in Schistosoma Infected Children

Start: Sep 2019Est. completion: Oct 2021288 patients
Phase 3Completed
NCT01558336Hikmapraziquantel

Schistosoma Haematobium Infections and Praziquantel

Start: Aug 2008Est. completion: Sep 2012520 patients
Phase 3Completed

Different Treatment Frequencies for Hepatic Fibrosis Due to Schistosomiasis

Start: Nov 2026Est. completion: Nov 2029600 patients
Phase 2/3Not Yet Recruiting
NCT04115072Merck & Co.Praziquantel 600Mg Oral Tablet x 5

Treatment of Female Genital Schistosomiasis (FGS) With Praziquantel: A Proof-of-Concept Study

Start: Sep 2019Est. completion: Feb 2020116 patients
Phase 2/3Completed

Praziquantel in Children Under Age 4

Start: Feb 2021Est. completion: Jun 2024354 patients
Phase 2Completed

An Open Label Dose Finding Safety and Efficacy in Children and Infants Infected With Schistosomiasis (S.Mansoni)

Start: Jun 2016Est. completion: Nov 2018444 patients
Phase 2Completed

Safety, Tolerability, and Immunogenicity Study of Sm-p80 + GLA-SE (SchistoShield(R)) Vaccine in Healthy Adults

Start: May 2022Est. completion: Mar 202445 patients
Phase 1Completed

A Phase Ib Study of the Safety, Reactogenicity, and Immunogenicity of Sm-TSP-2/Alhydrogel)(R) With or Without AP 10-701 for Intestinal Schistosomiasis in Healthy Exposed Adults

Start: May 2018Est. completion: Nov 201960 patients
Phase 1Completed

Praziquantel-Pharmacokinetic Study

Start: Jan 2012Est. completion: Aug 201347 patients
Phase 1Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.