Sarcopenia

Pipeline Programs

Companies

Clinical Trials

5 recruiting

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody

2100%

+ 30 programs with unclassified modality

Competitive Landscape

21 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

UNION therapeuticsDenmark - Hellerup

5 programs

Denosumab InjectionPhase 31 trial

Establishment and Application of Digital Diagnosis and Treatment System for SarcopeniaN/A1 trial

Transjugular Intrahepatic Portosystemic ShuntN/A1 trial

nutritional interventionN/A1 trial

symbioticN/A1 trial

Active Trials

NCT06380777Recruiting10,000Est. Dec 2028

NCT06794853Recruiting132Est. Dec 2027

NCT02873676Unknown200Est. Dec 2020

+2 more trials

MSDIreland - Ballydine

2 programs

Comparator: MK-0773Phase 21 trial

Blood Flow, Muscle Regeneration and SarcopeniaN/A1 trial

Active Trials

NCT01035060Completed68Est. Dec 2011

NCT00529659Completed170Est. Oct 2009

Sharp TherapeuticsPA - Pittsburgh

2 programs

Comparator: MK-0773Phase 2

Blood Flow, Muscle Regeneration and SarcopeniaN/A

SandozAustria - Kundl

2 programs

bimagrumabPhase 2Monoclonal Antibody1 trial

Active Trials

NCT02333331Completed217Est. Jun 2018

NCT02468674Completed160Est. Dec 2018

TNF PharmaceuticalsMD - Baltimore

1 program

MYMD-1 600MGPhase 21 trial

Active Trials

NCT05283486Completed40Est. Jun 2023

AbbottABBOTT PARK, IL

3 programs

Ensure Plus AdvanceN/A1 trial

Low-magnitude High-frequency VibrationN/A1 trial

Muscle Mass and Function in Chinese AdultsN/A1 trial

Active Trials

NCT05344313Completed47Est. Jun 2024

NCT05525039Recruiting200Est. Sep 2025

NCT02089971Completed412Est. Dec 2014

BiocorpFrance - Issoire

2 programs

Blue Whiting Protein HydrolysateN/A1 trial

InterventionN/A1 trial

Active Trials

NCT05637450Unknown184Est. Aug 2023

NCT05356559Unknown150Est. Jun 2023

BiophytisFrance - Paris

2 programs

No Drug and no aspecific interventionN/A1 trial

BIO101PHASE_21 trial

Active Trials

NCT03021798Completed218Est. Jun 2020

NCT03452488Completed233Est. Apr 2020

Merck & Co.RAHWAY, NJ

1 program

Blood Flow, Muscle Regeneration and SarcopeniaN/A

Human BioSciencesWV - Martinsburg

1 program

Cause and Importance of the Age-dependent SarcopeniaN/A1 trial

Active Trials

NCT02994901Completed150Est. Jul 2017

Cognition TherapeuticsPA - Pittsburgh

1 program

Combined endurance and resistance trainingN/A1 trial

Active Trials

NCT06507189Recruiting250Est. Aug 2029

Purdue PharmaCT - Stamford

1 program

Energy RestrictionN/A1 trial

Active Trials

NCT01692860Completed48Est. Jan 2015

OtsukaJapan - Tokushima

1 program

HINEX JellyN/A1 trial

Active Trials

NCT05926375Unknown60Est. Jun 2023

ImmunisCA - Irvine

1 program

IMM01-STEMN/A1 trial

Active Trials

NCT06784297Temporarily Not Available

NMD PharmaDenmark - Aarhus

1 program

Investigating Loss of Neuromuscular Junction Transmission Fidelity in Older AdultsN/A1 trial

Active Trials

NCT04904926Completed19Est. Sep 2021

AbiogenItaly - Pisa

1 program

OLEPN/A1 trial

Active Trials

NCT04702087Unknown54Est. Dec 2022

Angeles TherapeuticsCA - Los Angeles

1 program

Protein shake + Fish OilN/A1 trial

Active Trials

NCT04350762Terminated4Est. Dec 2020

Colorado TherapeuticsCO - Louisville

1 program

Resistance trainingN/A1 trial

Active Trials

NCT01083901Completed34Est. Mar 2011

Taiho PharmaJapan - Tokyo

1 program

Whey postbiotics derived from kefir lactic acid bacteriaN/A1 trial

Active Trials

NCT06144021Recruiting60Est. Dec 2024

Coordination PharmaceuticalsIL - Chicago

1 program

Whey protein plus collagenN/A1 trial

Active Trials

NCT04621383Completed67Est. Dec 2019

RegeneronTARRYTOWN, NY

1 program

REGN1033PHASE_2

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

2027

2028

2029

UNION therapeuticsDenosumab Injection

TNF PharmaceuticalsMYMD-1 600MG

BiophytisBIO101

Sandozbimagrumab

MSDComparator: MK-0773

UNION therapeuticsTransjugular Intrahepatic Portosystemic Shunt

Cognition TherapeuticsCombined endurance and resistance training

UNION therapeuticssymbiotic

Taiho PharmaWhey postbiotics derived from kefir lactic acid bacteria

UNION therapeuticsEstablishment and Application of Digital Diagnosis and Treatment System for Sarcopenia

BiocorpBlue Whiting Protein Hydrolysate

AbbottLow-magnitude High-frequency Vibration

AbbottEnsure Plus Advance

BiocorpIntervention

Showing 15 of 27 trials with date data

Clinical Trials (28)

Total enrollment: 13,383 patients across 28 trials

NCT06154707 UNION therapeuticsDenosumab Injection

Clinical Controlled Study on the Efficacy of Denosumab in Treating Osteoporosis in the Domestic Population and Its Impact on Sarcopenia-related Outcomes

Start: Feb 2024Est. completion: Mar 202586 patients

Phase 3Unknown

NCT05283486 TNF PharmaceuticalsMYMD-1 600MG

Evaluation of Efficacy, Tolerability, and Pharmacokinetics of MYMD1 for Chronic Inflammation and Sarcopenia/Frailty

Start: Feb 2022Est. completion: Jun 202340 patients

Phase 2Completed

NCT03452488 BiophytisBIO101

A Double-blind, Placebo-controlled, Randomized INTerventional Clinical Trial (SARA-INT)

Start: Feb 2017Est. completion: Apr 2020233 patients

Phase 2Completed

NCT02468674 Sandozbimagrumab

A 24-week Off-drug Extension Study in Sarcopenic Elderly Who Completed Treatment in the 6-month Core Study

Start: Jul 2015Est. completion: Dec 2018160 patients

Phase 2Completed

NCT02333331 Sandozbimagrumab

Dose Range Finding Study of Bimagrumab in Sarcopenia

Start: Dec 2014Est. completion: Jun 2018217 patients

Phase 2Completed

NCT00529659 MSDComparator: MK-0773

A Study of the Safety and Efficacy of MK-0773 in Women With Sarcopenia (Loss of Muscle Mass)(MK-0773-005)

Start: Oct 2007Est. completion: Oct 2009170 patients

Phase 2Completed

NCT06784297 ImmunisIMM01-STEM

INTERMEDIATE-SIZE PATIENT POPULATIONS EXPANDED ACCESS TO TREATMENT FOR SARCOPENIC OBESITY

N/ATemporarily Not Available

NCT06794853 UNION therapeuticsTransjugular Intrahepatic Portosystemic Shunt

Mechanism of TIPS to Improve Sarcopenia

Start: Jun 2025Est. completion: Dec 2027132 patients

N/ARecruiting

NCT06507189 Cognition TherapeuticsCombined endurance and resistance training

Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults (M3AX)

Start: Jan 2025Est. completion: Aug 2029250 patients

N/ARecruiting

NCT06347835 UNION therapeuticssymbiotic

Biomarker Identification and Nutritional Intervention of Primary Sarcopenia Based on Gut-muscle Axis

Start: Apr 2024Est. completion: Jan 2026120 patients

N/ANot Yet Recruiting

NCT06144021 Taiho PharmaWhey postbiotics derived from kefir lactic acid bacteria

Efficacy and Safety of Kefir Whey Postbiotics

Start: Dec 2023Est. completion: Dec 202460 patients

N/ARecruiting

NCT06380777 UNION therapeuticsEstablishment and Application of Digital Diagnosis and Treatment System for Sarcopenia

Establishment and Application of Digital Diagnosis and Treatment System for Sarcopenia

Start: Sep 2023Est. completion: Dec 202810,000 patients

N/ARecruiting

NCT05637450 BiocorpBlue Whiting Protein Hydrolysate

Fish Protein Supplementation and Sarcopenia Outcomes in Carehomes

Start: Jul 2023Est. completion: Aug 2023184 patients

N/AUnknown

NCT05525039 AbbottLow-magnitude High-frequency Vibration

RCT of Combination Effect of Vibration Treatment and HMB Supplementation on Myosteatosis and NMJ Degeneration

Start: Jan 2023Est. completion: Sep 2025200 patients

N/ARecruiting

NCT05344313 AbbottEnsure Plus Advance

Oral Nutritional Supplementation With HMB Enhance Muscle Quality in Sarcopenic Surgical Patients

Start: Jun 2022Est. completion: Jun 202447 patients

N/ACompleted

NCT05356559 BiocorpIntervention

Fish Protein Supplementation and Sarcopenia Outcomes in the Community

Start: Apr 2022Est. completion: Jun 2023150 patients

N/AUnknown

NCT05926375 OtsukaHINEX Jelly

Effect of HINEX Jelly on Nutritional Status in People With Possible Sarcopenia or Sarcopenia

Start: Jan 2022Est. completion: Jun 202360 patients

N/AUnknown

NCT04904926 NMD PharmaInvestigating Loss of Neuromuscular Junction Transmission Fidelity in Older Adults

Investigating Loss of Neuromuscular Junction Transmission Fidelity in Older Adults

Start: Mar 2021Est. completion: Sep 202119 patients

N/ACompleted

NCT04702087 AbiogenOLEP

Omega 3, Leucine, Probiotic Lactobacillus Paracasei PS23 on Muscle Mass in Sarcopenic Subjects

Start: Jan 2021Est. completion: Dec 202254 patients

N/AUnknown

NCT04350762 Angeles TherapeuticsProtein shake + Fish Oil

Nutritional Supplementation in the Elderly With Weight Loss

Start: Sep 2019Est. completion: Dec 20204 patients

N/ATerminated

NCT04621383 Coordination PharmaceuticalsWhey protein plus collagen

Effects of Whey Protein Supplementation Collagen Associated to Resistance Training in Older Woman

Start: May 2019Est. completion: Dec 201967 patients

N/ACompleted

NCT03021798 BiophytisNo Drug and no aspecific intervention

An OBServational Clinical Trial (SARA-OBS) in Sarcopenia and Sarcopenic Obesity in Patients Aged 65 Years and Over

Start: Feb 2017Est. completion: Jun 2020218 patients

N/ACompleted

NCT02994901 Human BioSciencesCause and Importance of the Age-dependent Sarcopenia

Cause and Importance of the Age-dependent Sarcopenia

Start: Nov 2016Est. completion: Jul 2017150 patients

N/ACompleted

NCT02873676 UNION therapeuticsnutritional intervention

Prevalence and Effect of Lifestyle Modification on Clinical Outcomes and Cost-effectiveness Ratio for Sarcopenia

Start: Mar 2016Est. completion: Dec 2020200 patients

N/AUnknown

NCT02089971 AbbottMuscle Mass and Function in Chinese Adults

Muscle Mass and Function in Chinese Adults

Start: Mar 2014Est. completion: Dec 2014412 patients

N/ACompleted

NCT01692860 Purdue PharmaEnergy Restriction

Effects of Milk Protein Concentrate on Overall Health During Weight Loss in Overweight/Obese Adults

Start: Jan 2012Est. completion: Jan 201548 patients

N/ACompleted

NCT01035060 MSDBlood Flow, Muscle Regeneration and Sarcopenia

Blood Flow, Muscle Regeneration and Sarcopenia

Start: Jun 2010Est. completion: Dec 201168 patients

N/ACompleted

NCT01083901 Colorado TherapeuticsResistance training

Acetaminophen and Impaired Musculoskeletal Adaptations to Exercise Training

Start: May 2006Est. completion: Mar 201134 patients

N/ACompleted

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals

5 actively recruiting trials targeting 13,383 patients

25 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.