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Rotator Cuff Tear

2
Pipeline Programs
15
Companies
16
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
1
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

15 companies ranked by most advanced pipeline stage

Bioinova
BioinovaCzech Republic - Prague
1 program
1
Suspension of human autologous MSC 3PPhase 1/21 trial
Active Trials
NCT03838666Terminated9Est. Nov 2015
Pfizer
PfizerNEW YORK, NY
1 program
1
BMP-655/ACS+Standard of care or Standard of carePhase 11 trial
Active Trials
NCT01122498Terminated23Est. Apr 2012
Arthrex
ArthrexCA - Santa Barbara
3 programs
Autologous conditioned plasmaN/A1 trial
Features to Predict Success With Nonoperative Treatment of Patients With Rotator Cuff TearsN/A
Immediate Postoperative TherapyN/A1 trial
Active Trials
NCT01170312Completed25Est. Aug 2012
NCT01383239Completed27Est. Jul 2016
Stryker
StrykerCA - San Jose
2 programs
AugmentationN/A1 trial
Conexa Reconstructive Tissue MatrixN/A1 trial
Active Trials
NCT00456781Completed79Est. Mar 2011
NCT01025037Completed61Est. Apr 2014
InGeneron
InGeneronGermany - Munich
1 program
Adipose Derived Regenerative CellsN/A1 trial
Active Trials
NCT03752827Active Not Recruiting168Est. Dec 2025
Zimmer Biomet
Zimmer BiometFL - Jacksonville
1 program
BioWick SureLock ImplantN/A1 trial
Active Trials
NCT03199391Completed71Est. May 2021
Mammoth Biosciences
Mammoth BiosciencesCA - Brisbane
1 program
Breg Polar Care Wave Cold Compression DeviceN/A1 trial
Active Trials
NCT07455474Completed50Est. Mar 2026
Dong-A ST
Dong-A STKorea - Seoul
1 program
ExperimentalN/A1 trial
Active Trials
NCT06590714Recruiting150Est. Aug 2025
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
Features to Predict Success With Nonoperative Treatment of Patients With Rotator Cuff TearsN/A1 trial
Active Trials
NCT00762580Completed452Est. Jan 2024
Baxter
BaxterCosta Rica - Cartago
1 program
OrthoADAPTN/A
Baxter International
1 program
OrthoADAPTN/A1 trial
Active Trials
NCT00957255Withdrawn0Est. Apr 2010
Xiros
XirosUK - Leeds
1 program
Pitch-PatchN/A1 trial
Active Trials
NCT05906004Not Yet Recruiting37Est. Dec 2029
Marius Pharmaceuticals
1 program
Progressive early passive and active movementN/A1 trial
Active Trials
NCT02969135Completed82Est. May 2020
CTM Biomedical
CTM BiomedicalON - Toronto
1 program
Rotator Cuff Repair with Allograft PatchN/A1 trial
Active Trials
NCT07027735Recruiting120Est. Jul 2027
Applied Biologics
Applied BiologicsAZ - Scottsdale
1 program
Superiority of augmented repairsN/A1 trial
Active Trials
NCT03379324Unknown260Est. Sep 2019

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
BioinovaSuspension of human autologous MSC 3P
PfizerBMP-655/ACS+Standard of care or Standard of care
CTM BiomedicalRotator Cuff Repair with Allograft Patch
XirosPitch-Patch
Dong-A STExperimental
Mammoth BiosciencesBreg Polar Care Wave Cold Compression Device
InGeneronAdipose Derived Regenerative Cells
Zimmer BiometBioWick SureLock Implant
Applied BiologicsSuperiority of augmented repairs
Marius PharmaceuticalsProgressive early passive and active movement
ArthrexImmediate Postoperative Therapy
ArthrexAutologous conditioned plasma
StrykerConexa Reconstructive Tissue Matrix
Baxter InternationalOrthoADAPT
StrykerAugmentation

Showing 15 of 16 trials with date data

Clinical Trials (16)

Total enrollment: 1,614 patients across 16 trials

NCT03838666BioinovaSuspension of human autologous MSC 3P

Utilization of AMSC to Enhance Rotator Cuff Repair - Safety and Efficacy

Start: Dec 2012Est. completion: Nov 20159 patients
Phase 1/2Terminated
NCT01122498PfizerBMP-655/ACS+Standard of care or Standard of care

A Safety Study Of BMP-655/ACS As An Adjuvant Therapy For Treatment Of Rotator Cuff Tears

Start: Jun 2010Est. completion: Apr 201223 patients
Phase 1Terminated
NCT07027735CTM BiomedicalRotator Cuff Repair with Allograft Patch

Decellularized Human Placental Extracellular Matrix Tissue for Rotator Cuff Repair Augmentation

Start: Aug 2026Est. completion: Jul 2027120 patients
N/ARecruiting
NCT05906004XirosPitch-Patch

Post-Market Clinical Follow-up (PMCF) Study of the Pitch-Patch for the Augmentation or Reinforcement of the Rotator Cuff

Start: May 2026Est. completion: Dec 202937 patients
N/ANot Yet Recruiting
NCT06590714Dong-A STExperimental

Perioperative Polmacoxib Reduce Opioid Consumption for Post Operative Pain After Rotator Cuff Tear.

Start: Aug 2024Est. completion: Aug 2025150 patients
N/ARecruiting
NCT07455474Mammoth BiosciencesBreg Polar Care Wave Cold Compression Device

Clinical Research Study of the Benefits of BREG Polar Care Wave to Reduce Opioid Use by Patients Having Undergone Arthroscopic Rotator Cuff Repair Shoulder Surgery

Start: Oct 2023Est. completion: Mar 202650 patients
N/ACompleted
NCT03752827InGeneronAdipose Derived Regenerative Cells

Autologous Adult Adipose-Derived Regenerative Cell Injection Into Chronic Partial-Thickness Rotator Cuff Tears

Start: May 2019Est. completion: Dec 2025168 patients
N/AActive Not Recruiting
NCT03199391Zimmer BiometBioWick SureLock Implant

BioWick SureLock Clinical Outcomes Study

Start: Apr 2017Est. completion: May 202171 patients
N/ACompleted
NCT03379324Applied BiologicsSuperiority of augmented repairs

Efficacy of an Amniotic Fluid Derived Allograft, (FlōGraft®) in Rotator Cuff Repairs: A Prospective Study

Start: Mar 2017Est. completion: Sep 2019260 patients
N/AUnknown
NCT02969135Marius PharmaceuticalsProgressive early passive and active movement

Progressive Active Exercise After Surgical Rotator Cuff Repair

Start: Feb 2017Est. completion: May 202082 patients
N/ACompleted
NCT01383239ArthrexImmediate Postoperative Therapy

Impact of Postoperative Management on Outcomes and Healing of Rotator Cuff Repairs

Start: Sep 2011Est. completion: Jul 201627 patients
N/ACompleted
NCT01170312ArthrexAutologous conditioned plasma

Arthroscopic Surgery and Platelet Rich Plasma In Rotator Cuff Tear Evaluation

Start: Sep 2010Est. completion: Aug 201225 patients
N/ACompleted
NCT01025037StrykerConexa Reconstructive Tissue Matrix

Outcomes in Rotator Cuff Repair Using Graft Reinforcement

Start: Oct 2009Est. completion: Apr 201461 patients
N/ACompleted
NCT00957255Baxter InternationalOrthoADAPT

Rotator Cuff Repair (RCR) With and Without OrthoADAPT Augmentation

Start: Mar 2009Est. completion: Apr 20100
N/AWithdrawn
NCT00456781StrykerAugmentation

Use of Graft Jacket for Rotator Cuff Repair

Start: Apr 2007Est. completion: Mar 201179 patients
N/ACompleted
NCT00762580Colorado TherapeuticsFeatures to Predict Success With Nonoperative Treatment of Patients With Rotator Cuff Tears

Features to Predict Success With Nonoperative Treatment of Patients With Rotator Cuff Tears

Start: Jan 2006Est. completion: Jan 2024452 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 actively recruiting trials targeting 1,614 patients
15 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.