Rotator Cuff Tear

2
Pipeline Programs
4
Companies
7
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
0
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
2 programs
2
BMP-655/ACS or Standard of CarePhase 11 trial
BMP-655/ACS+Standard of care or Standard of carePhase 11 trial
Active Trials
NCT00936559Terminated13Est. Feb 2012
NCT01122498Terminated23Est. Apr 2012
Arthrex
ArthrexCA - Santa Barbara
3 programs
Autologous conditioned plasmaN/A1 trial
Features to Predict Success With Nonoperative Treatment of Patients With Rotator Cuff TearsN/A1 trial
Immediate Postoperative TherapyN/A1 trial
Active Trials
NCT01170312CompletedEst. Aug 2012
NCT00762580CompletedEst. Jan 2024
NCT01383239CompletedEst. Jul 2016
Mammoth Biosciences
Mammoth BiosciencesCA - Brisbane
1 program
Breg Polar Care Wave Cold Compression DeviceN/A1 trial
Active Trials
NCT07455474CompletedEst. Mar 2026
AM-Pharma
AM-PharmaNetherlands - Utrecht
1 program
Surgical Management of Irreparable RC TearsN/A1 trial
Active Trials
NCT03878862RecruitingEst. Apr 2026

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
PfizerBMP-655/ACS or Standard of Care
PfizerBMP-655/ACS+Standard of care or Standard of care
Mammoth BiosciencesBreg Polar Care Wave Cold Compression Device
AM-PharmaSurgical Management of Irreparable RC Tears
ArthrexImmediate Postoperative Therapy
ArthrexAutologous conditioned plasma
ArthrexFeatures to Predict Success With Nonoperative Treatment of Patients With Rotator Cuff Tears

Clinical Trials (7)

Total enrollment: 36 patients across 7 trials

NCT00936559PfizerBMP-655/ACS or Standard of Care

Study Evaluating Safety Of BMP-655/ACS As An Adjuvant Therapy For Rotator Cuff Repair

Start: Sep 2010Est. completion: Feb 201213 patients
Phase 1Terminated
NCT01122498PfizerBMP-655/ACS+Standard of care or Standard of care

A Safety Study Of BMP-655/ACS As An Adjuvant Therapy For Treatment Of Rotator Cuff Tears

Start: Jun 2010Est. completion: Apr 201223 patients
Phase 1Terminated
NCT07455474Mammoth BiosciencesBreg Polar Care Wave Cold Compression Device

Clinical Research Study of the Benefits of BREG Polar Care Wave to Reduce Opioid Use by Patients Having Undergone Arthroscopic Rotator Cuff Repair Shoulder Surgery

Start: Oct 2023Est. completion: Mar 2026
N/ACompleted
NCT03878862AM-PharmaSurgical Management of Irreparable RC Tears

Surgical Management of Irreparable RC Tears

Start: Apr 2019Est. completion: Apr 2026
N/ARecruiting
NCT01383239ArthrexImmediate Postoperative Therapy

Impact of Postoperative Management on Outcomes and Healing of Rotator Cuff Repairs

Start: Sep 2011Est. completion: Jul 2016
N/ACompleted
NCT01170312ArthrexAutologous conditioned plasma

Arthroscopic Surgery and Platelet Rich Plasma In Rotator Cuff Tear Evaluation

Start: Sep 2010Est. completion: Aug 2012
N/ACompleted
NCT00762580ArthrexFeatures to Predict Success With Nonoperative Treatment of Patients With Rotator Cuff Tears

Features to Predict Success With Nonoperative Treatment of Patients With Rotator Cuff Tears

Start: Jan 2006Est. completion: Jan 2024
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 actively recruiting trials targeting 36 patients
4 companies competing in this space