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Rhinitis, Allergic, Perennial

48
Pipeline Programs
13
Companies
35
Clinical Trials
14
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
5
0
1
0
20
22
Early DiscoveryClinical DevelopmentMarket

On Market (14)

Approved therapies currently available

GSK
FLOVENT HFAApproved
fluticasone propionate
GSK
inhalation2004
395M Part D
GSK
ARNUITY ELLIPTAApproved
fluticasone furoate
GSK
inhalation2014
98M Part D
ALVESCOApproved
ciclesonide
Unknown Company
inhalation2008
35M Part D
Teva
QNASLApproved
beclomethasone dipropionate
Teva
nasal2012
5M Part D
OMNARISApproved
ciclesonide
Unknown Company
nasal2006
923K Part D
ZETONNAApproved
ciclesonide
Unknown Company
nasal2012
323K Part D
GSK
FLOVENT DISKUS 250Approved
fluticasone propionate
GSK
inhalation2000
GSK
FLOVENT DISKUS 100Approved
fluticasone propionate
GSK
inhalation2000
GSK
FLONASE SENSIMIST ALLERGY RELIEFApproved
fluticasone furoate
GSK
nasal2007
GSK
FLOVENT DISKUS 50Approved
fluticasone propionate
GSK
inhalation2000
GSK
FLONASE ALLERGY RELIEFApproved
fluticasone propionate
GSK
nasal2014
GSK
FLONASEApproved
fluticasone propionate
GSK
nasal1994
Teva
QVAR 80Approved
beclomethasone dipropionate
Teva
inhalation2000
Teva
QVAR 40Approved
beclomethasone dipropionate
Teva
inhalation2000

Competitive Landscape

13 companies ranked by most advanced pipeline stage

ViiV Healthcare
ViiV HealthcareNC - Durham
25 programs
1
1
14
7
Avamys aqueous nasal spray 110mcgPhase 4
FPNSPhase 4
FPNSPhase 4
Fluticasone furoate nasal sprayPhase 4
Fluticasone furoate nasal sprayPhase 4
+20 more programs
GSK
GSKLONDON, United Kingdom
13 programs
1
Fluticasone furoateN/A1 trial
Intermittent, sub-chronic and chronic Flixonase useN/A1 trial
Beclomethasone dipropionatePHASE_31 trial
Cetirizine Dry SyrupPHASE_31 trial
Cetirizine Dry SyrupPHASE_31 trial
+8 more programs
Active Trials
NCT01199757Completed540Est. Aug 2009
NCT01077609Completed1Est. Apr 2010
NCT00346775Completed97Est. Jun 2006
+10 more trials
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
4 programs
3
1
Ciclesonide nasal spray + placebo AzelastinePhase 41 trial
CiclesonidePhase 31 trial
CiclesonidePhase 31 trial
Ciclesonide nasalPhase 31 trial
Active Trials
NCT00659048Completed106Est. Dec 2005
NCT00659750Completed418Est. Apr 2005
NCT00658918Completed120Est. Nov 2005
+1 more trials
Teva
TevaIsrael - Petach Tikva
1 program
1
Beclomethasone dipropionate hydrofluoroalkane HFA Nasal AerosolPHASE_31 trial
Active Trials
NCT01134705Completed474Est. Oct 2010
MSD
MSDIreland - Ballydine
2 programs
1
1
MK-8237 tabletsPhase 3
MK-8237 6 DUPhase 1
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
2 programs
1
1
MK-8237 tabletsPhase 31 trial
MK-8237 6 DUPhase 11 trial
Active Trials
NCT01678807Completed195Est. May 2013
NCT01700192Completed1,482Est. Apr 2015
Chong Kun Dang Pharmaceutical
1 program
1
CKD-342Phase 31 trial
Active Trials
NCT02498509Completed459Est. May 2016
Hanlim Pharm
Hanlim PharmKorea - Seoul
2 programs
2
HL151Phase 11 trial
HL151Phase 11 trial
Active Trials
NCT02686294Completed30Est. Mar 2016
NCT02682745Completed30Est. Feb 2016
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
4 programs
Alesion®N/A1 trial
Alesion®N/A1 trial
EpinastinePHASE_31 trial
WAL801CL dry syrupPHASE_31 trial
Active Trials
NCT02238223Completed2,001
NCT02238236Completed3,793
NCT02182518Completed101
+1 more trials
UCB Pharma
UCB PharmaBelgium - Brussels
3 programs
KetotifenPHASE_31 trial
LevocetirizinePHASE_41 trial
LevocetirizinePHASE_41 trial
Active Trials
NCT00639587Completed149Est. Mar 2003
NCT00160589Completed729Est. Sep 2005
NCT00160680Completed62Est. Jun 2006
Sanofi
SanofiPARIS, France
2 programs
TriamcinolonePHASE_32 trials
FexofenadinePHASE_41 trial
Active Trials
NCT03317015Completed260Est. Jul 2017
NCT00132925Completed460Est. Feb 2006
NCT00741897Completed264
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
1 program
Qufeng Shengshi Fang and LoratadineN/A1 trial
Active Trials
NCT02653339Unknown180Est. Aug 2018
Stallergenes Greer
Stallergenes GreerFrance - Antony
1 program
300 IRPHASE_31 trial
Active Trials
NCT02443805Completed1,607Est. Jun 2018

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
GSKAvamys aqueous nasal spray 110mcg
AstraZenecaCiclesonide nasal spray + placebo Azelastine
UCB PharmaLevocetirizine
UCB PharmaLevocetirizine
SanofiFexofenadine
SanofiTriamcinolone
Stallergenes Greer300 IR
Chong Kun Dang PharmaceuticalCKD-342
Sharp TherapeuticsMK-8237 tablets
TevaBeclomethasone dipropionate hydrofluoroalkane HFA Nasal Aerosol
GSKfluticasone propionate
GSKBeclomethasone dipropionate
GSKGW685698X
GSKCetirizine Dry Syrup
GSKCetirizine Dry Syrup

Showing 15 of 35 trials with date data

Clinical Trials (35)

Total enrollment: 16,279 patients across 35 trials

NCT01270958GSKAvamys aqueous nasal spray 110mcg

A Phase-IV, Open-label Study to Evaluate Safety/Tolerability of Once-daily AVAMYS (TM) Aqueous Nasal Spray 110mcg Among Vietnamese Adult Patients With Established Perennial Allergic Rhinitis

Start: Aug 2009Est. completion: Feb 201060 patients
Phase 4Completed
NCT00806754AstraZenecaCiclesonide nasal spray + placebo Azelastine

Investigation of the Efficacy and Safety of Concomitant Administration of Ciclesonide Nasal Spray and Azelastine Nasal Spray in Patients (18 Years or Older) With Perennial Allergic Rhinitis (PAR) Not Adequately Controlled on an Intranasal Corticosteroid or Antihistamine Monotherapy (BY9010/M1-490)

Start: Nov 2006Est. completion: Aug 2007340 patients
Phase 4Completed
NCT00160589UCB PharmaLevocetirizine

LEADER (LEvocetirizine And DEsloratadine in Allergic Rhinitis)

Start: Apr 2005Est. completion: Sep 2005729 patients
Phase 4Completed
NCT00160680UCB PharmaLevocetirizine

ATAREAL (Antihistamine Treatment for Allergic Rhinitis in Real Life)

Start: Mar 2005Est. completion: Jun 200662 patients
Phase 4Completed
NCT00741897SanofiFexofenadine

Fexofenadine Study On Filipino Children for The Relief of Perennial And Intermittent Allergic Rhinitis

Start: Mar 2002264 patients
Phase 4Completed
NCT03317015SanofiTriamcinolone

A Study to Assess Efficacy and Safety of Nasacort® Nasal Spray in Comparison With Flixonase® Nasal Spray in Adults Suffering From Perennial Allergic Rhinitis (PAR)

Start: Nov 2016Est. completion: Jul 2017260 patients
Phase 3Completed

Efficacy & Safety of STG320 Sublingual Tablets of HDM Allergen Extracts in Adults and Adolescents With HDM-associated AR

Start: Sep 2015Est. completion: Jun 20181,607 patients
Phase 3Completed

Clinical Trial to Evaluate the Efficacy and Safety of CKD-342

Start: May 2015Est. completion: May 2016459 patients
Phase 3Completed

Efficacy and Safety Study of SCH 900237/MK-8237 in Children and Adults With House Dust Mite-Induced Allergic Rhinitis/Rhinoconjunctivitis (P05607)

Start: Jan 2013Est. completion: Apr 20151,482 patients
Phase 3Completed
NCT01134705TevaBeclomethasone dipropionate hydrofluoroalkane HFA Nasal Aerosol

Study in Adult and Adolescent Subjects With PAR (Perennial Allergic Rhinitis)

Start: May 2010Est. completion: Oct 2010474 patients
Phase 3Completed
NCT00398476GSKfluticasone propionate

Fluticasone Nasal Spray Patient Preference Study

Start: Dec 2006Est. completion: Dec 2006127 patients
Phase 3Completed
NCT00346775GSKBeclomethasone dipropionate

Validation Of Preference Module Of Experience With Allergic Rhinitis Nasal Sprays Questionnaire (EARNS-Q)

Start: May 2006Est. completion: Jun 200697 patients
Phase 3Completed

Long Term Safety Of GW685698X Via Nasal Biopsy

Start: Sep 2005Est. completion: Feb 2007125 patients
Phase 3Completed
NCT00257595GSKCetirizine Dry Syrup

Perennial Allergic Rhinitis In Pediatric Subjects

Start: Aug 200530 patients
Phase 3Completed
NCT00253058GSKCetirizine Dry Syrup

Study Of Perennial Allergic Rhinitis In Pediatrics

Start: Jul 2005286 patients
Phase 3Completed

Seasonal Allergic Rhinitis In Pediatric Subjects

Start: Mar 2005Est. completion: Nov 2005576 patients
Phase 3Completed
NCT00116883GSKGW685698X aqueous nasal spray

A Study Of GW685698X For The Treatment Of Perennial Allergic Rhinitis In Pediatrics

Start: Feb 2005Est. completion: Jul 200590 patients
Phase 3Completed

Perennial Allergic Rhinitis Study In Pediatric Subjects

Start: Feb 2005Est. completion: Nov 2005558 patients
Phase 3Completed
NCT00116818GSKGW685698X aqueous nasal spray

A Study of GW685698X for the Treatment Of Perennial Allergic Rhinitis in Adolescents and Adults

Start: Jan 2005Est. completion: May 200590 patients
Phase 3Completed

A Study To Evaluate The Efficacy And Safety Of A Once-Daily Investigational Nasal Spray In Adults And Adolescents With Perennial Allergic Rhinitis (PAR).

Start: Jan 2005Est. completion: May 2005288 patients
Phase 3Completed

Investigation of Potential Additive Inhibitory Effects on HPA-Axis of Ciclesonide Nasal Spray When Administered Concomitantly With Orally Inhaled Beclomethasone Dipropionate (HFA-BDP) in Patients With Perennial Allergic Rhinitis (PAR) (BY9010/M1-408)

Start: Dec 2004Est. completion: Dec 2005106 patients
Phase 3Completed
NCT00658918AstraZenecaCiclesonide nasal

To Assess the Safety of Ciclesonide, Applied as a Nasal Spray at Three Dose Levels, in the Treatment of Perennial Allergic Rhinitis in Pediatrics (BY9010/M1-405)

Start: Sep 2004Est. completion: Nov 2005120 patients
Phase 3Completed

To Assess the Safety and Efficacy of Ciclesonide Applied as a Nasal Spray in the Treatment of Perennial Allergic Rhinitis (BY9010/M1-402)

Start: Dec 2003Est. completion: Apr 2005418 patients
Phase 3Completed
NCT00132925SanofiTriamcinolone

An Efficacy and Safety Evaluation of Nasacort AQ in Children Ages 2-5 Years With Perennial Allergic Rhinitis

Start: Nov 2003Est. completion: Feb 2006460 patients
Phase 3Completed

Efficacy and Safety of Cetirizine Tablets Versus Ketotifen Dry Syrup in Children With Perennial Allergic Rhinitis

Start: Aug 2002Est. completion: Mar 2003149 patients
Phase 3Completed

WAL801CL (Epinastine Hydrochloride) Dry Syrup in Paediatric Perennial Allergic Rhinitis

Start: Jun 2001151 patients
Phase 3Completed

Epinastine + Pseudoephedrine SR (Slow Release) Versus Epinastine Alone in Patients With Perennial Allergic Rhinitis

Start: May 2000101 patients
Phase 3Completed

Repeated Dosing Clinical Trial of HL151

Start: Feb 2016Est. completion: Mar 201630 patients
Phase 1Completed

Single Dosing Clinical Trial of HL151

Start: Jan 2016Est. completion: Feb 201630 patients
Phase 1Completed

Safety Study of MK-8237 Treatment in House-Dust-Mite Allergic Adolescents (MK-8237-008)

Start: Oct 2012Est. completion: May 2013195 patients
Phase 1Completed
NCT02653339UNION therapeuticsQufeng Shengshi Fang and Loratadine

Effectiveness of Qufeng Shengshi Fang on Treatment of Allergic Rhinitis.

Start: Jun 2016Est. completion: Aug 2018180 patients
N/AUnknown
NCT01199757GSKFluticasone furoate

A Comparison of Patients on AVAMYS ® Versus NASONEX (A Trade Mark of Schering Corporation) and FLIXONASE ® on Key Health Outcome Measures

Start: Jul 2009Est. completion: Aug 2009540 patients
N/ACompleted
NCT01077609GSKIntermittent, sub-chronic and chronic Flixonase use

Flixonase Safety in Patients With Allergic Rhinitis (AR)

Start: Jan 2008Est. completion: Apr 20101 patients
N/ACompleted

Post Marketing Surveillance of Alesion® in Japanese Paediatric Patients With Allergic Rhinitis, Eczema/Dermatitis, Urticaria and Pruritus

Start: May 20053,793 patients
N/ACompleted

Postmarketing Surveillance to Investigate the Safety and Efficacy Information of Alesion® Tablet

Start: Apr 20042,001 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

20 late-stage (Phase 3) programs, potential near-term approvals
13 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.