Rhinitis, Allergic, Perennial

36
Pipeline Programs
7
Companies
26
Clinical Trials
15
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
16
20
Early DiscoveryClinical DevelopmentMarket

On Market (15)

Approved therapies currently available

U
BECLOMETHASONE DIPROPIONATEApproved
beclomethasone dipropionate
Unknown Company
inhalation2025
GSK
BECLOVENTApproved
beclomethasone dipropionate
GSK
inhalation1980
GSK
BECONASEApproved
beclomethasone dipropionate
GSK
nasal1981
GSK
FLONASEApproved
fluticasone propionate
GSK
nasal1994
GSK
FLONASE ALLERGY RELIEFApproved
fluticasone propionate
GSK
nasal2014
GSK
FLOVENTApproved
fluticasone propionate
GSK
inhalation1997
GSK
FLOVENT DISKUS 100Approved
fluticasone propionate
GSK
inhalation2000
GSK
FLOVENT DISKUS 250Approved
fluticasone propionate
GSK
inhalation2000
GSK
FLOVENT DISKUS 50Approved
fluticasone propionate
GSK
inhalation2000
GSK
FLOVENT HFAApproved
fluticasone propionate
GSK
inhalation2004
U
FLUTICASONE PROPIONATEApproved
fluticasone propionate
Unknown Company
topical2004
U
KENACORTApproved
triamcinolone
Unknown Company
oral1958
Teva
QNASLApproved
beclomethasone dipropionate
Teva
nasal2012
Teva
QVAR 40Approved
beclomethasone dipropionate
Teva
inhalation2000
Teva
QVAR 80Approved
beclomethasone dipropionate
Teva
inhalation2000

Competitive Landscape

7 companies ranked by most advanced pipeline stage

GSK
GSKLONDON, United Kingdom
13 programs
10
1
Avamys aqueous nasal spray 110mcgPhase 41 trial
Beclomethasone dipropionatePhase 31 trial
Cetirizine Dry SyrupPhase 31 trial
Cetirizine Dry SyrupPhase 31 trial
GW685698XPhase 31 trial
+8 more programs
Active Trials
NCT01199757Completed540Est. Aug 2009
NCT01077609Completed1Est. Apr 2010
NCT00346775Completed97Est. Jun 2006
+10 more trials
UP
UCB PharmaBelgium - Brussels
3 programs
1
2
LevocetirizinePhase 41 trial
LevocetirizinePhase 41 trial
KetotifenPhase 31 trial
Active Trials
NCT00639587Completed149Est. Mar 2003
NCT00160680Completed62Est. Jun 2006
NCT00160589Completed729Est. Sep 2005
Sanofi
SanofiPARIS, France
2 programs
1
1
FexofenadinePhase 41 trial
TriamcinolonePhase 32 trials
Active Trials
NCT03317015Completed260Est. Jul 2017
NCT00132925Completed460Est. Feb 2006
NCT00741897Completed264
Teva
TevaIsrael - Petach Tikva
1 program
1
1
Beclomethasone dipropionate hydrofluoroalkane HFA Nasal AerosolPhase 31 trial
Active Trials
NCT01134705Completed474Est. Oct 2010
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
Ciclesonide nasal spray + placebo AzelastinePhase 41 trial
Active Trials
NCT00806754Completed340Est. Aug 2007
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
4 programs
2
EpinastinePhase 31 trial
WAL801CL dry syrupPhase 31 trial
Alesion®N/A1 trial
Alesion®N/A1 trial
Active Trials
NCT02238236Completed3,793
NCT02238223Completed2,001
NCT02182518Completed101
+1 more trials
Stallergenes Greer
Stallergenes GreerFrance - Antony
1 program
1
300 IRPhase 31 trial
Active Trials
NCT02443805Completed1,607Est. Jun 2018

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
GSKAvamys aqueous nasal spray 110mcg
AstraZenecaCiclesonide nasal spray + placebo Azelastine
UCB PharmaLevocetirizine
UCB PharmaLevocetirizine
SanofiFexofenadine
SanofiTriamcinolone
Stallergenes Greer300 IR
TevaBeclomethasone dipropionate hydrofluoroalkane HFA Nasal Aerosol
GSKfluticasone propionate
GSKBeclomethasone dipropionate
GSKGW685698X
GSKCetirizine Dry Syrup
GSKCetirizine Dry Syrup
GSKGW685698X
GSKGW685698X aqueous nasal spray

Showing 15 of 26 trials with date data

Clinical Trials (26)

Total enrollment: 13,259 patients across 26 trials

NCT01270958GSKAvamys aqueous nasal spray 110mcg

A Phase-IV, Open-label Study to Evaluate Safety/Tolerability of Once-daily AVAMYS (TM) Aqueous Nasal Spray 110mcg Among Vietnamese Adult Patients With Established Perennial Allergic Rhinitis

Start: Aug 2009Est. completion: Feb 201060 patients
Phase 4Completed
NCT00806754AstraZenecaCiclesonide nasal spray + placebo Azelastine

Investigation of the Efficacy and Safety of Concomitant Administration of Ciclesonide Nasal Spray and Azelastine Nasal Spray in Patients (18 Years or Older) With Perennial Allergic Rhinitis (PAR) Not Adequately Controlled on an Intranasal Corticosteroid or Antihistamine Monotherapy (BY9010/M1-490)

Start: Nov 2006Est. completion: Aug 2007340 patients
Phase 4Completed
NCT00160589UCB PharmaLevocetirizine

LEADER (LEvocetirizine And DEsloratadine in Allergic Rhinitis)

Start: Apr 2005Est. completion: Sep 2005729 patients
Phase 4Completed
NCT00160680UCB PharmaLevocetirizine

ATAREAL (Antihistamine Treatment for Allergic Rhinitis in Real Life)

Start: Mar 2005Est. completion: Jun 200662 patients
Phase 4Completed
NCT00741897SanofiFexofenadine

Fexofenadine Study On Filipino Children for The Relief of Perennial And Intermittent Allergic Rhinitis

Start: Mar 2002264 patients
Phase 4Completed
NCT03317015SanofiTriamcinolone

A Study to Assess Efficacy and Safety of Nasacort® Nasal Spray in Comparison With Flixonase® Nasal Spray in Adults Suffering From Perennial Allergic Rhinitis (PAR)

Start: Nov 2016Est. completion: Jul 2017260 patients
Phase 3Completed

Efficacy & Safety of STG320 Sublingual Tablets of HDM Allergen Extracts in Adults and Adolescents With HDM-associated AR

Start: Sep 2015Est. completion: Jun 20181,607 patients
Phase 3Completed
NCT01134705TevaBeclomethasone dipropionate hydrofluoroalkane HFA Nasal Aerosol

Study in Adult and Adolescent Subjects With PAR (Perennial Allergic Rhinitis)

Start: May 2010Est. completion: Oct 2010474 patients
Phase 3Completed
NCT00398476GSKfluticasone propionate

Fluticasone Nasal Spray Patient Preference Study

Start: Dec 2006Est. completion: Dec 2006127 patients
Phase 3Completed
NCT00346775GSKBeclomethasone dipropionate

Validation Of Preference Module Of Experience With Allergic Rhinitis Nasal Sprays Questionnaire (EARNS-Q)

Start: May 2006Est. completion: Jun 200697 patients
Phase 3Completed

Long Term Safety Of GW685698X Via Nasal Biopsy

Start: Sep 2005Est. completion: Feb 2007125 patients
Phase 3Completed
NCT00257595GSKCetirizine Dry Syrup

Perennial Allergic Rhinitis In Pediatric Subjects

Start: Aug 200530 patients
Phase 3Completed
NCT00253058GSKCetirizine Dry Syrup

Study Of Perennial Allergic Rhinitis In Pediatrics

Start: Jul 2005286 patients
Phase 3Completed

Seasonal Allergic Rhinitis In Pediatric Subjects

Start: Mar 2005Est. completion: Nov 2005576 patients
Phase 3Completed
NCT00116883GSKGW685698X aqueous nasal spray

A Study Of GW685698X For The Treatment Of Perennial Allergic Rhinitis In Pediatrics

Start: Feb 2005Est. completion: Jul 200590 patients
Phase 3Completed

Perennial Allergic Rhinitis Study In Pediatric Subjects

Start: Feb 2005Est. completion: Nov 2005558 patients
Phase 3Completed
NCT00116818GSKGW685698X aqueous nasal spray

A Study of GW685698X for the Treatment Of Perennial Allergic Rhinitis in Adolescents and Adults

Start: Jan 2005Est. completion: May 200590 patients
Phase 3Completed

A Study To Evaluate The Efficacy And Safety Of A Once-Daily Investigational Nasal Spray In Adults And Adolescents With Perennial Allergic Rhinitis (PAR).

Start: Jan 2005Est. completion: May 2005288 patients
Phase 3Completed
NCT00132925SanofiTriamcinolone

An Efficacy and Safety Evaluation of Nasacort AQ in Children Ages 2-5 Years With Perennial Allergic Rhinitis

Start: Nov 2003Est. completion: Feb 2006460 patients
Phase 3Completed

Efficacy and Safety of Cetirizine Tablets Versus Ketotifen Dry Syrup in Children With Perennial Allergic Rhinitis

Start: Aug 2002Est. completion: Mar 2003149 patients
Phase 3Completed

WAL801CL (Epinastine Hydrochloride) Dry Syrup in Paediatric Perennial Allergic Rhinitis

Start: Jun 2001151 patients
Phase 3Completed

Epinastine + Pseudoephedrine SR (Slow Release) Versus Epinastine Alone in Patients With Perennial Allergic Rhinitis

Start: May 2000101 patients
Phase 3Completed
NCT01199757GSKFluticasone furoate

A Comparison of Patients on AVAMYS ® Versus NASONEX (A Trade Mark of Schering Corporation) and FLIXONASE ® on Key Health Outcome Measures

Start: Jul 2009Est. completion: Aug 2009540 patients
N/ACompleted
NCT01077609GSKIntermittent, sub-chronic and chronic Flixonase use

Flixonase Safety in Patients With Allergic Rhinitis (AR)

Start: Jan 2008Est. completion: Apr 20101 patients
N/ACompleted

Post Marketing Surveillance of Alesion® in Japanese Paediatric Patients With Allergic Rhinitis, Eczema/Dermatitis, Urticaria and Pruritus

Start: May 20053,793 patients
N/ACompleted

Postmarketing Surveillance to Investigate the Safety and Efficacy Information of Alesion® Tablet

Start: Apr 20042,001 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

16 late-stage (Phase 3) programs — potential near-term approvals
7 companies competing in this space