Refractive Errors

Pipeline Programs

Companies

Clinical Trials

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

AlconFORT WORTH, TX

18 programs

Air OptixPhase 42 trials

Air Optix DailyPhase 4

Air Optix ExtendedPhase 4

Air Optix Plus HydraGlydePhase 4

PRECISION1Phase 41 trial

+13 more programs

Active Trials

NCT03459131Completed15Est. Mar 2018

NCT04254003Completed48Est. Mar 2020

NCT03614130Completed22Est. Sep 2018

+17 more trials

SandozAustria - Kundl

1 program

Lotrafilcon B contact lenses with added wetting agentN/A1 trial

Active Trials

NCT03026257Completed323Est. Aug 2017

NovartisBASEL, Switzerland

1 program

Lotrafilcon B contact lenses with added wetting agentN/A

Johnson & JohnsonNEW BRUNSWICK, NJ

1 program

narafilcon A contact lensN/A1 trial

Active Trials

NCT01444313Completed40

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

Alconfemtosecond laser

AlconAir Optix

AlconVerofilcon A contact lenses

AlconVerofilcon A toric contact lenses

AlconLID018869+RepleniSH

AlconPhorcides Analytical Engine

AlconDT1 Toric contact lenses

AlconLID015385 contact lenses

AlconPRECISION1

AlconLID015385 contact lenses

AlconLID011121 contact lens

Showing 15 of 25 trials with date data

Clinical Trials (25)

Total enrollment: 1,813 patients across 25 trials

NCT01693939 Alconfemtosecond laser

Evaluation of the Post-LASIK Flap Thickness of the FS200 Femtosecond Laser Flap

Start: Feb 2012Est. completion: Apr 201230 patients

Phase 4Completed

NCT01556893 Alconfemtosecond laser

Creating LASIK Flaps With the LenSx Femtosecond Laser

Start: Apr 2012Est. completion: Mar 201320 patients

Phase 1Completed

NCT07036835 Alconfemtosecond laser

Clinical Investigation of a Femtosecond Laser for Corneal Flap Creation

Start: Aug 2025Est. completion: Jul 2026128 patients

N/AActive Not Recruiting

NCT06021353 Alconfemtosecond laser

Contralateral Study of WaveLight® Femtosecond Laser Devices for Corneal Flap Creation

Start: Oct 2023Est. completion: Dec 202447 patients

N/ACompleted

NCT05790928 AlconAir Optix

Air Optix Night and Day Aqua (AONDA) Retrospective Study 1

Start: Mar 2023Est. completion: Mar 2023108 patients

N/ACompleted

NCT05138783 AlconVerofilcon A contact lenses

Clinical Performance of Two Daily Disposable Soft Contact Lenses

Start: Jan 2022Est. completion: Mar 2022129 patients

N/ACompleted

NCT05039112 AlconVerofilcon A toric contact lenses

Clinical Comparison of 2 Daily Disposable Toric Soft Contact Lenses

Start: Sep 2021Est. completion: Nov 202164 patients

N/ACompleted

NCT04908488 AlconVerofilcon A toric contact lenses

Clinical Performance of Two Daily Disposable Toric Soft Contact Lenses

Start: Jul 2021Est. completion: Sep 2021115 patients

N/ACompleted

NCT04789382 AlconLID018869+RepleniSH

Three Daily Wear Monthly Replacement Silicone Hydrogel Contact Lenses With Two Multi-purpose Disinfecting Solution Combinations

Start: Apr 2021Est. completion: May 202136 patients

N/ACompleted

NCT04495829 AlconPhorcides Analytical Engine

Clinical and Refractive Outcomes After Contoura® Refractive Surgery Planned Using Phorcides Surgery Planning Software

Start: Jul 2020Est. completion: Apr 202170 patients

N/ACompleted

NCT04254003 AlconDT1 Toric contact lenses

Clinical Performance Evaluation of Two Daily Disposable Silicone Hydrogel Toric Contact Lenses

Start: Feb 2020Est. completion: Mar 202048 patients

N/ACompleted

NCT04207749 AlconLID015385 contact lenses

Clinical Evaluation of a Daily Wear Silicone Hydrogel Lens

Start: Jan 2020Est. completion: Dec 2020249 patients

N/ACompleted

NCT04205162 AlconPRECISION1

Evaluating the Initial Lens Handling Experience of Neophyte Contact Lens Wearers Fitted With Precision1 and 1-Day Acuvue Moist Contact Lenses

Start: Dec 2019Est. completion: Jun 202240 patients

N/ACompleted

NCT03920280 AlconLID015385 contact lenses

Clinical Evaluation of a Daily Wear Frequent Replacement Silicone Hydrogel Lens

Start: May 2019Est. completion: Oct 2019120 patients

N/ACompleted

NCT03614130 AlconLID011121 contact lens

Clinical Performance of a Silicone Hydrogel Contact Lens Following Six Nights of Extended Wear

Start: Aug 2018Est. completion: Sep 201822 patients

N/ACompleted

NCT03586167 AlconLID014341 contact lenses

Clinical Performance of a Monthly Replacement Silicone Hydrogel Lens

Start: Aug 2018Est. completion: Sep 201888 patients

N/ACompleted

NCT03560141 AlconLID011121 contact lens

Clinical Performance of a Silicone Hydrogel Contact Lens Following One Night of Extended Wear

Start: Jul 2018Est. completion: Jul 201812 patients

N/ACompleted

NCT03459131 AlconComfilcon A with Digital Zone Optics™ contact lenses

Clinical Evaluation of Two Monthly Contact Lenses

Start: Mar 2018Est. completion: Mar 201815 patients

N/ACompleted

NCT03115216 Alconfemtosecond laser

The Femtosecond Laser in Residency Training (FLIRT) Pilot Study

Start: Jul 2017Est. completion: Jul 20180

N/AWithdrawn

NCT03021707 Alconfemtosecond laser

Early Feasibility Study of UV-Femtosecond Laser Assisted Lenticular Extraction

Start: Mar 2017Est. completion: Oct 20197 patients

N/ACompleted

NCT03026257 SandozLotrafilcon B contact lenses with added wetting agent

Clinical Assessment of a HYDRAGLYDE® Regimen

Start: Feb 2017Est. completion: Aug 2017323 patients

N/ACompleted

NCT02575911 Alconfemtosecond laser

Accuracy of LASIK Flaps Created With the LenSx® Femtosecond Laser - A Pilot Study

Start: Oct 2015Est. completion: Apr 201634 patients

N/ACompleted

NCT02060461 Alconfemtosecond laser

LASIK Flap Thickness and Visual Outcomes Using the WaveLight FS200 Femtosecond Laser

Start: Aug 2012Est. completion: Sep 201633 patients

N/ACompleted

NCT01444313 Johnson & Johnsonnarafilcon A contact lens

Prospective Study of the Health Benefits of Ultra-Violet Filtering Contact Lenses

Start: Jan 201140 patients

N/ACompleted

NCT01100411 AlconAir Optix

Changes in Invitro and ex Vivo Lens Metrology With Daily Wear Contact Lenses

Start: Mar 2010Est. completion: Jul 201035 patients

N/ACompleted

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.