Refractive Error

Pipeline Programs

Companies

Clinical Trials

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

AlconFORT WORTH, TX

15 programs

Balafilcon A contact lensN/A1 trial

Balafilcon A contact lensesN/A1 trial

Clear Care Plus contact lens solutionN/A1 trial

FID 114657 eye dropsN/A1 trial

FID 120947A contact lens disinfecting solutionN/A1 trial

+10 more programs

Active Trials

NCT01629706Completed92Est. Jan 2014

NCT00725153Completed55Est. Sep 2008

NCT02413333Completed133Est. Aug 2015

+21 more trials

Johnson & JohnsonNEW BRUNSWICK, NJ

6 programs

ELITA SystemN/A1 trial

ExperimentalN/A1 trial

IntraLase iFS femtosecond laser and patient interfaceN/A1 trial

etafilcon AN/A1 trial

senofilcon A toric soft contact lensN/A1 trial

+1 more programs

Active Trials

NCT05713253Terminated96Est. Feb 2025

NCT06209476Completed30Est. Feb 2024

NCT03789669Completed200Est. Mar 2023

+3 more trials

NovartisBASEL, Switzerland

3 programs

Delefilcon A Multifocal Contact Lenses with Molded MarkN/A

Delefilcon A contact lensesN/A

Delefilcon A multifocal contact lensesN/A

SandozAustria - Kundl

3 programs

Delefilcon A Multifocal Contact Lenses with Molded MarkN/A1 trial

Delefilcon A contact lensesN/A1 trial

Delefilcon A multifocal contact lensesN/A1 trial

Active Trials

NCT02939170Completed87Est. Dec 2016

NCT02750813Completed252Est. Aug 2016

NCT02871375Completed170Est. Nov 2016

AbbottABBOTT PARK, IL

1 program

STAR S4IR LASIK with iDesign AberrometerN/A1 trial

Active Trials

NCT01220466Completed77Est. Dec 2011

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

Johnson & JohnsonExperimental

Johnson & JohnsonELITA System

AlconVerofilcon A contact lenses

Johnson & JohnsonIntraLase iFS femtosecond laser and patient interface

Alconverofilcon A contact lenses

AlconVerofilcon A contact lenses

AlconFID122819 contact lenses

SandozDelefilcon A Multifocal Contact Lenses with Molded Mark

Showing 15 of 37 trials with date data

Clinical Trials (37)

Total enrollment: 3,485 patients across 37 trials

NCT06209476 Johnson & JohnsonExperimental

Clinical Investigation on Assessing the Repeatability and Reproducibility of Central and Peripheral Refractive Error

Start: Jan 2024Est. completion: Feb 202430 patients

N/ACompleted

NCT05713253 Johnson & JohnsonELITA System

A PHASED, PROSPECTIVE, MULTI-CENTER STUDY OF THE ELITA SYSTEM

Start: Feb 2023Est. completion: Feb 202596 patients

N/ATerminated

NCT04942925 AlconVerofilcon A contact lenses

Clinical Comparison of Two Daily Disposable Contact Lenses - Pilot Study 3

Start: Jul 2021Est. completion: Sep 202160 patients

N/ACompleted

NCT04865354 AlconVerofilcon A contact lenses

Clinical Comparison of Two Daily Disposable Contact Lenses

Start: May 2021Est. completion: Jun 2021170 patients

N/ACompleted

NCT04527978 AlconVerofilcon A contact lenses

Clinical Comparison of 2 Daily Disposable Contact Lenses - Pilot Study 1

Start: Sep 2020Est. completion: Nov 202056 patients

N/ACompleted

NCT04528017 AlconVerofilcon A contact lenses

Clinical Comparison of 2 Daily Disposable Contact Lenses - Pilot Study 2

Start: Sep 2020Est. completion: Oct 202056 patients

N/ACompleted

NCT04201639 AlconVerofilcon A contact lenses

Evaluating the Performance of Precision1 Daily Disposable Contact Lens in a Group of Heavy Digital Device Users

Start: Dec 2019Est. completion: Sep 202132 patients

N/ACompleted

NCT03969290 AlconVerofilcon A contact lenses

Clinical Performance of Two Daily Disposable Contact Lenses - Study 1

Start: Jun 2019Est. completion: Aug 201969 patients

N/ACompleted

NCT03888469 AlconVerofilcon A contact lenses

Clinical Comparison of DDT2 Contact Lens and a Daily Disposable Contact Lens - Study 1

Start: May 2019Est. completion: Jun 201992 patients

N/ACompleted

NCT03888482 AlconVerofilcon A contact lenses

Clinical Comparison of DDT2 Contact Lens and a Daily Disposable Contact Lens - Study 2

Start: Apr 2019Est. completion: Jun 2019154 patients

N/ACompleted

NCT03789669 Johnson & JohnsonIntraLase iFS femtosecond laser and patient interface

A Prospective, Multi-Center Evaluation of Corneal Flap Creation Using Cheetah Femtosecond Laser System and Cheetah Patient Interface

Start: Dec 2018Est. completion: Mar 2023200 patients

N/ACompleted

NCT03349632 Alconverofilcon A contact lenses

Clinical Comparison of 4 Daily Disposable Soft Contact Lenses

Start: Jan 2018Est. completion: Feb 201868 patients

N/ACompleted

NCT03305770 AlconVerofilcon A contact lenses

DD T2 Daily Disposable Registration Trial

Start: Oct 2017Est. completion: Feb 2018107 patients

N/ACompleted

NCT03095027 AlconFID122819 contact lenses

Clinical Performance of a Silicone Hydrogel for Daily Disposable Wear

Start: Apr 2017Est. completion: May 201754 patients

N/ACompleted

NCT02939170 SandozDelefilcon A Multifocal Contact Lenses with Molded Mark

Initial Performance of a Daily Disposable Contact Lens Featuring Molded Marks

Start: Nov 2016Est. completion: Dec 201687 patients

N/ACompleted

NCT02871375 SandozDelefilcon A multifocal contact lenses

Clinical Assessment of DAILIES TOTAL1® (DT1) Multifocal

Start: Aug 2016Est. completion: Nov 2016170 patients

N/ACompleted

NCT02771145 AlconFID 120947A contact lens disinfecting solution

Clinical Evaluation of the Safety and Efficacy of FID 120947A

Start: May 2016Est. completion: Jan 201791 patients

N/ACompleted

NCT02750813 SandozDelefilcon A contact lenses

ACUVUE® OASYS® 1-DAY vs DAILIES TOTAL1®

Start: Apr 2016Est. completion: Aug 2016252 patients

N/ACompleted

NCT02710292 AlconNarafilcon A contact lenses

Clinical Evaluation of DAILIES TOTAL 1® Performance in a Japanese Population

Start: Apr 2016Est. completion: Sep 2016104 patients

N/ACompleted

NCT02696317 AlconSenofilcon A contact lenses with HydraLuxe™

Clinical Evaluation of ACUVUE® OASYS® 1-Day and ACUVUE® OASYS®

Start: Mar 2016Est. completion: Jun 201684 patients

N/ACompleted

NCT02517567 AlconNarafilcon A contact lenses

DAILIES TOTAL1® - Comparative Assessment of Tear Film Evaporation

Start: Sep 2015Est. completion: Apr 201637 patients

N/ACompleted

NCT02402127 AlconNarafilcon A contact lenses

Lubricity Post-Wear - Competitive Lenses Pilot

Start: May 2015Est. completion: Jul 201524 patients

N/ACompleted

NCT02388763 AlconStenfilcon A contact lenses

Clinical Evaluation of MyDay™ and 1-DAY ACUVUE® TruEye®

Start: Apr 2015Est. completion: Sep 201566 patients

N/ACompleted

NCT02413333 AlconClear Care Plus contact lens solution

Clear Care® Plus vs. PeroxiClear™

Start: Apr 2015Est. completion: Aug 2015133 patients

N/ACompleted

NCT02293538 AlconFID 114657 eye drops

Formula Identification (FID) 114657 in Contact Lens Wearers

Start: Nov 2014Est. completion: Jul 2015234 patients

N/ACompleted

NCT02252133 AlconNarafilcon A contact lenses

DAILIES TOTAL1® Lens Centration in a Japanese Population

Start: Oct 2014Est. completion: Nov 201453 patients

N/ACompleted

NCT02089191 AlconStenfilcon A contact lenses

Tear Film Stability of DAILIES® AquaComfort Plus® Contact Lenses vs. MyDay® Daily Disposable Contact Lenses

Start: Mar 2014Est. completion: Apr 201431 patients

N/ACompleted

NCT01996709 AlconHydrogen peroxide-based contact lens solution

Effectiveness of a Marketed One-Step Peroxide Lens Care Solution in Symptomatic Contact Lens Wearers

Start: Dec 2013Est. completion: May 2014142 patients

N/ACompleted

NCT01941485 AlconWaveLight® Refractive Suite

WaveLight® Refractive Flap Accuracy Study

Start: Oct 2013Est. completion: Feb 201560 patients

N/ACompleted

NCT01941498 AlconWavelight® Refractive Suite

WaveLight® Refractive Myopic Study

Start: Sep 2013Est. completion: Aug 2014104 patients

N/ACompleted

NCT01629706 AlconBalafilcon A contact lens

Determination of Cell Population in Solution-Induced Corneal Staining (SICS) and Symptomatic Versus Asymptomatic Lens Wearers

Start: Sep 2012Est. completion: Jan 201492 patients

N/ACompleted

NCT01371552 AlconNarafilcon A contact lenses

Performance Evaluation of a New Daily Disposable Silicone Hydrogel Lens

Start: May 2011Est. completion: Aug 2011119 patients

N/ACompleted

NCT01220466 AbbottSTAR S4IR LASIK with iDesign Aberrometer

Performance and Acceptability of iDesign

Start: Oct 2010Est. completion: Dec 201177 patients

N/ACompleted

NCT00708032 Johnson & Johnsonspectacles

Clinical Performance of a New Daily Disposable Contact Lens Worn in a Neophyte Population.

Start: Jun 2008Est. completion: Dec 200974 patients

N/ACompleted

NCT00725153 AlconBalafilcon A contact lenses

Evaluation of Deposits on Contact Lenses Worn Daily Wear

Start: Mar 2008Est. completion: Sep 200855 patients

N/ACompleted

NCT00639353 Johnson & Johnsonsenofilcon A toric soft contact lens

Silicone Hydrogel Contact Lenses on Low Astigmatism in Japan

Start: Feb 2008102 patients

N/ATerminated

NCT01163760 Johnson & Johnsonetafilcon A

Clinical Evaluation of Two Daily Disposable Contact Lenses

Start: Sep 2007Est. completion: Sep 200750 patients

N/ACompleted

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

6 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.