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Postmenopausal Symptoms

10
Pipeline Programs
5
Companies
6
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
4
0
0
0
3
3
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

Ascend Therapeutics
ESTROGELApproved
estradiol
Ascend Therapeutics
Estrogen [EPC]transdermal2004
1M Part D

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Ascend Therapeutics
2 programs
2
EstrogelPhase 41 trial
ESTROGEL(estradiol)Phase 4
Active Trials
NCT00160173Completed221Est. Sep 2005
Noven Pharmaceuticals
2 programs
1
1
BrisdellePhase 31 trial
BrisdellePhase 11 trial
Active Trials
NCT01829919Completed24Est. Aug 2011
NCT01361308Completed614Est. Feb 2012
MSD
MSDIreland - Ballydine
2 programs
1
1
EsmirtazapinePhase 31 trial
Comparator: Estrace 0.5 mgPhase 11 trial
Active Trials
NCT00820664Completed29Est. May 2009
NCT00535288Completed946Est. Jan 2006
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
2 programs
1
1
EsmirtazapinePhase 3
Comparator: Estrace 0.5 mgPhase 1
MenoGeniX
MenoGeniXCO - Aurora
1 program
1
G-CSFPhase 11 trial
Active Trials
NCT03640754Completed61Est. Feb 2022

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Ascend TherapeuticsEstrogel
Noven PharmaceuticalsBrisdelle
MSDEsmirtazapine
MenoGeniXG-CSF
Noven PharmaceuticalsBrisdelle
MSDComparator: Estrace 0.5 mg

Clinical Trials (6)

Total enrollment: 1,895 patients across 6 trials

Efficacy Study Comparing 0.9 g and 1.25 g Estrogel With Placebo for Vasomotor Symptoms and Vulvar and Vaginal Atrophy

Start: Dec 2004Est. completion: Sep 2005221 patients
Phase 4Completed

Efficacy/Safety Study of Brisdelle™ (Formerly Known as Mesafem) in the Treatment of Vasomotor Symptoms (VMS)

Start: May 2011Est. completion: Feb 2012614 patients
Phase 3Completed
NCT00535288MSDEsmirtazapine

Dose-Finding Safety and Efficacy Trial of Org 50081 (Esmirtazapine) in the Treatment of Vasomotor Symptoms (177001/P06472/MK-8265-013)

Start: Sep 2004Est. completion: Jan 2006946 patients
Phase 3Completed

A Study of the Safety and Effect of Repeated Administration of G-CSF on Hot Flashes in Postmenopausal Women

Start: Aug 2018Est. completion: Feb 202261 patients
Phase 1Completed

Pharmacokinetic Evaluation of Brisdelle™ (Formerly Known as Mesafem) Following Single & Repeat Oral Administration in Healthy Postmenopausal Women

Start: Jul 2011Est. completion: Aug 201124 patients
Phase 1Completed
NCT00820664MSDComparator: Estrace 0.5 mg

A Clinical Study to Evaluate the Effects of Estrogen in Healthy Postmenopausal Women

Start: Dec 2008Est. completion: May 200929 patients
Phase 1Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

3 late-stage (Phase 3) programs, potential near-term approvals
5 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.