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Post-operative Pain

13
Pipeline Programs
12
Companies
20
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
5
0
4
4
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

12 companies ranked by most advanced pipeline stage

Avanos Medical
Avanos MedicalBelgium - Zavantem
2 programs
1
RopivacainePhase 42 trials
ON-Q Pump® with continuous infusion of bupivacaineN/A
Active Trials
NCT05642416Completed240Est. Dec 2024
NCT04130464Recruiting120Est. Dec 2026
Spine BioPharma
Spine BioPharmaNY - New York
1 program
1
Dronabinol 2.5mg CapPhase 41 trial
Active Trials
NCT04346407Unknown90Est. Sep 2023
AtriCure
AtriCureCA - Pleasanton
1 program
1
Intercostal Nerve CryoablationPhase 42 trials
Active Trials
NCT05731973Completed50Est. Oct 2025
NCT05144828Completed33Est. Dec 2024
Lundbeck
LundbeckDenmark - Copenhagen
1 program
1
RopivacainePhase 41 trial
Active Trials
NCT00968955Completed120Est. Jun 2010
Talphera
TalpheraCA - San Mateo
3 programs
3
Sufentanil NanoTab PCA System/15 mcgPhase 31 trial
Sufentanil NanoTab PCA System/15 mcgPhase 31 trial
Sufentanil Tablet 30 mcgPhase 31 trial
Active Trials
NCT01539538Completed357Est. Dec 2012
NCT01539642Completed172Est. Feb 2013
NCT02356588Completed161Est. Aug 2015
Pfizer
PfizerNEW YORK, NY
1 program
1
lyricaPhase 31 trial
Active Trials
NCT01391858Completed80Est. Jun 2013
Vivozon
VivozonKorea - Gyeonggi
5 programs
5
VVZ-149 InjectionsPhase 21 trial
VVZ-149 InjectionsPhase 21 trial
VVZ-149 injectionsPhase 21 trial
VVZ-149 injectionsPhase 21 trial
VVZ-149 injectionsPhase 21 trial
Active Trials
NCT02489526Completed60Est. Aug 2016
NCT02992041Completed69Est. Apr 2018
NCT02844725Completed60Est. Feb 2017
+2 more trials
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
2 programs
BupivicaineN/A1 trial
ON-Q Pump® with continuous infusion of bupivacaineN/A1 trial
Active Trials
NCT01916590Terminated7Est. May 2014
NCT05131178Recruiting100Est. May 2027
Providence Therapeutics
1 program
Bilateral paravertebral block with 0.25% ropivicaine with 1:400,000 epinephrineN/A1 trial
Active Trials
NCT06008821Unknown224Est. Nov 2025
Regenesis Biomedical
Regenesis BiomedicalAZ - Scottsdale
1 program
Pulsed Radiofrequency EnergyN/A1 trial
Active Trials
NCT01694199Terminated139Est. Dec 2012
Regenesis
RegenesisAZ - Scottsdale
1 program
Pulsed Radiofrequency EnergyN/A
Heron Therapeutics
1 program
Bupivacaine HCI without epinephrinePHASE_21 trial
Active Trials
NCT04911062Completed32Est. Aug 2022

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Avanos MedicalRopivacaine
AtriCureIntercostal Nerve Cryoablation
Spine BioPharmaDronabinol 2.5mg Cap
Avanos MedicalRopivacaine
LundbeckRopivacaine
TalpheraSufentanil Tablet 30 mcg
TalpheraSufentanil NanoTab PCA System/15 mcg
TalpheraSufentanil NanoTab PCA System/15 mcg
Pfizerlyrica
Heron TherapeuticsBupivacaine HCI without epinephrine
VivozonVVZ-149 injections
VivozonVVZ-149 Injections
VivozonVVZ-149 injections
VivozonVVZ-149 Injections
VivozonVVZ-149 injections

Showing 15 of 20 trials with date data

Clinical Trials (20)

Total enrollment: 2,164 patients across 20 trials

Intermittent Bolus vs Continuous Infusion Via ESP Catheters RCT

Start: Oct 2022Est. completion: Dec 2024240 patients
Phase 4Completed
NCT05144828AtriCureIntercostal Nerve Cryoablation

Efficacy of Intercostal CryoAnalgesia in Robotic Lung Resection

Start: Feb 2022Est. completion: Dec 202433 patients
Phase 4Completed
NCT04346407Spine BioPharmaDronabinol 2.5mg Cap

Dronabinol for Post-operative Pain After Lumbar Fusion

Start: Sep 2020Est. completion: Sep 202390 patients
Phase 4Unknown

Intraperitoneal Infusion of Analgesic for Postoperative Pain Management

Start: Sep 2019Est. completion: Dec 2026120 patients
Phase 4Recruiting

Effect of Local Infiltration Analgesia in Total Hip Arthroplasty

Start: Sep 2009Est. completion: Jun 2010120 patients
Phase 4Completed
NCT02356588TalpheraSufentanil Tablet 30 mcg

A Trial Evaluating the Efficacy and Safety of the Sublingual Sufentanil Tablet 30 mcg for Post-Operative Pain After Abdominal Surgery

Start: Feb 2015Est. completion: Aug 2015161 patients
Phase 3Completed
NCT01539538TalpheraSufentanil NanoTab PCA System/15 mcg

A Multicenter, Randomized, Open-Label, Parallel-Group Trial to Compare the Efficacy and Safety of the Sufentanil NanoTab PCA System/15 mcg (Zalviso™)to Intravenous Patient-Controlled Analgesia With Morphine for the Treatment of Acute Post-Operative Pain

Start: Apr 2012Est. completion: Dec 2012357 patients
Phase 3Completed
NCT01539642TalpheraSufentanil NanoTab PCA System/15 mcg

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of the Sufentanil NanoTab PCA System/15 mcg (Zalviso™) for the Treatment of Post-Operative Pain in Patients After Open Abdominal Surgery

Start: Feb 2012Est. completion: Feb 2013172 patients
Phase 3Completed

Postoperative Pain and Morphine Consumption After Mastectomy - Lyrica

Start: Dec 2006Est. completion: Jun 201380 patients
Phase 3Completed
NCT04911062Heron TherapeuticsBupivacaine HCI without epinephrine

HTX-011 in Spinal Surgery

Start: Apr 2022Est. completion: Aug 202232 patients
Phase 2Completed
NCT03347266VivozonVVZ-149 injections

Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injection for Postoperative Pain Following Total Hip Arthroplasty.

Start: Dec 2017Est. completion: Jul 201812 patients
Phase 2Completed
NCT02992041VivozonVVZ-149 Injections

Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injections for Post-Operative Pain Following Laparoscopic Colorectomy

Start: Dec 2016Est. completion: Apr 201869 patients
Phase 2Completed
NCT02844725VivozonVVZ-149 injections

Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injection for Post-operative Pain Following Gastrectomy

Start: Jun 2016Est. completion: Feb 201760 patients
Phase 2Completed
NCT02489526VivozonVVZ-149 Injections

Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injections for Post-Operative Pain Following Colorectal Surgery

Start: Sep 2015Est. completion: Aug 201660 patients
Phase 2Completed
NCT02522598VivozonVVZ-149 injections

Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injection for Post-operative Pain Following Gastrectomy

Start: Aug 2015Est. completion: Feb 201638 patients
Phase 2Completed
NCT05731973AtriCureIntercostal Nerve Cryoablation

Intercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatum

Start: Dec 2023Est. completion: Oct 202550 patients
N/ACompleted
NCT06008821Providence TherapeuticsBilateral paravertebral block with 0.25% ropivicaine with 1:400,000 epinephrine

Paravertebral Block for Improvement of Quality of Recovery Following Cardiac Surgery

Start: Oct 2023Est. completion: Nov 2025224 patients
N/AUnknown
NCT05131178Colorado TherapeuticsON-Q Pump® with continuous infusion of bupivacaine

Post-operative Cesarean Trial of Pain Control

Start: Nov 2021Est. completion: May 2027100 patients
N/ARecruiting
NCT01694199Regenesis BiomedicalPulsed Radiofrequency Energy

Pulsed Radiofrequency Energy to Treat Post-Bunionectomy Pain

Start: Sep 2012Est. completion: Dec 2012139 patients
N/ATerminated

Effectiveness of Continuous Femoral Nerve Block Versus Single Shot Femoral Nerve Block for Pain Control

Start: Jul 2011Est. completion: May 20147 patients
N/ATerminated

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

4 late-stage (Phase 3) programs, potential near-term approvals
2 actively recruiting trials targeting 2,164 patients
12 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.