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Polypoidal Choroidal Vasculopathy

4
Pipeline Programs
7
Companies
50
Clinical Trials
5 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
0
4
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Innovation Pharmaceuticals
2 programs
2
Faricimab Injection [Vabysmo]Phase 41 trial
Intravitreal AfliberceptPhase 41 trial
Active Trials
NCT06709339Recruiting120Est. Aug 2028
NCT02495181Completed50Est. Dec 2019
Sandoz
SandozAustria - Kundl
1 program
1
Verteporfin Photodynamic TherapyPhase 4
Bayer
BayerLEVERKUSEN, Germany
1 program
1
afliberceptPhase 45 trials
Active Trials
NCT07389980Recruiting50Est. Dec 2028
NCT07365371Not Yet Recruiting174Est. Dec 2027
NCT07129239Not Yet Recruiting180Est. Feb 2027
+2 more trials
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
2 programs
ConberceptN/A1 trial
non-interventionalN/A
Active Trials
NCT05229237Completed500Est. Dec 2021
Genentech
GenentechCA - Oceanside
1 program
ranibizumab 2.0mgPHASE_1_2
Regeneron
RegeneronTARRYTOWN, NY
1 program
Intravitreal aflibercept injection 2.0mgPHASE_41 trial
Active Trials
NCT01871376Completed25Est. Sep 2016
T-Therapeutics
T-TherapeuticsUK - Cambridge
1 program
Intravitreal aflibercept injection 2.0mgPHASE_4

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
Bayeraflibercept
Innovation PharmaceuticalsFaricimab Injection [Vabysmo]
Bayeraflibercept
Bayeraflibercept
Bayeraflibercept
Bayeraflibercept
Bayeraflibercept
Bayeraflibercept
Bayeraflibercept
Bayeraflibercept
Bayeraflibercept
Bayeraflibercept
Innovation PharmaceuticalsIntravitreal Aflibercept
Bayeraflibercept
Bayeraflibercept

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 172,086 patients across 50 trials

NCT07365371Bayeraflibercept

A Prospective, Multicenter, Open-label, Randomized Clinical Trial to Evaluate the Efficacy, Durability, and Safety of Aflibercept 8mg in Different Treatment Regimens in Chinese Patients With Polypoidal Choroidal Vasculopathy (PCV)

Start: Jan 2026Est. completion: Dec 2027174 patients
Phase 4Not Yet Recruiting
NCT06709339Innovation PharmaceuticalsFaricimab Injection [Vabysmo]

Study to Investigate the Efficacy, Safety and Durability of Faricimab in Caucasian Patients With Polypoidal Choroidal Vasculopathy (MONDEGO)

Start: Aug 2025Est. completion: Aug 2028120 patients
Phase 4Recruiting
NCT06591598Bayeraflibercept

A Study to Learn About the Blood Levels of Aflibercept When High-dose Aflibercept is Injected in Both Eyes of Participants With Diabetic Macular Edema or Neovascular Age-related Macular Degeneration

Start: Sep 2024Est. completion: Oct 202551 patients
Phase 4Completed
NCT05473715Bayeraflibercept

A Study to Learn How Well Aflibercept Injected Into the Eye Works and How Safe it is When Given in Customized Treatment Intervals in Patients With an Eye Disease Called Neovascular Age-related Macular Degeneration After Start of Treatment

Start: Apr 2023Est. completion: Jul 20233 patients
Phase 4Terminated
NCT04655482Bayeraflibercept

Treat-and-extend Using Aflibercept for Type 3 Neovascularization

Start: Feb 2021Est. completion: Aug 202430 patients
Phase 4Unknown
NCT03780361Bayeraflibercept

Changes in Inflammatory Biomarkers Including Soluble CD14 and Hyperreflective Foci in DME Patients Treated With Aflibercept (FORESIGHT)

Start: May 2019Est. completion: Feb 202423 patients
Phase 4Completed
NCT03117634Bayeraflibercept

An Open Label-study to Compare the Efficacy of Aflibercept Monotherapy for Polypoidal Choroidal Vasculopathy

Start: Dec 2017Est. completion: Jan 202154 patients
Phase 4Completed
NCT03453281Bayeraflibercept

Early Anatomical, Physiological, and Clinical Changes in Diabetic Macular Edema After Intravitreal Aflibercept Injection

Start: Oct 2017Est. completion: May 201836 patients
Phase 4Completed
NCT02924987Bayeraflibercept

Effect of Aflibercept (Eylea®) in the Management of Bevacizumab (Avastin®) Resistant Diabetic Macular Edema

Start: Nov 2016Est. completion: Nov 201740 patients
Phase 4Unknown
NCT02800642Bayeraflibercept

Evaluation of a Treat and Extend Regimen of Intravitreal Aflibercept for Macular Edema Secondary to CRVO

Start: Jun 2016Est. completion: Jul 2019162 patients
Phase 4Completed
NCT02633852Bayeraflibercept

Multicenter Study to Evaluate the Efficacy of Treat and Extend Regimen of Aflibercept (EYLEA) as a Second Line Treatment for Diabetic Macular Edema

Start: May 2016Est. completion: Sep 201848 patients
Phase 4Completed
NCT03169660Bayeraflibercept

Intravitreal Aflibercept for Submacular Hemorrhage

Start: Dec 2015Est. completion: Jan 201929 patients
Phase 4Completed

Randomized, Double-masked, Sham-controlled Phase 4 Study, Efficacy, Safety, and Tolerability of Intravitreal Aflibercept Monotherapy Compared to Aflibercept With Adjunctive Photodynamic Therapy in Patients With Polypoidal Choroidal Vasculopathy

Start: Nov 2015Est. completion: Dec 201950 patients
Phase 4Completed
NCT02072408Bayeraflibercept

Efficacy and Safety of Intravitreal Vascular Endothelial Growth Factor Trap-eye in Patients With Polyploidal Choroidal Vasculopathy

Start: Feb 2014Est. completion: Nov 201746 patients
Phase 4Completed
NCT01918878Bayeraflibercept

Aflibercept (EYLEA)as Secondary or Third Line Treatment for Neovascular Age-related Macular Degeneration.

Start: Oct 2013Est. completion: Apr 201648 patients
Phase 4Unknown
NCT01950741Bayeraflibercept

Effect of Intravitreal VEGF-Trap Eye on Polypoidal Choroidal Vasculopathy

Start: Sep 2013Est. completion: Aug 201548 patients
Phase 4Completed
NCT01896284Bayeraflibercept

Study to Evaluate Efficacy of Aflibercept in Neovascular Age-related Macular Degeneration Patients Non Responders to Anti-Vascular Endothelial Growth Factor

Start: Jul 2013Est. completion: Jun 201546 patients
Phase 4Completed
NCT02309281Bayeraflibercept

Intravitreal Aflibercept in Neovascular AMD With Limited Response to Ranibizumab

Start: May 2013Est. completion: Jul 201433 patients
Phase 4Completed
NCT01871376RegeneronIntravitreal aflibercept injection 2.0mg

Intravitreal Aflibercept Injection for Polypoidal Choroidal Vasculopathy With Hemorrhage or Exudation

Start: May 2013Est. completion: Sep 201625 patients
Phase 4Completed
NCT07389980Bayeraflibercept

Prospective Trial of the Efficacy and Safety of a Personalized Regimen of High-dose Aflibercept 8mg on Treatment-naive Polypoidal Choroidal Vasculopathy: the PALLAS Trial

Start: Dec 2026Est. completion: Dec 202850 patients
Phase 3Recruiting
NCT07129239Bayeraflibercept

High Dose (HD) Aflibercept Switch in Neovascular Age-related Macular Degeneration (nAMD): to Load or Maintain (HEIRLOOM)

Start: Aug 2025Est. completion: Feb 2027180 patients
Phase 3Not Yet Recruiting
NCT06422507Bayeraflibercept

A Study to Learn More About How Well 8 Milligram Aflibercept Works and How Safe it is in Chinese Participants With Diabetic Macular Edema

Start: May 2024Est. completion: Mar 2026333 patients
Phase 3Completed
NCT04015180Bayeraflibercept

Extension Study to Evaluate the Long-term Outcomes of Subjects in Study 20090

Start: Mar 2020Est. completion: Sep 2025100 patients
Phase 3Completed
NCT04004208Bayeraflibercept

Aflibercept for Retinopathy of Prematurity - Intravitreal Injection Versus Laser Therapy

Start: Sep 2019Est. completion: Feb 2021113 patients
Phase 3Completed
NCT04113538Bayeraflibercept

Treat and Extend Analysis Trial With Aflibercept in Wet-AMD

Start: Jul 2019Est. completion: May 202340 patients
Phase 3Unknown
NCT03639675Bayeraflibercept

Study to Learn How the Drug Aflibercept Works in in Japanese Patients With Increased Eye Pressure That is Caused by New Blood Vessels Growing in the Eye (Neovascular Glaucoma or NVG). Safety of the Drug and Patients' Tolerability of the Drug Injection is Also Studied

Start: Oct 2018Est. completion: Mar 201916 patients
Phase 3Completed
NCT02396316Bayeraflibercept

Japanese Phase 3 Study of Aflibercept in Neovascular Glaucoma Patients

Start: Apr 2015Est. completion: Sep 201654 patients
Phase 3Completed
NCT02157077Bayeraflibercept

Aflibercept After Ranibizumab in Exudative Age-related Macular Degeneration

Start: Dec 2013Est. completion: Dec 201590 patients
Phase 3Completed
NCT01521559Bayeraflibercept

Study to Assess the Clinical Efficacy and Safety of Intravitreal Aflibercept Injection (IAI;EYLEA®;BAY86-5321) in Patients With Branch Retinal Vein Occlusion (BRVO)

Start: Apr 2012Est. completion: Mar 2014183 patients
Phase 3Completed
NCT01363440Bayeraflibercept

Study of Intravitreal Aflibercept Injection (IAI; EYLEA®; BAY86-5321) in Patients With Diabetic Macular Edema

Start: May 2011Est. completion: Nov 2014466 patients
Phase 3Completed
NCT00964795Bayeraflibercept

Open-label Extension Study of Intravitreal Aflibercept Injection (IAI; EYLEA®; BAY86-5321) in Neovascular ("Wet") Age-related Macular Degeneration (AMD)

Start: Dec 2009Est. completion: Aug 2013323 patients
Phase 3Completed
NCT04429503Bayeraflibercept

Study of a High-Dose Aflibercept in Participants With Diabetic Eye Disease

Start: Jun 2020Est. completion: Jun 2024660 patients
Phase 2/3Completed
NCT04126317Bayeraflibercept

Safety, Tolerability, and Efficacy of Aflibercept in Patients With Neovascular Age-Related Macular Degeneration

Start: Nov 2019Est. completion: Nov 2021106 patients
Phase 2Completed
NCT02712008Bayeraflibercept

Anti-vasculaR Endothelial Growth Factor plUs Anti-angiopoietin 2 in Fixed comBination therapY: Evaluation for the Treatment of Diabetic Macular Edema

Start: Mar 2016Est. completion: Jul 2017302 patients
Phase 2Completed
NCT02661711Bayeraflibercept

Aflibercept for Macular Oedema With Underlying Retinitis Pigmentosa (AMOUR) Study

Start: Mar 2016Est. completion: Oct 201730 patients
Phase 2Completed
NCT06929143Bayeraflibercept

A Study to Learn More About the Use of Aflibercept in Routine Medical Practice in Japanese Participants With Neovascular Age-related Macular Degeneration and Diabetic Macular Edema

Start: Apr 2025Est. completion: Jul 20273,000 patients
N/AActive Not Recruiting
NCT06315556Bayeraflibercept

An Observational Study to Collect Data on How Aflibercept (Eylea) Given Using a Paediatric Dosing Device is Used in Preterm Babies With Retinopathy of Prematurity in the United Kingdom (UK)

Start: Mar 2024Est. completion: Apr 2027200 patients
N/ARecruiting
NCT05705258Bayeraflibercept

A Study to Collect Data on the Use of Eylea in Babies Born Too Early Who Have a Condition of the Eye Where Blood Vessels Grow Abnormally in the Retina (Retinopathy of Prematurity)

Start: Mar 2023Est. completion: Mar 202775 patients
N/ARecruiting
NCT05791695Bayeraflibercept

A Study of the Incidence of Intraocular Inflammation and Suspected Endophthalmitis Among Patients Treated With Aflibercept, Vial and Pre-filled Syringe, 2014-2022

Start: Sep 2022Est. completion: Sep 2023155,413 patients
N/ACompleted
NCT04793100Bayeraflibercept

Spontaneous Retinal Artery Pulses (SPARs) as a Prognostic Determinant of Central Retinal Vein Occlusions (CRVO) in Patients With or Without Intravitreal Aflibercept Injections

Start: Mar 2021Est. completion: Mar 202560 patients
N/ACompleted
NCT04137120Bayeraflibercept

Study to Gather Information on the Safety and Use of Aflibercept Injections Into the Eye for the Treatment of Eye Disorders in Mexican Routine Clinical Practice

Start: Feb 2021Est. completion: Feb 202373 patients
N/ACompleted
NCT05639660Bayeraflibercept

Clinical Implication of Aflibercept in PCV Treatment in China

Start: Jan 2021Est. completion: Nov 20241,000 patients
N/AUnknown
NCT04519619Bayeraflibercept

Study to Learn More About Safety of Aflibercept Injection in Japanese Patients With Neovascular Glaucoma (NVG)

Start: Nov 2020Est. completion: Jun 2028480 patients
N/ARecruiting
NCT03939767Bayeraflibercept

Assessment of Proactive Treatments in Patients With Wet Age-related Macular Degeneration (wAMD) Which Have Never Undergone Treatment of This Particular Disease

Start: May 2019Est. completion: Oct 20231,563 patients
N/ACompleted
NCT03290794Bayeraflibercept

Structured Post-marketing Surveillance to Collect the Safety Data of Intravitreal Aflibercept Injection (IVT-AFL) in Patients of Wet Age-related Macular Degeneration During Real World Clinical Practice

Start: Feb 2019Est. completion: May 2023100 patients
N/ACompleted
NCT03714308Bayeraflibercept

Aflibercept Injection Into the Vitreous Body of the Eye: Study to Learn More About Patient Relevant Outcomes, Real World Treatment Patterns and How Well the Treatment Works for Patients Suffering From Abnormal Growth of New Blood Vessels Under the Retina.

Start: Jan 2019Est. completion: May 2023554 patients
N/ACompleted

Conbercept for Polypoidal Choroidal Vasculopathy(START Study)

Start: May 2018Est. completion: Dec 2021500 patients
N/ACompleted
NCT03382587Bayeraflibercept

Observational Study to Assess Intravitreal Aflibercept Injections Used in a "Treat and Extend" Regimen in Treatment-naïve Wet Age-related Macular Degeneration Patients

Start: Dec 2017Est. completion: Nov 2018163 patients
N/ACompleted
NCT03161912Bayeraflibercept

A Study to Evaluate the Effectiveness of Intravitreal Aflibercept in Patients With Diabetic Macular Edema and/or Macular Edema Secondary to Retinal Vein Occlusion, Which Either Have or Have Not Been Pretreated for Their Disease

Start: Nov 2017Est. completion: Dec 20212,481 patients
N/ACompleted
NCT03278262Bayeraflibercept

The Impact of Baseline Visual Acuity on the Treatment Outcomes in Patients Treated With AflIbercept in Real-life Clinical Setting

Start: Sep 2017Est. completion: Dec 20172,312 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

5 actively recruiting trials targeting 172,086 patients
7 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.