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PNH

3
Pipeline Programs
3
Companies
3
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
2
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

2 companies ranked by most advanced pipeline stage

CANbridge Pharmaceuticals
2 programs
1
1
CAN106 20 mg/kgPhase 1/21 trial
CAN106Phase 11 trial
Active Trials
NCT05095168Completed31Est. Nov 2021
NCT05539248Unknown78Est. Dec 2025
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
ALXN1210Phase 1/21 trial
Active Trials
NCT02598583Completed13Est. Mar 2021

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
CANbridge PharmaceuticalsCAN106 20 mg/kg
AstraZenecaALXN1210
CANbridge PharmaceuticalsCAN106

Clinical Trials (3)

Total enrollment: 122 patients across 3 trials

NCT05539248CANbridge PharmaceuticalsCAN106 20 mg/kg

A Study on the Safety, Tolerability, Efficacy, Pharmacokinetics and Pharmacodynamics of CAN106 in Subjects With PNH

Start: Mar 2022Est. completion: Dec 202578 patients
Phase 1/2Unknown
NCT02598583AstraZenecaALXN1210

Dose-Escalation Study of ALXN1210 IV in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Start: Nov 2015Est. completion: Mar 202113 patients
Phase 1/2Completed
NCT05095168CANbridge PharmaceuticalsCAN106

Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of a Single Ascending Dose (SAD) of CAN106 Administered Intravenously (IV) in Healthy Subjects

Start: Feb 2021Est. completion: Nov 202131 patients
Phase 1Completed

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

3 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.