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Pneumococcal Infections

84
Pipeline Programs
14
Companies
50
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
12
5
15
0
45
7
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Vaccine
20100%
+ 93 programs with unclassified modality

Competitive Landscape

14 companies ranked by most advanced pipeline stage

Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
26 programs
2
1
5
17
1
ProDiax-23Phase 41 trial
Prevnar 13™Phase 31 trial
Prevnar 13™Phase 31 trial
Rotarix™Phase 31 trial
V114Phase 31 trial
+21 more programs
Active Trials
NCT01215175Completed150Est. Jan 2011
NCT03848065Completed133Est. Jun 2020
NCT02531373Completed338Est. Apr 2017
+23 more trials
MSD
MSDIreland - Ballydine
26 programs
2
1
5
17
1
ProDiax-23Phase 4
Prevnar 13™Phase 3
Prevnar 13™Phase 3
Rotarix™Phase 3
V114Phase 3
+21 more programs
Pfizer
PfizerNEW YORK, NY
23 programs
2
2
4
8
2
Pneumo 23Phase 41 trial
PrevenarPhase 41 trial
13-valent Pneumococcal Conjugate VaccinePhase 3Vaccine1 trial
13-valent Pneumococcal Conjugate VaccinePhase 3Vaccine1 trial
13-valent Pneumococcal Conjugate VaccinePhase 3Vaccine1 trial
+18 more programs
Active Trials
NCT01899365Completed1,475Est. Oct 2017
NCT03276754Terminated530Est. Jun 2022
NCT00488371Completed250Est. Apr 2007
+32 more trials
Sinovac Biotech
Sinovac BiotechChina - Beijing
5 programs
1
1
3
Experimental 23-valent PPVPhase 41 trial
Experimental 23-valent PneumococcalPhase 41 trial
Investigational 23-valent PPVPhase 41 trial
investigational 23-valent PPVPhase 31 trial
Investigational 13-valent Pneumococcal Polysaccharide Conjugate VaccinePhase 1Vaccine1 trial
Active Trials
NCT05092386Completed310Est. May 2024
NCT02451969Completed1,760Est. Feb 2017
NCT05477693Completed1,800Est. Apr 2023
+2 more trials
CanSino Biologics
CanSino BiologicsChina - Tianjin
3 programs
1
2
13-Valent Pneumococcal Polysaccharide Conjugate Vaccine(CRM197,TT)Phase 3Vaccine1 trial
PCV13iPhase 31 trial
13-Valent Pneumococcal Polysaccharide Conjugate Vaccine(CRM197,TT)Phase 1Vaccine1 trial
Active Trials
NCT04100772Completed237Est. Aug 2022
NCT04841369Completed3,420Est. Sep 2022
NCT07017777Recruiting600Est. May 2028
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
2 programs
1
1
Pneumovax 23Phase 21 trial
Pneumovax 23Phase 11 trial
Active Trials
NCT00479323Completed250Est. Aug 2008
NCT00170612Completed552Est. Aug 2008
GPN Vaccines
GPN VaccinesAustralia - Canberra
2 programs
1
1
Gamma-PN3Phase 1/21 trial
Gamma-PN3Phase 11 trial
Active Trials
NCT05667740Completed118Est. Oct 2023
NCT05982314Completed60Est. Aug 2024
BravoVax
BravoVaxChina - Wuhan
1 program
1
13-Valent Pneumococcal Polysaccharide Conjugate VaccinePhase 1Vaccine1 trial
Active Trials
NCT05602480Unknown264Est. Dec 2024
Valneva
ValnevaAustria - Vienna
1 program
1
IC47Phase 11 trial
Active Trials
NCT00873431Completed32Est. Feb 2010
Merck & Co.
Merck & Co.RAHWAY, NJ
18 programs
V114PHASE_1
V114 Medium DosePHASE_1_2
Pneumococcal Conjugate VaccinePHASE_2Vaccine
V114PHASE_2
V114 Lot 1PHASE_2
+13 more programs
ViiV Healthcare
ViiV HealthcareNC - Durham
2 programs
10-valent pneumococcal conjugate vaccine, PCV10N/AVaccine
PCV GSK1024850AN/A
GSK
GSKLONDON, United Kingdom
2 programs
10-valent pneumococcal conjugate vaccine, PCV10N/AVaccine1 trial
PCV GSK1024850AN/A1 trial
Active Trials
NCT04912297Completed186Est. May 2013
NCT01311024Completed2,341Est. Dec 2017
Human BioSciences
Human BioSciencesWV - Martinsburg
1 program
Immunogenicity of PCV-7 Vaccine in VLBW InfantsN/AVaccine1 trial
Active Trials
NCT00273325Completed368Est. Mar 2009
Sanofi
SanofiPARIS, France
1 program
Pneumococcal VaccinePHASE_1Vaccine1 trial
Active Trials
NCT01444001Completed63Est. Aug 2007

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
Sinovac BiotechExperimental 23-valent Pneumococcal
Sinovac BiotechExperimental 23-valent PPV
Sinovac BiotechInvestigational 23-valent PPV
Sharp TherapeuticsProDiax-23
PfizerPrevenar
PfizerPneumo 23
CanSino BiologicsPCV13i
CanSino Biologics13-Valent Pneumococcal Polysaccharide Conjugate Vaccine(CRM197,TT)
Sharp TherapeuticsV114
Sharp TherapeuticsV114
Sharp TherapeuticsRotarix™
Sharp TherapeuticsV114
Sharp TherapeuticsV114
Sharp TherapeuticsV114
Sharp TherapeuticsV114

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 45,271 patients across 50 trials

NCT05731115Sinovac BiotechExperimental 23-valent Pneumococcal

Lot-to-lot Consistency of 23-valent Pneumococcal Polysaccharide Vaccine

Start: Feb 2023Est. completion: May 20231,800 patients
Phase 4Completed
NCT05477693Sinovac BiotechExperimental 23-valent PPV

Immunogenicity and Safety of 23-valent Pneumococcal Polysaccharide Vaccine

Start: Oct 2022Est. completion: Apr 20231,800 patients
Phase 4Completed
NCT04989465Sinovac BiotechInvestigational 23-valent PPV

A Clinical Trial of 23-valent Pneumococcal Polysaccharide Vaccine

Start: Sep 2021Est. completion: Sep 2021600 patients
Phase 4Completed

Immunogenicity After Revaccination With 23-valent Pneumococcal Polysaccharide Vaccine: Healthy Elderly People Versus Diabetic Patients

Start: May 2021Est. completion: Apr 2022254 patients
Phase 4Unknown

A Study To Assess The Safety And Effectiveness Of Prevenar In Chinese Children Who Have Not Previously Received A Vaccine Against Pneumococcal Bacteria

Start: Sep 2010Est. completion: Sep 2012505 patients
Phase 4Completed

Immunogenicity and Safety Study of Pneumococcal 7-Valent Conjugate Vaccine in Sickle Cell Disease Infants.

Start: May 2001Est. completion: Nov 200251 patients
Phase 4Terminated

A Study to Evaluate the Immunogenicity and Safety of 13-valent Pneumococcal Conjugate Vaccine (PCV13i) in Healthy Infants Aged 2 Months (Minimum 6 Weeks)

Start: Nov 2025Est. completion: May 2028600 patients
Phase 3Recruiting
NCT04841369CanSino Biologics13-Valent Pneumococcal Polysaccharide Conjugate Vaccine(CRM197,TT)

Phase III Clinical Trial of a Candidate PCV13 in Healthy People Aged 6 Weeks and Above (PICTPCV13i)

Start: Apr 2021Est. completion: Sep 20223,420 patients
Phase 3Completed

Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 in Healthy Japanese Infants (V114-033)

Start: Jul 2020Est. completion: Dec 2021694 patients
Phase 3Completed

Safety and Immunogenicity of V114 in Children Infected With Human Immunodeficiency Virus (HIV) (V114-030/PNEU-WAY PED)

Start: Nov 2019Est. completion: May 2021407 patients
Phase 3Completed

Safety, Tolerability, and Immunogenicity of V114 in Healthy Infants (V114-025)

Start: Sep 2019Est. completion: Aug 20211,184 patients
Phase 3Completed

Safety, Tolerability, and Immunogenicity of a 3-dose Regimen of V114 in Healthy Infants (PNEU-PED-EU-2/V114-026)

Start: Aug 2019Est. completion: Oct 20211,191 patients
Phase 3Completed

Safety and Immunogenicity of Catch-up Vaccination Regimens of V114 (V114-024)

Start: Jun 2019Est. completion: Dec 2020606 patients
Phase 3Completed

Safety, Tolerability, and Immunogenicity of V114 in Healthy Infants (V114-029)

Start: Jun 2019Est. completion: May 20211,720 patients
Phase 3Completed

Safety and Immunogenicity of V114 in Healthy Adults (V114-019/PNEU-AGE)

Start: Jun 2019Est. completion: Mar 20201,205 patients
Phase 3Completed

Lot-to-Lot Consistency of V114 in Healthy Adults (V114-020)

Start: Jun 2019Est. completion: Apr 20202,340 patients
Phase 3Completed

A Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 in Children With Sickle Cell Disease (V114-023/PNEU-SICKLE)

Start: Jan 2019Est. completion: Jun 2020104 patients
Phase 3Completed

A Study to Evaluate the Safety and Tolerability of V114 and Prevnar 13™ in Healthy Infants (V114-031/PNEU-LINK)

Start: Dec 2018Est. completion: Mar 20212,409 patients
Phase 3Completed

A Study to Evaluate the Interchangeability of V114 and Prevnar 13™ in Healthy Infants (V114-027/PNEU-DIRECTION)

Start: Oct 2018Est. completion: Dec 2020900 patients
Phase 3Completed

A Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 When Administered Concomitantly With Influenza Vaccine in Healthy Adults 50 Years of Age or Older (V114-021/PNEU-FLU)

Start: Sep 2018Est. completion: Jun 20191,200 patients
Phase 3Completed

A Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 in Allogeneic Hematopoietic Stem Cell Transplant Recipients (V114-022/PNEU-STEM)

Start: Sep 2018Est. completion: Nov 2021277 patients
Phase 3Completed

A Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 Followed by PNEUMOVAX™23 in Adults at Increased Risk for Pneumococcal Disease (V114-017/PNEU-DAY)

Start: Jul 2018Est. completion: Jan 20201,515 patients
Phase 3Completed

A Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 Followed by PNEUMOVAX™23 in Adults Infected With Human Immunodeficiency Virus (HIV) (V114-018)

Start: Jul 2018Est. completion: Jan 2020302 patients
Phase 3Completed

A Study Assessing 13-valent Pneumococcal Conjugate Vaccine in Healthy Chinese Infants and Young Children

Start: Jun 2018Est. completion: Oct 2023936 patients
Phase 3Completed

A Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 Followed by PNEUMOVAX™23 in Healthy Adults 50 Years of Age or Older (V114-016/PNEU-PATH)

Start: Jun 2018Est. completion: Dec 2019652 patients
Phase 3Completed
NCT02451969Sinovac Biotechinvestigational 23-valent PPV

Safety and Immunogenicity Study of 23-valent Pneumococcal Polysaccharide Vaccine in Healthy Children, Adults and Elderly

Start: Apr 2015Est. completion: Feb 20171,760 patients
Phase 3Completed

Evaluation of the Safety and Immunogenicity of Sequential Administration of Prevnar 13™ and Pneumovax™ 23 in Healthy Participants 50 Years of Age and Older (V110-029)

Start: Aug 2014Est. completion: Jul 2015400 patients
Phase 3Completed
NCT01692886Pfizer13-valent Pneumococcal Conjugate Vaccine

A Study Evaluating 13-Valent Pneumococcal Conjugate Vaccine (13vPnC) In Healthy Infants In China

Start: Aug 2012Est. completion: Apr 20141,674 patients
Phase 3Completed
NCT01646398Pfizer13-valent Pneumococcal Conjugate Vaccine

A Phase 3 Trial Evaluating the Safety, Tolerability, and Immunogenicity of a 13-valent Pneumococcal Conjugate Vaccine in Japanese Elderly Adults Aged 65 Years Old and Older

Start: Jun 2012Est. completion: Oct 2012764 patients
Phase 3Completed
NCT01432262Pfizervaccine-13vPnC

13-valent Pneumococcal Conjugate Vaccine Study in Adults => 50 Years of Age in Mexico

Start: Jul 2011Est. completion: Dec 2011324 patients
Phase 3Completed
NCT00853749Pfizer13-valent Pneumococcal Conjugate Vaccine

Immune Response In Children Revaccinated With Pneumococcal Conjugate Vaccine

Start: May 2009Est. completion: Dec 200989 patients
Phase 3Completed
NCT00500266Pfizer13-valent Pneumococcal Conjugate Vaccine

Study Evaluating Safety of 13-Valent Pneumococcal Conjugate Vaccine in Healthy Elderly Subjects

Start: May 2008Est. completion: May 20091,053 patients
Phase 3Completed
NCT00508742Pfizer13-valent Pneumococcal Conjugate Vaccine

Study Evaluating the Impact of a 13-valent Pneumococcal Conjugate Vaccine on Nasopharyngeal Colonization

Start: Dec 2007Est. completion: Aug 20111,866 patients
Phase 3Completed
NCT00500357Pfizer13-valent Pneumococcal Conjugate Vaccine

Study Evaluating a 13-valent Pneumococcal Conjugate Vaccine in Elderly Subjects

Start: Nov 2007Est. completion: Jan 2010105 patients
Phase 3Completed
NCT00546572Pfizer13-valent Pneumococcal Conjugate Vaccine

Study Evaluating The Safety, Tolerability And Immunogenicity Of A 13-Valent Pneumococcal Conjugate Vaccine (13vPnC)

Start: Nov 2007Est. completion: Jul 2010938 patients
Phase 3Completed
NCT00562354Pfizer13-valent Pneumococcal Conjugate Vaccine

Study Evaluating 13-valent Pneumococcal Conjugate Vaccine in Healthy Japanese Adults Aged >= 50 Years

Start: Oct 2007Est. completion: Dec 2007271 patients
Phase 3Completed
NCT00492557Pfizer13-valent pneumococcal conjugate vaccine

Study Evaluating Safety and Immunogenicity of 13-Valent Pneumococcal Conjugate Vaccine With Influenza Vaccine in Adults

Start: Sep 2007Est. completion: Feb 20081,185 patients
Phase 3Completed
NCT00452452Pfizer13-valent Pneumococcal Conjugate Vaccine

Study Evaluating 13-valent Pneumococcal Conjugate Vaccine Catch-Up Regimens in Older Infants and Children

Start: Jul 2007Est. completion: Mar 2008355 patients
Phase 3Completed
NCT00452790Pfizer13-valent Pneumococcal Conjugate Vaccine

Study Evaluating 13-valent Pneumococcal Conjugate Vaccine in Healthy Infants in India

Start: Jun 2007Est. completion: Feb 2010708 patients
Phase 3Completed
NCT00427895Pfizer13-valent pneumococcal conjugate vaccine

Study Comparing a 13-valent Pneumococcal Conjugate Vaccine With 23-valent Pneumococcal Polysaccharide Vaccine in Adults

Start: Feb 2007Est. completion: Aug 20112,141 patients
Phase 3Completed
NCT00373958Pfizer13-valent Pneumococcal Conjugate Vaccine

Study Comparing 13-valent Pneumococcal Conjugate Vaccine With 7-valent Pneumococcal Conjugate Vaccine

Start: Sep 2006Est. completion: Jun 2008666 patients
Phase 3Completed

Trial to Evaluate the Safety, Tolerability, and Immunogenicity of A Multivalent Group B Streptococcus Vaccine When Administered Concomitantly With Tdap in Healthy Nonpregnant Women

Start: Aug 2022Est. completion: Apr 2023306 patients
Phase 2Completed

Study to Evaluate the Safety and Immunogenicity of a Multivalent Pneumococcal Vaccine Given With Prevnar 13 in Healthy Infants

Start: Jun 2018Est. completion: Nov 2020565 patients
Phase 2Terminated

Trial to Evaluate the Safety and Immunogenicity of a Multivalent Pneumococcal Vaccine in Healthy Infants

Start: Apr 2018Est. completion: Feb 2020460 patients
Phase 2Completed

A Trial To Evaluate A Multivalent Pneumococcal Conjugate Vaccine In Healthy Adults 50-85 Years Of Age

Start: Oct 2017Est. completion: May 2019511 patients
Phase 2Completed

Trial to Evaluate the Safety and Immunogenicity of a Multivalent Pneumococcal Conjugate Vaccine in Adults 60 Through 64 Years of Age

Start: Oct 2017Est. completion: Dec 2018444 patients
Phase 2Completed

A Study to Evaluate the Safety, Tolerability, and Immunogenicity of Two Lots of V114 in Healthy Infants (V114-008)

Start: Mar 2017Est. completion: Oct 20181,051 patients
Phase 2Completed

Safety, Tolerability, and Immunogenicity of V114 Compared to Prevnar 13™ in PPSV23-vaccinated Healthy Adults ≥65 Years of Age (V114-007)

Start: Oct 2015Est. completion: Jan 2016253 patients
Phase 2Completed

Safety, Tolerability, and Immunogenicity of Two Formulations of V114 in Healthy Adults 50 Years of Age or Older (V114-006)

Start: Oct 2015Est. completion: Jan 2016690 patients
Phase 2Completed

PNEUMOCELL - Conjugated Pneumococcal Vaccination in Patients With Immunoglobulin G-deficiency

Start: May 2013Est. completion: Dec 201320 patients
Phase 2Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

45 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 45,271 patients
14 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.