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Pneumococcal Disease

34
Pipeline Programs
7
Companies
36
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
6
0
2
0
24
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Vaccine
12100%
+ 30 programs with unclassified modality

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
25 programs
4
2
12
2
13-valent pneumococcal conjugate vaccinePhase 4Vaccine1 trial
Blood drawPhase 41 trial
13-valent Pneumococcal Conjugate VaccinePhase 3Vaccine1 trial
13vPnCPhase 31 trial
20-valent pneumococcal conjugate vaccinePhase 3Vaccine1 trial
+20 more programs
Active Trials
NCT00757575Completed28,511Est. Oct 2010
NCT01564771Completed293Est. Apr 2013
NCT00471770Completed1,000Est. Feb 2008
+25 more trials
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
6 programs
6
Pneumovax™ 23Phase 31 trial
V114Phase 31 trial
V116Phase 31 trial
V116Phase 31 trial
V116Phase 31 trial
+1 more programs
Active Trials
NCT01734239Completed102Est. Oct 2013
NCT04633226Completed58Est. Nov 2022
NCT05569954Completed1,484Est. Feb 2025
+3 more trials
MSD
MSDIreland - Ballydine
6 programs
6
Pneumovax™ 23Phase 3
V114Phase 3
V116Phase 3
V116Phase 3
V116Phase 3
+1 more programs
EuBiologics
EuBiologicsKorea - Seoul
1 program
1
EuPCV15Phase 11 trial
Active Trials
NCT04830358Completed60Est. Feb 2021
ViiV Healthcare
ViiV HealthcareNC - Durham
1 program
1
PhtD vaccine with/without adjuvantPhase 1Vaccine
Merck & Co.
Merck & Co.RAHWAY, NJ
2 programs
Pneumovax™ 23PHASE_3
V114PHASE_3
GSK
GSKLONDON, United Kingdom
1 program
PhtD vaccine with/without adjuvantPHASE_1Vaccine1 trial
Active Trials
NCT01767402Completed150Est. Nov 2004

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Pfizer13-valent pneumococcal conjugate vaccine
PfizerBlood draw
Pfizer20-valent pneumococcal conjugate vaccine
Sharp TherapeuticsV116
Sharp TherapeuticsV116
Pfizer20-valent pneumococcal conjugate vaccine
Sharp TherapeuticsV116
Sharp TherapeuticsV116
Pfizer20vPnC
Pfizer20-valent pneumococcal conjugate vaccine
Sharp TherapeuticsV114
Pfizer20vPnC
Pfizer20-valent pneumococcal conjugate vaccine
Pfizer20-valent pneumococcal conjugate vaccine
Pfizer20vPnC

Showing 15 of 36 trials with date data

Clinical Trials (36)

Total enrollment: 64,008 patients across 36 trials

NCT05329259Pfizer13-valent pneumococcal conjugate vaccine

A Study to Describe the Safety of a Vaccine (Called 13vPnC) in Healthy People 18 to 49 Years of Age in India

Start: Oct 2022Est. completion: Nov 2022200 patients
Phase 4Completed

A Study to Assess the Antibody Response of Healthy Chinese Children Who Have Been Vaccinated Previously With 4-doses of Prevenar (a Pneumococcal Vaccine) as Babies and Toddlers

Start: Nov 2010Est. completion: Mar 2011335 patients
Phase 4Completed
NCT05875727Pfizer20-valent pneumococcal conjugate vaccine

A Study to Learn About the Safety and Immune Response of 20vPnC in Adults in India.

Start: Aug 2023Est. completion: Oct 2023405 patients
Phase 3Completed

Safety and Immunogenicity of V116 in Vaccine-naïve Japanese Older Adults (V116-009, STRIDE-9)

Start: Jan 2023Est. completion: May 2023450 patients
Phase 3Completed

Safety and Immunogenicity of V116 in Pneumococcal Vaccine-naïve Adults 50 Years of Age or Older (V116-010, STRIDE-10)

Start: Nov 2022Est. completion: Feb 20251,484 patients
Phase 3Completed
NCT05512819Pfizer20-valent pneumococcal conjugate vaccine

A Study to Describe the Safety and Immunogenicity of 20vPnC in Infants in India and Taiwan

Start: Sep 2022Est. completion: Sep 2025541 patients
Phase 3Completed

A Study to Evaluate the Safety, Tolerability, Immunogenicity, and Lot Consistency of V116 in Adults 18 to 49 Years of Age (V116-004, STRIDE-4)

Start: Aug 2022Est. completion: May 20232,162 patients
Phase 3Completed

Safety and Immunogenicity of V116 in Adults Living With Human Immunodeficiency Virus (HIV) (V116-007, STRIDE-7)

Start: Jul 2022Est. completion: Jan 2024313 patients
Phase 3Completed

20-valent Pneumococcal Conjugate Vaccine Safety and Immunogenicity Study in Pneumococcal Vaccine-Naïve Adults 60 Years of Age and Older in Japan, Korea, and Taiwan

Start: Jun 2021Est. completion: May 20221,425 patients
Phase 3Completed
NCT04887948Pfizer20-valent pneumococcal conjugate vaccine

Safety and Immunogenicity Study of 20vPnC When Coadministered With a Booster Dose of BNT162b2

Start: May 2021Est. completion: Dec 2021570 patients
Phase 3Completed

Safety and Immunogenicity of V114 in Healthy Infants in South Korea (V114-036)

Start: Feb 2021Est. completion: Nov 202258 patients
Phase 3Completed

Safety and Immunogenicity Study of 20vPnC in Healthy Children 15 Months Through 17 Years of Age

Start: Dec 2020Est. completion: Apr 2022839 patients
Phase 3Completed
NCT04530838Pfizer20-valent pneumococcal conjugate vaccine

20-valent Pneumococcal Conjugate Vaccine Safety and Immunogenicity Study in Healthy Japanese Infants

Start: Sep 2020Est. completion: Apr 2022668 patients
Phase 3Completed
NCT04546425Pfizer20-valent pneumococcal conjugate vaccine

20-valent Pneumococcal Conjugate Vaccine Safety and Immunogenicity Study of a 3-Dose Series in Healthy Infants

Start: Sep 2020Est. completion: Feb 20231,258 patients
Phase 3Completed

Safety and Immunogenicity of 20vPnC Coadministered With SIIV in Adults ≥65 Years of Age

Start: Sep 2020Est. completion: Jun 20211,796 patients
Phase 3Completed
NCT04379713Pfizer20-valent pneumococcal conjugate vaccine

20-valent Pneumococcal Conjugate Vaccine Safety Study in Healthy Infants

Start: May 2020Est. completion: Aug 20221,511 patients
Phase 3Completed
NCT04382326Pfizer20-valent pneumococcal conjugate vaccine

20-valent Pneumococcal Conjugate Vaccine Safety and Immunogenicity Study of a 4-Dose Series in Healthy Infants

Start: May 2020Est. completion: Sep 20221,997 patients
Phase 3Completed

Trial to Evaluate the Safety and Immunogenicity of 3 Lots of 20-valent Pneumococcal Conjugate Vaccine in Pneumococcal Vaccine-Naïve Adults

Start: Feb 2019Est. completion: Oct 20191,710 patients
Phase 3Completed

Trial to Evaluate the Safety and Immunogenicity of a 20-Valent Pneumococcal Vaccine in Adults 65 Years of Age or Older With Prior Pneumococcal Vaccination

Start: Feb 2019Est. completion: Feb 2020875 patients
Phase 3Completed

Trial to Evaluate the Safety and Immunogenicity of a 20-valent Pneumococcal Conjugate Vaccine in Pneumococcal Vaccine-naïve Adults

Start: Dec 2018Est. completion: Dec 20193,902 patients
Phase 3Completed

A Phase III Clinical Trial to Study the Safety and Immunogenicity of Pneumovax™ 23 (V110) in Participants From the Russian Population (V110-018)

Start: Jun 2013Est. completion: Oct 2013102 patients
Phase 3Completed
NCT00743652Pfizer13-valent Pneumococcal Conjugate Vaccine

Study Evaluating the Impact of the 13-valent Pneumococcal Conjugate Vaccine (13vPnC) in Alaskan Native Children.

Start: Jan 2009Est. completion: Sep 2010373 patients
Phase 3Completed

A Study to Learn About How a New Pneumococcal Vaccine Works in Children

Start: Jul 2024Est. completion: Feb 2026225 patients
Phase 2Completed

A Study to Learn About How a New Pneumococcal Vaccine Works in Infants

Start: Jul 2024Est. completion: May 2027605 patients
Phase 2Active Not Recruiting

A Study to Learn About How Safe and Effective is 20vPnC and 13vPnC Vaccines in Chinese Adults

Start: Jul 2025Est. completion: Jan 2026400 patients
Phase 1Completed

A Study to Understand the Safety of the 20vPnC Vaccine in Healthy Chinese Adults, Children, and Infant

Start: Jun 2025Est. completion: May 2027200 patients
Phase 1Active Not Recruiting
NCT05831124PfizerLow dose multivalent pneumococcal conjugate vaccine formulation A

A Study to Learn About a Type of Pneumococcal Vaccine With a New Ingredient (PF-07872411) Intended to Enhance the Effects of the Vaccine Which is Given to Adults

Start: Apr 2023Est. completion: Jun 202490 patients
Phase 1Completed

Safety and Immunogenicity of Pneumococcal Conjugate Formulations in Healthy Adults 18 Through 49 Years of Age

Start: Aug 2022Est. completion: Oct 2022394 patients
Phase 1Completed

Safety and Immunogenicity of the 'EuPCV15' in Healthy Korean Adults

Start: May 2020Est. completion: Feb 202160 patients
Phase 1Completed
NCT01767402GSKPhtD vaccine with/without adjuvant

Study to Evaluate Safety, Reactogenicity and Immunogenicity of the Pneumococcal Protein PhtD Vaccine in Healthy Adults

Start: Oct 2003Est. completion: Nov 2004150 patients
Phase 1Completed
NCT06622109Pfizer20-valent pneumococcal conjugate vaccine

A Study to Learn About the Safety of PREVENAR 20 Vaccine in Infants Aged Between Two to Six Months

Start: Nov 2024Est. completion: Dec 20261,100 patients
N/AActive Not Recruiting

Safety Surveillance of Pneumococcal 13-valent Conjugate Vaccine Among Filipinos

Start: Dec 2011Est. completion: May 20143,006 patients
N/ACompleted
NCT01564771PfizerNon Intervention

Serotype Distribution of Chest X-ray Confirmed Pneumococcal Community Acquired Pneumonia in the Adult Population in Greece, Over 1 Year.

Start: Jan 2011Est. completion: Apr 2013293 patients
N/ACompleted
NCT00757575PfizerDisease Burden of Pneumonia, Meningitis and Bacteremia Among Children in Japan: Pneumonet Japan

Disease Burden of Pneumonia, Meningitis and Bacteremia Among Children in Japan: Pneumonet Japan

Start: Feb 2008Est. completion: Oct 201028,511 patients
N/ACompleted
NCT00471770PfizerPneumoniae Epidemiology Study in China

Pneumoniae Epidemiology Study in China

Start: Feb 2007Est. completion: Feb 20081,000 patients
N/ACompleted
NCT00234338PfizerStudy Evaluating Prevenar in High-Risk Children

Study Evaluating Prevenar in High-Risk Children

Start: Oct 2005Est. completion: Apr 20075,000 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

24 late-stage (Phase 3) programs, potential near-term approvals
7 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.