Pharyngitis

12
Pipeline Programs
3
Companies
14
Clinical Trials
4
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
2
0
4
6
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 8 programs with unclassified modality

On Market (4)

Approved therapies currently available

U
ANJESOApproved
meloxicam
Unknown Company
intravenous2020
Pfizer
BEXTRAApproved
valdecoxib
Pfizer
oral2001
Boehringer Ingelheim
MOBICApproved
meloxicam
Boehringer Ingelheim
oral2000
U
VIVLODEXApproved
meloxicam
Unknown Company
oral2015

Competitive Landscape

3 companies ranked by most advanced pipeline stage

Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
7 programs
2
3
2
Benzidamine hydrochloridePhase 41 trial
MeloxicamPhase 41 trial
AmbroxolPhase 31 trial
Ambroxol LozengePhase 31 trial
Ambroxol hydrochloridePhase 31 trial
+2 more programs
Active Trials
NCT01361802Completed494
NCT02183038Completed390
NCT00525044Completed249Est. Jan 2008
+4 more trials
Pfizer
PfizerNEW YORK, NY
1 program
1
1
valdecoxibPhase 3Small Molecule5 trials
Active Trials
NCT00260325Completed20Est. Apr 2006
NCT00648258Completed130Est. Apr 2004
NCT00647829Completed197Est. Dec 2003
+2 more trials
Jerusalem Pharmaceuticals
Jerusalem PharmaceuticalsIsrael - Ramallah
1 program
rapid streptococcal testingN/A1 trial
Active Trials
NCT00535093Completed7,000Est. Jul 2009

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Pfizervaldecoxib
Pfizervaldecoxib
Pfizervaldecoxib
Pfizervaldecoxib
Boehringer IngelheimMeloxicam
Boehringer IngelheimBenzidamine hydrochloride
Boehringer IngelheimAmbroxol
Boehringer IngelheimAmbroxol hydrochloride
Boehringer IngelheimAmbroxol Lozenge
Pfizervaldecoxib
Pfizervaldecoxib
Boehringer IngelheimAmbroxol Spray
Boehringer IngelheimMeloxicam low
Jerusalem Pharmaceuticalsrapid streptococcal testing

Clinical Trials (14)

Total enrollment: 10,317 patients across 14 trials

Effect of Valdecoxib Pretreatment on Pain and Secondary Hyperalgesia in Healthy Volunteers

Start: Aug 2004Est. completion: Apr 200620 patients
Phase 4Completed

A Double Blind, Double Dummy, Randomized, Comparative Study Of The Efficacy And Safety Of Valdecoxib 40 Mg Twice Daily, As Needed In The First Menstrual Cycle Day And Then Once A Day, And Piroxicam 40 Mg Once A Day In The Treatment Of Patients With Primary Dysmenorrhea

Start: Jan 2003Est. completion: Jul 2003154 patients
Phase 4Completed

Perioperative Inflammation and Cyclooxygenase 2 (COX-2)

Start: Nov 2002Est. completion: Jan 200630 patients
Phase 4Completed

Randomized, Double Blind, Multicenter Study of the Safety and Efficacy of Valdecoxib 40 mg Once Daily Compared With Diclofenac 75 mg Twice Daily in Acute Low Back Pain

Start: Nov 2002Est. completion: May 2003340 patients
Phase 4Completed

Efficacy and Safety of Meloxicam Suspension Versus Diclofenac Suspension or Nimesulide Suspension in Patients With a Diagnosis of Acute, Non-bacterial Pharyngitis, Pharyngotonsillitis or Laryngitis

Start: Aug 2001128 patients
Phase 4Completed
NCT02178293Boehringer IngelheimBenzidamine hydrochloride

Ketoprofen Lysine Salt as Mouthwash in Acute Phlogosis of the Pharyngeal Cavity Versus Benzidamine Hydrochloride

Start: Sep 1998214 patients
Phase 4Completed

Double-blind Trial to Investigate Efficacy and Tolerance of Ambroxol Lozenges 20 mg in Sore Throat

Start: Aug 2007Est. completion: Jan 2008249 patients
Phase 3Completed
NCT00148499Boehringer IngelheimAmbroxol hydrochloride

Efficacy and Tolerability of Ambroxol Lozenge 20 mf in Relieving Pain of Sore Throat in Pat. With Acute/Viralpharyngitis

Start: Oct 2005Est. completion: Jun 2006751 patients
Phase 3Completed

Ambroxol Lozenges 20mg in Relieving the Pain of Sore Throat in Adolescent Patients With Acute Viral Pharyngitis

Start: Apr 2005Est. completion: Nov 2005220 patients
Phase 3Completed

A Double-Blind, Double Dummy, Randomized Comparison Study Of The Efficacy And Safety Of Valdecoxib 10mg Once Daily And Naproxen 500mg Twice Daily In Treating The Signs And Symptoms Of Osteoarthritis Of The Knee Or Hip In Taiwan

Start: Jul 2003Est. completion: Apr 2004130 patients
Phase 3Completed

A Comparison Of Valdecoxib 20 Mg Twice Daily and 40 Mg Daily and Placebo In The Treatment Of Sore Throat

Start: Feb 2003Est. completion: Dec 2003197 patients
Phase 3Completed

Ambroxol Spray Sore Throat Study

Start: May 2011494 patients
Phase 2Completed

Efficacy and Safety of Meloxicam vs. Naproxen Sodium in Patients With Acute Non Bacterial Pharyngitis or Pharyngo-tonsillitis

Start: Jul 1998390 patients
Phase 2Completed
NCT00535093Jerusalem Pharmaceuticalsrapid streptococcal testing

An Assessment of Rapid Streptococcal Tests in Community Clinics in Israel

Start: Oct 2007Est. completion: Jul 20097,000 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

4 late-stage (Phase 3) programs — potential near-term approvals
3 companies competing in this space