Pharmacokinetics of Isavuconazole

25
Pipeline Programs
2
Companies
8
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
25
0
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
25100%

Competitive Landscape

2 companies ranked by most advanced pipeline stage

BP
Basilea PharmaceuticaSwitzerland - Allschwil
17 programs
17
IsavuconazolePhase 1Small Molecule
IsavuconazolePhase 1Small Molecule
IsavuconazolePhase 1Small Molecule
IsavuconazolePhase 1Small Molecule
IsavuconazolePhase 1Small Molecule
+12 more programs
Astellas
AstellasChina - Shenyang
8 programs
8
IsavuconazolePhase 1Small Molecule1 trial
IsavuconazolePhase 1Small Molecule1 trial
IsavuconazolePhase 1Small Molecule1 trial
IsavuconazolePhase 1Small Molecule1 trial
isavuconazolePhase 1Small Molecule1 trial
+3 more programs
Active Trials
NCT02128893Completed24Est. Feb 2014
NCT01657825Completed20Est. Jul 2012
NCT01565720Completed161Est. Jun 2012
+5 more trials

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
AstellasIsavuconazole
Astellasisavuconazole
AstellasIsavuconazole
Astellasisavuconazole
Astellasisavuconazole
AstellasIsavuconazole
Astellasisavuconazole
AstellasIsavuconazole

Clinical Trials (8)

Total enrollment: 354 patients across 8 trials

NCT02128893AstellasIsavuconazole

A Study to Evaluate the Effect of Multiple Doses of Esomeprazole on the Pharmacokinetics of Isavuconazole

Start: Jan 2014Est. completion: Feb 201424 patients
Phase 1Completed
NCT01657890Astellasisavuconazole

Study of the Pharmacokinetics of Isavuconazole in Healthy Non-Elderly and Elderly Male and Female Subjects

Start: Jun 2012Est. completion: Jan 201328 patients
Phase 1Completed
NCT01657825AstellasIsavuconazole

Drug Interaction Study of Isavuconazole and Warfarin in Healthy Male Subjects

Start: Jun 2012Est. completion: Jul 201220 patients
Phase 1Completed
NCT01597986Astellasisavuconazole

Drug Interaction Study of Isavuconazole and Oral Contraceptive Containing Ethinyl Estradiol and Norethindrone

Start: Apr 2012Est. completion: Jun 201224 patients
Phase 1Completed
NCT01555866Astellasisavuconazole

Study of the Effect of Renal Impairment on the Pharmacokinetics of Isavuconazole.

Start: Mar 2012Est. completion: Apr 201349 patients
Phase 1Completed
NCT01565720AstellasIsavuconazole

Study of the Effect of Repeat Doses of Isavuconazole on Cardiac Repolarization

Start: Mar 2012Est. completion: Jun 2012161 patients
Phase 1Completed
NCT01535547Astellasisavuconazole

Drug Interaction Study of Isavuconazole and Tacrolimus

Start: Dec 2011Est. completion: Jan 201224 patients
Phase 1Completed
NCT01406171AstellasIsavuconazole

Drug Interaction Study of Isavuconazole and Midazolam

Start: May 2011Est. completion: Jun 201124 patients
Phase 1Completed

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 companies competing in this space