Pharmacokinetics

57
Pipeline Programs
25
Companies
50
Clinical Trials
6
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
49
0
0
0
0
8
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
375%
Peptide
125%
+ 47 programs with unclassified modality

On Market (6)

Approved therapies currently available

U
ARIPIPRAZOLEApproved
aripiprazole
Unknown Company
Atypical Antipsychotic [EPC]oral2019
U
COLCHICINEApproved
colchicine
Unknown Company
oral2019
Takeda
COLCRYSApproved
colchicine
Takeda
Alkaloid [EPC]oral2009
U
GLOPERBAApproved
colchicine
Unknown Company
Alkaloid [EPC]oral2019
U
MEZOFYApproved
aripiprazole
Unknown Company
oral2025
U
OPIPZAApproved
aripiprazole
Unknown Company
Atypical Antipsychotic [EPC]oral2024

Competitive Landscape

24 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
5 programs
4
1
AripiprazolePhase 4Small Molecule1 trial
Nicergoline from ChinaPhase 11 trial
RosuvastatinPhase 1Small Molecule1 trial
Treatment APhase 11 trial
Treatment APhase 11 trial
Active Trials
NCT04176367Completed40Est. Sep 2020
NCT05898672Completed12Est. Aug 2023
NCT01181700Completed42Est. Jan 2011
+2 more trials
Takeda
TakedaTOKYO, Japan
1 program
1
ColchicinePhase 41 trial
Active Trials
NCT01084278Completed40Est. Feb 2011
Teva
TevaIsrael - Petach Tikva
5 programs
5
Beclomethasone dipropionate BAIPhase 11 trial
Progesterone vaginal ring,Phase 11 trial
TEV-48125 - 1Phase 11 trial
TV-45070Phase 11 trial
lipegfilgrastimPhase 11 trial
Active Trials
NCT02030457Completed72Est. Jun 2014
NCT02092571Completed56Est. Aug 2014
NCT02673567Completed64Est. Feb 2017
+2 more trials
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
4 programs
4
AZD1386Phase 15 trials
AZD6140Phase 11 trial
AZD9742Phase 11 trial
AZD9977 immediate releasePhase 11 trial
Active Trials
NCT01019928Completed14Est. Jan 2011
NCT00976534Terminated90Est. Feb 2010
NCT00945178Terminated11Est. Sep 2009
+5 more trials
Bayer
BayerLEVERKUSEN, Germany
4 programs
4
BAY1841788Phase 11 trial
BAY2327949Phase 11 trial
MicrogynonPhase 11 trial
Naproxen Sodium,Phase 11 trial
Active Trials
NCT02894385Completed29Est. Dec 2017
NCT04004195Completed32Est. Jun 2020
NCT02170038Completed16Est. Mar 2015
+1 more trials
Astellas
AstellasChina - Shenyang
3 programs
3
ASP3652Phase 11 trial
ASP3652Phase 12 trials
YM150Phase 11 trial
Active Trials
NCT01815684Completed26Est. Dec 2012
NCT02034734Completed14Est. Dec 2012
NCT01958047Completed64Est. Sep 2012
+1 more trials
UP
UCB PharmaBelgium - Brussels
3 programs
3
CDP6038Phase 11 trial
PadsevonilPhase 11 trial
SumatriptanPhase 11 trial
Active Trials
NCT01276119Completed67Est. Oct 2009
NCT03480243Completed28Est. Aug 2018
NCT00614029Completed54
DS
Daiichi SankyoChina - Shanghai
3 programs
3
DS-8500aPhase 11 trial
DS-8500aPhase 11 trial
MilademetanPhase 11 trial
Active Trials
NCT02790671Completed26Est. Jun 2016
NCT02790684Completed12Est. Jun 2016
NCT03614455Completed36Est. Oct 2018
BP
Basilea PharmaceuticaSwitzerland - Allschwil
3 programs
3
VNRX-7145Phase 11 trial
VNRX-7145Phase 1
ledaborbactam etzadroxilPhase 11 trial
Active Trials
NCT05488678CompletedEst. Nov 2023
NCT06665555CompletedEst. Mar 2025
Alkermes
AlkermesDUBLIN 4, Ireland
2 programs
2
ALKS 5461Phase 11 trial
ItraconazolePhase 1Small Molecule1 trial
Active Trials
NCT02068105CompletedEst. Mar 2014
NCT02272764CompletedEst. Nov 2014
Vaxart
VaxartSOUTH SAN FRANCISCO, CA
2 programs
2
BTA-C585 oral capsulesPhase 11 trial
BTA-C585 oral capsulesPhase 11 trial
Active Trials
NCT02558413CompletedEst. Dec 2015
NCT02668367CompletedEst. Feb 2016
Scynexis
ScynexisJERSEY CITY, NJ
2 programs
2
DABPhase 11 trial
PRAPhase 11 trial
Active Trials
NCT04092725CompletedEst. Jan 2020
NCT04092751CompletedEst. Dec 2019
XBiotech
XBiotechAUSTIN, TX
2 programs
2
HutrukinPhase 11 trial
NatrunixTMPhase 11 trial
Active Trials
NCT05098080Completed24Est. Apr 2024
NCT05099510Unknown24Est. Jun 2022
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
2 programs
2
levothyroxinePhase 11 trial
levothyroxinePhase 11 trial
Active Trials
NCT01465633Completed24Est. Nov 2003
NCT01465646Completed24Est. Dec 2003
Alzamend Neuro
Alzamend NeuroATLANTA, GA
1 program
1
AL001Phase 11 trial
Active Trials
NCT06921590Active Not RecruitingEst. Dec 2025
Amgen
AmgenTHOUSAND OAKS, CA
1 program
1
ApremilastPhase 11 trial
Active Trials
NCT02802735Completed28Est. Aug 2016
Alumis
AlumisSOUTH SAN FRANCISCO, CA
1 program
1
ESK-001Phase 11 trial
Active Trials
NCT05330858Completed14Est. Sep 2022
Eagle Pharmaceuticals
Eagle PharmaceuticalsNJ - Woodcliff Lake
1 program
1
Fulvestrant for Injectable SuspensionPhase 11 trial
Active Trials
NCT03324061CompletedEst. Jul 2018
J&
Johnson & JohnsonNEW BRUNSWICK, NJ
1 program
1
JNJ-31001074Phase 15 trials
Active Trials
NCT00915668Withdrawn0Est. Mar 2011
NCT00915746Completed14Est. Dec 2009
NCT00915434Completed20Est. Nov 2009
+2 more trials
Bausch + Lomb
Bausch + LombNJ - Bridgewater
1 program
1
LE GelPhase 11 trial
Active Trials
NCT01736527Completed12Est. Apr 2013
Cinclus Pharma
Cinclus PharmaSweden - Stockholm
1 program
1
Linaprazan gluratePhase 11 trial
Active Trials
NCT05469854Unknown113Est. Dec 2024
M&
Merck & Co.RAHWAY, NJ
1 program
1
MK-1064Phase 11 trial
Active Trials
NCT02549014Completed16Est. Sep 2009
Recordati
RecordatiFrance - Saint-Victor
1 program
1
Pasireotide cartridge with reusable ServoPenPhase 1Peptide1 trial
Active Trials
NCT07312643Completed40Est. Feb 2026
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
1 program
1
VNRX-7145Phase 11 trial
Active Trials
NCT05527834CompletedEst. Feb 2023

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
PfizerAripiprazole
TakedaColchicine
AstraZenecaAZD1386
AstraZenecaAZD1386
AstraZenecaAZD1386
Johnson & JohnsonJNJ-31001074
RecordatiPasireotide cartridge with reusable ServoPen
Alzamend NeuroAL001
Basilea Pharmaceuticaledaborbactam etzadroxil
PfizerRosuvastatin
XBiotechHutrukin
Basilea PharmaceuticaVNRX-7145
Allergy TherapeuticsVNRX-7145
Cinclus PharmaLinaprazan glurate
AlumisESK-001

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 1,345 patients across 50 trials

NCT01188668PfizerAripiprazole

Open Label Drug Interaction Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) 100mg On The Pharmacokinetics Of Aripiprazole When Coadministered To Healthy Subjects

Start: Aug 2010Est. completion: Oct 201038 patients
Phase 4Completed

Healthy and Renal Impairment Study of Colcrys (Colchicine, USP)

Start: May 2010Est. completion: Feb 201140 patients
Phase 4Completed

Esophageal Hypersensitivity Study in Patients With Gastroesophageal Reflux Disease (GERD)

Start: Nov 2009Est. completion: Jan 201114 patients
Phase 2Completed

Study to Evaluate Efficacy, Safety, Tolerability and Pharmacokinetics of AZD1386 in Patients With Peripheral Neuropathic Pain

Start: Sep 2009Est. completion: Feb 201090 patients
Phase 2Terminated

Study to Investigate the Analgesic Efficacy of a Single Dose of AZD1386

Start: Apr 2008Est. completion: Jun 2008103 patients
Phase 2Completed

A Study to Evaluate the Pharmacokinetic Drug Interaction Between Multiple Doses of JNJ-31001074 and a Single Dose of an Oral Contraceptive Containing Ethinyl Estradiol and Levonorgestrel in Women

Est. completion: Mar 20110
Phase 1Withdrawn
NCT07312643RecordatiPasireotide cartridge with reusable ServoPen

Study in Healthy Subjects to Investigate the Relative Bioavailability and Safety of Pasireotide After Single Subcutaneous Dose Administration Using a Reusable ServoPen With Cartridge as Compared to Administration Using a Syringe Drawn From an Ampule

Start: Dec 2025Est. completion: Feb 202640 patients
Phase 1Completed

A Study to Investigate Lithium Brain/Plasma Pharmacokinetics and Safety of an AL001 Oral Capsule Compared to a Marketed Immediate-release Lithium Carbonate Capsule in Healthy Adult Subjects

Start: May 2025Est. completion: Dec 2025
Phase 1Active Not Recruiting
NCT06665555Basilea Pharmaceuticaledaborbactam etzadroxil

Plasma and Intrapulmonary Pharmacokinetics of Ceftibuten and Ledaborbactam in Healthy Male and Female Participants 18 to ≤55 Years of Age

Start: Nov 2024Est. completion: Mar 2025
Phase 1Completed
NCT05898672PfizerRosuvastatin

A Study to Learn About the Study Medicine Called Nirmatrelvir/Ritonavir in People Who Are Healthy Volunteers Co-administered the Medicine Rosuvastatin

Start: Jun 2023Est. completion: Aug 202312 patients
Phase 1Completed

Hutrukin to Analyze Safety and PK in Healthy Volunteers

Start: Apr 2023Est. completion: Apr 202424 patients
Phase 1Completed

Ceftibuten/VNRX-7145 in Participants With Varying Degrees of Renal Function

Start: Oct 2022Est. completion: Nov 2023
Phase 1Completed

Food Effect on Ceftibuten/VNRX-7145 in Healthy Participants

Start: Sep 2022Est. completion: Feb 2023
Phase 1Completed
NCT05469854Cinclus PharmaLinaprazan glurate

A Study to Investigate the Pharmacokinetics and ECG Effects of Linaprazan Glurate

Start: Jul 2022Est. completion: Dec 2024113 patients
Phase 1Unknown

Relative Bioavailability of ESK-001 Tablet Versus Liquid in Healthy Participants

Start: Mar 2022Est. completion: Sep 202214 patients
Phase 1Completed

Natrunix Safety PK Study in Healthy Volunteers

Start: Jan 2022Est. completion: Jun 202224 patients
Phase 1Unknown
NCT04176367PfizerNicergoline from China

An Bioequivalence Study Comparing Nicergoline 10 mg Tablet Manufactured in China With Nicergoline 10 mg Tablet Manufactured in Italy Under Fasted and Fed Conditions in Healthy Chinese Participants

Start: Dec 2019Est. completion: Sep 202040 patients
Phase 1Completed

Study to Evaluate the Effect of SCY-078 (Ibrexafungerp) on the PK of Pravastatin in Healthy Subjects

Start: Nov 2019Est. completion: Dec 2019
Phase 1Completed

Study to Evaluate the Effect of SCY-078 on the PK of Dabigatran in Healthy Subjects

Start: Sep 2019Est. completion: Jan 2020
Phase 1Completed

Study to Investigate Safety, Absorption, Elimination, and Drug Effect of BAY2327949 in Participants With Different Renal Function Status

Start: Jul 2019Est. completion: Jun 202032 patients
Phase 1Completed

Pharmacokinetics (PK) Drug Interaction Study of Milademetan and Itraconazole or Posaconazole in Healthy Participants

Start: Jul 2018Est. completion: Oct 201836 patients
Phase 1Completed

Study to Evaluate the Effect of Coadministered Erythromycin on the Pharmacokinetics and Safety of Padsevonil

Start: Mar 2018Est. completion: Aug 201828 patients
Phase 1Completed
NCT03324061Eagle PharmaceuticalsFulvestrant for Injectable Suspension

Study to Evaluate the Safety, Tolerability, and PK of Fulvestrant After IM Administration

Start: Nov 2017Est. completion: Jul 2018
Phase 1Completed

Effect of Hepatic and Renal Impairment on the Pharmacokinetics, Safety and Tolerability of BAY1841788 (ODM-201)

Start: Sep 2016Est. completion: Dec 201729 patients
Phase 1Completed

Study to Evaluate the Pharmacokinetics of Single and Multiple Doses of Apremilast in Healthy Adult Male Korean Subjects

Start: Jun 2016Est. completion: Aug 201628 patients
Phase 1Completed

A Study to Determine the Effects of Itraconazole on the Pharmacokinetics (PK) of DS-8500 in Healthy Subjects

Start: May 2016Est. completion: Jun 201626 patients
Phase 1Completed

A Study Assessing the Mass Balance of a Single Oral Dose of [14C] DS-8500a in Healthy Subjects

Start: May 2016Est. completion: Jun 201612 patients
Phase 1Completed
NCT02673567TevaTEV-48125 - 1

To Assess Pharmacokinetics, Safety and Tolerability of TEV-48125 in Japanese and Caucasian Healthy Subjects After a Single Subcutaneous (SC) Administration of TEV-48125

Start: Mar 2016Est. completion: Feb 201764 patients
Phase 1Completed
NCT02668367VaxartBTA-C585 oral capsules

Safety and Pharmacokinetics Study of Multiple Ascending Doses of BTA-C585 in Healthy Volunteers

Start: Nov 2015Est. completion: Feb 2016
Phase 1Completed
NCT02560363AstraZenecaAZD9977 immediate release

A Study to Compare the Pharmacokinetics of Different Formulations of AZD9977 and the Influence of Food in Healthy Male Subjects

Start: Nov 2015Est. completion: Jan 20160
Phase 1Withdrawn
NCT02558413VaxartBTA-C585 oral capsules

Phase 1 Safety and Pharmacokinetics Study of Single Ascending Doses of BTA-C585 in Healthy Volunteers

Start: Aug 2015Est. completion: Dec 2015
Phase 1Completed

A Drug-Drug Interaction Study of ALKS 5461 in Healthy Volunteers

Start: Oct 2014Est. completion: Nov 2014
Phase 1Completed
NCT02306915Tevalipegfilgrastim

PK, PD, Safety and Tolerability of Lipegfilgrastim in Healthy Japanese and Caucasian Participants

Start: Oct 2014Est. completion: May 201548 patients
Phase 1Completed

Study to Characterize the Pharmacokinetics and Safety of TV-45070 Ointment in Healthy Volunteers

Start: Aug 2014Est. completion: Feb 201545 patients
Phase 1Completed

Clinical Study Investigating the Conversion of the Contraceptive Compound Norethisterone Within the Body Towards the Contraceptive Compound Ethinylestradiol

Start: Jun 2014Est. completion: Mar 201516 patients
Phase 1Completed
NCT02092571TevaProgesterone vaginal ring,

A Pharmacokinetic Study to Evaluate the Bioequivalence of 2 Progesterone Vaginal Rings in Postmenopausal Women

Start: Feb 2014Est. completion: Aug 201456 patients
Phase 1Completed

A Study of ALKS 5461 in Healthy Volunteers

Start: Jan 2014Est. completion: Mar 2014
Phase 1Completed
NCT02030457TevaBeclomethasone dipropionate BAI

A Study to Investigate the Pharmacokinetics and Safety of Beclomethasone Dipropionate Administered by Breath-Actuated Inhaler and Metered-Dose Inhaler in Healthy Adults

Start: Dec 2013Est. completion: Jun 201472 patients
Phase 1Completed

Tear Fluid Levels of Loteprednol Etabonate Ophthalmic Gel 0.5% Following a Single Instillation

Start: Jan 2013Est. completion: Apr 201312 patients
Phase 1Completed

A Study to Investigate the Appearance and Disappearance of ASP3652 in Blood and Spinal Fluid in Healthy Male Subjects

Start: Sep 2012Est. completion: Dec 201214 patients
Phase 1Completed

A Study to Assess the Safety, Tolerability and Effects of Single Ascending Doses of ASP3652 in Healthy Subjects

Start: Aug 2012Est. completion: Dec 201226 patients
Phase 1Completed

A Study to Assess the Effect of Race on How a Single Dose of ASP3652 is Taken up, Metabolized and Distributed Through the Bodies of Young, Healthy Male and Female Subjects, and Its Safety and Tolerability

Start: Jul 2012Est. completion: Sep 201264 patients
Phase 1Completed

A Study To Estimate The Time Course Of PF-00241939 Concentration In The Blood After Dosing With Oral Inhalation From Dry Powder Inhalers

Start: Oct 2010Est. completion: Jan 201142 patients
Phase 1Completed

Open Label Study, Assessing the Effect of Diltiazem or Ketoconazole on the Pharmacokinetics of AZD9742 in Healthy Volunteers

Start: May 2010Est. completion: Jul 201028 patients
Phase 1Completed

A Drug Interaction Study of JNJ-31001074 and Ketoconazole in Healthy Volunteers

Start: Nov 2009Est. completion: Dec 200914 patients
Phase 1Completed

Double-blind Placebo-controlled 2-part Study Assessing the Safety, Tolerability and PK of AZD1386 in Healthy Volunteers

Start: Aug 2009Est. completion: Sep 200911 patients
Phase 1Terminated

A Single Dose Study of the Safety, Pharmacokinetics and Pharmacodynamics of MK-1064 (MK-1064-001)

Start: Jul 2009Est. completion: Sep 200916 patients
Phase 1Completed

A Study to Estimate the Time Course of PF-00241939 Concentration in the Blood Following Dosing by Oral Inhalation From Dry Powder Inhalers

Start: Jun 2009Est. completion: Jul 200936 patients
Phase 1Completed

A Study to Characterize the Pharmacokinetics and Effect of Food on JNJ-31001074 in Healthy Volunteers

Start: Jun 2009Est. completion: Nov 200920 patients
Phase 1Completed

A Study to Evaluate Pharmacokinetics, Safety and Tolerability After a Single Dose Administration of of JNJ-31001074 in Children (6-11 Years) With Attention Deficit Hyperactivity Disorder (ADHD)

Start: May 2009Est. completion: Nov 200918 patients
Phase 1Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

25 companies competing in this space