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Peripheral Arterial Disease

17
Pipeline Programs
30
Companies
50
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
6
1
1
1
3
5
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
480%
Monoclonal Antibody
120%
+ 137 programs with unclassified modality

Competitive Landscape

68 companies ranked by most advanced pipeline stage

Medtronic
12 programs
1
2
Drug Eluting Balloon AngioplastyPhase 41 trial
stent placementPhase 41 trial
SimvastatinPhase 1Small Molecule
Atherectomy CatheterN/A1 trial
Axys EX deviceN/A1 trial
+7 more programs
Active Trials
NCT02169921Completed51Est. May 2016
NCT04282161Withdrawn0Est. Feb 2024
NCT01366482Completed121Est. May 2014
+8 more trials
Boston Scientific
1
Jetstream Atherectomy SystemPhase 41 trial
Jetstream Atherectomy SystemN/A1 trial
Jetstream Atherectomy SystemN/A1 trial
Peripheral Registry of Endovascular Clinical Outcomes "The PRIME Registry"N/A
Active Trials
NCT03847233Completed31Est. May 2020
NCT02733653Completed60Est. Dec 2017
NCT01273623Completed55Est. Mar 2012
AngioDynamics
3 programs
1
Atherectomy System (Auryon)Phase 4
Auryon Atherectomy SystemN/A1 trial
Auryon Laser SystemN/A1 trial
Active Trials
NCT07472439Not Yet Recruiting50Est. May 2030
NCT05284240Completed60Est. Sep 2024
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
1
RanolazinePhase 41 trial
Active Trials
NCT00657514Withdrawn0Est. Jun 2009
Alvogen
AlvogenNJ - Morristown
2 programs
2
DP-R202Phase 31 trial
clopidogrelPhase 3
Active Trials
NCT02393612Completed151Est. Apr 2014
Prevail Therapeutics
1
OrforglipronPhase 3
Martin Pharmaceuticals
1
Allogeneic Mesenchymal Stromal CellPhase 2/31 trial
Active Trials
NCT03042572Unknown60Est. Jul 2021
Mercator MedSystems
1
TemsirolimusPhase 21 trial
Balloon AngioplastyN/A1 trial
Active Trials
NCT02469532Completed31Est. Jan 2018
NCT03942601Terminated10Est. Apr 2021
BioTherapeutics Inc
1
FGF-1Phase 1/21 trial
Active Trials
NCT00424866Unknown24Est. Jun 2022
Bayer
BayerLEVERKUSEN, Germany
3 programs
1
Paclitaxel-coated balloon catheter angioplastyPhase 11 trial
IloprostN/A1 trial
rivaroxabanN/A5 trials
Active Trials
NCT01458041Completed126Est. Dec 2014
NCT07142655Completed1,500Est. Oct 2025
NCT06193863Active Not Recruiting61Est. Dec 2026
+4 more trials
Purdue Pharma
2 programs
1
Home-based leg heat therapyPhase 11 trial
Heat TherapyN/A1 trial
Active Trials
NCT03763357Withdrawn0Est. Dec 2022
NCT05335161Completed6Est. Feb 2024
ReNeuron
1 program
1
CTX DPPhase 11 trial
Active Trials
NCT01916369Completed5Est. Jan 2018
Sharp Therapeutics
1
SimvastatinPhase 1Small Molecule
MSD
MSDIreland - Ballydine
1 program
1
SimvastatinPhase 1Small Molecule1 trial
Active Trials
NCT00720577Completed164Est. Aug 2007
Shockwave Medical
Intravascular LithotripsyN/A2 trials
Peripheral Intravascular LithotripsyN/A
Shockwave Intravenous lithotripsy with a Supera stentN/A1 trial
Shockwave Lithoplasty SystemN/A1 trial
Shockwave Lithoplasty SystemN/A1 trial
+4 more programs
Active Trials
NCT07512128Not Yet Recruiting185Est. Dec 2032
NCT05858905Completed55Est. Apr 2025
NCT05147363Unknown50Est. Dec 2022
+6 more trials
Endologix
6 programs
DETOUR SystemN/A1 trial
DETOUR SystemN/A1 trial
PQ Bypass Guide Wire Delivery SystemN/A1 trial
PQ Bypass Stent Graft SystemN/A1 trial
PQ Bypass System for Femoropopliteal BypassN/A1 trial
+1 more programs
Active Trials
NCT03119233Completed202Est. Nov 2023
NCT06315023Recruiting450Est. Jun 2032
NCT01930071Completed4Est. Jun 2015
+3 more trials
Abbott
AbbottABBOTT PARK, IL
6 programs
JETi 6F and 8F Thrombectomy systemN/A1 trial
NavigationN/A1 trial
Peripheral Registry of Endovascular Clinical Outcomes "The PRIME Registry"N/A1 trial
Peripheral vascular flow reserve measurementN/A1 trial
SCOPE-CLI: Shifting Care and Outcomes for Patients With Endangered LimbsN/A1 trial
+1 more programs
Active Trials
NCT06434779Not Yet Recruiting200Est. May 2026
NCT03585387Completed12Est. Jun 2020
NCT02786173Completed1,000Est. Nov 2021
+3 more trials
Avinger
5 programs
AtherectomyN/A1 trial
Atherectomy CatheterN/A1 trial
Pantheris SystemN/A2 trials
Wildcat CatheterN/A1 trial
Wolverine SystemN/A1 trial
Active Trials
NCT04793581Recruiting60Est. Aug 2025
NCT03192696Completed127Est. Dec 2021
NCT02126540Withdrawn0Est. Jul 2016
+3 more trials
Veryan Medical
4 programs
BioMimics 3D StentN/A1 trial
BioMimics 3D Vascular Stent SystemN/A1 trial
BioMimics 3D Vascular Stent SystemN/A1 trial
Femoropopliteal stentingN/A1 trial
Active Trials
NCT02900924Completed507Est. Sep 2021
NCT04640597Unknown500Est. Sep 2025
NCT02400905Completed271Est. Dec 2019
+1 more trials
Biotronik
BiotronikGermany - Berlin
4 programs
Oscar Peripheral Multifunctional CatheterN/A1 trial
Paclitaxel releasing angioplasty balloonN/A1 trial
Passeo-18 Lux DCBN/A1 trial
Passeo-18 Lux DCBN/A1 trial
Active Trials
NCT06758921Recruiting200Est. Jan 2026
NCT02912715Completed158Est. Aug 2020
NCT03052296Completed44Est. Nov 2019
+1 more trials
Cordis
CordisFL - Miami Lakes
4 programs
PMCF Study for Peripheral Arteries Above the Knee (ATK)N/A1 trial
S.M.A.R.T. RADIANZ™ Vascular Stent SystemN/A1 trial
SELUTION SLR™ 018 DEBN/A1 trial
SELUTION SLR™ DEB 014N/A1 trial
Active Trials
NCT05312580Completed387Est. Nov 2022
NCT05399680Completed151Est. Nov 2023
NCT05132361Active Not Recruiting300Est. Dec 2030
+1 more trials
Surmodics
SurmodicsMN - Eden Prairie
4 programs
Pounce Thrombectomy SystemN/A1 trial
SUNDANCE™ Drug Coated BalloonN/A1 trial
SurVeil Drug Coated BalloonN/A1 trial
Surmodics SurVeil DCBN/A1 trial
Active Trials
NCT05868161Recruiting500Est. Jul 2026
NCT04107298Completed35Est. Jan 2024
NCT02648620Completed13Est. Feb 2020
+1 more trials
Cagent Vascular
4 programs
SerranatorN/A1 trial
SerranatorN/A1 trial
Serranator® AltoN/A1 trial
Serranator™ Alto PTA Serration Balloon CatheterN/A1 trial
Active Trials
NCT03693963Completed49Est. Oct 2020
NCT05161039Unknown20Est. Jul 2022
NCT03538392Withdrawn0Est. Dec 2019
+1 more trials
Reflow Medical
Reflow MedicalCA - San Clemente
3 programs
Bare Temporary Spur Stent SystemN/A1 trial
Temporary Spur Stent SystemN/A1 trial
Temporary Spur Stent SystemN/A1 trial
Active Trials
NCT05358353Completed130Est. May 2025
NCT04162418Completed26Est. Sep 2023
NCT03807531Active Not Recruiting100Est. Jun 2028
Alliance Pharmaceuticals
3 programs
Combined - PAD and CADN/A1 trial
SELUTION SLR™ 018 DEBN/A
SELUTION SLR™ DEB 014N/A
Active Trials
NCT03564080Completed57Est. Sep 2022
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
2 programs
Ankle-brachial indexN/A1 trial
Patient reported outcomesN/A1 trial
Active Trials
NCT00928629Completed1,000Est. Oct 2009
NCT03898570Completed100Est. Mar 2021
Cardio Flow
2 programs
Cardio Flow FreedomFlow™ Orbital Atherectomy System treatmentN/A
Orbital Circumferential AtherectomyN/A
Flow Medical
2 programs
Cardio Flow FreedomFlow™ Orbital Atherectomy System treatmentN/A1 trial
Orbital Circumferential AtherectomyN/A1 trial
Active Trials
NCT03365154Completed10Est. Nov 2018
NCT03635190Completed112Est. Oct 2021
Libra Therapeutics
Cardio Flow FreedomFlow™ Orbital Atherectomy System treatmentN/A
Orbital Circumferential AtherectomyN/A
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
2 programs
Dipyridamole 200mg and Aspirin 25mg bid:N/A1 trial
BIWH 3PHASE_11 trial
Active Trials
NCT00906035Terminated25Est. Apr 2010
NCT02215824Terminated7

+38 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Bayerrivaroxaban
Bayerrivaroxaban
Bayerrivaroxaban
Bayerrivaroxaban
Bayerrivaroxaban
Bayerrivaroxaban
Bayerrivaroxaban
Bayerrivaroxaban
MedtronicDrug Eluting Balloon Angioplasty
Bayerrivaroxaban
Medtronicstent placement
Boston ScientificJetstream Atherectomy System
GuerbetDotarem
Colorado TherapeuticsRanolazine
Bristol Myers SquibbStepwise therapy for dyslipidemia, hypertension and diabetes

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 98,480 patients across 50 trials

NCT05797376Bayerrivaroxaban

Effects of aSPIrin Versus Aspirin Plus Low-dose RIvaroxaban on Carotid aTherosclerotic Plaque Inflammation

Start: Aug 2021Est. completion: Dec 202492 patients
Phase 4Completed
NCT06986369Bayerrivaroxaban

Effects of Rivaroxaban on Vascular FMD in Patients With Stable Atherosclerotic Vascular Diseases

Start: May 2021Est. completion: Mar 2024140 patients
Phase 4Completed
NCT04853719Bayerrivaroxaban

Rivaroxaban 2.5 mg BID and Aspirin for Intermittent Claudication in PAD Patients

Start: Apr 2021Est. completion: Nov 202288 patients
Phase 4Completed
NCT04757857Bayerrivaroxaban

COVID-19 Antithrombotic Rivaroxaban Evaluation

Start: Sep 2020Est. completion: Aug 2022660 patients
Phase 4Terminated
NCT04263038Bayerrivaroxaban

Clinical Surveillance vs. Anticoagulation for Low-risk Patients With Isolated Subsegmental Pulmonary Embolism

Start: May 2020Est. completion: May 2026276 patients
Phase 4Recruiting
NCT04073316Bayerrivaroxaban

AntiCoagulants and COGnition

Start: Feb 2020Est. completion: Feb 202348 patients
Phase 4Unknown
NCT02584660Bayerrivaroxaban

A Study of Rivaroxaban for Early Discharge of Low Risk Pulmonary Embolism From the Emergency Department

Start: Oct 2015Est. completion: Mar 2017114 patients
Phase 4Completed
NCT02116036Bayerrivaroxaban

Rivaroxaban for Antiphospholipid Antibody Syndrome

Start: Sep 2014Est. completion: Sep 201781 patients
Phase 4Completed
NCT02212470MedtronicDrug Eluting Balloon Angioplasty

Drug Eluting Balloon Angioplasty Versus Nitinol Stent Implantation in the Superficial Femoral Artery

Start: Jul 2014Est. completion: Oct 201985 patients
Phase 4Completed
NCT02066662Bayerrivaroxaban

Rivaroxaban Compared to Vitamin K Antagonist Upon Development of Cardiovascular Calcification

Start: Jul 2013Est. completion: Mar 2020192 patients
Phase 4Completed
NCT01412463Medtronicstent placement

DURABILITY+ : a Prospective, Multi-center, Controlled Study With the Everflex+ Stent in SFA Lesions

Start: May 2011Est. completion: Jan 201360 patients
Phase 4Completed
NCT01273623Boston ScientificJetstream Atherectomy System

The Jetstream G3™ Calcium Study

Start: Jan 2011Est. completion: Mar 201255 patients
Phase 4Completed

Efficacy Evaluation of Dotarem Compared to Gadovist in the Diagnosis of Peripheral Arterial Disease

Start: Oct 2009Est. completion: Jan 2012189 patients
Phase 4Completed

Ranolazine Versus Placebo Effects on Exercise Tolerance in Patients With Heart Disease and Peripheral Arterial Disease

Start: May 2008Est. completion: Jun 20090
Phase 4Withdrawn
NCT00144937Bristol Myers SquibbStepwise therapy for dyslipidemia, hypertension and diabetes

Multifactorial Intervention on Cardiovascular Risk Factors in Subjects With Peripheral Arterial Disease

Start: Mar 2003Est. completion: Aug 2005120 patients
Phase 4Unknown
NCT03969953Bayerrivaroxaban

Treatment of Cardiovascular Disease With Low Dose Rivaroxaban in Advanced Chronic Kidney Disease

Start: Jan 2021Est. completion: Oct 20251,753 patients
Phase 3Completed
NCT04662684Bayerrivaroxaban

Medically Ill Hospitalized Patients for COVID-19 THrombosis Extended ProphyLaxis With Rivaroxaban ThErapy: The MICHELLE Trial

Start: Oct 2020Est. completion: Aug 2021320 patients
Phase 3Completed
NCT04324463Bayerrivaroxaban

Anti-Coronavirus Therapies to Prevent Progression of Coronavirus Disease 2019 (COVID-19) Trial

Start: Apr 2020Est. completion: Dec 20226,667 patients
Phase 3Completed
NCT02846532Bayerrivaroxaban

Pharmacokinetic, Pharmacodynamic, Safety, and Efficacy Study of Rivaroxaban for Thromboprophylaxis in Pediatric Participants 2 to 8 Years of Age After the Fontan Procedure

Start: Nov 2016Est. completion: Jul 2020112 patients
Phase 3Completed
NCT02746185Bayerrivaroxaban

Cancer Associated Thrombosis, a Pilot Treatment Study Using Rivaroxaban

Start: Sep 2016Est. completion: Apr 2018159 patients
Phase 3Completed
NCT02832544Bayerrivaroxaban

INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Non-Inferiority

Start: Aug 2016Est. completion: Aug 20224,565 patients
Phase 3Completed
NCT02833948Bayerrivaroxaban

Comparison of a Rivaroxaban-based Strategy With an Antiplatelet-based Strategy Following Successful TAVR for the Prevention of Leaflet Thickening and Reduced Leaflet Motion as Evaluated by Four-dimensional, Volume-rendered Computed Tomography (4DCT)

Start: May 2016Est. completion: Mar 2019231 patients
Phase 3Completed
NCT02583191Bayerrivaroxaban

Rivaroxaban in the Treatment of Venous Thromboembolism (VTE) in Cancer Patients

Start: Mar 2016Est. completion: Aug 2019246 patients
Phase 3Terminated
NCT02556203Bayerrivaroxaban

Global Study Comparing a rivAroxaban-based Antithrombotic Strategy to an antipLatelet-based Strategy After Transcatheter aortIc vaLve rEplacement to Optimize Clinical Outcomes

Start: Dec 2015Est. completion: Nov 20181,653 patients
Phase 3Terminated
NCT02401594Bayerrivaroxaban

PROphylaxis in NOn Major Orthopaedic Surgery

Start: Dec 2015Est. completion: Apr 20183,608 patients
Phase 3Terminated
NCT02403596Bayerrivaroxaban

Blood-sparing During Hip Prosthesis Surgery With Exacyl® in Patients Treated With Rivaroxaban

Start: Oct 2015Est. completion: Aug 2017231 patients
Phase 3Completed
NCT02555878Bayerrivaroxaban

A Study to Evaluate the Efficacy and Safety of Rivaroxaban Venous Thromboembolism (VTE) Prophylaxis in Ambulatory Cancer Participants

Start: Sep 2015Est. completion: Aug 2018841 patients
Phase 3Completed
NCT02313909Bayerrivaroxaban

Rivaroxaban Versus Aspirin in Secondary Prevention of Stroke and Prevention of Systemic Embolism in Patients With Recent Embolic Stroke of Undetermined Source (ESUS)

Start: Dec 2014Est. completion: Feb 20187,213 patients
Phase 3Terminated
NCT02123524Bayerrivaroxaban

Rivaroxaban Anticoagulation for Superficial Vein Thrombosis

Start: Nov 2014Est. completion: Dec 201885 patients
Phase 3Completed
NCT02064439Bayerrivaroxaban

Reduced-dosed Rivaroxaban in the Long-term Prevention of Recurrent Symptomatic VTE(Venous Thromboembolism)

Start: Mar 2014Est. completion: Nov 20163,365 patients
Phase 3Completed
NCT02111564Bayerrivaroxaban

A Study of Rivaroxaban (JNJ-39039039) on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients

Start: Jan 2014Est. completion: May 201812,024 patients
Phase 3Completed
NCT01839357Bayerrivaroxaban

Exploring the Efficacy of Once Daily Oral Rivaroxaban for Treatment of Thrombus in Left Atrial/Left Atrial Appendage in Subjects With Nonvalvular Atrial Fibrillation or Atrial Flutter

Start: Aug 2013Est. completion: Dec 201460 patients
Phase 3Completed
NCT01830543Bayerrivaroxaban

A Study Exploring Two Strategies of Rivaroxaban (JNJ39039039; BAY-59-7939) and One of Oral Vitamin K Antagonist in Patients With Atrial Fibrillation Who Undergo Percutaneous Coronary Intervention

Start: May 2013Est. completion: Jul 20162,124 patients
Phase 3Completed
NCT01776424Bayerrivaroxaban

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

Start: Feb 2013Est. completion: Jun 202127,395 patients
Phase 3Completed
NCT01729871Bayerrivaroxaban

A Study Exploring Two Treatment Strategies in Patients With Atrial Fibrillation Who Undergo Catheter Ablation Therapy

Start: Feb 2013Est. completion: Oct 2014253 patients
Phase 3Completed

Clinical Trial to Evaluate Efficacy and Safety of DP-R202 and Anplag in Patients With Artery Occlusive Disease

Start: Oct 2012Est. completion: Apr 2014151 patients
Phase 3Completed
NCT01674647Bayerrivaroxaban

Explore the Efficacy and Safety of Once-daily Oral Rivaroxaban for the Prevention of Cardiovascular Events in Subjects With Nonvalvular Atrial Fibrillation Scheduled for Cardioversion

Start: Oct 2012Est. completion: Jan 20141,504 patients
Phase 3Completed
NCT01499953Bayerrivaroxaban

Superficial Vein Thrombosis (SVT) Treated With Rivaroxaban Versus Fondaparinux

Start: Apr 2012Est. completion: May 2016472 patients
Phase 3Completed
NCT01516840Bayerrivaroxaban

Venous Thromboembolism (VTE) Treatment Study in Japanese Deep Vein Thrombosis (DVT) Patients

Start: Mar 2012Est. completion: Jan 201460 patients
Phase 3Completed
NCT01516814Bayerrivaroxaban

Venous Thromboembolism (VTE) Treatment Study in Japanese Pulmonary Embolism (PE) Patients

Start: Feb 2012Est. completion: Nov 201340 patients
Phase 3Completed
NCT01206972Bayerrivaroxaban

Dose-confirmatory Bridging Study in Total Knee Replacement

Start: Oct 2010Est. completion: Jun 2011302 patients
Phase 3Completed
NCT01205932Bayerrivaroxaban

Dose-confirmatory Bridging Study in Total Hip Replacement

Start: Sep 2010Est. completion: Aug 2011402 patients
Phase 3Completed
NCT01094886Bayerrivaroxaban

Switching Drug Therapy for the Prevention of Blood Clot Formation From Enoxaparin to Rivaroxaban After Orthopedic Surgery for Either Total Hip or Total Knee Replacement

Start: Mar 2010Est. completion: Dec 201056 patients
Phase 3Completed
NCT00809497Lee's PharmaceuticalPropionyl-L-carnitine Tablets

A Clinical Study on Efficacy & Safety Profile of Propionyl-L-carnitine Tablets for Peripheral Arterial Diseases

Start: May 2008Est. completion: Jan 2011239 patients
Phase 3Completed
NCT00571649Bayerrivaroxaban

Venous Thromboembolic Event (VTE) Prophylaxis in Medically Ill Patients

Start: Dec 2007Est. completion: Nov 20108,101 patients
Phase 3Completed

A Study to Assess the Cholesterol Lowering Effect of Ezetimibe/Simvastatin Combination Tablet Compared to Another Cholesterol Lowering Drug in Elderly Patients With High Cholesterol at High or Moderately High Risk for Coronary Heart Disease (0653A-128)

Start: Nov 2007Est. completion: Mar 20091,289 patients
Phase 3Completed
NCT00494871Bayerrivaroxaban

Efficacy and Safety of Rivaroxaban for the Prevention of Stroke in Subjects With Non-Valvular Atrial Fibrillation

Start: Jun 2007Est. completion: Jan 20101,280 patients
Phase 3Completed
NCT00439777Bayerrivaroxaban

Oral Direct Factor Xa Inhibitor Rivaroxaban in Patients With Acute Symptomatic Pulmonary Embolism - The EINSTEIN PE Study

Start: Mar 2007Est. completion: Dec 20114,833 patients
Phase 3Completed
NCT00440193Bayerrivaroxaban

Oral Direct Factor Xa Inhibitor Rivaroxaban in Patients With Acute Symptomatic Deep Vein Thrombosis - The EINSTEIN DVT Study

Start: Mar 2007Est. completion: Apr 20103,449 patients
Phase 3Completed
NCT00439725Bayerrivaroxaban

Once - Daily Oral Direct Factor Xa Inhibitor Rivaroxaban In The Long-Term Prevention Of Recurrent Symptomatic Venous Thromboembolism In Patients With Symptomatic Deep-Vein Thrombosis Or Pulmonary Embolism. The Einstein-Extension Study

Start: Feb 2007Est. completion: Sep 20091,197 patients
Phase 3Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

3 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 98,480 patients
30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.