Peripheral Arterial Disease

11
Pipeline Programs
24
Companies
39
Clinical Trials
5 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
4
0
3
0
2
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 40 programs with unclassified modality

Competitive Landscape

23 companies ranked by most advanced pipeline stage

Guerbet
GuerbetFrance - Villepinte
1 program
1
DotaremPhase 41 trial
Active Trials
NCT01026389Completed189Est. Jan 2012
Bristol Myers Squibb
1 program
1
Stepwise therapy for dyslipidemia, hypertension and diabetesPhase 41 trial
Active Trials
NCT00144937Unknown120Est. Aug 2005
LP
Lee's PharmaceuticalChina - Guangzhou
2 programs
1
1
Propionyl-L-carnitine TabletsPhase 31 trial
Propionyl L-carnitine HydrochloridePhase 11 trial
Active Trials
NCT02786069Completed16Est. Jan 2016
NCT00809497Completed239Est. Jan 2011
Alvogen
AlvogenNJ - Morristown
1 program
1
DP-R202Phase 31 trial
Active Trials
NCT02393612Completed151Est. Apr 2014
Celularity
CelularityFLORHAM PARK, NJ
2 programs
1
1
3 x 10^6 cellsPhase 21 trial
3 x 10^6 cellsPhase 11 trial
Active Trials
NCT01859117CompletedEst. Oct 2016
NCT02264288TerminatedEst. Feb 2018
Vericel
VericelCAMBRIDGE, MA
1 program
1
Ixmyelocel-TPhase 21 trial
Active Trials
NCT00468000Completed86Est. Mar 2011
Sanofi
SanofiPARIS, France
1 program
1
XRP0038Phase 21 trial
Active Trials
NCT00368797Completed125Est. Apr 2005
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
2 programs
1
BIWH 3Phase 11 trial
Dipyridamole 200mg and Aspirin 25mg bid:N/A1 trial
Active Trials
NCT00906035Terminated25Est. Apr 2010
NCT02215824Terminated7
M&
Merck & Co.RAHWAY, NJ
1 program
1
SimvastatinPhase 1Small Molecule1 trial
Active Trials
NCT00720577Completed164Est. Aug 2007
Abbott
AbbottABBOTT PARK, IL
6 programs
JETi 6F and 8F Thrombectomy systemN/A1 trial
NavigationN/A1 trial
Peripheral Registry of Endovascular Clinical Outcomes "The PRIME Registry"N/A1 trial
Peripheral vascular flow reserve measurementN/A1 trial
SCOPE-CLI: Shifting Care and Outcomes for Patients With Endangered LimbsN/A
+1 more programs
Active Trials
NCT06434779Not Yet Recruiting200Est. May 2026
NCT03585387Completed12Est. Jun 2020
NCT02786173Completed1,000Est. Nov 2021
+2 more trials
Biotronik
BiotronikGermany - Berlin
4 programs
Oscar Peripheral Multifunctional CatheterN/A1 trial
Paclitaxel releasing angioplasty balloonN/A1 trial
Passeo-18 Lux DCBN/A1 trial
Passeo-18 Lux DCBN/A1 trial
Active Trials
NCT06758921Recruiting200Est. Jan 2026
NCT02912715Completed158Est. Aug 2020
NCT03052309Completed106Est. Apr 2021
+1 more trials
C
CordisFL - Miami Lakes
4 programs
PMCF Study for Peripheral Arteries Above the Knee (ATK)N/A1 trial
S.M.A.R.T. RADIANZ™ Vascular Stent SystemN/A1 trial
SELUTION SLR™ 018 DEBN/A1 trial
SELUTION SLR™ DEB 014N/A1 trial
Active Trials
NCT05312580Completed387Est. Nov 2022
NCT05399680Completed151Est. Nov 2023
NCT05132361Active Not Recruiting300Est. Dec 2030
+1 more trials
Reflow Medical
Reflow MedicalCA - San Clemente
3 programs
Bare Temporary Spur Stent SystemN/A1 trial
Temporary Spur Stent SystemN/A1 trial
Temporary Spur Stent SystemN/A1 trial
Active Trials
NCT05358353Completed130Est. May 2025
NCT04162418Completed26Est. Sep 2023
NCT03807531Active Not Recruiting100Est. Jun 2028
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
2 programs
Ankle-brachial indexN/A1 trial
Patient reported outcomesN/A1 trial
Active Trials
NCT00928629Completed1,000Est. Oct 2009
NCT03898570Completed100Est. Mar 2021
Alliance Pharmaceuticals
2 programs
Combined - PAD and CADN/A1 trial
SELUTION SLR™ 018 DEBN/A
Active Trials
NCT03564080Completed57Est. Sep 2022
Acist Medical Systems
Acist Medical SystemsMN - Eden Prairie
1 program
Fractional Flow ReserveN/A1 trial
Active Trials
NCT05079906WithdrawnEst. Jun 2024
Avantec Vascular
Avantec VascularCA - Sunnyvale
1 program
Golazo® Peripheral Atherectomy SystemN/A1 trial
Active Trials
NCT06321575RecruitingEst. Nov 2026
Vascular Technology
1 program
PaclitaxelN/A1 trial
Active Trials
NCT04647643CompletedEst. Dec 2021
OrbusNeich
OrbusNeichChina - Hong Kong
1 program
Percutaneous Transluminal Angioplasty with a paclitaxel drug-coated balloonN/A1 trial
Active Trials
NCT06832631Recruiting284Est. Apr 2029
Zylox-Tonbridge
Zylox-TonbridgeChina - Hangzhou
1 program
Peripheral Drug-eluting Stent SystemN/A1 trial
Active Trials
NCT07122167RecruitingEst. Feb 2027
Genesis Therapeutics
Genesis TherapeuticsCA - Burlingame
1 program
Shockwave Medical Peripheral Intravascular LithotripsyN/A1 trial
Active Trials
NCT05434676UnknownEst. Jul 2023
Treadwell Therapeutics
1 program
Treadwell TredlrN/A1 trial
Active Trials
NCT03891641TerminatedEst. Jun 2020
Contego Medical
Contego MedicalNC - Raleigh
1 program
peripheral balloon angioplastyN/A1 trial
Active Trials
NCT03271710CompletedEst. Dec 2018

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
GuerbetDotarem
Bristol Myers SquibbStepwise therapy for dyslipidemia, hypertension and diabetes
AlvogenDP-R202
Lee's PharmaceuticalPropionyl-L-carnitine Tablets
Celularity3 x 10^6 cells
VericelIxmyelocel-T
SanofiXRP0038
Lee's PharmaceuticalPropionyl L-carnitine Hydrochloride
Celularity3 x 10^6 cells
Merck & Co.Simvastatin
Boehringer IngelheimBIWH 3
AbbottPeripheral vascular flow reserve measurement
Zylox-TonbridgePeripheral Drug-eluting Stent System
OrbusNeichPercutaneous Transluminal Angioplasty with a paclitaxel drug-coated balloon
BiotronikOscar Peripheral Multifunctional Catheter

Showing 15 of 39 trials with date data

Clinical Trials (39)

Total enrollment: 6,053 patients across 39 trials

Efficacy Evaluation of Dotarem Compared to Gadovist in the Diagnosis of Peripheral Arterial Disease

Start: Oct 2009Est. completion: Jan 2012189 patients
Phase 4Completed
NCT00144937Bristol Myers SquibbStepwise therapy for dyslipidemia, hypertension and diabetes

Multifactorial Intervention on Cardiovascular Risk Factors in Subjects With Peripheral Arterial Disease

Start: Mar 2003Est. completion: Aug 2005120 patients
Phase 4Unknown

Clinical Trial to Evaluate Efficacy and Safety of DP-R202 and Anplag in Patients With Artery Occlusive Disease

Start: Oct 2012Est. completion: Apr 2014151 patients
Phase 3Completed
NCT00809497Lee's PharmaceuticalPropionyl-L-carnitine Tablets

A Clinical Study on Efficacy & Safety Profile of Propionyl-L-carnitine Tablets for Peripheral Arterial Diseases

Start: May 2008Est. completion: Jan 2011239 patients
Phase 3Completed
NCT02264288Celularity3 x 10^6 cells

Efficacy and Safety of Intramuscular PDA-002 in Subjects Who Have Diabetic Foot Ulcer With and Without Peripheral Arterial Disease

Start: Oct 2014Est. completion: Feb 2018
Phase 2Terminated
NCT00468000VericelIxmyelocel-T

Use of Ixmyelocel-T (Formerly Vascular Repair Cells [VRC]) in Patients With Peripheral Arterial Disease to Treat Critical Limb Ischemia

Start: Apr 2007Est. completion: Mar 201186 patients
Phase 2Completed

Efficacy and Safety Study of NV1FGF in Patients With Severe Peripheral Artery Occlusive Disease

Start: Mar 2002Est. completion: Apr 2005125 patients
Phase 2Completed
NCT02786069Lee's PharmaceuticalPropionyl L-carnitine Hydrochloride

A Single-dose Escalation Safety and PK Study for PLC in Healthy Chinese

Start: Jun 2015Est. completion: Jan 201616 patients
Phase 1Completed
NCT01859117Celularity3 x 10^6 cells

Study of Human Placenta-derived Cells (PDA002) to Evaluate the Safety and Effectiveness in Subjects With PAD and DFU

Start: May 2013Est. completion: Oct 2016
Phase 1Completed

Study to Evaluate the Effect of Simvastatin, Losartan and Pioglitazone on Patients With Peripheral Arterial Disease.

Start: Dec 2005Est. completion: Aug 2007164 patients
Phase 1Completed

Investigation of Safety, Pharmacokinetics and Pharmacodynamics of Different Doses of BIWH 3 in Patients With Chronic Critical Limb Ischaemia

Start: Oct 20027 patients
Phase 1Terminated
NCT06014242AbbottPeripheral vascular flow reserve measurement

Peripheral Microvascular Resistance as a Predictor for Limb Salvage

Start: Sep 2025Est. completion: Sep 20260
N/AWithdrawn
NCT07122167Zylox-TonbridgePeripheral Drug-eluting Stent System

Post-market Registry Study on the Safety and Efficacy of ZENFLEX Pro™ Peripheral Drug-eluting Stent System for Femoropopliteal Artery Lesions

Start: Jun 2025Est. completion: Feb 2027
N/ARecruiting
NCT06832631OrbusNeichPercutaneous Transluminal Angioplasty with a paclitaxel drug-coated balloon

VITUS Post-Market Registry

Start: May 2025Est. completion: Apr 2029284 patients
N/ARecruiting
NCT06758921BiotronikOscar Peripheral Multifunctional Catheter

Prospective, Multicenter, Single-Arm Observational Study to Confirm the Safety and Clinical Performance of the Oscar Peripheral Multifunctional Catheter for the Dilatation of Lesions in the Femoral, Popliteal and Infrapopliteal Arteries (BIO-OSCAR First)

Start: Dec 2024Est. completion: Jan 2026200 patients
N/ARecruiting
NCT06434779AbbottJETi 6F and 8F Thrombectomy system

Investigating Efficacy and Safety of JETi® in Arterial Occlusions in FEM-POP and Prox BTK-Lesions (JETART)

Start: Jul 2024Est. completion: May 2026200 patients
N/ANot Yet Recruiting
NCT06321575Avantec VascularGolazo® Peripheral Atherectomy System

The Golazo® Peripheral Atherectomy System for a Safe and Effective Atherectomy (GREAT Trial)

Start: Jun 2024Est. completion: Nov 2026
N/ARecruiting
NCT05132361CordisSELUTION SLR™ 018 DEB

SELUTION4SFA Trial

Start: Dec 2022Est. completion: Dec 2030300 patients
N/AActive Not Recruiting
NCT05358353Reflow MedicalBare Temporary Spur Stent System

A Prospective Single-Arm Multicenter StuDy of the BarE TEmporary SPur StEnt System foR the tREatment of Vascular Lesions Located in the infrapoplitEal Arteries beLow the Knee (DEEPER REVEAL)

Start: Oct 2022Est. completion: May 2025130 patients
N/ACompleted
NCT05399680CordisS.M.A.R.T. RADIANZ™ Vascular Stent System

Evaluation of Safety and Efficacy of the S.M.A.R.T. RADIANZ™ Vascular Stent System in the Treatment of Iliac and Femoropopliteal Lesions Via Transradial Access

Start: Jun 2022Est. completion: Nov 2023151 patients
N/ACompleted
NCT05312580CordisPMCF Study for Peripheral Arteries Above the Knee (ATK)

PMCF Study for Peripheral Arteries Above the Knee (ATK)

Start: Jun 2022Est. completion: Nov 2022387 patients
N/ACompleted
NCT05055297CordisSELUTION SLR™ DEB 014

SELUTION4BTK Trial

Start: May 2022Est. completion: Jul 2032376 patients
N/ARecruiting
NCT05079906Acist Medical SystemsFractional Flow Reserve

Assessment of Superficial Femoral Artery Lesions With FFR From the ACIST Navvus® Catheter

Start: May 2022Est. completion: Jun 2024
N/AWithdrawn
NCT05434676Genesis TherapeuticsShockwave Medical Peripheral Intravascular Lithotripsy

SOLUTION Trial in China

Start: Jun 2021Est. completion: Jul 2023
N/AUnknown

Real-World Safety Analysis of Paclitaxel Devices Used for the Treatment of Peripheral Arterial Disease

Start: Nov 2020Est. completion: Dec 2021
N/ACompleted
NCT04162418Reflow MedicalTemporary Spur Stent System

A Study of the TEmporary Spur StEnt System for the Treatment of Lesions Located in the InfraPoplitEal ARteries Using a LIMUS-base DCB

Start: Feb 2020Est. completion: Sep 202326 patients
N/ACompleted
NCT03807531Reflow MedicalTemporary Spur Stent System

A Study of the Temporary Spur Stent for the Treatment of Narrowing and Blockages in the Arteries Below the Knee

Start: Jul 2019Est. completion: Jun 2028100 patients
N/AActive Not Recruiting
NCT03941314AbbottSupera® Peripheral Stent System

A Superiority Trial of the SUPERA Peripheral Stent System in Patients With Femoro-popliteal Artery Disease

Start: Jun 2019Est. completion: Mar 2026300 patients
N/AActive Not Recruiting

Momentum-enabled Treadling Methodology to Improve Gait and Enhance Mobility

Start: Jun 2019Est. completion: Jun 2020
N/ATerminated
NCT03898570AstraZenecaPatient reported outcomes

Distributed Registry

Start: Apr 2019Est. completion: Mar 2021100 patients
N/ACompleted

Cardiac Positioning System in Peripheral Angioplasty Procedure.

Start: Feb 2019Est. completion: Jun 202012 patients
N/ACompleted

Assessing the Feasibility of Including Patients With Peripheral Artery Disease in to an Established Cardiac Rehabilitation Service.

Start: Jul 2018Est. completion: Sep 202257 patients
N/ACompleted
NCT03271710Contego Medicalperipheral balloon angioplasty

Study to Evaluate the Lower Extremity Intervention With Integrated Embolic Protection Using the Vanguard IEP System

Start: Sep 2017Est. completion: Dec 2018
N/ACompleted
NCT03052296BiotronikPasseo-18 Lux DCB

BIOLUX P-III SPAIN All-Comers Registry

Start: Mar 2017Est. completion: Nov 201944 patients
N/ACompleted
NCT03052309BiotronikPasseo-18 Lux DCB

BIOLUX P-III BENELUX All-Comers Registry

Start: Feb 2017Est. completion: Apr 2021106 patients
N/ACompleted
NCT02912715BiotronikPaclitaxel releasing angioplasty balloon

BIOLUX P-IV CHINA ( BIOTRONIK )

Start: Oct 2016Est. completion: Aug 2020158 patients
N/ACompleted
NCT02786173AbbottPeripheral Registry of Endovascular Clinical Outcomes "The PRIME Registry"

Peripheral Registry of Endovascular Clinical Outcomes "The PRIME Registry"

Start: Jan 2013Est. completion: Nov 20211,000 patients
N/ACompleted
NCT00928629AstraZenecaAnkle-brachial index

Audit and Screening Study to Determine the Prevalence of Peripheral Arterial Disease

Start: Jun 2009Est. completion: Oct 20091,000 patients
N/ACompleted
NCT00906035Boehringer IngelheimDipyridamole 200mg and Aspirin 25mg bid:

The Vascular Biology of Dipyridamole in Peripheral Arterial Disease (PAD)

Start: Sep 2002Est. completion: Apr 201025 patients
N/ATerminated

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 late-stage (Phase 3) programs — potential near-term approvals
5 actively recruiting trials targeting 6,053 patients
24 companies competing in this space