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Pelvic Organ Prolapse

6
Pipeline Programs
18
Companies
32
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
0
5
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

16 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
2 programs
1
Conjugated Estrogens CreamPhase 41 trial
Vaginal estrogenN/A
Active Trials
NCT02431897Completed206Est. May 2023
Astellas
AstellasChina - Shenyang
2 programs
2
PremarinPhase 41 trial
SolifenacinPhase 41 trial
Active Trials
NCT01778985Completed30Est. Apr 2013
NCT01092624Terminated94Est. Oct 2011
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
1
DermaPure®Phase 4
Tissue Regenix
Tissue RegenixTX - Universal City
1 program
1
DermaPure®Phase 41 trial
Active Trials
NCT03939715Unknown50Est. May 2022
Human BioSciences
Human BioSciencesWV - Martinsburg
2 programs
1
TVTPhase 21 trial
Vaginal estrogenN/A1 trial
Active Trials
NCT01648751Terminated21Est. Mar 2023
NCT00460434Completed337Est. Mar 2011
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
10 programs
ISFFN/A1 trial
Laparoscopic uterosacral ligament suspension with hysterectomyN/A1 trial
Procedure: GYNECARE PROSIMA* Pelvic Floor Repair SystemN/A1 trial
TVT-ON/A1 trial
The Follow-up of Mesh/Native Tissue Complications Study(Part II)N/A1 trial
+5 more programs
Active Trials
NCT01760603Unknown75Est. Dec 2017
NCT06418438Not Yet Recruiting314Est. Nov 2027
NCT01396122Unknown150Est. Mar 2016
+7 more trials
Coloplast
ColoplastAustralia - Mulgrave
6 programs
AxisN/A1 trial
Exair Prolapse Repair SystemN/A1 trial
Exair Transvaginal MeshN/A1 trial
Restorelle Direct Fix AN/A1 trial
pelvic organ prolapse repairN/A1 trial
+1 more programs
Active Trials
NCT01541748Completed74Est. Nov 2018
NCT02162628Terminated79Est. Dec 2015
NCT03271294Completed80Est. Aug 2015
+3 more trials
Boston Scientific
Boston ScientificCA - Valencia
3 programs
Prolapse RepairN/A1 trial
Traditional vaginal positioning deviceN/A
Uphold Lightweight Vaginal Support SystemN/A1 trial
Active Trials
NCT01945580Completed374Est. Feb 2020
NCT01917968Completed289Est. Feb 2020
Intuitive Surgical
Intuitive SurgicalCA - Sunnyvale
2 programs
Performing robotic supracervical hysterectomyN/A1 trial
Traditional vaginal positioning deviceN/A1 trial
Active Trials
NCT01618994Completed14Est. Jan 2012
NCT02367235Completed52Est. Apr 2018
Olympus
OlympusPA - Center Valley
1 program
3D mode of the 3D Laparoscopic Video SystemN/A1 trial
Active Trials
NCT02258230Completed194Est. Mar 2018
Escala Medical
Escala MedicalIsrael - Misgav
1 program
Apyx deviceN/A1 trial
Active Trials
NCT03991455Completed17Est. May 2022
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
1 program
Immediate catheter removalN/A1 trial
Active Trials
NCT02189291Completed72Est. Dec 2018
Providence Therapeutics
1 program
Laparoscopic sacral hysteropexyN/A1 trial
Active Trials
NCT01377142Completed148Est. Dec 2015
Integra LifeSciences
Integra LifeSciencesAustralia - Clayton
1 program
MatriStem Pelvic Floor MatrixN/A1 trial
Active Trials
NCT02021279Completed161Est. Apr 2021
PFM Medical
PFM MedicalCA - Carlsbad
1 program
Post-market Clinical Follow-up of the SRS ImplantN/A1 trial
Active Trials
NCT05170074Active Not Recruiting175Est. Sep 2026
Francis Medical
Francis MedicalMN - Maple Grove
1 program
sacrospinous Ligament FixationN/A

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
ColoplastAxis Dermis biologic mesh repair for pelvic organ prolapse
Tissue RegenixDermaPure®
PfizerConjugated Estrogens Cream
AstellasPremarin
AstellasSolifenacin
Human BioSciencesTVT
UNION therapeuticstotal colpocleisis
UNION therapeuticsLaparoscopic uterosacral ligament suspension with hysterectomy
UNION therapeuticssacrospinous ligament fixation
UNION therapeuticsself-cut mesh procedure
PFM MedicalPost-market Clinical Follow-up of the SRS Implant
Escala MedicalApyx device
UNION therapeuticssacrospinous Ligament Fixation
UNION therapeuticsThe Follow-up of Mesh/Native Tissue Complications Study(Part II)
Coloplastpelvic organ prolapse repair

Showing 15 of 32 trials with date data

Clinical Trials (32)

Total enrollment: 7,080 patients across 32 trials

NCT06263985ColoplastAxis Dermis biologic mesh repair for pelvic organ prolapse

Axis(TM) Solvent-dehydrate Dermal Allograft in the Treatment of Pelvic Organ Prolapse.

Start: Nov 2021Est. completion: May 202550 patients
Phase 4Unknown

Surgical Intervention With DermaPure vs Native Tissue in Pelvic Organ Prolapse

Start: Apr 2020Est. completion: May 202250 patients
Phase 4Unknown
NCT02431897PfizerConjugated Estrogens Cream

Investigation to Minimize Prolapse Recurrence of the Vagina Using Estrogen

Start: Dec 2016Est. completion: May 2023206 patients
Phase 4Completed

Effect of Preoperative Estrogen Treatment on Connective Tissues of the Pelvic Floor

Start: Dec 2012Est. completion: Apr 201330 patients
Phase 4Completed

Clinical Trial of Solifenacin Versus Placebo Plus Pessary for Women With Vaginal Prolapse

Start: Mar 2010Est. completion: Oct 201194 patients
Phase 4Terminated

Outcomes Following Vaginal Prolapse Repair and Mid Urethral Sling Trial

Start: May 2007Est. completion: Mar 2011337 patients
Phase 2Completed

Safety and Efficacy of Different Procedures of Colpocleisis: a Randomized Controlled Trial

Start: Jul 2024Est. completion: Nov 2027330 patients
N/ANot Yet Recruiting
NCT06418438UNION therapeuticsLaparoscopic uterosacral ligament suspension with hysterectomy

A Randomized Controlled Trail of Uterosacral Ligament Suspension in the Treatment of Pelvic Organ Prolapse

Start: Jun 2024Est. completion: Nov 2027314 patients
N/ANot Yet Recruiting
NCT06418451UNION therapeuticssacrospinous ligament fixation

A Randomized Controlled Trial of Modified Ischial Spinous Fascia Fixation and Sacrospinous Ligament Fixation in the Treatment of Pelvic Organ Prolapse

Start: Jun 2024Est. completion: Nov 2027370 patients
N/ANot Yet Recruiting
NCT05938881UNION therapeuticsself-cut mesh procedure

Long-term Success Rate of Transvaginal Mesh for the Treatment of Pelvic Organ Prolapse: The Extended RCT Study

Start: Jun 2023Est. completion: Mar 2033336 patients
N/ARecruiting
NCT05170074PFM MedicalPost-market Clinical Follow-up of the SRS Implant

Post-market Clinical Follow-up of the SRS Implant

Start: Apr 2022Est. completion: Sep 2026175 patients
N/AActive Not Recruiting

Evaluation of Safety and Efficacy of the Apyx™ Device for the Repair of Pelvic Organ Prolapse (POP)

Start: Oct 2019Est. completion: May 202217 patients
N/ACompleted
NCT03782285UNION therapeuticssacrospinous Ligament Fixation

Sacrospinous Ligament Fixation With Conventional Surgical Instruments in Chinese Apical Prolapse Female Patients

Start: Nov 2018Est. completion: Sep 2019100 patients
N/AUnknown
NCT03617211UNION therapeuticsThe Follow-up of Mesh/Native Tissue Complications Study(Part II)

The Follow-up of Mesh/Native Tissue Complications Study(Part II)

Start: Jun 2018Est. completion: Dec 20231,530 patients
N/AUnknown
NCT03098641Coloplastpelvic organ prolapse repair

Smartmesh Technology in Pelvic Floor Repair Procedures

Start: May 2017Est. completion: Sep 2017272 patients
N/ACompleted
NCT02367235Intuitive SurgicalTraditional vaginal positioning device

Analysis of Procedural Times Using Colpassist for Robotic-Assisted Sacrocolpopexy; a Randomized Controlled Trial

Start: Jan 2015Est. completion: Apr 201852 patients
N/ACompleted
NCT02258230Olympus3D mode of the 3D Laparoscopic Video System

Laparoscopic Three-dimensional Versus Two-dimensional Sacral Colpopexy and Paravaginal Repair

Start: Dec 2014Est. completion: Mar 2018194 patients
N/ACompleted
NCT02162628ColoplastExair Prolapse Repair System

Exair® Versus Native Tissue Repair for Prolapse

Start: Aug 2014Est. completion: Dec 201579 patients
N/ATerminated
NCT02162615ColoplastRestorelle Direct Fix A

Restorelle® Mesh Versus Native Tissue Repair for Prolapse

Start: Aug 2014Est. completion: Nov 2021810 patients
N/ACompleted
NCT02189291Oregon TherapeuticsImmediate catheter removal

Study to Assess Duration of Indwelling Catheter After Sacrocolpopexy

Start: Jul 2014Est. completion: Dec 201872 patients
N/ACompleted
NCT02021279Integra LifeSciencesMatriStem Pelvic Floor Matrix

ACell MatriStem Pelvic Floor Matrix Versus Native Tissue Repair, Comparative Study

Start: Jun 2014Est. completion: Apr 2021161 patients
N/ACompleted

Xenform Postmarket Surveillance Study

Start: Feb 2014Est. completion: Feb 2020374 patients
N/ACompleted

Outcomes of Pelvic Surgery With and Without Anti-incontinence Procedure in Occult Stress Urinary Incontinence Patients

Start: Jan 2014Est. completion: Jan 2017196 patients
N/AUnknown
NCT01917968Boston ScientificUphold Lightweight Vaginal Support System

Uphold LITE Post-Market Surveillance Study

Start: Oct 2013Est. completion: Feb 2020289 patients
N/ACompleted
NCT03271294ColoplastExair Transvaginal Mesh

Prospective Performance Analysis of the Exair(TM) Prolapse Repair System in the Treatment of Pelvic Organ Prolapse

Start: Apr 2013Est. completion: Aug 201580 patients
N/ACompleted

Ischia Spinous Fascia Fixation Surgery for Pelvic Organ Prolapse

Start: Dec 2012Est. completion: Dec 201775 patients
N/AUnknown
NCT01670682UNION therapeuticsischia spinous fascia fixation

Ischia Spinous Fascia Fixation Procedure Versus Modified Total Pelvic Floor Reconstructive Surgery for Pelvic Organ Prolapse Stage III

Start: Aug 2012Est. completion: Aug 201680 patients
N/AUnknown

Vaginal Estrogen and Pelvic Floor Physical Therapy in Women With Symptomatic Mild Prolapse

Start: May 2012Est. completion: Mar 202321 patients
N/ATerminated

Axis™ Allograft Dermis for Female Pelvic Floor Repair: a Prospective Post Market Study

Start: Nov 2011Est. completion: Nov 201874 patients
N/ACompleted
NCT01377142Providence TherapeuticsLaparoscopic sacral hysteropexy

Vaginal Uphold Hysteropexy and Laparoscopic Sacral Hysteropexy for the Treatment of Uterovaginal Pelvic Organ Prolapse

Start: Jun 2011Est. completion: Dec 2015148 patients
N/ACompleted
NCT01618994Intuitive SurgicalPerforming robotic supracervical hysterectomy

Validation Study for Robotic Surgery Simulator

Start: Apr 2011Est. completion: Jan 201214 patients
N/ACompleted
NCT01396122UNION therapeuticsProcedure: GYNECARE PROSIMA* Pelvic Floor Repair System

Clinical Performance of GYNECARE PROSIMA* Pelvic Floor Repair System for Symptomatic Pelvic Organ Prolapse

Start: Mar 2011Est. completion: Mar 2016150 patients
N/AUnknown

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 actively recruiting trials targeting 7,080 patients
18 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.