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Pelvic Organ Prolapse

6
Pipeline Programs
18
Companies
32
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
0
5
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

16 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
2 programs
1
Conjugated Estrogens CreamPhase 41 trial
Vaginal estrogenN/A
Active Trials
NCT02431897Completed206Est. May 2023
Astellas
AstellasChina - Shenyang
2 programs
2
PremarinPhase 41 trial
SolifenacinPhase 41 trial
Active Trials
NCT01778985Completed30Est. Apr 2013
NCT01092624Terminated94Est. Oct 2011
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
1
DermaPure®Phase 41 trial
Active Trials
NCT03939715Unknown50Est. May 2022
Tissue Regenix
Tissue RegenixTX - Universal City
1 program
1
DermaPure®Phase 4
Human BioSciences
Human BioSciencesWV - Martinsburg
2 programs
1
TVTPhase 21 trial
Vaginal estrogenN/A1 trial
Active Trials
NCT01648751Terminated21Est. Mar 2023
NCT00460434Completed337Est. Mar 2011
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
10 programs
ISFFN/A1 trial
Laparoscopic uterosacral ligament suspension with hysterectomyN/A1 trial
Procedure: GYNECARE PROSIMA* Pelvic Floor Repair SystemN/A1 trial
TVT-ON/A1 trial
The Follow-up of Mesh/Native Tissue Complications Study(Part II)N/A1 trial
+5 more programs
Active Trials
NCT01760603Unknown75Est. Dec 2017
NCT06418438Not Yet Recruiting314Est. Nov 2027
NCT01396122Unknown150Est. Mar 2016
+6 more trials
Coloplast
ColoplastAustralia - Mulgrave
6 programs
AxisN/A1 trial
Exair Prolapse Repair SystemN/A1 trial
Exair Transvaginal MeshN/A1 trial
Restorelle Direct Fix AN/A1 trial
pelvic organ prolapse repairN/A1 trial
+1 more programs
Active Trials
NCT01541748Completed74Est. Nov 2018
NCT02162628Terminated79Est. Dec 2015
NCT03271294Completed80Est. Aug 2015
+3 more trials
Boston Scientific
Boston ScientificCA - Valencia
3 programs
Prolapse RepairN/A1 trial
Traditional vaginal positioning deviceN/A
Uphold Lightweight Vaginal Support SystemN/A1 trial
Active Trials
NCT01945580Completed374Est. Feb 2020
NCT01917968Completed289Est. Feb 2020
Intuitive Surgical
Intuitive SurgicalCA - Sunnyvale
2 programs
Performing robotic supracervical hysterectomyN/A1 trial
Traditional vaginal positioning deviceN/A1 trial
Active Trials
NCT01618994Completed14Est. Jan 2012
NCT02367235Completed52Est. Apr 2018
Olympus
OlympusPA - Center Valley
1 program
3D mode of the 3D Laparoscopic Video SystemN/A1 trial
Active Trials
NCT02258230Completed194Est. Mar 2018
Escala Medical
Escala MedicalIsrael - Misgav
1 program
Apyx deviceN/A1 trial
Active Trials
NCT03991455Completed17Est. May 2022
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
1 program
Immediate catheter removalN/A1 trial
Active Trials
NCT02189291Completed72Est. Dec 2018
Providence Therapeutics
1 program
Laparoscopic sacral hysteropexyN/A1 trial
Active Trials
NCT01377142Completed148Est. Dec 2015
Integra LifeSciences
Integra LifeSciencesAustralia - Clayton
1 program
MatriStem Pelvic Floor MatrixN/A1 trial
Active Trials
NCT02021279Completed161Est. Apr 2021
PFM Medical
PFM MedicalCA - Carlsbad
1 program
Post-market Clinical Follow-up of the SRS ImplantN/A1 trial
Active Trials
NCT05170074Active Not Recruiting175Est. Sep 2026
Francis Medical
Francis MedicalMN - Maple Grove
1 program
sacrospinous Ligament FixationN/A1 trial
Active Trials
NCT03782285Unknown100Est. Sep 2019

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
ColoplastAxis Dermis biologic mesh repair for pelvic organ prolapse
Colorado TherapeuticsDermaPure®
PfizerConjugated Estrogens Cream
AstellasPremarin
AstellasSolifenacin
Human BioSciencesTVT
UNION therapeuticstotal colpocleisis
UNION therapeuticsLaparoscopic uterosacral ligament suspension with hysterectomy
UNION therapeuticssacrospinous ligament fixation
UNION therapeuticsself-cut mesh procedure
PFM MedicalPost-market Clinical Follow-up of the SRS Implant
Escala MedicalApyx device
Francis Medicalsacrospinous Ligament Fixation
UNION therapeuticsThe Follow-up of Mesh/Native Tissue Complications Study(Part II)
Coloplastpelvic organ prolapse repair

Showing 15 of 32 trials with date data

Clinical Trials (32)

Total enrollment: 7,080 patients across 32 trials

NCT06263985ColoplastAxis Dermis biologic mesh repair for pelvic organ prolapse

Axis(TM) Solvent-dehydrate Dermal Allograft in the Treatment of Pelvic Organ Prolapse.

Start: Nov 2021Est. completion: May 202550 patients
Phase 4Unknown

Surgical Intervention With DermaPure vs Native Tissue in Pelvic Organ Prolapse

Start: Apr 2020Est. completion: May 202250 patients
Phase 4Unknown
NCT02431897PfizerConjugated Estrogens Cream

Investigation to Minimize Prolapse Recurrence of the Vagina Using Estrogen

Start: Dec 2016Est. completion: May 2023206 patients
Phase 4Completed

Effect of Preoperative Estrogen Treatment on Connective Tissues of the Pelvic Floor

Start: Dec 2012Est. completion: Apr 201330 patients
Phase 4Completed

Clinical Trial of Solifenacin Versus Placebo Plus Pessary for Women With Vaginal Prolapse

Start: Mar 2010Est. completion: Oct 201194 patients
Phase 4Terminated

Outcomes Following Vaginal Prolapse Repair and Mid Urethral Sling Trial

Start: May 2007Est. completion: Mar 2011337 patients
Phase 2Completed

Safety and Efficacy of Different Procedures of Colpocleisis: a Randomized Controlled Trial

Start: Jul 2024Est. completion: Nov 2027330 patients
N/ANot Yet Recruiting
NCT06418438UNION therapeuticsLaparoscopic uterosacral ligament suspension with hysterectomy

A Randomized Controlled Trail of Uterosacral Ligament Suspension in the Treatment of Pelvic Organ Prolapse

Start: Jun 2024Est. completion: Nov 2027314 patients
N/ANot Yet Recruiting
NCT06418451UNION therapeuticssacrospinous ligament fixation

A Randomized Controlled Trial of Modified Ischial Spinous Fascia Fixation and Sacrospinous Ligament Fixation in the Treatment of Pelvic Organ Prolapse

Start: Jun 2024Est. completion: Nov 2027370 patients
N/ANot Yet Recruiting
NCT05938881UNION therapeuticsself-cut mesh procedure

Long-term Success Rate of Transvaginal Mesh for the Treatment of Pelvic Organ Prolapse: The Extended RCT Study

Start: Jun 2023Est. completion: Mar 2033336 patients
N/ARecruiting
NCT05170074PFM MedicalPost-market Clinical Follow-up of the SRS Implant

Post-market Clinical Follow-up of the SRS Implant

Start: Apr 2022Est. completion: Sep 2026175 patients
N/AActive Not Recruiting

Evaluation of Safety and Efficacy of the Apyx™ Device for the Repair of Pelvic Organ Prolapse (POP)

Start: Oct 2019Est. completion: May 202217 patients
N/ACompleted
NCT03782285Francis Medicalsacrospinous Ligament Fixation

Sacrospinous Ligament Fixation With Conventional Surgical Instruments in Chinese Apical Prolapse Female Patients

Start: Nov 2018Est. completion: Sep 2019100 patients
N/AUnknown
NCT03617211UNION therapeuticsThe Follow-up of Mesh/Native Tissue Complications Study(Part II)

The Follow-up of Mesh/Native Tissue Complications Study(Part II)

Start: Jun 2018Est. completion: Dec 20231,530 patients
N/AUnknown
NCT03098641Coloplastpelvic organ prolapse repair

Smartmesh Technology in Pelvic Floor Repair Procedures

Start: May 2017Est. completion: Sep 2017272 patients
N/ACompleted
NCT02367235Intuitive SurgicalTraditional vaginal positioning device

Analysis of Procedural Times Using Colpassist for Robotic-Assisted Sacrocolpopexy; a Randomized Controlled Trial

Start: Jan 2015Est. completion: Apr 201852 patients
N/ACompleted
NCT02258230Olympus3D mode of the 3D Laparoscopic Video System

Laparoscopic Three-dimensional Versus Two-dimensional Sacral Colpopexy and Paravaginal Repair

Start: Dec 2014Est. completion: Mar 2018194 patients
N/ACompleted
NCT02162628ColoplastExair Prolapse Repair System

Exair® Versus Native Tissue Repair for Prolapse

Start: Aug 2014Est. completion: Dec 201579 patients
N/ATerminated
NCT02162615ColoplastRestorelle Direct Fix A

Restorelle® Mesh Versus Native Tissue Repair for Prolapse

Start: Aug 2014Est. completion: Nov 2021810 patients
N/ACompleted
NCT02189291Oregon TherapeuticsImmediate catheter removal

Study to Assess Duration of Indwelling Catheter After Sacrocolpopexy

Start: Jul 2014Est. completion: Dec 201872 patients
N/ACompleted
NCT02021279Integra LifeSciencesMatriStem Pelvic Floor Matrix

ACell MatriStem Pelvic Floor Matrix Versus Native Tissue Repair, Comparative Study

Start: Jun 2014Est. completion: Apr 2021161 patients
N/ACompleted

Xenform Postmarket Surveillance Study

Start: Feb 2014Est. completion: Feb 2020374 patients
N/ACompleted

Outcomes of Pelvic Surgery With and Without Anti-incontinence Procedure in Occult Stress Urinary Incontinence Patients

Start: Jan 2014Est. completion: Jan 2017196 patients
N/AUnknown
NCT01917968Boston ScientificUphold Lightweight Vaginal Support System

Uphold LITE Post-Market Surveillance Study

Start: Oct 2013Est. completion: Feb 2020289 patients
N/ACompleted
NCT03271294ColoplastExair Transvaginal Mesh

Prospective Performance Analysis of the Exair(TM) Prolapse Repair System in the Treatment of Pelvic Organ Prolapse

Start: Apr 2013Est. completion: Aug 201580 patients
N/ACompleted

Ischia Spinous Fascia Fixation Surgery for Pelvic Organ Prolapse

Start: Dec 2012Est. completion: Dec 201775 patients
N/AUnknown
NCT01670682UNION therapeuticsischia spinous fascia fixation

Ischia Spinous Fascia Fixation Procedure Versus Modified Total Pelvic Floor Reconstructive Surgery for Pelvic Organ Prolapse Stage III

Start: Aug 2012Est. completion: Aug 201680 patients
N/AUnknown

Vaginal Estrogen and Pelvic Floor Physical Therapy in Women With Symptomatic Mild Prolapse

Start: May 2012Est. completion: Mar 202321 patients
N/ATerminated

Axis™ Allograft Dermis for Female Pelvic Floor Repair: a Prospective Post Market Study

Start: Nov 2011Est. completion: Nov 201874 patients
N/ACompleted
NCT01377142Providence TherapeuticsLaparoscopic sacral hysteropexy

Vaginal Uphold Hysteropexy and Laparoscopic Sacral Hysteropexy for the Treatment of Uterovaginal Pelvic Organ Prolapse

Start: Jun 2011Est. completion: Dec 2015148 patients
N/ACompleted
NCT01618994Intuitive SurgicalPerforming robotic supracervical hysterectomy

Validation Study for Robotic Surgery Simulator

Start: Apr 2011Est. completion: Jan 201214 patients
N/ACompleted
NCT01396122UNION therapeuticsProcedure: GYNECARE PROSIMA* Pelvic Floor Repair System

Clinical Performance of GYNECARE PROSIMA* Pelvic Floor Repair System for Symptomatic Pelvic Organ Prolapse

Start: Mar 2011Est. completion: Mar 2016150 patients
N/AUnknown

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 actively recruiting trials targeting 7,080 patients
18 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.