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Patent Foramen Ovale

1
Pipeline Programs
4
Companies
6
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

3 companies ranked by most advanced pipeline stage

Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
3 programs
1
SildenafilPhase 11 trial
Does Patent Foramen Ovale Size Matter in Men and WomenN/A1 trial
PFO ClosureN/A1 trial
Active Trials
NCT03904277Completed28Est. Jan 2023
NCT03904290Unknown10Est. Dec 2024
NCT03945643Completed82Est. Jul 2023
Abbott
AbbottABBOTT PARK, IL
2 programs
Device closure with the AMPLATZER PFO OccluderN/A1 trial
Device closure with the AMPLATZER PFO OccluderN/A1 trial
Active Trials
NCT00584064Approved For Marketing
NCT00583401No Longer Available
Medtronic
MedtronicNJ - Phillipsburg
1 program
CeraFlexN/A1 trial
Active Trials
NCT02621528Completed120Est. Feb 2020

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Oregon TherapeuticsSildenafil
Oregon TherapeuticsDoes Patent Foramen Ovale Size Matter in Men and Women
Oregon TherapeuticsPFO Closure
MedtronicCeraFlex

Clinical Trials (6)

Total enrollment: 240 patients across 6 trials

NCT03945643Oregon TherapeuticsSildenafil

Is Blood Flow Through IPAVA and PFO Related to Breath-hold and SCUBA Diving-induced Pulmonary Hypertension?

Start: Jul 2019Est. completion: Jul 202382 patients
Phase 1Completed
NCT00584064AbbottDevice closure with the AMPLATZER PFO Occluder

Emergency/Compassionate Use PFO Occluder

N/AApproved For Marketing
NCT00583401AbbottDevice closure with the AMPLATZER PFO Occluder

PFO ACCESS Registry

N/ANo Longer Available
NCT03904277Oregon TherapeuticsDoes Patent Foramen Ovale Size Matter in Men and Women

Does Patent Foramen Ovale Size Matter in Men and Women

Start: Oct 2018Est. completion: Jan 202328 patients
N/ACompleted
NCT03904290Oregon TherapeuticsPFO Closure

Does Patent Foramen Ovale Closure Improve Exercise Capacity & Prevent Blood Flow Through Intrapulmonary Shunt

Start: Apr 2018Est. completion: Dec 202410 patients
N/AUnknown
NCT02621528MedtronicCeraFlex

Lifetech CeraFlex™ Post-Market Surveillance Study

Start: Oct 2015Est. completion: Feb 2020120 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.