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Overactive Bladder Syndrome

6
Pipeline Programs
11
Companies
16
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
0
0
0
4
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

10 companies ranked by most advanced pipeline stage

Sandoz
SandozAustria - Kundl
2 programs
2
DarifenacinPhase 3
DarifenacinPhase 3
Pfizer
PfizerNEW YORK, NY
2 programs
2
SPM 907Phase 31 trial
SPM 907Phase 31 trial
Active Trials
NCT00220376CompletedEst. Jul 2007
NCT00220363CompletedEst. Feb 2005
Imbrium Therapeutics
1 program
1
V117957Phase 1
Purdue Pharma
Purdue PharmaCT - Stamford
1 program
1
V117957Phase 11 trial
Active Trials
NCT06024642Completed51Est. May 2024
Axonics
AxonicsCA - Irvine
1 program
Axonics SystemN/A1 trial
Active Trials
NCT05543382Terminated31Est. Dec 2024
Takeda
TakedaTOKYO, Japan
1 program
PropiverineN/A1 trial
Active Trials
NCT02024945Completed437Est. Dec 2011
URO-1
URO-1NC - Greensboro
1 program
Repris NeedleN/A1 trial
Active Trials
NCT04982120Unknown40Est. Jul 2022
Medtronic
MedtronicNJ - Phillipsburg
1 program
Sacral neuromodulationN/A1 trial
Active Trials
NCT05313984Completed93Est. Dec 2021
Laborie
LaborieNH - Portsmouth
1 program
percutaneous tibial nerve stimulationN/A1 trial
Active Trials
NCT03559946Terminated5Est. Mar 2020
Novartis
NovartisBASEL, Switzerland
1 program
DarifenacinPHASE_35 trials
Active Trials
NCT00703703Completed117Est. Oct 2008
NCT00413790Completed162Est. Sep 2007
NCT00366002Completed500Est. Sep 2007
+2 more trials

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
NovartisDarifenacin
NovartisDarifenacin
NovartisDarifenacin
PfizerSPM 907
NovartisDarifenacin
PfizerSPM 907
NovartisDarifenacin
NovartisDarifenacin
Purdue PharmaV117957
NovartisDarifenacin
NovartisDarifenacin
AxonicsAxonics System
URO-1Repris Needle
Laboriepercutaneous tibial nerve stimulation
MedtronicSacral neuromodulation

Showing 15 of 16 trials with date data

Clinical Trials (16)

Total enrollment: 3,177 patients across 16 trials

Pharmacologic Effects of Darifenacin and Tolterodine on Cardiovascular Parameters in Healthy Subjects

Start: Nov 2006Est. completion: Sep 2007162 patients
Phase 4Completed

Patient's Perception of Treatment Outcome With Darifenacin by Patients With Overactive Bladder

Start: Jun 2006Est. completion: Sep 2007500 patients
Phase 4Completed

Efficacy, Safety, and Tolerability of Darifenacin in Patients Aged > 65 Years With Overactive Bladder

Start: Apr 2005Est. completion: Jun 2006400 patients
Phase 4Completed

Long-Term Open-Label Extension Trial for Subjects Completing the Phase 3 Trial of Fesoterodine (SP584) for the Treatment of Overactive Bladder Syndrome

Start: Apr 2004Est. completion: Jul 2007
Phase 3Completed

A 12-Week Study to Evaluate the Efficacy of Darifenacin to Increase the Warning Time in Patients With Overactive Bladder.

Start: Apr 2004Est. completion: Dec 2004445 patients
Phase 3Completed

A Multicenter Trial to Investigate Fesoterodine Sustained Release in Overactive Bladder Syndrome

Start: Jan 2004Est. completion: Feb 2005
Phase 3Completed

A Long-Term Safety, Tolerability and Efficacy Study of Darifenacin in Adult Patients With Overactive Bladder

Start: Apr 2002Est. completion: Jan 2005718 patients
Phase 3Completed

Cognitive Effects of Darifenacin and Oxybutynin Extended Release in Volunteers Aged 60 and Over

Start: Feb 2005Est. completion: May 2005150 patients
Phase 2Completed

Study of V117957 in Overactive Bladder Syndrome

Start: Jun 2022Est. completion: May 202451 patients
Phase 1Completed

Pharmacologic Effects of Darifenacin and Tolterodine on Cardiovascular Parameters in Healthy Subjects

Start: May 2008Est. completion: Oct 2008117 patients
Phase 1Completed

Study to Compare How the Body Changes the Blood Level of Darifenacin Tablet Form vs. the Modified Release Liquid Form in Healthy Subjects

Start: Jun 2006Est. completion: Sep 200728 patients
Phase 1Completed
NCT05543382AxonicsAxonics System

Cycling Study With the Axonics System

Start: Aug 2022Est. completion: Dec 202431 patients
N/ATerminated
NCT04982120URO-1Repris Needle

Use of Repris Needle in Bladder Injection

Start: Oct 2018Est. completion: Jul 202240 patients
N/AUnknown
NCT03559946Laboriepercutaneous tibial nerve stimulation

Condensed Percutaneous Tibial Nerve Stimulation (PTNS) Protocol

Start: Jun 2018Est. completion: Mar 20205 patients
N/ATerminated
NCT05313984MedtronicSacral neuromodulation

OptiLUTS Part C: the Development of a Symptom Assessment Tool in Sacral Neuromodulation.

Start: Mar 2018Est. completion: Dec 202193 patients
N/ACompleted

Efficacy, Tolerability and Impact on Quality of Life of Propiverine in Patients With Overactive Bladder Syndrome

Start: Nov 2010Est. completion: Dec 2011437 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

4 late-stage (Phase 3) programs, potential near-term approvals
11 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.