Overactive Bladder

26
Pipeline Programs
11
Companies
50
Clinical Trials
8
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
0
5
0
4
14
Early DiscoveryClinical DevelopmentMarket

On Market (8)

Approved therapies currently available

U
MIRABEGRONApproved
mirabegron
Unknown Company
oral2025
U
MYRBETRIQApproved
mirabegron
Unknown Company
beta3-Adrenergic Agonist [EPC]oral2012
U
MYRBETRIQ GRANULESApproved
mirabegron
Unknown Company
beta3-Adrenergic Agonist [EPC]oral2021
U
OXYBUTYNINApproved
oxybutynin
Unknown Company
transdermal2014
U
OXYBUTYNIN CHLORIDEApproved
oxybutynin
Unknown Company
oral2017
U
SOLIFENACIN SUCCINATEApproved
solifenacin succinate
Unknown Company
oral2022
Astellas
VESICAREApproved
solifenacin succinate
Astellas
oral2004
Astellas
VESICARE LSApproved
solifenacin succinate
Astellas
oral2020

Competitive Landscape

11 companies ranked by most advanced pipeline stage

Astellas
AstellasChina - Shenyang
15 programs
2
1
1
4
SolifenacinPhase 41 trial
SolifenacinPhase 41 trial
mirabegronPhase 41 trial
solifenacinPhase 45 trials
Solifenacin succinatePhase 31 trial
+10 more programs
Active Trials
NCT01901120Completed1,263Est. Sep 2016
NCT01919047Completed10,711Est. Jul 2014
NCT00901251Completed50Est. May 2009
+25 more trials
Pfizer
PfizerNEW YORK, NY
5 programs
2
2
DETRUSITOLPhase 41 trial
FesoterodinePhase 41 trial
SPM 907Phase 21 trial
fesoterodine fumaratePhase 24 trials
Tolterodine tartrateN/A1 trial
Active Trials
NCT01488578Completed11,157Est. Mar 2011
NCT00220389CompletedEst. Jun 2007
NCT01566760Completed24Est. Jul 2012
+5 more trials
Bayer
BayerLEVERKUSEN, Germany
3 programs
1
OxybutyninPhase 31 trial
DarifenacinN/A1 trial
Darifenacin, EmselexN/A1 trial
Active Trials
NCT00921245Completed9Est. Feb 2009
NCT00786448Completed5,821Est. Feb 2006
NCT04534491Completed855Est. Jun 2011
Teva
TevaIsrael - Petach Tikva
1 program
1
Oxybutinyn Vaginal Ring 4mgPhase 31 trial
Active Trials
NCT00782769Completed240Est. Jul 2010
LP
Lee's PharmaceuticalChina - Guangzhou
1 program
1
Propiverine HydrochloridePhase 31 trial
Active Trials
NCT01512004Completed324Est. Aug 2011
Ipsen
IpsenChina - Tianjin
1 program
1
Botulinum toxin type APhase 21 trial
Active Trials
NCT00578097Terminated81Est. Dec 2009
Ferring Pharmaceuticals
Ferring PharmaceuticalsArgentina - Buenos Aires
1 program
1
Tolterodine tartrate extended release capsulesPhase 21 trial
Active Trials
NCT01729819Completed106Est. Nov 2014
M&
Merck & Co.RAHWAY, NJ
1 program
1
Vibegron 100 mgPhase 11 trial
Active Trials
NCT01628042Completed32Est. Jan 2013
Amber Therapeutics
2 programs
Amber UI SystemN/A1 trial
Picostim AmberN/A1 trial
Active Trials
NCT05241379CompletedEst. Apr 2024
NCT05256498WithdrawnEst. Dec 2022
Fempulse
1 program
FemPulse SystemN/A1 trial
Active Trials
NCT06347380CompletedEst. Jul 2025
BlueWind Medical
BlueWind MedicalIsrael - Herzliya
1 program
The RENOVA tibial nerve stimulation systemN/A1 trial
Active Trials
NCT03019094WithdrawnEst. Dec 2018

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
PfizerFesoterodine
AstellasVesicare
Astellassolifenacin
Astellasmirabegron
Astellassolifenacin
Astellassolifenacin
Astellassolifenacin
Astellassolifenacin
Astellassolifenacin
Astellassolifenacin
Astellassolifenacin
Astellassolifenacin
AstellasSolifenacin
Astellassolifenacin
AstellasSolifenacin

Showing 15 of 49 trials with date data

Clinical Trials (50)

Total enrollment: 12,606 patients across 50 trials

NCT03946124PfizerFesoterodine

Fall Prevention in Older Adults With OAB

Start: Jul 2015Est. completion: Jul 201774 patients
Phase 4Completed

VESIcare For Improving OAB Symptoms in Patients Undergoing IGRT of the Prostate

Start: Feb 2013Est. completion: Jan 20148 patients
Phase 4Terminated

Post Marketing Study to Evaluate the Efficacy and Safety of Solifenacin in Patients With OAB (Overactive Bladder) After TURP (Trans-urethral Resection of Prostate) or PVP (Photoselective Vaporization of Prostate)

Start: Dec 2012Est. completion: Oct 201368 patients
Phase 4Completed

A Study to Evaluate the Effect of Mirabegron + Solifenacin in Overactive Bladder Patients

Start: Oct 2012Est. completion: Jul 2013223 patients
Phase 4Completed

Incontinence & Intimate Partners: Assessing the Contribution of Treatment

Start: Mar 2012Est. completion: Jun 2017138 patients
Phase 4Completed

Therapy of the Overactive Bladder Syndrome

Start: Jan 2012Est. completion: Mar 201566 patients
Phase 4Completed

Effectiveness and Safety Study of Solifenacin Succinate and Solifenacin Succinate + Estrogen to Treat OAB in Postmenopausal Women

Start: Oct 2011Est. completion: Oct 2013200 patients
Phase 4Completed

Pilot Trial Of Urinary Nerve Growth Factor (NGF) As Biomarker for Male Lower Urinary Tract Symptoms

Start: Oct 2011Est. completion: Jul 201410 patients
Phase 4Completed

A Study to Assess Efficacy and Safety With Solifenacin Succinate to Improve Urinary Continence After Robotic Assisted Radical Prostatectomy

Start: Aug 2011Est. completion: Oct 2013640 patients
Phase 4Completed

A Study to Compare Two Medications With an Inactive Medication and Look at the Effect on a Person's Mental Ability

Start: Apr 2010Est. completion: Dec 201026 patients
Phase 4Completed

A Study to Evaluate Response of Over Active Bladder Symptom Score to Solifenacin Treatment

Start: Apr 2010Est. completion: Sep 2011100 patients
Phase 4Completed

Study of 2 Doses of Solifenacin Succinate in Female Subjects With Overactive Bladder.

Start: Jan 2010Est. completion: Jun 2011547 patients
Phase 4Completed

Reproducibility Study of OABSS and Its Response to Treatment

Start: Sep 2009Est. completion: May 201350 patients
Phase 4Completed

Solifenacin Flexible Dosing Study in Frequent Micturition Patients With and Without Urgency

Start: Apr 2009Est. completion: Jun 2010291 patients
Phase 4Completed

A Study to Evaluate Add on Effect of Solifenacin in Men With Overactive Bladder Symptoms After Tamsulosin Monotherapy for 4 Weeks

Start: Mar 2009Est. completion: Dec 2010307 patients
Phase 4Completed

Clinical Study of Solifenacin Succinate in Patients With Bladder Symptoms Due to Spinal Cord Injury or Multiple Sclerosis

Start: Mar 2008Est. completion: Jan 2011249 patients
Phase 4Completed

Study of VESIcare® In Overactive Bladder (OAB) Subjects to Evaluate Symptom Bother and Health Related Quality of Life

Start: Aug 2007Est. completion: Jul 2008768 patients
Phase 4Completed

Study to Compare the Safety and Efficacy of Solifenacin With Oxybutynin for the Treatment of Overactive Bladder (VECTOR)

Start: Dec 2006Est. completion: Feb 2008132 patients
Phase 4Completed

A Study of Solifenacin With Bladder Training Versus Solifenacin Alone in Patients With Overactive Bladder (SOLAR)

Start: May 2006Est. completion: May 2007643 patients
Phase 4Completed

Assessing the OAB-8 Questionnaire as a Tool to Measure Treatment Outcome

Start: Feb 2006Est. completion: Mar 2006100 patients
Phase 4Unknown
NCT00189800AstellasSolifenacin succinate

A Study of Solifenacin Succinate Compared to Tolterodine in Patients With Overactive Bladder

Phase 3Completed

A Clinical Study to Investigate How Solifenacin Fluid is Taken up, How Long it Stays in the Body and How Effective and Safe it is in Treating Children Aged From 6 Months to Less Than 5 Years With Symptoms of Neurogenic Detrusor Overactivity (NDO)

Start: Sep 2013Est. completion: Dec 201523 patients
Phase 3Completed

A Study to Investigate How Safe and Effective Solifenacin Solution is in Treating Children/Adolescents With Symptoms of Overactive Bladder (OAB) Who Completed Study 905-CL-076

Start: Oct 2012Est. completion: Oct 2014148 patients
Phase 3Completed

A Study to Assess the Long Term Effect, Safety and Metabolism of a Solifenacin Liquid Suspension in Participants 5 to 18 Years of Age With Neurogenic Detrusor Overactivity

Start: Aug 2012Est. completion: Apr 201676 patients
Phase 3Completed

Study to Gather Information About the Actual Use of an Adhesive Patch Placed on the Skin to Deliver Oxytrol Through the Skin Into the Bloodstream.

Start: May 2010Est. completion: Jun 2011855 patients
Phase 3Completed
NCT01512004Lee's PharmaceuticalPropiverine Hydrochloride

Propiverine Hydrochloride Extended-Release Capsule for Overactive Bladder

Start: Jan 2010Est. completion: Aug 2011324 patients
Phase 3Completed

A Long-term Study of YM178 in Symptomatic Overactive Bladder Patients

Start: Dec 2008Est. completion: Mar 2010204 patients
Phase 3Completed
NCT00782769TevaOxybutinyn Vaginal Ring 4mg

A Safety Extension Study of DR-OXY-301

Start: Sep 2008Est. completion: Jul 2010240 patients
Phase 3Completed
NCT00658684Pfizerfesoterodine fumarate

Long Term Study To Evaluate the Safety, Tolerability and Efficacy of Fesoterodine for Overactive Bladder.

Start: Feb 2008Est. completion: Aug 2009153 patients
Phase 3Completed
NCT00425100Pfizerfesoterodine fumarate

A Clinical Trial To Assess Fesoterodine On Treatment Satisfaction And Symptom Improvement In Overactive Bladder Patients

Start: Jan 2007Est. completion: Oct 2007516 patients
Phase 3Completed

Behavioral Modification and Vesicare Versus Vesicare Alone for Urge Incontinence in Patients With Overactive Bladder

Start: Sep 2006Est. completion: Sep 200812 patients
Phase 3Terminated

A Double-Blind, Paralleled Study Comparing Efficacy/Safety of Solifenacin to Tolterodine in Overactive Bladder Patients

Start: Sep 2006Est. completion: Mar 2008246 patients
Phase 3Completed

Efficacy & Safety Study of VESIcare® (Solifenacin Succinate) in Patients Wishing to Switch From Detrol LA® for Treatment of Overactive Bladder

Start: Jun 2004Est. completion: Aug 2005441 patients
Phase 3Completed

A Multicenter VESIcare® Efficacy and Safety Study for the Treatment of Urgency Associated With Overactive Bladder (OAB)

Start: May 2004Est. completion: Sep 2005739 patients
Phase 3Completed

Solifenacin Succinate Versus Tolterodine 4mg Once Daily

Start: Jul 2003Est. completion: Oct 20041,355 patients
Phase 3Completed

A Study of YM178 in Patients With Symptomatic Overactive Bladder (DRAGON)

Est. completion: Mar 20071,108 patients
Phase 2Completed
NCT01729819Ferring PharmaceuticalsTolterodine tartrate extended release capsules

Interventional Clinical Trial in Patients in Overactive Bladder With Nocturia in Women

Start: Jan 2013Est. completion: Nov 2014106 patients
Phase 2Completed

Bacterial Genomic Sequencing in Overactive Bladder

Start: Jul 2012Est. completion: Aug 2014134 patients
Phase 2Completed
NCT00578097IpsenBotulinum toxin type A

Efficacy and Safety Study of Botulinum Toxin Type-A (Dysport®) in Continent Female Subjects Suffering From Idiopathic Overactive Bladder

Start: Feb 2008Est. completion: Dec 200981 patients
Phase 2Terminated
NCT00561951Pfizerfesoterodine fumarate

Dose-Finding Study To Evaluate The Efficacy, Tolerability And Safety Of Fesoterodine In Comparison To Placebo For Overactive Bladder.

Start: Nov 2007Est. completion: Jan 2009951 patients
Phase 2Completed

Two Phase Extension Trial of SP668 to Investigate the Safety and Tolerability of Sustained Release Fesoterodine in Subjects With Overactive Bladder: a Double-Blind Phase Followed by an Open-Label Extension Phase

Start: Jun 2003Est. completion: Jun 2007
Phase 2Completed

A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Mirabegron Oral Suspension in Pediatric Subjects From 3 to Less Than 12 Years of Age With Neurogenic Detrusor Overactivity (NDO) or Overactive Bladder (OAB)

Start: Dec 2015Est. completion: Sep 20169 patients
Phase 1Completed
NCT01628042Merck & Co.Vibegron 100 mg

A Single Dose Study of the Pharmacokinetics of Vibegron (MK-4618) in Participants With Renal Insufficiency (MK-4618-014)

Start: Jul 2012Est. completion: Jan 201332 patients
Phase 1Completed
NCT01566760Pfizerfesoterodine fumarate

A Study To Estimate The Effects Of Food On Drug Fesoterodine Fumarate And The Pharmacokinetics Of 5-Hydroxymethyl Tolterodine (5-HMT) In Healthy Volunteers

Start: May 2012Est. completion: Jul 201224 patients
Phase 1Completed

Single Dose Study to Measure Blood Levels and Safety of a Drug for Children With Overactive Bladder

Start: Mar 2012Est. completion: Aug 201214 patients
Phase 1Completed

Single-dose Study to Assess Pharmacokinetics of Solifenacin Succinate Suspension in Children and Adolescents

Start: Oct 2010Est. completion: Aug 201142 patients
Phase 1Completed

A Study to Evaluate How Tamsulosin (at 1 Dose) and Solifenacin (at 2 Different Doses) Are Taken up From the Intestine, Distributed Through the Body and Eliminated From the Body When Administered in Combination as a Single Tablet (Called EC905)

Start: Apr 2010Est. completion: Jul 201027 patients
Phase 1Completed

A Study to Evaluate Whether Food Has an Effect on the Uptake of Solifenacin and Tamsulosin When Administered in a Combination Tablet

Start: Apr 2010Est. completion: Jun 201052 patients
Phase 1Completed

A Study to Compare the Amount of Drug in the Blood After a Single Tablet EC905 Containing Solifenacin and Tamsulosin is Taken by Healthy Males Compared to Separate Tablets of Solifenacin and Tamsulosin

Start: Mar 2010Est. completion: Jul 201030 patients
Phase 1Completed

Relative Bioavailability Study of Solifenacin Succinate Liquid Suspension (Fed and Fasting) Versus VESIcare Tablet (Fasting) in Healthy Volunteers

Start: Sep 2009Est. completion: Nov 200924 patients
Phase 1Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

4 late-stage (Phase 3) programs — potential near-term approvals
11 companies competing in this space