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Out-Of-Hospital Cardiac Arrest

1
Pipeline Programs
16
Companies
16
Clinical Trials
3 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
0
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

16 companies ranked by most advanced pipeline stage

Chiesi
ChiesiBrazil - Santana de Parnaíba
1 program
1
Cangrelor 50 MGPhase 41 trial
Active Trials
NCT04005729Completed30Est. Nov 2021
Zoll
ZollCA - San Jose
4 programs
AMSAN/A1 trial
Audiovisual FeedbackN/A1 trial
Automated External DefibrillatorN/A1 trial
Target Temperature Management of 34°CN/A1 trial
Active Trials
NCT03237910Terminated31Est. Jul 2021
NCT01258244Completed101Est. Feb 2015
NCT04446585Recruiting260Est. Jan 2027
+1 more trials
PEEL Therapeutics
PEEL TherapeuticsUT - Salt Lake City
2 programs
Double Sequential DefibrillationN/A
ER-REBOA catheterN/A1 trial
Active Trials
NCT06071910RecruitingEst. Dec 2026
Guardian Therapeutics
Guardian TherapeuticsMA - Lexington
1 program
Audiovisual FeedbackN/A
Defence Therapeutics
Defence TherapeuticsBC - Vancouver
1 program
CarbonCool® Cooling VestN/A1 trial
Active Trials
NCT07421882Not Yet Recruiting50Est. Mar 2027
Egle Therapeutics
Egle TherapeuticsFrance - Paris
1 program
Dispatcher protocol changeN/A1 trial
Active Trials
NCT04784117CompletedEst. Dec 2022
EMS
EMSBrazil - Hortolândia
1 program
Double Sequential DefibrillationN/A1 trial
Active Trials
NCT04080986Completed405Est. Aug 2022
Response Pharmaceuticals
Response PharmaceuticalsVA - Falls Church
1 program
Fluxmed GrH portable pneumotachographN/A1 trial
Active Trials
NCT04237727Completed241Est. Dec 2025
Berlin Heart
Berlin HeartTX - The Woodlands
1 program
German Cardiac Arrest RegistryN/A
Eppendorf
EppendorfGermany - Hamburg
1 program
German Cardiac Arrest RegistryN/A1 trial
Active Trials
NCT05142124Recruiting400Est. Jun 2027
Orion Pharma
Orion PharmaUK - Reading
1 program
Low normal PaCO2N/A
Orion
OrionUK - Cambridge
1 program
Low normal PaCO2N/A1 trial
Active Trials
NCT02698917Completed123Est. May 2018
Masimo
MasimoIRVINE, CA
1 program
ORI measurementN/A1 trial
Active Trials
NCT03653325Completed100Est. Jan 2022
Nielsen BioSciences
Nielsen BioSciencesCA - San Diego
1 program
Target temperature 36°CN/A1 trial
Active Trials
NCT01020916Completed950Est. Jul 2013
Integrated Biosciences
Integrated BiosciencesCA - San Carlos
1 program
Targeted temperature management to 33°CN/A1 trial
Active Trials
NCT02908308Completed1,900Est. Dec 2022
One Biosciences
One BiosciencesFrance - Paris
1 program
Rapid infusion of 2 liters of 4oC normal salinePHASE_2_31 trial
Active Trials
NCT00391469CompletedEst. Aug 2013

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
ChiesiCangrelor 50 MG
One BiosciencesRapid infusion of 2 liters of 4oC normal saline
Defence TherapeuticsCarbonCool® Cooling Vest
PEEL TherapeuticsER-REBOA catheter
ZollAutomated External Defibrillator
EppendorfGerman Cardiac Arrest Registry
EMSDouble Sequential Defibrillation
Response PharmaceuticalsFluxmed GrH portable pneumotachograph
ZollAMSA
MasimoORI measurement
Integrated BiosciencesTargeted temperature management to 33°C
OrionLow normal PaCO2
Egle TherapeuticsDispatcher protocol change
ZollTarget Temperature Management of 34°C
ZollAudiovisual Feedback

Showing 15 of 16 trials with date data

Clinical Trials (16)

Total enrollment: 4,741 patients across 16 trials

NCT04005729ChiesiCangrelor 50 MG

Cangrelor in Comatose Survivors of OHCA Undergoing Primary PCI

Start: Jul 2019Est. completion: Nov 202130 patients
Phase 4Completed
NCT00391469One BiosciencesRapid infusion of 2 liters of 4oC normal saline

Induction of Mild Hypothermia Following Out-of-hospital Cardiac Arrest

Start: Dec 2007Est. completion: Aug 2013
Phase 2/3Completed
NCT07421882Defence TherapeuticsCarbonCool® Cooling Vest

PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE)

Start: Feb 2026Est. completion: Mar 202750 patients
N/ANot Yet Recruiting
NCT06071910PEEL TherapeuticsER-REBOA catheter

Emergency Resuscitative Endovascular Balloon Occlusion of the Aorta in Out of Hospital Cardiac Arrest

Start: Jun 2024Est. completion: Dec 2026
N/ARecruiting
NCT04446585ZollAutomated External Defibrillator

Cardiac Arrest in Residential Areas With Mobile First-responder Activation

Start: Dec 2021Est. completion: Jan 2027260 patients
N/ARecruiting
NCT05142124EppendorfGerman Cardiac Arrest Registry

German Cardiac Arrest Registry

Start: Jul 2021Est. completion: Jun 2027400 patients
N/ARecruiting
NCT04080986EMSDouble Sequential Defibrillation

DOuble SEquential External Defibrillation for Refractory VF

Start: Sep 2019Est. completion: Aug 2022405 patients
N/ACompleted
NCT04237727Response PharmaceuticalsFluxmed GrH portable pneumotachograph

CAvent-Ventilation During Advanced Cardiopulmonary Resuscitation in Out-of-hospital Cardiac Arrest- an Observational Study

Start: May 2019Est. completion: Dec 2025241 patients
N/ACompleted
NCT03237910ZollAMSA

Real Time Amplitude Spectrum Area to Guide Defibrillation

Start: Apr 2019Est. completion: Jul 202131 patients
N/ATerminated
NCT03653325MasimoORI measurement

ORI to Reduce Hyperoxia After Out Hospital Cardiac Arrest

Start: Nov 2018Est. completion: Jan 2022100 patients
N/ACompleted
NCT02908308Integrated BiosciencesTargeted temperature management to 33°C

Targeted Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest

Start: Nov 2017Est. completion: Dec 20221,900 patients
N/ACompleted
NCT02698917OrionLow normal PaCO2

Carbon Dioxide, Oxygen and Mean Arterial Pressure After Cardiac Arrest and Resuscitation

Start: Mar 2016Est. completion: May 2018123 patients
N/ACompleted
NCT04784117Egle TherapeuticsDispatcher protocol change

Out-of-hospital Cardiac Arrest Epidemiology and Outcomes in Kaunas 2016-2021

Start: Jan 2016Est. completion: Dec 2022
N/ACompleted
NCT02035839ZollTarget Temperature Management of 34°C

Finding the Optimal Cooling tempeRature After Out-of-HoSpiTal Cardiac Arrest

Start: Mar 2014Est. completion: Apr 2016150 patients
N/ACompleted
NCT01258244ZollAudiovisual Feedback

Arizona Prehospital CPR Quality Improvement Project

Start: Dec 2010Est. completion: Feb 2015101 patients
N/ACompleted
NCT01020916Nielsen BioSciencesTarget temperature 36°C

Target Temperature Management After Cardiac Arrest

Start: Nov 2010Est. completion: Jul 2013950 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

3 actively recruiting trials targeting 4,741 patients
16 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.