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Osteoarthritis of the Knee

28
Pipeline Programs
30
Companies
39
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
0
12
0
11
2
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

28 companies ranked by most advanced pipeline stage

Chong Kun Dang Pharmaceutical
2 programs
2
ImotunPhase 41 trial
Imotun capsulePhase 41 trial
Active Trials
NCT01756937Completed287Est. Feb 2017
NCT01743287Completed234Est. Apr 2015
Apimeds
ApimedsMATAWAN, NJ
2 programs
2
Apitox, purified honeybee toxin, lyophilized in salinePhase 31 trial
honeybee venomPhase 31 trial
Active Trials
NCT01112722Completed363Est. Dec 2016
NCT00949754Completed40Est. Apr 2010
Shionogi
ShionogiJapan - Osaka
2 programs
2
DuloxetinePhase 3
DuloxetinePhase 3
Prevail Therapeutics
2 programs
2
DuloxetinePhase 3
DuloxetinePhase 3
Seikagaku
SeikagakuJapan - Ibaraki
2 programs
2
Gel-200Phase 31 trial
Gel-200Phase 31 trial
Active Trials
NCT00450112Completed202Est. Jun 2009
NCT00449696Completed379Est. Dec 2007
Anika Therapeutics
Anika TherapeuticsMA - Bedford
1 program
1
CingalPhase 31 trial
Active Trials
NCT02381652Completed242Est. May 2015
Sandoz
SandozAustria - Kundl
1 program
1
Diclofenac Sodium GelPhase 3
Medtronic
MedtronicNJ - Phillipsburg
1 program
1
PennsaidPhase 31 trial
Active Trials
NCT01511939Completed22Est. May 2013
Stryker
StrykerCA - San Jose
6 programs
2
1
Bone morphogenetic protein 7Phase 21 trial
Bone morphogenetic protein 7Phase 11 trial
Intra-articular Injection of OP-1 to affected kneePhase 11 trial
Flex IM rodN/A1 trial
Stryker Triathlon Tritanium primary kneeN/A1 trial
+1 more programs
Active Trials
NCT02543489Unknown100Est. Sep 2019
NCT02373761Unknown27
NCT02552095Completed63Est. Sep 2018
+3 more trials
Pfizer
PfizerNEW YORK, NY
2 programs
1
ADL5859Phase 21 trial
MeloxicamN/A1 trial
Active Trials
NCT01430559Completed408Est. Mar 2013
NCT00979953Completed408Est. Jun 2010
Noven Pharmaceuticals
2 programs
1
1
Diclofenac Sodium Active Topical Patch 1Phase 21 trial
HP-5000 Topical PatchPhase 11 trial
Active Trials
NCT04882319Completed200Est. Mar 2022
NCT03277066Completed289Est. Sep 2019
Abbott
AbbottABBOTT PARK, IL
2 programs
2
ABT-652Phase 21 trial
ABT-652 NSAIDPhase 21 trial
Active Trials
NCT01207115Completed322Est. May 2011
NCT01444365Completed202Est. Apr 2012
AbbVie
AbbVieNORTH CHICAGO, IL
2 programs
2
ABT-652Phase 2
ABT-652 NSAIDPhase 2
Astellas
AstellasChina - Shenyang
1 program
1
ASP7962Phase 21 trial
Active Trials
NCT02611466Completed215Est. Sep 2017
Can-Fite BioPharma
Can-Fite BioPharmaIsrael - Petach Tikva
1 program
1
CF101Phase 21 trial
Active Trials
NCT00837291Withdrawn0Est. Jan 2019
Centrexion Therapeutics
1 program
1
CNTX-4975Phase 21 trial
Active Trials
NCT00667654Completed54Est. Aug 2016
Olatec Therapeutics
Olatec TherapeuticsNY - New York
1 program
1
OLT1177 GelPhase 21 trial
Active Trials
NCT01768975Completed79Est. Aug 2013
Helixmith
HelixmithKorea - Seoul
1 program
1
PG201Phase 21 trial
Active Trials
NCT01122485Withdrawn0Est. Sep 2009
restor3d
restor3dNC - Durham
3 programs
Total Knee ArthroplastyN/A1 trial
Total knee arthroplasty patientsN/A1 trial
iTotal G2 CR Knee Replacement SystemN/A1 trial
Active Trials
NCT02079493Terminated40Est. May 2015
NCT02228538Terminated7Est. Sep 2016
NCT01820650Terminated359Est. Oct 2023
Avanos Medical
Avanos MedicalBelgium - Zavantem
2 programs
Cooled RadiofrequencyN/A1 trial
Cooled RadiofrequencyN/A1 trial
Active Trials
NCT03381248Completed177Est. Jul 2020
NCT04145011Completed153Est. Oct 2022
Regeneron
RegeneronTARRYTOWN, NY
2 programs
REGN475PHASE_1_2
REGN5069PHASE_21 trial
Active Trials
NCT03956550Terminated259Est. Oct 2020
Ferring Pharmaceuticals
Ferring PharmaceuticalsArgentina - Buenos Aires
2 programs
1.2% Sodium HyaluronatePHASE_31 trial
Sodium hyaluronatePHASE_41 trial
Active Trials
NCT00988091Completed596Est. Apr 2011
NCT00422643Unknown60Est. Oct 2007
Zimmer Biomet
Zimmer BiometFL - Jacksonville
1 program
InstrumentN/A1 trial
Active Trials
NCT01072019Completed25Est. May 2014
Spire Therapeutics
Spire TherapeuticsUT - Salt Lake City
1 program
Knee Osteoarthritis Risk in Retired Professional FootballersN/A1 trial
Active Trials
NCT02098044Unknown1,300Est. Dec 2018
Medacta
MedactaSwitzerland - Castel San Pietro
1 program
Multicentre GMK UNI Anatomical Cementless Study - FRN/A1 trial
Active Trials
NCT06715917Active Not Recruiting249Est. Mar 2032
Nektar Therapeutics
Nektar TherapeuticsSAN FRANCISCO, CA
1 program
NKTR-181PHASE_21 trial
Active Trials
NCT01619839Completed296Est. Sep 2013
Teva
TevaIsrael - Petach Tikva
1 program
TV-45070PHASE_21 trial
Active Trials
NCT02068599Completed389Est. May 2015
Biosplice Therapeutics
1 program
LorecivivintPHASE_31 trial
Active Trials
NCT04931667Terminated72Est. Dec 2021

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Chong Kun Dang PharmaceuticalImotun
Chong Kun Dang PharmaceuticalImotun capsule
Ferring PharmaceuticalsSodium hyaluronate
Biosplice TherapeuticsLorecivivint
Anika TherapeuticsCingal
ApimedsApitox, purified honeybee toxin, lyophilized in saline
MedtronicPennsaid
Ferring Pharmaceuticals1.2% Sodium Hyaluronate
SeikagakuGel-200
SeikagakuGel-200
RegeneronREGN5069
Can-Fite BioPharmaCF101
Noven PharmaceuticalsDiclofenac Sodium Active Topical Patch 1
AstellasASP7962
TevaTV-45070

Showing 15 of 39 trials with date data

Clinical Trials (39)

Total enrollment: 8,557 patients across 39 trials

Efficacy and Safety of Imotun Capsule in Osteoarthritis of the Knee

Start: Jan 2013Est. completion: Feb 2017287 patients
Phase 4Completed

The Study to Evaluate Efficacy and Safety of Imotun Capsule in Osteoarthritis of the Knee

Start: Dec 2012Est. completion: Apr 2015234 patients
Phase 4Completed

The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator

Start: Mar 2007Est. completion: Oct 200760 patients
Phase 4Unknown

3-year, Open-Label Study Evaluating Safety, Tolerability, and Efficacy of Lorecivivint in Knee Osteoarthritis

Start: Jul 2021Est. completion: Dec 202172 patients
Phase 3Terminated

Repeat Injection of Cingal® for Osteoarthritis of the Knee

Start: Feb 2015Est. completion: May 2015242 patients
Phase 3Completed
NCT01112722ApimedsApitox, purified honeybee toxin, lyophilized in saline

Apitox, Honeybee Toxin for Pain and Inflammation of Osteoarthritis

Start: Dec 2013Est. completion: Dec 2016363 patients
Phase 3Completed

Trial to See if Topical Pennsaid for Knee Pain Affects Coagulation Values in Patients Who Are Also Taking Anticoagulants

Start: Feb 2012Est. completion: May 201322 patients
Phase 3Completed
NCT00988091Ferring Pharmaceuticals1.2% Sodium Hyaluronate

Investigation of 1.2% Sodium Hyaluronate for Treatment of Painful Chronic Osteoarthritis of the Knee

Start: Sep 2009Est. completion: Apr 2011596 patients
Phase 3Completed

Gel-200 Extension and Open-Label Study in Osteoarthritis of the Knee

Start: Mar 2007Est. completion: Jun 2009202 patients
Phase 3Completed

Gel-200 Versus Placebo in Osteoarthritis of the Knee

Start: Sep 2006Est. completion: Dec 2007379 patients
Phase 3Completed

A Study to Examine the Efficacy and Safety of REGN5069 in Patients With Pain Due to Osteoarthritis of the Knee

Start: May 2019Est. completion: Oct 2020259 patients
Phase 2Terminated

A Study of the Efficacy and Safety of CF101 to Patients With Osteoarthritis of the Knee

Start: Nov 2018Est. completion: Jan 20190
Phase 2Withdrawn
NCT03277066Noven PharmaceuticalsDiclofenac Sodium Active Topical Patch 1

A 4-week Study to Evaluate the Efficacy and Safety of HP-5000 in Subjects With Knee Osteoarthritis

Start: Sep 2017Est. completion: Sep 2019289 patients
Phase 2Completed

A Study to Assess the Analgesic Efficacy of ASP7962 in Patients With Pain Due to Osteoarthritis of the Knee

Start: Feb 2016Est. completion: Sep 2017215 patients
Phase 2Completed

A Study to Evaluate the Safety and Efficacy of Topically Applied TV-45070 (Ointment) in Participants With Primary Osteoarthritis (OA) Affecting a Single Knee

Start: Apr 2014Est. completion: May 2015389 patients
Phase 2Completed

Phase 2 Efficacy Trial of OLT1177 Gel in Subjects With Moderate to Severe Pain Associated With OA of the Knee

Start: Jan 2013Est. completion: Aug 201379 patients
Phase 2Completed

A Phase 2 Study To Assess The Efficacy, Tolerability, And Safety OF NKTR-181 In Subjects With Chronic OA Knee Pain

Start: Jun 2012Est. completion: Sep 2013296 patients
Phase 2Completed
NCT01444365AbbottABT-652 NSAID

A Study of ABT-652 in Combination With a Nonsteroidal Anti-Inflammatory Drug (NSAID) in Adults With Osteoarthritis Pain of the Knee

Start: Oct 2011Est. completion: Apr 2012202 patients
Phase 2Completed

A Study of ABT-652 in Adults With Osteoarthritis Pain of the Knee

Start: Sep 2010Est. completion: May 2011322 patients
Phase 2Completed
NCT01111045StrykerBone morphogenetic protein 7

Dose Finding Study of Bone Morphogenetic Protein 7 (BMP-7) in Subjects With Osteoarthritis (OA) of the Knee

Start: Apr 2010Est. completion: Aug 2011355 patients
Phase 2Completed
NCT00949754Apimedshoneybee venom

Apitox, Honeybee Venom Treatment for Osteoarthritis Pain and Inflammation

Start: Oct 2009Est. completion: Apr 201040 patients
Phase 2Completed

Efficacy and Safety Study Evaluating ADL5859 and ADL5747 in Participants With Pain Due to Osteoarthritis of the Knee

Start: Oct 2009Est. completion: Jun 2010408 patients
Phase 2Completed

Safety and Tolerability of 4975 in the Treatment of Moderate to Severe Knee Pain Due to Osteoarthritis (OA)

Start: Aug 2007Est. completion: Aug 201654 patients
Phase 2Completed

Efficacy and Safety Study of PG201 Tablet in Patients With Osteoarthritis

Start: Dec 2006Est. completion: Sep 20090
Phase 2Withdrawn

Irritation and Sensitization Study of HP-5000 Topical System

Start: Jun 2021Est. completion: Mar 2022200 patients
Phase 1Completed
NCT01133613StrykerBone morphogenetic protein 7

Double-Blind, Randomized, Single Dose Escalation Safety Study of Intraarticular Bone Morphogenic Protein (38A BMP-7) in Subjects With Osteoarthritis (OA) of the Knee

Start: May 2010Est. completion: Oct 201151 patients
Phase 1Completed
NCT00456157StrykerIntra-articular Injection of OP-1 to affected knee

A Phase 1, Double-Blind, Randomized, Single Dose Escalation Safety Study of Intra-articular OP-1 in Subjects With Osteoarthritis of the Knee

Start: Mar 2007Est. completion: Nov 200833 patients
Phase 1Completed
NCT04145011Avanos MedicalCooled Radiofrequency

Coolief Cooled Radiofrequency vs. Conventional Radiofrequency to Manage OA Knee Pain

Start: Oct 2019Est. completion: Oct 2022153 patients
N/ACompleted
NCT03381248Avanos MedicalCooled Radiofrequency

Cooled Radiofrequency vs. Hyaluronic Acid to Manage Knee Pain

Start: Dec 2017Est. completion: Jul 2020177 patients
N/ACompleted
NCT06715917MedactaMulticentre GMK UNI Anatomical Cementless Study - FR

Multicentre GMK UNI Anatomical Cementless Study - FR

Start: Mar 2017Est. completion: Mar 2032249 patients
N/AActive Not Recruiting
NCT02373761StrykerStryker Triathlon Tritanium primary knee

A Prospective Radiostereometric Analysis (RSA) and Clinical Evaluation of the Triathlon Tritanium Total Knee Replacement

Start: Feb 201527 patients
N/AUnknown
NCT02098044Spire TherapeuticsKnee Osteoarthritis Risk in Retired Professional Footballers

Knee Osteoarthritis Risk in Retired Professional Footballers

Start: Nov 2014Est. completion: Dec 20181,300 patients
N/AUnknown
NCT02079493restor3dTotal Knee Arthroplasty

Prospective Functional Outcome Study of the Knee

Start: Jan 2014Est. completion: May 201540 patients
N/ATerminated
NCT02228538restor3dTotal knee arthroplasty patients

Total Knee Arthroplasty Functional Outcomes Study Research Design

Start: Oct 2013Est. completion: Sep 20167 patients
N/ATerminated
NCT02552095StrykerTriathlon PKR

Triathlon PKR Study in Japan

Start: Jun 2013Est. completion: Sep 201863 patients
N/ACompleted
NCT01820650restor3diTotal G2 CR Knee Replacement System

A Prospective, Multicenter Study to Evaluate the ConforMIS iTotal® (CR) Knee Replacement System

Start: Feb 2013Est. completion: Oct 2023359 patients
N/ATerminated

Flex Intramedullary Rod Study

Start: Dec 2012Est. completion: Sep 2019100 patients
N/AUnknown

Effect Of Meloxicam Versus Placebo In Mainland Chinese Patients With Osteoarthritis Of The Knee

Start: Oct 2011Est. completion: Mar 2013408 patients
N/ACompleted

A Randomized Prospective Trial of Total Knee Arthroplasty Options Comparing Standard Knee Cutting Guides and MRI Generated Patient Specific Custom Cutting Guides

Start: Mar 2010Est. completion: May 201425 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

11 late-stage (Phase 3) programs, potential near-term approvals
30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.