Osteoarthritis of the Knee

13
Pipeline Programs
11
Companies
11
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
1
7
0
4
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

10 companies ranked by most advanced pipeline stage

Ferring Pharmaceuticals
Ferring PharmaceuticalsArgentina - Buenos Aires
2 programs
1
1
Sodium hyaluronatePhase 41 trial
1.2% Sodium HyaluronatePhase 31 trial
Active Trials
NCT00988091Completed596Est. Apr 2011
NCT00422643Unknown60Est. Oct 2007
Apimeds
ApimedsMATAWAN, NJ
2 programs
1
1
Apitox, purified honeybee toxin, lyophilized in salinePhase 31 trial
honeybee venomPhase 21 trial
Active Trials
NCT00949754CompletedEst. Apr 2010
NCT01112722CompletedEst. Dec 2016
Anika Therapeutics
Anika TherapeuticsMA - Bedford
1 program
1
CingalPhase 31 trial
Active Trials
NCT02381652CompletedEst. May 2015
BT
1 program
1
LorecivivintPhase 31 trial
Active Trials
NCT04931667TerminatedEst. Dec 2021
Regeneron
RegeneronTARRYTOWN, NY
2 programs
1
1
REGN5069Phase 21 trial
REGN475Phase 1/2
Active Trials
NCT03956550Terminated259Est. Oct 2020
AbbVie
AbbVieNORTH CHICAGO, IL
2 programs
2
ABT-652Phase 2
ABT-652 NSAIDPhase 2
Pfizer
PfizerNEW YORK, NY
1 program
1
ARRY-371797, p38 inhibitor; oralPhase 21 trial
Active Trials
NCT01366014Completed157Est. Jun 2012
Nektar Therapeutics
Nektar TherapeuticsSAN FRANCISCO, CA
1 program
1
NKTR-181Phase 21 trial
Active Trials
NCT01619839CompletedEst. Sep 2013
Teva
TevaIsrael - Petach Tikva
1 program
1
TV-45070Phase 21 trial
Active Trials
NCT02068599Completed389Est. May 2015
Medacta
MedactaSwitzerland - Castel San Pietro
1 program
Multicentre GMK UNI Anatomical Cementless Study - FRN/A1 trial
Active Trials
NCT06715917Active Not RecruitingEst. Mar 2032

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Ferring PharmaceuticalsSodium hyaluronate
Biosplice TherapeuticsLorecivivint
Anika TherapeuticsCingal
ApimedsApitox, purified honeybee toxin, lyophilized in saline
Ferring Pharmaceuticals1.2% Sodium Hyaluronate
RegeneronREGN5069
TevaTV-45070
Nektar TherapeuticsNKTR-181
PfizerARRY-371797, p38 inhibitor; oral
Apimedshoneybee venom
MedactaMulticentre GMK UNI Anatomical Cementless Study - FR

Clinical Trials (11)

Total enrollment: 1,461 patients across 11 trials

NCT00422643Ferring PharmaceuticalsSodium hyaluronate

The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator

Start: Mar 2007Est. completion: Oct 200760 patients
Phase 4Unknown
NCT04931667Biosplice TherapeuticsLorecivivint

3-year, Open-Label Study Evaluating Safety, Tolerability, and Efficacy of Lorecivivint in Subjects With Osteoarthritis of the Knee

Start: Jul 2021Est. completion: Dec 2021
Phase 3Terminated
NCT02381652Anika TherapeuticsCingal

Repeat Injection of Cingal® for Osteoarthritis of the Knee

Start: Feb 2015Est. completion: May 2015
Phase 3Completed
NCT01112722ApimedsApitox, purified honeybee toxin, lyophilized in saline

Apitox, Honeybee Toxin for Pain and Inflammation of Osteoarthritis

Start: Dec 2013Est. completion: Dec 2016
Phase 3Completed
NCT00988091Ferring Pharmaceuticals1.2% Sodium Hyaluronate

Investigation of 1.2% Sodium Hyaluronate for Treatment of Painful Chronic Osteoarthritis of the Knee

Start: Sep 2009Est. completion: Apr 2011596 patients
Phase 3Completed
NCT03956550RegeneronREGN5069

A Study to Examine the Efficacy and Safety of REGN5069 in Patients With Pain Due to Osteoarthritis of the Knee

Start: May 2019Est. completion: Oct 2020259 patients
Phase 2Terminated
NCT02068599TevaTV-45070

A Study to Evaluate the Safety and Efficacy of Topically Applied TV-45070 (Ointment) in Participants With Primary Osteoarthritis (OA) Affecting a Single Knee

Start: Apr 2014Est. completion: May 2015389 patients
Phase 2Completed
NCT01619839Nektar TherapeuticsNKTR-181

A Phase 2 Study To Assess The Efficacy, Tolerability, And Safety OF NKTR-181 In Subjects With Chronic OA Knee Pain

Start: Jun 2012Est. completion: Sep 2013
Phase 2Completed
NCT01366014PfizerARRY-371797, p38 inhibitor; oral

A Study of ARRY-371797 in Patients With Osteoarthritis of the Knee

Start: Jun 2011Est. completion: Jun 2012157 patients
Phase 2Completed
NCT00949754Apimedshoneybee venom

Apitox, Honeybee Venom Treatment for Osteoarthritis Pain and Inflammation

Start: Oct 2009Est. completion: Apr 2010
Phase 2Completed
NCT06715917MedactaMulticentre GMK UNI Anatomical Cementless Study - FR

Multicentre GMK UNI Anatomical Cementless Study - FR

Start: Mar 2017Est. completion: Mar 2032
N/AActive Not Recruiting

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

4 late-stage (Phase 3) programs — potential near-term approvals
11 companies competing in this space