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Osteoarthritis Knee Pain

4
Pipeline Programs
3
Companies
5
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
4
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

3 companies ranked by most advanced pipeline stage

Prevail Therapeutics
4 programs
4
DuloxetinePhase 31 trial
DuloxetinePhase 31 trial
DuloxetinePhase 31 trial
DuloxetinePhase 31 trial
Active Trials
NCT00433290Completed256Est. May 2008
NCT00408421Completed231Est. Oct 2007
NCT01018680Completed524Est. Apr 2011
+1 more trials
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
1 program
DuloxetinePHASE_3
Saol Therapeutics
Saol TherapeuticsGA - Roswell
1 program
SL1002PHASE_31 trial
Active Trials
NCT07226258Recruiting150Est. Feb 2027

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Saol TherapeuticsSL1002
Prevail TherapeuticsDuloxetine
Prevail TherapeuticsDuloxetine
Prevail TherapeuticsDuloxetine
Prevail TherapeuticsDuloxetine

Clinical Trials (5)

Total enrollment: 1,585 patients across 5 trials

NCT07226258Saol TherapeuticsSL1002

Phase III Study to Assess the Safety and Efficacy of SL1002 for Osteoarthritis Knee Pain

Start: Nov 2025Est. completion: Feb 2027150 patients
Phase 3Recruiting
NCT01018680Prevail TherapeuticsDuloxetine

A Study Comparing Duloxetine Versus Placebo in Patients Taking a Nonsteroidal Anti-inflammatory Drug (NSAID) for Knee Pain Due to Osteoarthritis

Start: Nov 2009Est. completion: Apr 2011524 patients
Phase 3Completed
NCT00945945Prevail TherapeuticsDuloxetine

A Study of Duloxetine in Patients With Osteoarthritis Knee Pain

Start: Jul 2009Est. completion: May 2010424 patients
Phase 3Completed
NCT00433290Prevail TherapeuticsDuloxetine

Duloxetine vs. Placebo in the Treatment of Osteoarthritis Knee Pain

Start: Feb 2007Est. completion: May 2008256 patients
Phase 3Completed
NCT00408421Prevail TherapeuticsDuloxetine

Duloxetine Versus Placebo for Osteoarthritis Knee Pain

Start: Nov 2006Est. completion: Oct 2007231 patients
Phase 3Completed

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

4 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 1,585 patients
3 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.